Visible-light photocatalysed synthesis of coumarin derivatives

Tetrahedron Letters, Journal Year: 2024, Volume and Issue: 142, P. 155099 - 155099

Published: May 7, 2024

Language: Английский

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Structural Optimization of Natural Plant Products: Construction, Pesticidal Activities, and Toxicology Study of New 2-Isopropanol-4-methoxy-7-alkyl/aryloxycarbonyl-(E)-vinyl-2,3-dihydrobenzofurans

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 9, 2025

Recently, the structural optimization of natural bioactive products has been one important ways to discover new pesticide candidates. Based on osthole as a lead compound, herein, series 2-isopropanol-4-methoxy-7-alkyl/aryloxycarbonyl-(E)-vinyl-2,3-dihydrobenzofuran derivatives were synthesized. Steric configurations compounds 3, 4, 6, 9, 11, 29, and 31 confirmed by X-ray monocrystallography. Notably, an efficient method for preparation 2-isopropanol-2,3-dihydrobenzofurans from epoxidation rearrangement reactions was developed. Against Plutella xylostella Linnaeus, compound (R = CH2CH2Ph; LC50: 0.759 mg/mL) displayed 1.9-fold insecticidal activity compared that osthole; against Tetranychus cinnabarinus Boisduval, 34 (CH2)9CH3; 0.401 exhibited 3.3-fold acaricidal good control effects those osthole. By scanning electron microscope (SEM) imaging method, it demonstrated may be related damage cuticle layer crest T. cinnabarinus. Compound could further studied potential acaricide.

Language: Английский

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Formulation of Ethyl Cellulose Nanoparticles Encapsulated with Osthole Provides Long-Lasting Plant Protection against a Major Pest Mite

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

The broader use of botanical pesticides has been limited by shorter residual activity on plants, slower onset action, and higher costs compared with conventional pesticides. These challenges could be overcome the development simple, cost-effective, long-lasting preventive nanocomposites for In this study, we successfully developed a low-cost ethyl cellulose (EC)-based delivery system pesticide osthole (OST), designed to provide extended protection against Tetranychus urticae infestations. A comparative analysis three (graphene oxide (GO)-OST, EC-OST, chitosan (CS)-OST) revealed that EC-OST exhibited superior thermal stability, UV resistance, controlled release OST payload, strong acaricidal activity. degradation leaf surfaces was reduced encapsulation in EC, while its penetration into plant tissues improved. When applied leaves, an increase T. mortality, reduction reproduction egg adhesion, impairment feeding behavior through searching times were observed. peak occurrence infestation delayed 10 days following application reducing damage protecting plants more than 20 days. This nanoinsecticide allows low-frequency application, farmers' production costs, increasing profitability, thereby offering great potential promoting protection.

Language: Английский

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Immunomodulatory Effects of Selected Non-Nutritive Bioactive Compounds and Their Role in Optimal Nutrition

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(2), P. 89 - 89

Published: Jan. 31, 2025

The contemporary approach to nutrition increasingly considers the role of non-nutritive bioactive compounds in modulating immune system and maintaining health. This article provides up-to-date insight into immunomodulatory effects selected compounds, including micro- macronutrients, vitamins, as well other health-promoting substances, such omega-3 fatty acids, probiotics, prebiotics, postbiotics (including butyric acid sodium butyrate), coenzyme Q10, lipoic acid, plant-derived components phenolic flavonoids, coumarins, alkaloids, polyacetylenes, saponins, carotenoids, terpenoids. Micro- zinc, selenium, magnesium, iron, play a pivotal regulating response protecting against oxidative stress. Vitamins, especially vitamins C, D, E, B, are vital for optimal functioning they facilitate production cytokines, differentiation immunological cells, neutralization free radicals, among functions. Omega-3 acids exhibit strong anti-inflammatory enhance cell function. Probiotics, modulate intestinal microbiota, thereby promoting integrity barrier communication between microbiota system. Coenzyme renowned its antioxidant attributes, participates protection cells from stress promotes energy processes essential Sodium butyrate regeneration epithelium, which is crucial maintenance homeostasis. emphasizes necessity an integrative that not only nutritional but also non-nutritional provide adequate support Without them, will never function properly, because it has been adapted this course evolution. data presented may serve foundation further research potential applications prevention treatment diseases associated with dysfunction.

Language: Английский

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Privileged natural product compound classes for anti-inflammatory drug development

Natural Product Reports, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

This review highlights six privileged classes of natural products – coumarins, polyphenols, labdane diterpenoids, sesquiterpene lactones, isoquinoline and indole alkaloids—for potential anti-inflammatory drug development.

Language: Английский

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