The Role of STING-Mediated Activation of Dendritic Cells in Cancer Immunotherapy DOI Creative Commons
Ana Rita Salgado Ribeiro, Theresa Neuper, Jutta Horejs‐Hoeck

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 10685 - 10697

Published: Oct. 1, 2024

The signaling pathway that comprises cyclic guanosine monophosphate-adenosine monophosphate (cGAMP or GMP-AMP) synthase (cGAS) and Stimulator of Interferon Genes (STING) is emerging as a druggable target for immunotherapy, with tumor-resident dendritic cells (DC) playing critical role in mediating its effects. STING receptor part the DNA-sensing cellular machinery, can trigger secretion pro-inflammatory mediators, priming effector T initiating specific antitumor responses. Yet, recent studies have highlighted dual activation context cancer: either promote responses enhance tumor progression. This dichotomy often depends on cell type which cGAS-STING induced mode, namely acute versus chronic. Of note, at DC level appears to be particularly important eradication. review outlines contribution different conventional plasmacytoid subsets describes mechanisms underlying STING-mediated DCs cancer. We further highlight how plays an intricate modulating function embedded tissue. Additionally, we discuss strategies being employed harness cancer treatment, such development synthetic agonists nano-based delivery systems, spotlighting current techniques used prompt engagement specifically DCs.

Language: Английский

The Role of STING-Mediated Activation of Dendritic Cells in Cancer Immunotherapy DOI Creative Commons
Ana Rita Salgado Ribeiro, Theresa Neuper, Jutta Horejs‐Hoeck

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 10685 - 10697

Published: Oct. 1, 2024

The signaling pathway that comprises cyclic guanosine monophosphate-adenosine monophosphate (cGAMP or GMP-AMP) synthase (cGAS) and Stimulator of Interferon Genes (STING) is emerging as a druggable target for immunotherapy, with tumor-resident dendritic cells (DC) playing critical role in mediating its effects. STING receptor part the DNA-sensing cellular machinery, can trigger secretion pro-inflammatory mediators, priming effector T initiating specific antitumor responses. Yet, recent studies have highlighted dual activation context cancer: either promote responses enhance tumor progression. This dichotomy often depends on cell type which cGAS-STING induced mode, namely acute versus chronic. Of note, at DC level appears to be particularly important eradication. review outlines contribution different conventional plasmacytoid subsets describes mechanisms underlying STING-mediated DCs cancer. We further highlight how plays an intricate modulating function embedded tissue. Additionally, we discuss strategies being employed harness cancer treatment, such development synthetic agonists nano-based delivery systems, spotlighting current techniques used prompt engagement specifically DCs.

Language: Английский

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