Journal of Materials Science, Journal Year: 2025, Volume and Issue: unknown
Published: May 2, 2025
Language: Английский
Neural Regeneration Research, Journal Year: 2024, Volume and Issue: 20(4), P. 1042 - 1057
Published: April 3, 2024
Spinal cord injuries impose a notably economic burden on society, mainly because of the severe after-effects they cause. Despite ongoing development various therapies for spinal injuries, their effectiveness remains unsatisfactory. However, deeper understanding metabolism has opened up new therapeutic opportunity in form metabolic reprogramming. In this review, we explore changes that occur during consequences, and tools available Normal is characterized by independent cellular intercellular coupling. injury results disorders include disturbances glucose metabolism, lipid mitochondrial dysfunction. These lead to corresponding pathological changes, including failure axonal regeneration, accumulation scarring, activation microglia. To rescue at level, potential reprogramming approaches have emerged, replenishing substrates, reconstituting couplings, targeting alter cell fate. The evidence suggests holds great promise as next-generation approach treatment injury. further advance injury, future efforts should focus neurometabolism, more advanced metabolomics technologies, design highly effective interventions.
Language: Английский
Citations
4
Advanced Science, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 18, 2024
Abstract Spinal cord injury (SCI) is a severe to the central nervous system, and its treatment always major medical challenge. Proinflammatory cell death considered an important factor affecting neuroinflammation prognosis after injury. PANoptosis, newly discovered type of proinflammatory death, regulates activation executioner molecules apoptosis, pyroptosis necroptosis through PANoptosome, providing new target for therapeutic intervention SCI. However, role regulatory mechanism in SCI are not yet elucidated. Here, based on proteomic data, YBX1 expression significantly increased neurons Guided by RIP‐seq, subsequent experiments reveal that promotes ZBP1 stabilizing Zbp1 mRNA, thereby aggravating ZBP1‐mediated PANoptosis. Furthermore, E3 ubiquitin ligase TRIM56 identified as endogenous inhibitor via molecular docking IP/MS analysis. Mechanistically, bound promoted ubiquitination, accelerating degradation. Taken together, these findings novel function regulating PANoptosis pathogenesis verified functions promote ubiquitin‐proteasomal degradation YBX1, insights into strategies.
Language: Английский
Citations
4
ACS Biomaterials Science & Engineering, Journal Year: 2023, Volume and Issue: 9(10), P. 5709 - 5723
Published: Sept. 15, 2023
Spinal cord injury is an impact-induced disabling condition. A series of pathological changes after spinal (SCI) are usually associated with oxidative stress, inflammation, and apoptosis. These eventually lead to paralysis. The short half-life low bioavailability many drugs also limit the use in SCI. In this study, we designed nanovesicles derived from macrophages encapsulating selenium nanoparticles (SeNPs) metformin (SeNPs-Met-MVs) be used treatment can cross blood–spinal barrier (BSCB) deliver SeNPs Met site exert anti-inflammatory reactive oxygen species scavenging effects. Transmission electron microscopy (TEM) images showed that SeNPs-Met-MVs particle size was approximately 125 ± 5 nm. Drug release assays exhibited sustained encapsulation by macrophage cell membrane. cumulative 80% over 36 h. vitro cellular experiments vivo animal demonstrated decreased (ROS) malondialdehyde (MDA) levels, increased superoxide dismutase (SOD) glutathione peroxidase (GSH-Px) activities, reduced expression inflammatory (TNF-α, IL-1β, IL-6) apoptotic (cleaved caspase-3) cytokines tissue addition, motor function mice significantly improved treatment. Therefore, have a promising future
Language: Английский
Citations
10
European Journal of Immunology, Journal Year: 2023, Volume and Issue: 54(1)
Published: Oct. 12, 2023
Spinal cord injury (SCI) affects hundreds of thousands people in the United States, and while some effects are broadly recognized (deficits to locomotion, fine motor control, quality life), systemic consequences SCI less well-known. The spinal regulates immunological visceral functions; this control is often disrupted by injury, resulting viscera including gut, spleen, liver, bone marrow, kidneys experiencing local tissue inflammation physiological dysfunction. extent pathology depends on level, severity, time post-injury. In review, we describe metabolic across several organs. Since infection disorders primary reasons for reduced lifespan after SCI, it imperative that research continues focus these deleterious aspects improve life span individuals with SCI.
Language: Английский
Citations
10
Asian Pacific Journal of Tropical Biomedicine, Journal Year: 2025, Volume and Issue: 15(1), P. 34 - 42
Published: Jan. 1, 2025
Objective: To assess the protective effects of trigonelline against spinal cord injury (SCI) in rats. Methods: Rats (Sprague-Dawley, male) were randomly assigned to seven groups ( n =15 per group): normal, sham, SCI control (1% DMSO), methylprednisolone (30 mg/kg), and (50, 100, 200 mg/kg). received respective treatment daily for 28 days. was induced by using a temporary aneurysm clip. Behavioral, biochemical, histological analyses performed investigate neuroprotective effect trigonelline. Results: Trigonelline (100 mg/kg) effectively P <0.05) mitigated SCI-induced changes mechano-tactile sensation, allodynia, hyperalgesia, motor nerve conduction velocity. It notably downregulated apoptotic (Bax caspase-3) inflammatory (COX-II) markers, while upregulating Bcl-2 BDNF mRNA expression <0.05). Furthermore, alleviated alterations mitochondrial complex levels, resulting enhanced nicotinamide adenine dinucleotide dehydrogenase, succinate redox activity, cytochrome-C levels. Histological examination tissue indicated that significantly ameliorated damage caused SCI, thereby improving neuronal degeneration, cell infiltration, necrosis. Conclusions: shows properties rats reducing inflammation, stabilizing enzyme complexes, modulating neurotrophic factors. Thus, holds promise as potential agent.
Language: Английский
Citations
0
Nano Today, Journal Year: 2025, Volume and Issue: 61, P. 102643 - 102643
Published: Jan. 20, 2025
Language: Английский
Citations
0
Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13
Published: Jan. 29, 2025
Spinal cord injury (SCI) results in severe disruption of communication between the brain and body, causing motor, sensory, autonomic dysfunctions. While SCI mammals leads to permanent impairment due limited regenerative capacity, certain non-mammalian species, such as Xenopus laevis larval stages, exhibit remarkable abilities. During spinal regeneration, neural stem precursor cells (NSPCs) surrounding central canal rapidly proliferate response SCI, compensating for cellular loss, restoring continuity, generating new neurons reestablish lost connections. It has been described that mitochondria metabolism play essential roles cell proliferation, self-renewal, differentiation. However, mitochondrial metabolic during regeneration remains unexplored. This study uses electron confocal microscopy investigate NSPCs following SCI. We observed a rapid transient after characterized by localization, decrease number per section, an increase area circularity. Furthermore, adopted swollen phenotype, which did not impair function or energy balance. morphological shift was accompanied membrane potential switch favoring glycolysis. Therefore, these findings demonstrate toward glycolysis occurs regeneration.
Language: Английский
Citations
0
Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 315 - 346
Published: Jan. 1, 2025
Language: Английский
Citations
0
IBRO Neuroscience Reports, Journal Year: 2025, Volume and Issue: 18, P. 293 - 299
Published: Feb. 6, 2025
Spinal cord injury (SCI) is a debilitating condition of the nervous system that imposes considerable challenges for subjects, such as bladder and bowel incontinence infections. The standard therapeutic strategy methylprednisolone utilization accompanied by surgical decompression. However, achieving an effective therapy with minimum side effects SCI still puzzle. Nowadays, mesenchymal stem cell (MSC) has received much consideration in scientific communities light its pharmacological properties, instance, anti-inflammatory, regenerative, analgesic, immunomodulatory influences. Despite mentioned advantages MSCs, their tumorigenic potential limiting agent wide application. Recent documents show use conditioned medium (CM) derived from MSCs can largely solve these problems. CM encompasses neuroprotective growth factors cytokines, factor (SCF), vascular endothelial (VEGF), glial line-derived neurotrophic (GDNF). persuasive evidence experimental studies revealed originating have role amelioration SCI. Hence, current papers, we will review summarize indicating anti-SCI mechanisms MSC-derived relying data.
Language: Английский
Citations
0
Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101624 - 101624
Published: Feb. 28, 2025
Traumatic spinal cord injury (SCI) is a major clinical challenge, imposing significant burden on both patients and healthcare systems. The complexity of SCI stems from its multifactorial pathogenesis, incorporating variety regulating factors. Despite the exploration mechanisms pathophysiology development biomedical therapies, current interventions are still limited to surgical rehabilitative care. This study introduces an approach protect mitochondria-a pivotal factor in pathogenesis-through use poly(glycerol succinate)-based hydrogel. To regulate process, PEGylated succinate) (PPGS), was designed synthesized via novel method, combined with recent findings that emphasize roles glycerol-based hydrogel soft tissue regeneration. Building these, innovative, bioenergetically-active hydrogel, acrylated (APPGS), which improves mitochondrial function after injury, targeting treatment, developed. evidence, supported by vivo vitro assays, affirms therapeutic efficacy APPGS contexts. represents advancement substantial potential for application therapy, offering new avenue addressing complex challenges management.
Language: Английский
Citations
0