Mitochondrial transplantation for cardioprotection and induction of angiogenesis in ischemic heart disease

Stem Cell Research & Therapy, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 7, 2025

To date, the regenerative potential of mitochondrial transplantation (MT) has been extensively investigated under several pathologies. Among various cardiovascular diseases, ischemic heart disease (IHD), most prevalent pathological condition in human medicine, is induced by coronary artery narrowing, or occlusion, leading to bulk necrotic changes and fibrosis within myocardium. Data associated with pro-angiogenic activity mitochondria have not completely elucidated terms cardiac tissue regeneration. Here, we aimed highlight recent studies advantages related application mass How which mechanisms, can reduce aberrant myocardial remodeling via different pathways such as angiogenesis de novo blood formation was discussed detail. We hope that data from current review article help us understand molecular cellular mechanisms transplanted exert their properties

Language: Английский

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A novel carbazole-pyrimidine-based dual mode fluorescent probe for detection of acidic and basic pH in biological systems

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2025, Volume and Issue: 330, P. 125709 - 125709

Published: Jan. 6, 2025

Language: Английский

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DNA Methylation in Periodontal Disease: A Focus on Folate, Folic Acid, Mitochondria, and Dietary Intervention

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3225 - 3225

Published: March 30, 2025

Although periodontal disease (PD) is reported to be associated with changes in various genes and proteins both invading bacteria the host, its molecular mechanism of pathogenesis remains unclear. Changes immune inflammatory play a significant role PD pathogenesis. Some reports relate alterations cellular epigenetic patterns characteristics, while several high-throughput analyses indicate thousands differentially methylated patients controls. Furthermore, DNA methylation inflammation-related have been linked efficacy therapy, as demonstrated by findings related cytochrome C oxidase II gene. Distinct mesenchymal stem cells from controls persisted despite reversal phenotypic PD. Methyl groups for are supplied S-adenosylmethionine, which synthesized involvement folate, an essential nutrient known maintaining mitochondrial homeostasis, compromised Folate may benefit through antioxidant action against reactive oxygen nitrogen species that overproduced dysfunctional mitochondria. As such, methylation, dietary quality control interact In this narrative/hypothesis review, we demonstrate how may, turn, improved potentially altering nucleus Therefore, folate-based intervention recommended prevention adjunct therapy. At same time, further research needed on mechanisms beneficial effects folate studies.

Language: Английский

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The Role of Aging and Senescence in Bone Marrow Transplantation Outcome

Advances in experimental medicine and biology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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Stroke in Pregnancy Brings Epigenetic Changes in Correlation with Affected Mitochondrial Dynamics and Inflammasome Mediated Apoptosis in Rodents

Journal of the American Heart Association, Journal Year: 2025, Volume and Issue: unknown

Published: May 2, 2025

Background Pregnancy may be a risk factor for stroke in females. Stroke pregnancy influences mitochondrial dynamics as well the inflammatory responses mothers. However, limited studies are available that report any epigenetic changes offspring following In present study we investigate effect of possible modifier correlated with dysfunctional and exacerbated inflammasome mediated apoptosis offsprings. Methods Results Female male Sprague Dawley rats were housed same cage 1:2 ratio to ensure successful pregnancy. was induced by middle cerebral artery occlusion at gestational day 17. After delivery F1 generation, bloods collected from dams hormonal study. Brains harvested both generation biochemical, histological, genetic, molecular, studies. dams, an increased fission decreased fusion observed compared normal their generation. Similarly, enhanced reactive oxygen species depolarization also dams. Exacerbated signaling evident this Changes histone‐methylation corresponding inflammation Conclusions The reports occurrence modifications towards dysfunction pregnant

Language: Английский

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Exercise epigenetics is fueled by cell bioenergetics: Supporting role on brain plasticity and cognition

Free Radical Biology and Medicine, Journal Year: 2024, Volume and Issue: 220, P. 43 - 55

Published: April 25, 2024

Language: Английский

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Regulation of glucose metabolism: effects on oocyte, preimplantation embryo, assisted reproductive technology and embryonic stem cell

Heliyon, Journal Year: 2024, Volume and Issue: 10(19), P. e38551 - e38551

Published: Sept. 28, 2024

Language: Английский

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Artificial mitochondrial transplantation (AMT) reverses aging of mesenchymal stromal cells and improves their immunomodulatory properties in LPS-induced synoviocytes inflammation

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Journal Year: 2024, Volume and Issue: 1871(7), P. 119806 - 119806

Published: Aug. 3, 2024

Nowadays, regenerative medicine techniques are usually based on the application of mesenchymal stromal cells (MSCs) for repair or restoration injured damaged tissues. However, effectiveness autologous therapy is limited as therapeutic potential MSCs declines due to patient's age, health condition and prolonged in vitro cultivation a result decreased growth rate. For that reason, there an urgent need develop strategies enabling rejuvenation prior transplantation order enhance their vivo efficiency. In presented study, we attempted mimic naturally occurring mitochondrial transfer (MT) between neighbouring verify whether artificial MT (AMT) could reverse aging improve biological properties. mitochondria were isolated from healthy donor equine adipose-derived (ASCs) transferred into metabolically impaired recipient ASCs derived metabolic syndrome (EMS) affected horses, which subsequently subjected various analytical methods cellular molecular outcomes applied AMT. Mitochondria characterized by apoptosis, senescence endoplasmic reticulum stress while insulin sensitivity was enhanced. Furthermore, observed increased fragmentation associated PARKIN protein accumulation, indicates elimination dysfunctional organelles via mitophagy. AMT further promoted physioxia regulated autophagy fluxes. Additionally, rejuvenated displayed improved anti-inflammatory activity toward LPS-stimulated synoviocytes. The findings highlight promising alternative effective method rejuvenation, therapies properties being strongly deteriorated patients' condition.

Language: Английский

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The Role of Mitochondrial Homeostasis in Mesenchymal Stem Cell Therapy—Potential Implications in the Treatment of Osteogenesis Imperfecta

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(10), P. 1297 - 1297

Published: Sept. 29, 2024

Osteogenesis imperfecta (OI) is a hereditary disorder characterized by bones that are fragile and prone to breaking. The efficacy of existing therapies for OI limited, they associated with potentially harmful side effects. primarily due mutation collagen type I hence impairs bone regeneration. Mesenchymal stem cell (MSC) therapy an attractive strategy take advantage the potential benefits these multipotent cells address underlying molecular defects differentiating osteoblasts, paracrine effects, or immunomodulation. maintenance mitochondrial homeostasis essential component improving curative MSCs in affecting differentiation, signaling, immunomodulatory functions MSCs. In this review, we highlight MSC-based pathway introduce MSC regulation mechanism homeostasis. Strategies aiming modulate metabolism reduce oxidative stress, as well innovative strategies based on use compounds (resveratrol, NAD+, α-KG), antioxidants, nanomaterials, analyzed. These findings may enable development new treatment OI, ultimately resulting improved patient outcomes.

Language: Английский

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The Role of Insulin Within the Socio-Psycho-Biological Framework in Type 2 Diabetes—A Perspective from Psychoneuroimmunology

Biomedicines, Journal Year: 2024, Volume and Issue: 12(11), P. 2539 - 2539

Published: Nov. 7, 2024

The interplay between socio-psychological factors and biological systems is pivotal in defining human health disease, particularly chronic non-communicable diseases. Recent advancements psychoneuroimmunology mitochondrial psychobiology have emphasized the significance of psychological as critical determinants disease onset, progression, recurrence, severity. These insights align with evolutionary biology, psychology, psychiatry, highlighting inherent social nature humans. This study proposes a theory that expands insulin's role beyond traditional metabolic functions, incorporating it into Mitochondrial Information Processing System (MIPS) exploring from an medicine perspective to explore its function processing responses. narrative review comprises data preclinical animal studies, longitudinal cohort cross-sectional machine learning analyses, randomized controlled trials, investigates insulin disease. result proposal for theoretical framework substance within socio-psycho-biological framework, emphasizing extensive roles Type 2 Diabetes Mellitus (T2DM) musculoskeletal disorders neurodegeneration exemplifies this narrative. We suggest further research towards comprehensive treatment protocol meeting expectations, where psychosocial interventions plays essential role. By supporting concept 'insulin resilience' suggesting use heart rate variability assess resilience, we aim provide integrative approach managing levels monitoring effectiveness interventions. strategy addresses broader factors, ultimately improving outcomes individuals T2DM complications while providing new

Language: Английский

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