Clinical Comparison of the COVID Waves 2-5. An Inpatient Retrospective Comparative Analysis from Karachi, Pakistan

Open Forum Infectious Diseases, Journal Year: 2025, Volume and Issue: 12(3)

Published: Feb. 7, 2025

Abstract Background Each coronavirus disease 2019 (COVID-19) wave is unique in its clinical presentation and outcome. In this study, we compared the characteristics outcomes of COVID waves 2–5 inpatient settings. Methods A retrospective study was conducted at Sindh Infectious Diseases Hospital Research Center on adult patients who were admitted with a positive polymerase chain reaction from July 2020 to March 2022. SPSS 26 used analyze data. Results total 3190 COVID-19 admitted. Wave 2 had highest percentage discharges mortality (81%; P = .0001). Cytokine release syndrome most common 3 (32.7%; Severe admission predominant 4 (79.4%; .0001), rates intubation (27.1%; septic shock (24.3%; progression (50.8%; 5, majority elderly (median age, 68 years) mild (22.4%; comorbidities (84.6%; ratio acute kidney injury high (29.2%; Mortality lowest (18.9%; .0001) (42.5%; .0001; odds ratio, 3.18; 95% CI, 2.6–3.8; 2). Conclusions some other waves, 4, driven by Delta variant, being deadliest one terms severity outcomes.

Language: Английский

Allergische Reaktionen auf COVID-19-Impfstoffe – noch relevant?

hautnah, Journal Year: 2025, Volume and Issue: unknown

Published: March 31, 2025

Obesity-Related Complications Including Dysglycemia Based on 1-h Post-Load Plasma Glucose in Children and Adolescents Screened before and after COVID-19 Pandemic

Nutrients, Journal Year: 2024, Volume and Issue: 16(15), P. 2568 - 2568

Published: Aug. 5, 2024

Childhood obesity, with its metabolic complications, is a problem of public health. The International Diabetes Federation (IDF) has recommended glucose levels 1 h post oral load (1h-PG) > 155–209 mg/dL as diagnostic for intermediate hyperglycemia (IH), while >209 type 2 diabetes (T2D). aim the study was to assess occurrence prediabetes, IH, and T2D in children adolescents simple obesity according criteria American Association (ADA) IDF, effect COVID-19 pandemic on these disorders. Analysis included 263 screened either prepandemic (PRE—113 cases) or post-pandemic period (POST—150 cases). All underwent OGTT measurements insulin every 0.5 h, lipid profile, other tests; indices if resistance (IR): HOMA, QUICKI, Matsuda index, AUC (glu/ins) were calculated. incidence T2D, IH higher POST respect PRE, significant differences IR, except HOMA. Significant observed assessed parameters metabolism among groups normal tolerance (NGT), some similarities between (based 1h-PG) prediabetes. Increased frequency dysglycemia after pandemic. Metabolic profile patients at 1h-PG “intermediate” NGT

Language: Английский