Discover Oncology,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Nov. 16, 2024
Breast
cancer
is
one
of
the
most
threatening
women
health
diseases
worldwide
and
its
molecular
heterogeneity
offers
a
range
response
to
therapy.
The
role
polyamine
metabolism
receiving
increasing
attention.
Polyamine
not
only
plays
an
important
in
occurrence
development
breast
cancer,
but
also
interacts
with
tumor
immune
microenvironment.
In
this
work,
we
applied
single-cell
RNA-sequencing
(scRNA-seq)
systems
immunological
approaches
interrogate
cell
infiltration
gene-to-gene
co-expressions
bulk
transcriptomes
cancer.
We
acquired
sample
data
from
Cancer
Genome
Atlas
(TCGA)
Gene
Expression
Omnibus
(GEO),
evaluated
status
22
types
using
CIBERSORTx
tool,
respectively.
By
leveraging
Retrospective
various
technologies
including
gene
expression
methylation,
identified
46
proliferation-associated
co-expression
modules
weighted
coexpression
network
analysis
(WGCNA)
approach
along
machine
learning
models
which
turn
delineated
single
level
expressions
features
that
these
selected
module
possessed.
observed
substantial
cellular
microenvironment,
where
lineage-specific
patterns
were
highly
associated
progression.
Moreover,
correlated
could
function
as
regulators
tumors
for
risk
scores
different
patient
groups
defined
by
high-
low-risk.
findings
study
shed
new
light
upon
classification
prognostic
assessment
personalized
treatment
Agronomy,
Journal Year:
2025,
Volume and Issue:
15(1), P. 201 - 201
Published: Jan. 15, 2025
Polyamines
(PAs)
are
low-molecular-weight
compounds
that
contain
amino
groups.
PAs
present
in
a
variety
of
organisms,
including
plants,
animals
and
microorganisms.
In
the
main
putrescine
(PUT),
spermidine
(SPD)
spermine
(SPM).
They
play
crucial
physiological
roles
plant
development,
flowering,
fruit
set,
growth,
ripening
metabolic
processes.
addition,
components
diet
have
role
health
disease.
Furthermore,
been
demonstrated
to
help
overcome
negative
effects
adverse
environmental
factors
both
biotic
abiotic
stresses.
Thus,
objective
this
review
was
examine
recent
literature
regarding
mentioned
apart
from
impact
preharvest
treatments,
applied
at
different
stages
on
fresh
crop
yield
quality
properties
harvest,
their
maintenance
during
storage,
with
special
emphasis
content
bioactive
antioxidant
activity.
Moreover,
addressed
other
processes
affecting
such
as
flowering
set.
Seminars in Immunopathology,
Journal Year:
2025,
Volume and Issue:
47(1)
Published: Jan. 21, 2025
The
intestinal
epithelium
is
a
rapidly
self-renewing
tissue;
the
rapid
turnover
prevents
invasion
of
pathogens
and
harmful
components
from
lumen,
preventing
inflammation
infectious
diseases.
Intestinal
epithelial
barrier
function
depends
on
cell
proliferation
junctions,
as
well
state
immune
system
in
lamina
propria.
Polyamines,
particularly
putrescine,
spermidine,
spermine,
are
essential
for
many
functions
play
crucial
role
mammalian
cellular
homeostasis,
such
that
growth,
proliferation,
differentiation,
maintenance,
through
multiple
biological
processes,
including
translation,
transcription,
autophagy.
Although
vital
polyamines
normal
growth
has
been
known
since
1980s,
recent
studies
have
provided
new
insights
into
this
topic
at
molecular
level,
eukaryotic
initiation
factor-5A
hypusination
autophagy,
with
advances
polyamine
biology
cells
using
technologies.
This
review
summarizes
our
understanding
regulating
normal,
non-cancerous,
function,
particular
focus
renewal,
differentiation
Biomolecules,
Journal Year:
2025,
Volume and Issue:
15(2), P. 270 - 270
Published: Feb. 12, 2025
The
gut-brain-cancer
axis
represents
a
novel
and
intricate
connection
between
the
gut
microbiota,
neurobiology,
cancer
progression.
Recent
advances
have
accentuated
significant
role
of
microbiota
metabolites
in
modulating
systemic
processes
that
influence
both
brain
health
tumorigenesis.
This
paper
explores
emerging
concept
metabolite-mediated
modulation
within
connection,
focusing
on
key
such
as
short-chain
fatty
acids
(SCFAs),
tryptophan
derivatives,
secondary
bile
acids,
lipopolysaccharides
(LPS).
While
microbiota's
impact
immune
regulation,
neuroinflammation,
tumor
development
is
well
established,
gaps
remain
grasping
how
specific
contribute
to
neuro-cancer
interactions.
We
discuss
with
potential
implications
for
neurobiology
cancer,
indoles
polyamines,
which
yet
be
extensively
studied.
Furthermore,
we
review
preclinical
clinical
evidence
linking
dysbiosis,
altered
metabolite
profiles,
tumors,
showcasing
limitations
research
gaps,
particularly
human
longitudinal
studies.
Case
studies
investigating
microbiota-based
interventions,
including
dietary
changes,
fecal
transplantation,
probiotics,
demonstrate
promise
but
also
indicate
hurdles
translating
these
findings
therapies.
concludes
call
standardized
multi-omics
approaches
bi-directional
frameworks
integrating
microbiome,
neuroscience,
oncology
develop
personalized
therapeutic
strategies
patients.
Frontiers in Immunology,
Journal Year:
2025,
Volume and Issue:
16
Published: Feb. 18, 2025
Growing
attention
has
been
directed
toward
the
critical
role
of
polyamines
in
tumor
microenvironment
and
immune
regulation.
Polyamines,
primarily
comprising
putrescine,
spermidine,
spermine,
are
tightly
regulated
through
coordinated
biosynthesis,
catabolism,
transport,
with
distinct
metabolic
patterns
between
normal
cancerous
tissues.
Emerging
evidence
highlights
pivotal
polyamine
metabolism
initiation,
progression,
metastasis.
This
review
aims
to
elucidate
differences
catabolism
tissues,
as
well
associated
alterations
epigenetic
modifications
resistance
checkpoint
blockade
driven
by
metabolism.
Polyamine
influences
both
cells
modulating
cell
phenotypes-shifting
them
towards
either
suppression
or
evasion
within
microenvironment.
Additionally,
impacts
immunotherapy
its
regulation
key
enzymes.
also
explores
potential
therapeutic
targets
summarizes
roles
inhibitors
combination
for
cancer
treatment,
offering
a
novel
perspective
on
strategies.
Current Opinion in Oncology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 21, 2025
Purpose
of
review
Normal
and
malignant
prostate
engage
in
high
rates
de
novo
polyamine
synthesis.
This
considers
how
metabolism
regulates
cancer
initiation
progression.
Recent
findings
The
androgen
receptor
(AR)
establishes
a
metabolic
program
to
drive
robust
synthesis
the
normal
prostate.
Upon
transformation,
this
AR-driven
persists
is
optimized
for
oncogenesis
by
proto-oncogene
MYC
and/or
alterations
PI3K
signaling.
A
deeper
understanding
function
polyamines
may
be
obtained
considering
their
Summary
support
ongoing
research
into
role
driving
progression
suggest
targeting
remains
promising
therapeutic
strategy
prevention
treatment
cancer.
European Journal of Immunology,
Journal Year:
2025,
Volume and Issue:
55(4)
Published: April 1, 2025
ABSTRACT
The
fate
of
immune
cells
is
fundamentally
linked
to
their
metabolic
program,
which
also
influenced
by
the
landscape
environment.
tumor
microenvironment
represents
a
unique
system
for
intercellular
interactions,
where
tumor‐derived
metabolites
suppress
effector
CD8
+
T
and
promote
tumor‐promoting
macrophages,
reinforcing
an
immune‐suppressive
niche.
This
review
will
discuss
recent
advancements
in
metabolism
research,
exploring
interplay
between
various
effects
on
within
microenvironment.
Cell Death and Disease,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: April 17, 2025
Abstract
Osteosarcoma,
the
most
prevalent
malignant
bone
tumor
among
adolescents,
frequently
exhibits
limited
responsiveness
to
immunotherapy,
a
challenge
attributed
poorly
understood
underlying
mechanisms.
Here,
we
identify
enhanced
polyamine
biosynthesis
as
key
driver
of
osteosarcoma
progression
and
immunotherapy
resistance.
We
show
that
cell
proliferation
growth
rely
on
availability
disruption
synthesis
significantly
boosts
cytotoxic
efficacy
TCR-engineered
T
cells
against
cells.
Mechanistically,
reveal
knockdown
antizyme
inhibitor
1
(
AZIN1
)
or
suppression
production
reduces
MYC
expression,
leading
diminished
viability
via
downregulation
cycle-related
genes.
Furthermore,
reduced
levels
are
associated
with
changes
in
expression
immunomodulatory
cytokines
human
leukocyte
antigen
molecules,
pointing
potential
link
T-cell-mediated
cytotoxicity.
Collectively,
our
findings
establish
pivotal
role
for
AZIN1-polyamine
axis
immune
evasion,
support
development
novel
immunotherapeutic
strategies
targeting
combat
this
aggressive
cancer.
Cell Death and Disease,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: April 23, 2025
Abstract
Prostate
cancer
is
the
fifth
cause
of
death
by
worldwide,
second
in
incidence
male
population.
The
definition
molecular
basis
its
development
and
oncogenic
signals
driving
lethality
continue
to
be
important
objectives
prostate
research.
Prior
work
from
others
us
has
demonstrated
that
loss
PGC1α
expression
results
a
metabolic,
signaling
transcriptional
reprogramming
supports
metastatic
disease.
However,
we
do
not
fully
understand
spectrum
tumor
suppressive
effects
regulated
this
co-regulator.
Here
show
governs
non-cell
autonomous
paracrine
suppression
cancer.
A
systematic
analysis
landscapes
associated
revealed
alters
genes
encoding
for
secreted
proteins.
Cell
secretome
studies
corroborated
PGC1α-dependent
ERRα
regulation
cells
suppresses
growth
exposed
their
conditioned
media,
independently
androgen
receptor
status.
integration
vitro
vivo
secretomics
data
genetic
perturbation
assays
spermidine
synthase
as
target
mediator
metabolic
effect.
Moreover,
activity
regulatory
axis
PGC1α-ERRα-SRM
was
reflected
patients
had
prognostic
value.
Altogether,
provides
unprecedented
evidence
role
PGC1α,
which
broadens
view
co-regulator
multifactorial
suppressor
