Recent advances in biological and medicinal profile of schiff bases and their metal complexes: An updated version (2018–2023)

Results in Chemistry, Journal Year: 2024, Volume and Issue: 7, P. 101350 - 101350

Published: Jan. 1, 2024

Schiff bases are most the widely used class of molecules in organic as well inorganic chemistry and known for fabricating stable metal complexes. their complexes utilized pharmaceutically medicinally important scaffolds because versatile biological profile. So herein, this review, we summarized recently developed biologically active with V, Fe, Co, Ni, Cu, Zn, Zr, Rh, Pd, Cd, Sn, Ir, Pt, Pb metals. The anti-bacterial, anti-fungal, anti-viral, anti-microbial, anti-cancer, corrosion inhibiting studies have been compiled present review. Anti-bacterial activities has described against both gram-positive (S. aureus, B. subtilis) gram-negative (E. coli, proteus) bacteria. anti-fungal action various Candida albicans, tropicalis, glabrata, Aspergillusniger, other fungal strains included. in-vitro anti-viral examination in-silico evaluation main protease (MPro) protein SARS-CoV-2 virus (PDB ID: 7BZ5, 6LU7, 7C8U), chikungunya nsP4 4RY5) HIV-1 6MQA) also summarized. Additionally, results cytotoxic properties cell lines including MCF-7, HeLa, HCT116, Dalton's Lymphoma, SGC-7901, BGC-823, HEK-293, HEPG2, DU-145 discussed. Thus ultimately, review highlights recent development (2018–2023) base potency strains.

Language: Английский

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Synthesis and Spectroscopic Characterization of Schiff Base Metal Complexes, Biological Activity, and Molecular Docking Studies

ACS Omega, Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 9, 2024

New cobalt(II), copper(II), and zinc(II) Schiff metal complexes were synthesized by the condensation reaction of 4-nitrobenzene-1,2-diamine with 3–4-(diethylamino)-2-hydroxybenzaldehyde. Fourier transform infrared, nuclear magnetic resonance, ultraviolet–visible, electron paramagnetic high-resolution electrospray ionization mass spectrometry powder X-ray diffraction used to characterize H2L its complexes. Conductance measurements, moment estimation, estimation have all been determined discussed. The electrochemical properties compounds discussed using cyclic voltammetry. molecular structures optimized B3LYP functional 6-31G (d,p) basis set, their parameters quantum chemical these predicted through charge distribution orbital analysis. biological compounds' antioxidant, antifungal, antibacterial activity studied Furthermore, docked HER2-associated target proteins in breast cancer.

Language: Английский

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Chitosan-Based Schiff Bases (CSBs) and Their Metal Complexes: Promising Antimicrobial Agents

Molecules, Journal Year: 2025, Volume and Issue: 30(2), P. 207 - 207

Published: Jan. 7, 2025

The scientific interest in the chemical modification of chitosan to increase its solubility and application has led conjugation with Schiff bases, which are interesting scaffolds endowed diverse biological properties. resultant chitosan-based bases (CSBs) widely studied literature due myriad activities exerted, both catalytic biological, including anticancer, anti-inflammatory, antioxidant, especially antimicrobial ones. Antimicrobial resistance (AMR) is one major public health challenges twenty-first century because it represents a threat prevention treatment growing number bacterial, parasitic, viral, fungal infections that no longer treatable available drugs. Thus, this review, we present brief outline CSBs as well their complexes metals, particular focus on recent regarding effect these captivating derivatives.

Language: Английский

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Preparation of gelatin-chitosan bilayer film loaded citral nanoemulsion as pH and enzyme stimuli-responsive antibacterial material for food packaging

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 254, P. 127620 - 127620

Published: Oct. 26, 2023

Language: Английский

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Effect of central metal ion on some pharmacological properties of new Schiff base complexes. Anticancer, antioxidant, kinetic/thermodynamic and computational studies

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2024, Volume and Issue: 325, P. 125034 - 125034

Published: Aug. 25, 2024

Language: Английский

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Unveiling the molecular association of novel benzohydrazide-substituted Schiff base complexes with human serum albumin

Inorganic Chemistry Communications, Journal Year: 2024, Volume and Issue: 162, P. 112200 - 112200

Published: Feb. 16, 2024

Language: Английский

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Novel Schiff base derivatives containing 4,5-disubstituted thiazole as potential antibiofilm, anti-inflammatory and antioxidant agents: Green synthesis, molecular docking and ADME analysis

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1311, P. 138401 - 138401

Published: April 18, 2024

Language: Английский

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Recent advances on the DNA interaction properties of Schiff bases and their metal complexes

Applied Organometallic Chemistry, Journal Year: 2024, Volume and Issue: 38(6)

Published: April 25, 2024

Cancer has become the second leading reason for death in world. Cell biology states that bulk of anti‐cancer medications focuses on DNA. A study how complexes metals interact with DNA is crucial creation effective chemotherapy drugs. The interactions Schiff base and their metal are a thrust area many researchers, papers have reported them. An amino molecule reacts carbonyl group to form variety chemicals called bases. Many studies shown bases compounds affect biological processes. Due potential use as novel reagents biotechnology medicine, research between transition nucleic acids grown significantly during past few decades. It was several may intercalate Small molecules can attach themselves through different ways, such intercalation groove binding. main method measure nuclease activity gel electrophoresis, ligand alone had much lower than complex. To set stage this analysis, brief overview provided. Further, review provides an brought forth by complexes. also draws attention new developments prospective bioactive core cleavage

Language: Английский

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A Novel Rhodamine Functionalized Schiff Base Type Ratiometric Fluorescent Chemosensor for the Sensing of Hg2+ Ions; Experimental and Theoretical Approach

Journal of Fluorescence, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 30, 2025

Language: Английский

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Advances in Coordination Chemistry of Schiff Base Complexes: A Journey from Nanoarchitectonic Design to Biomedical Applications

Topics in Current Chemistry, Journal Year: 2025, Volume and Issue: 383(1)

Published: Feb. 3, 2025

Language: Английский

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