Metformin in Antiviral Therapy: Evidence and Perspectives DOI Creative Commons
Iryna Halabitska, Pavlo Petakh, Oleh Lushchak

et al.

Viruses, Journal Year: 2024, Volume and Issue: 16(12), P. 1938 - 1938

Published: Dec. 18, 2024

Metformin, a widely used antidiabetic medication, has emerged as promising broad-spectrum antiviral agent due to its ability modulate cellular pathways essential for viral replication. By activating AMPK, metformin depletes energy reserves that viruses rely on, effectively limiting the replication of pathogens such influenza, HIV, SARS-CoV-2, HBV, and HCV. Its role in inhibiting mTOR pathway, crucial protein synthesis reactivation, is particularly significant managing infections caused by CMV, EBV. Furthermore, reduces oxidative stress reactive oxygen species (ROS), which are critical replicating arboviruses Zika dengue. The drug also regulates immune responses, differentiation, inflammation, disrupting life cycle HPV potentially other viruses. These diverse mechanisms suppress replication, enhance system functionality, contribute better clinical outcomes. This multifaceted approach highlights metformin’s potential an adjunctive therapy treating wide range infections.

Language: Английский

Targeting Mitochondrial Dysfunction in Cerebral Ischemia: Advances in Pharmacological Interventions DOI Creative Commons
И. Ф. Беленичев, Olena Popazova, Nina Bukhtiyarova

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(1), P. 108 - 108

Published: Jan. 18, 2025

The study of mitochondrial dysfunction has become increasingly pivotal in elucidating the pathophysiology various cerebral pathologies, particularly neurodegenerative disorders. Mitochondria are essential for cellular energy metabolism, regulation reactive oxygen species (ROS), calcium homeostasis, and execution apoptotic processes. Disruptions function, driven by factors such as oxidative stress, excitotoxicity, altered ion balance, lead to neuronal death contribute cognitive impairments several brain diseases. Mitochondrial can arise from genetic mutations, ischemic events, hypoxia, other environmental factors. This article highlights critical role progression diseases discusses need targeted therapeutic strategies attenuate damage, restore enhance neuroprotection.

Language: Английский

Citations

1
mRNA vaccine platforms: linking infectious disease prevention and cancer immunotherapy DOI Creative Commons
Dariush Haghmorad, Majid Eslami,

Niloufar Orooji

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: March 12, 2025

The advent of mRNA vaccines, accelerated by the global response to COVID-19 pandemic, marks a transformative shift in vaccine technology. In this article, we discuss development, current applications, and prospects vaccines for both prevention treatment infectious diseases oncology. By leveraging capacity encode antigens within host cells directly, provide versatile scalable platform suitable addressing broad spectrum pathogens tumor-specific antigens. We highlight recent advancements design, innovative delivery mechanisms, ongoing clinical trials, with particular emphasis on their efficacy combating diseases, such as COVID-19, Zika, influenza, well emerging potential cancer immunotherapy. also address critical challenges, including stability, optimization immune responses, broader issue accessibility. Finally, review strategies advancing next-generation aim overcoming limitations technology enhancing preventive therapeutic approaches oncological diseases.

Language: Английский

Citations

1
Metformin as a disease-modifying therapy in osteoarthritis: bridging metabolism and joint health DOI Creative Commons
Iryna Halabitska, Pavlo Petakh, Oleksandr Kamyshnyi

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: March 19, 2025

Background Osteoarthritis (OA) and impaired glucose tolerance (IGT) frequently coexist, leading to compounded clinical metabolic challenges. This study investigates the effects of metformin in improving both outcomes (pain, stiffness, physical function) parameters (inflammatory markers, lipid profile, BMI) patients with knee OA IGT. Methods The included 60 diagnosed Participants were divided into two groups: 26 received standard treatment without (Without Metf), while 34 (500 mg twice daily) for 3 months, addition (With Metf). Clinical assessments (WOMAC, Lequesne Algofunctional Index, KOOS, VAS) markers (CRP, NLR, SOD, measured before treatment, after 1 month, months. Results With Metf group showed significantly greater improvements pain, function, quality life compared Without group. Metformin also led significant reductions inflammatory profiles health indicators. demonstrated enhanced BMI, waist-to-hip ratio, waist-to-height ratio. Furthermore, need increased NSAID doses was predicted by factors such as pain severity markers. Conclusion effectively alleviates osteoarthritis symptoms improves Further research is needed explore its long-term on joint health, potential role management

Language: Английский

Citations

0
The Bidirectional Relationship Between the Gut Microbiome and Mental Health: A Comprehensive Review DOI Open Access

Kanchanbala Rathore,

Neha Shukla, Sunil G. Naik

et al.

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: March 19, 2025

The gut microbiome plays a fundamental role in mental health, influencing mood, cognition, and emotional regulation through the gut-brain axis. This bidirectional communication system connects gastrointestinal CNS, facilitated by microbial metabolites, neurotransmitters, immune interactions. Recent research highlights association between dysbiosis psychiatric disorders, including anxiety, depression, stress-related conditions. Key findings indicate that altered diversity, decreased short-chain fatty acid (SCFA) production, increased neuroinflammation contribute to health disturbances. paper explores mechanism linking brain function, neurotransmitter synthesis, vagus nerve signaling, hypothalamic-pituitary-adrenal (HPA) axis modulation. Additionally, it evaluates potential of microbiome-targeted interventions, such as probiotics, prebiotics, dietary modifications, fecal microbiota transplantation (FMT), alleviating symptoms. Microbiome sequencing bioinformatics advances further support development personalized microbiome-based interventions. Despite promising evidence, challenges inter-individual variability, methodological inconsistencies, need for longitudinal studies remain. Future should focus on standardizing assessment techniques optimizing therapeutic applications. Integrating precision psychiatry with diagnostics holds immense transforming treatment.

Language: Английский

Citations

0
Unraveling the gut microbiota’s role in obesity: key metabolites, microbial species, and therapeutic insights DOI Creative Commons

M. Iqbal,

Yu Qian, Jingqun Tang

et al.

Journal of Bacteriology, Journal Year: 2025, Volume and Issue: unknown

Published: April 4, 2025

ABSTRACT Obesity, characterized by excessive fat accumulation, stems from an imbalance between energy intake and expenditure, with the gut microbiota playing a crucial role. This review highlights how influences metabolic pathways, inflammation, adipose tissue regulation in obesity. Specific bacteria metabolites, such as lipopolysaccharides (LPS) short-chain fatty acids (SCFAs), modulate permeability, harvest, impacting obesity development. Certain bacteria, including Clostridium XIVb , Dorea spp., Enterobacter cloacae Collinsella aerofaciens promote increasing inflammatory response through LPS translocation into bloodstream. Conversely, beneficial like Akkermansia muciniphila Lactobacillus Bifidobacterium spp. enhance barrier integrity, regulate SCFA production, fasting-induced factor, which collectively support health reducing storage inflammation. Metabolites SCFAs (acetate, propionate, butyrate) interact G-protein coupled receptors to lipid metabolism browning of white (WAT), thus enhancing thermogenesis expenditure. However, contributes insulin resistance highlighting dual roles these microbial metabolites both supporting disrupting function. Therapeutic interventions targeting microbiota, promoting WAT activating brown (BAT), hold promise for management. personalized approaches are necessary due individual microbiome variability. Further research is essential translate insights microbiota-based clinical therapies.

Language: Английский

Citations

0
Multi-omic analyses of the development of obesity-related depression linked to the gut microbe Anaerotruncus colihominis and its metabolite glutamate DOI
Zhengyan Chang,

Yefei Zhu,

Ping Wang

et al.

Science Bulletin, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Genetic Predictors of Paxlovid Treatment Response: The Role of IFNAR2, OAS1, OAS3, and ACE2 in COVID-19 Clinical Course DOI Open Access
Mykhailo Buchynskyi, Iryna Kamyshna, Iryna Halabitska

et al.

Journal of Personalized Medicine, Journal Year: 2025, Volume and Issue: 15(4), P. 156 - 156

Published: April 17, 2025

Background: This study investigated the role of genetic polymorphisms in IFNAR2, OAS1, OAS3, and ACE2 as predictors Paxlovid treatment response, specifically examining their influence on clinical course laboratory parameters COVID-19 patients. Methods: We analyzed impact genes associated with interferon pathway (IFNAR2 rs2236757), antiviral response (OAS1 rs10774671, OAS3 rs10735079), viral entry (ACE2 rs2074192) individuals treated Paxlovid. Results: Our findings suggest that variations these may modulate immune coagulation pathways context during infection. Specifically, IFNAR2 rs2236757 G allele was alterations inflammatory markers, while OAS1 influenced parameters. Furthermore, specific genotypes were linked to changes such oxygen saturation, leukocyte count, liver function markers Paxlovid-treated Conclusions: These results highlight potential considering factors understanding individual responses informing future personalized approaches.

Language: Английский

Citations

0
Unlocking the gut-liver axis: microbial contributions to the pathogenesis of metabolic-associated fatty liver disease DOI Creative Commons
Mykhailo Buchynskyi, Iryna Kamyshna, Iryna Halabitska

et al.

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16

Published: April 25, 2025

Metabolic dysfunction-associated fatty liver disease (MAFLD) is a complex metabolic disorder characterized by hepatic lipid accumulation and subsequent inflammation. This condition closely linked to syndrome obesity, with its prevalence rising due sedentary lifestyles high-calorie diets. The pathogenesis of MAFLD involves multiple factors, including insulin resistance, lipotoxicity, oxidative stress, inflammatory responses. gut microbiota plays crucial role in development, dysbiosis contributing inflammation through various mechanisms, such as enhanced intestinal permeability the translocation bacterial products like lipopolysaccharide (LPS). Microbial metabolites, short-chain acids (SCFAs) bile acids, influence function immune responses, potential implications for progression. Specific microbiome signatures have been identified patients, offering diagnostic therapeutic targets. Moreover, gut-derived toxins, endotoxins, lipopolysaccharides, trimethylamine-N-oxide significantly damage inflammation, highlighting interplay between health. review comprehensively examines MAFLD, focusing on underlying pathogenic biomarkers, emerging microbiome-targeted strategies management.

Language: Английский

Citations

0
Metformin in Antiviral Therapy: Evidence and Perspectives DOI Creative Commons
Iryna Halabitska, Pavlo Petakh, Oleh Lushchak

et al.

Viruses, Journal Year: 2024, Volume and Issue: 16(12), P. 1938 - 1938

Published: Dec. 18, 2024

Metformin, a widely used antidiabetic medication, has emerged as promising broad-spectrum antiviral agent due to its ability modulate cellular pathways essential for viral replication. By activating AMPK, metformin depletes energy reserves that viruses rely on, effectively limiting the replication of pathogens such influenza, HIV, SARS-CoV-2, HBV, and HCV. Its role in inhibiting mTOR pathway, crucial protein synthesis reactivation, is particularly significant managing infections caused by CMV, EBV. Furthermore, reduces oxidative stress reactive oxygen species (ROS), which are critical replicating arboviruses Zika dengue. The drug also regulates immune responses, differentiation, inflammation, disrupting life cycle HPV potentially other viruses. These diverse mechanisms suppress replication, enhance system functionality, contribute better clinical outcomes. This multifaceted approach highlights metformin’s potential an adjunctive therapy treating wide range infections.

Language: Английский

Citations

1