Epigenetics in obesity: Mechanisms and advances in therapies based on natural products

Pharmacology Research & Perspectives, Journal Year: 2024, Volume and Issue: 12(1)

Published: Jan. 31, 2024

Obesity is a major risk factor for morbidity and mortality because it has close relationship to metabolic illnesses, such as diabetes, cardiovascular diseases, some types of cancer. With no drugs available, the mainstay obesity management remains lifestyle changes with exercise dietary modifications. In light tremendous disease burden unmet therapeutics, fresh perspectives on pathophysiology drug discovery are needed. The development epigenetics provides compelling justification how environmental, lifestyle, other factors contribute pathogenesis obesity. Furthermore, epigenetic dysregulations can be restored, been reported that certain natural products obtained from plants, tea polyphenols, ellagic acid, urolithins, curcumin, genistein, isothiocyanates, citrus isoflavonoids, were shown inhibit weight gain. These substances have great antioxidant potential interest they also modify mechanisms. Therefore, understanding modifications target primary cause mechanisms anti-obesity effects phytochemicals prove rational strategies prevent develop novel therapeutic interventions. Thus, current review aimed summarize advances in therapies based provide evidence several targets.

Language: Английский

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Obesity as a Risk Factor of Severe Outcome of COVID-19: A Pair-Matched 1:2 Case–Control Study

Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(12), P. 4055 - 4055

Published: June 15, 2023

The nature of the association between obesity and poor prognosis COVID-19 without evaluation other co-pathologies associated has not yet been clearly evaluated. aim present pair-matched case-control study was to investigate outcome patients with SARS-CoV-2 infection in obese non-obese matched considering gender, age, number comorbidities, Charlson Comorbidity Index.All adults hospitalized for BMI ≥ 30 kg/m2 were included (Cases). For each Case, two < pair age (±5 years), comorbidities (excluding obesity), Index (±1) enrolled (Controls).Of 1282 followed during period, 141 282 case control groups, respectively. Considering matching variables, there no statistical difference groups. Patients Control group developed more frequently a mild-moderate disease (67% vs. 46.1%, respectively), whereas prone need intensive care treatment (41.8% 26.6%, respectively; p = 0.001). Moreover, prevalence death hospitalization higher Case than (12.1% 6.4%, 0.046).We confirmed an severe COVID-19, also factors COVID-19. Thus, infection, subjects should be evaluated early antiviral avoid development course.

Language: Английский

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The liver in Greco-Arabic and Islamic medicine

Clinical Liver Disease, Journal Year: 2024, Volume and Issue: 23(1)

Published: Jan. 1, 2024

LIVER MEDICINE IN ISLAM AND ITS LEGENDARY PROPONENTSMedicine was an integral feature of medieval Muslim culture although millennia before the advent Islam it had been practiced in Mesopotamia, ancient Egypt, and Persia—known as Iran since 1935—and elsewhere Asia.1 Islamic physicians, philosophers, scholars wide-ranging interests health disease, scientific understanding basis illness grew, they searched for causes disease probed possible treatments cures.1 civilization once occupied territory from India East to Atlantic West, later spilled out Arabia into Syria, Persia whereas commercial reach encompassed Latin America China everywhere between.1 thinkers Baghdad Toledo translated, Arabic, philosophical works Greek; Eastern Christian language Syriac; Pahlavi (from pre-Islamic Persia); Sanskrit. Translations were started during Caliphate that began 632 ce, included extant medical literature handed down giants Greek Roman Medicine (especially highly influential savants Hippocrates Galen), other Alexandria, Egypt. Then followed endorsement embellishment by fabled Arab Persian thought leaders science, engineering, philosophy, medicine. Data expertly gathered cataloged, encyclopedias published so others could easily identify, source, understand pearls what was, even then, a bewildering compendium texts variety languages. became known Arabic appellation Unani2,3 (or Unani Tibb, meaning Medicine) which translates strictly Ionian) indicates its pedigree having derived originally medicine,4 also explains English designation Greco-Arab, though there influences too. Nowadays, or Tibb refers alternative holistic system medicine has practised Indian subcontinent South Asia, introduction 8th century ce.3,4 There is some intriguing evidence may have arrived with Asian campaign (327–325 bce) Alexander Great.4 Developed Greco-Roman Buqrat Jalinoos (Urdu Galen, respectively) influenced teachings, doctrines2,3 espouse 7 basic physiological principles (The so-called Umoor-e-Tabiya comprised Akhlaat [Humors], Arkan [Elements], Mizaj [Temperaments], Arwaah [Life forces], Aaza [Organs Systems], Quwa [Faculties Powers], Afa'al [Functions]. These can be combined, eg, blood hot wet, phlegm cold moist, yellow bile dry, black dry.), include among 4 Hippocratic body humors (written Urdu): dam (blood), balgham (phlegm, ie, mucus, lungs), safra (yellow bile, liver), sauda (black gallbladder) responsible sanguine, phlegmatic, choleretic, melancholic dispositions—the same corresponding physical elements—air, water, fire, earth, respectively, "temperaments" qualities)—cold, hot, dry (Figure 1).FIGURE 1: (A) Image woodcut Physiognomische Fragmente, zur Beförderung der Menschenkenntnis und Menschenliebe (1775–1778) Johann Caspar Lavater, depicting humors: phlegmatic (upper left, mucus phlegm, phlegma φλέγμα), choleric right, xanthe chole ξανθη χολή), sanguine (lower blood, haima αἷμα), melaina μέλαινα χολή). (B) The association between elements—fire, air (depicted on outside figure)—and phlegm), enveloped inside qualities: cold. natural state (physis, φύσις), good (eucrasis/eucrasia, εὐκρᾶσις/ία), achieved when proper blending balance elements, qualities, amount strength. When these are disproportionate, is, dyscrasia (δυσκρασία) ensues. Reproduced permission Rothschuh.5Theories relating mathematics, astrology, astronomy, alchemy, religion, architecture, textiles, agriculture entertained, elaborated extended upon adding findings their own astute observations fresh discoveries, led new conclusions. seemingly no end ingenuity, creativity, inventiveness such diverse fields surgery,6 poetry, eloquently, colorfully graphically reported7 Professor Salim TS A-Hassani (Emeritus Mechanical Engineering Honorary Professorial Fellow at Faculty Humanities, University Manchester, United Kingdom). In addition, investigators, principally 1st ce improved age-old techniques distillation 2) crystallization, use alcohol antiseptic. Deriving or, more likely, preceding innovations, came fabrication dark eye shadow (al-koh'l al-kuhul, كحولa)—that fashionable Egypt—by means sublimation stibnite (an antimony ore) fine gray-black powder replaced customary time-honored lead-containing galenite ore ground thick pigment. 1530, Swiss physician Paracelsus applied term alcohol, Latinized form al-koh'l, another popular product distillation, namely wine, spirit wine (known ethanol 1892), spirits (referring vapors arise process), vernacular hard liquor.8FIGURE 2: Engraving Mary Maria Jewess (Latin: Prophetissa Prophetissima Michael Maier's book Symbola Aurea Mensae Duodecim Nationum, 1617), early alchemist who lived 3rd centuries whose inventions crucial perfection process reported Adam Rogers, his 2014 book, Proof: science booze. Houghton Mifflin Harcourt, Boston. Mary's name survives her invention, bain-marie (Mary's bath), water bath device limits temperature process. Inset: An Alembic apparatus, invented Jewess, used Rhazes preparation kerosene. Credit: Wellcome Collection https://creativecommons.org/licenses/by/4.0/Islamic physicians devised complex interpretations pertaining medications, clinical practice, nature diagnoses, treatments, cures. fact, Western doctors actually first learned medicine, including reading translations treatises recognized celebrated West.9 back languages, followed. (Arab slid decline following devastation Mongols [1258 ce], ascendancy Turkish Ottoman Empire, 14th conquest armies Al-Andalus [الأَنْدَلُس] Empire Iberian Peninsula. This Reconquista "Christian" Iberia culminated surrender Nasrid kingdom Grenada Sultan Abu 'Abdallah Muhammad XII, forces united Spanish Crown Ferdinand II Aragon Queen Isabella I Castile 1492,10 under whom dominions Spain fully united. And coincidentally, Moors [a European, now somewhat derogatory {from ancient, Berber-speaking, Mauri}, inhabitants Mahgreb, Peninsula {Al-Andadalus}, Sicily Malta controlled 711 1492 ce] Jews alike expelled 1492, eventually entire Peninsula.) centers learning grown famous mosques, hospitals often established sites. apprentices observe learn practical fashion, seasoned physicians. world produced greatest history. They made advances surgery,7 built hospitals11 3), welcomed women profession.12FIGURE 3: Mansuri Hospital Cairo, important teaching hospital. Sailko, Wikipedia Commons, https://creativecommons.org/licenses/by-sa/3.0/Most prominent polymaths 2 clinicians: Bakr ibn Zakariya' al-Razi (c864–c925 ce) (أبو بکر محمد بن زکریاء الرازي) (al)-Razi (Latinized "Rhazes," Figure 4A), 'Ali al-Husayn bin Abdullah al-Hassan Sina al-Balkhi al-Bukhari علي الحسين عبد الله الحسن سينا البلخي البخاري) (980–1037 4B), aka "Avicenna," moniker probably misinterpretation Sina, heard ears. General Prologue Canterbury Tales (A collection 24 stories, written Middle Geoffrey Chaucer 1387 1400, presented part story-telling contest group pilgrims traveled together London visit shrine Saint Thomas Beckett Cathedral. Aside surviving manuscripts questionable originality, printed version William Caxton 1476.), (c1340s–1400), renowned poet, author, civil servant, mentioned authorities intellects11; international reputations. third polymath, "Averroes" Abū l-Walīd Muḥammad Ibn ʾAḥmad Rušd [1126–1198] [أبو الوليد ابن احمد رشد.] hailed 12th Andalusia, where he campaigned fervently restoration Aristotelianism thinking, especially familiar Europe.FIGURE 4: Statues Avicenna, Scholars Pavilion Nations Vienna, Austria. Yamaha5, https://creativecommons.org/licenses/by-sa/3.0/.The cardiocentrist Egyptians attributed intelligence, emotions, sensation heart, treated reverential deference not removing mummification. parallel lungs, intestines, stomach, liver removed, owner afterlife, stored specific canopic jar protected god Imsety, son Horus 5). On hand, Greco-Arab tortuous path laid mentors identify one body's major organs. Aristotle (384–322 bce), long-time disciple Plato tutor Alexander, 13-year-old King Phillip Macedonia future conqueror world, saw origin, albeit indirectly, Vital Heat heart (also called innate heat [calidum innatum]). considered cardinal organ, located strategically center vascular system, befits noblest organs.13 For Aristotle, only active organ fertilized hen's egg but source blood—the life force—with richly endowed. keeping prevailing views physiology, origin vessels through vital heat, maintained pneuma (spirit soul), distributed throughout body, brain. Consequently, unquestionably seat soul for, observed "when cold, individual dies." Aristotle's ideas expressed explicitly formidable text biology, De Partibus Animalium (Περὶ ζῴων μορίων, Greek),14 translated Treatises 11-14 Kitāb al-Hayawān (كتاب الحيوان), ultimately Latin.15FIGURE 5: Four jars containing, left liver, guarded respectively gods, Sons Horus—namely human Imsety; Hapy, baboon; Duamtef, jackal; Qebehsenuef, falcon. Canopic containers mummification process, store preserve viscera afterlife. commonly either carved limestone pottery. micrograph mummy histology, courtesy series editor, Dr A. Reuben, received generous gift late Peter Scheuer (1928–2006), leading histopathologists generation. Hieroglyphs sons Egyptian jars.And yet decidedly Hepatocentric, least until 1628, Harvey showed pumping circulated around both systemic minor pulmonary circuits. accurately disciples school, referred "The Hippocratics"), predated reasoned that, "If we able live life, because our liver." force digestion, maturation, attraction, repulsion accomplished. forces, organs digest food transform it, after attraction retention. If liver's transformative weakened, diseases occur dropsy (a contraction archaic edema, hydrops, ýdropos ύδρωπος húdōr ὕδωρ, water) control fluid undermined. cure must therefore accomplished returning normal equilibrium. Following footsteps hero, Hippocrates, Galen (131–200 ce), opined "master organ" emerges all formed fetus. "On usefulness parts body" (Περί χρείας μορίων Greek, usu partium Latin),16 described warm moist favorite description found parlance, promoted Prophet) wherein fire (one ultimate elements—along air, earth—of matter composed, according theory 5th BCE philosopher Empedocles17) burned perpetually, supposedly bile. spirit, brain via heart. To resolve any confusion Renaissance readers, clarified—admittedly, entirely successfully—that "… were, hearthstone animal governed." almost erroneously involved formation, principal instrument sanguification (sanguifactionis officina) (fons venarum) facilitate circulation manufactured liver. (As know, case hematopoiesis, here wrong.) Ancient Greeks, housed soul, emotions. Hepa, root terms scientifically describe liver-related topics (as hepatology), word hèpar (η′παρ), stem hedoné (ηδονη), pleasure.18 Many mundanely friction caused motion arteries, expounded edition Chambers's 1728 Cyclopædia 6), follows: "For 'tis hence this than Attrition Parts Blood; occasion'd circulatory Motion Arteries."FIGURE 6: First Cyclopaedia Universal Dictionary Arts Sciences. London: James John Kimpton; 1728. Two-volume folio 19th-century paneled calf, ruled black, spines compartments raised bands, lettered gilt, armorial crest letter titles red engraved folding frontispiece volume I, 19 plates (plate XIV parts), folding, anatomy plate browned usual, double columns throughout. Frontispiece edition. Ephraim Chambers (1680–1111), inspired Harris's Lexicon Technicum set compile comprehensive work dedicated George, Second elected Royal Society 1729. His Cyclopedia model encyclopedias, Encyclopaedia Britannica.Greco-Arab brain, 3 which, incidentally, historically vied each dominance.19 humor proposed Hippocratics supported results imbalance duskrasía δυσκρασία, "bad mixture," contrast harmony eucrasia, eukrâsis εὐκρᾶσις) bodily (3 originate made/stored spleen, gallbladder), above portrayed 1. character moods persons, conveyed words choleric, melancholic, depend relative abundance humors, distinctive attributes; dry. Incidentally, Galen's about physiology prevailed 14 centuries, Renaissance. According herbs correct diseases.20 born 9th Afshana near Bukhara Maverounnahr, Central arguably most polymaths—known Al-Shaykh al-Ra'is Main Sheykh) Al-Mu ́ xallim al-Thani Teacher, Aristotle). He many skills professional roles, authorship approximately 450 books articles, 240 still exist today, 40 focus Among two significant contributions Book Healing" (کتاب الشفاء, Kitab al-shifa'), expansive encyclopedia based Aristotelian tradition modified Neo-platonic theology, Canon Medicine" (Al-Qanun fi-l-tibb, القانون في الطب), entitled Law Medicine." Avicenna completed 7) 1020 5-volume textbook (Avicenna, 5 Volume Set. studies Seyyed Hossein Nasr PhD [Editor], Laleh Bakhtiar [Translator]. Kazi Publications Inc., Chicago 2015.). Rome 1593, Gerard Cremona century. displaced Al-Razi, others, essential several schools world. At universities Leuven Belgium, Montpellier France, Salermo Italy, Germany, studied well middle 17th century, Padua, Italy 1715. Later, English, French, German, history Within pages, recommendations practice. Hebrew Avicenna's Canon, Naples 1491/2, 1, Medieval C. Gruner, did appear 1930. standards practice Europe, provided India. States California, Los Angeles, Yale University, New Haven, Connecticut, History courses. Osler (1921),21The ever written" remained bible longer period work."FIGURE 7: A page Medicine. Ali Esfandiari, 2007. 1484 CE translation Texas Health San Antonio. (C) set. Studies Nasr, (editor), (translator). Chicago; 2015.Avicenna nutritive vegetative faculties," "…the manufacture dense humors…," vessels. Further, agreed notion "is etc." above), stated breath, "the power heat." indicated malfunction lead diseases, fortunately corrected appropriate herbal intervention.20,22,23 context, medicinal properties herb Hypericum perforatum, recently traditional jaundice, gallstones, rheumatoid arthritis, inflammatory conditions (it should noted therapy), Tamarix nilotica (Ehrenb.) Bunge treatment problems.23 assertion separates moisture anticipated Starling's discovery millennium later,24 lymph production Danish physician,Thomas Bartholin [1616–1680], course, Starling, discovered lymphatic system). distortion architecture cirrhosis chronic leads ascites, condition overflow liver.25 without facilities investigation, introduced criteria diagnosing era emphasis examination.26 Al-Razi) chemist, alchemist, pharmacist, philosopher, scholar 865 925 ce. distinguish measles smallpox, records indicate Persia, treating rich poor alike. devices, spatulas, flasks, mortars, phials, methods kerosene, termed naft abyad (نفط ابيض "white naphtha"), using apparatus alembic allegedly Maria/Mary inset), excelled distillation. prolific, penning 200 extensive discussions pharmacy (Rhazes Pharmacist) mercurial ointments. Known "Father Pediatrics," wrote likely Pediatrics separate field doctor write immunology allergy. allergic asthma, recognize fever defense mechanism against infection. 33 cases, told histories patients visited, describing features diagnosis every them, septic arthritis abscess Indeed, separately hepatology entitled, "About Liver" Dar Hey'ateh Kabed (Persian ﻛﺒﺪ ﻫﻴﺄﺕ ﺩﺭ). And, happens, Marwān 'Abd al-Malik Zuhr ( أبو مروان الملك زهر, Avenzoar), Andalusian Seville, abdomen, treatment, Al-Taysir last died. As Avenzoar's contemporary, close friend collaborator, رشد, Averroes), jurist passionate strong proponent Aristotelianism, earned him admiring supporters hostile detractors, particularly Nonetheless, used, illogically expediently seems, acronym recent randomized trial anticoagulants atrial fibrillation.27 Enter, ʿImran Mūsā Maymūn ʿUbayd Allāh, otherwise "Moses 'son Amram' Maimon Obadians, Cordoban" (أَبُو عَمْرَان مُوسَى بْن مَيْمُون عُبَيْد ٱللّٰه) Rambam, (רמב״ם), Rabbi Moses (Moshe) ben Maimonides 8). Sephardic Jewish prolific Torah Ages. time, preeminent astronomer served personal Saladin28 (Saladin epithet ethnic Kurd Yusuf Ayyub Shadi [c. 1137–1193], Egypt founded Ayyubid dynasty, defeated Crusaders Battle Hattin 1187, thereby re-establishing military dominance Levant). (1138–1204) Córdoba, Al-Andalus, Almoravid illustrious ancestry tracing House David Israel. worked rabbi, physician, Morocco After died reburied Tiberias, banks Sea Galilee (Lake Kinneret). sciences. contemporary Averroes, Al-Farabi (Persian: ابونصر فارابی, Arabic: نصر الفارابي, Alpharabius, c. 872–c. 951), metaphysics, ethics logic, political sciences, cosmology, mathematics music theory.FIGURE 8: "traditional portrait" imaginative representation Maimonides—since true likeness exists—possibly American illustrator Arthur Burdett Frost. depicted signature picture unequivocally authentic resembles numerous verified signatures Cairo Geniza. Manuscript Maimonides. Judeo-Arabic letters. Originally Encyclopedia (1901–1906), Funk Wagnalis, York. bronze statue Maimonides, sculptor Amadeo Olmos Ruiz, erected 1964 Plaza de Tiberiades old quarter Cordoba (Maimonide's birthplace), quite synagogue. sculptured face remarkably similar statues authentic28. feet shiny due frequent touching, luck, visitors. Courtesy: Ajay Suresh, https://creativecommons.org/licenses/by/2.0/deed.enMaimonides polymath worlds, knowledgeable humorism. writings generations,29 detailed wide spectrum observations, experience, interpretation authoritative others.30 emphasized moderation healthy lifestyle. hepatitis uncannily accurate,31 signs inflammation eight number high fever, thirst, complete anorexia, tongue initially then turns biliary vomitus, egg-yolk color green, pain right side ascends up claviclew. Occasionally mild cough heaviness, felt spreads widely…." MEDICATIONS ISLAMIC Plant-derived compounds generally accessible mostly affordable, deep belief remedies harmless alternatives synthetic drugs. Thus, complementary supplements, consumption weight loss nostrums risen sharply States,31 long indigenous groups, Far East. Up 65% taking preparations like, bad outcomes hepatotoxicity, pre-existent damage reduce reparative responses additional injur

Language: Английский

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Anti-obesity effects of a standardized ethanol extract of Eisenia bicyclis by regulating the AMPK signaling pathway in 3T3-L1 cells and HFD-induced mice

Food & Function, Journal Year: 2024, Volume and Issue: 15(12), P. 6424 - 6437

Published: Jan. 1, 2024

Obesity requires treatment to mitigate the potential development of further metabolic disorders, including diabetes, hyperlipidemia, tumor growth, and non-alcoholic fatty liver disease. We investigated anti-obesity effect a 30% ethanol extract Eisenia bicyclis (Kjellman) Setchell (EEB) on 3T3-L1 preadipocytes high-fat diet (HFD)-induced obese C57BL/6 mice. Adipogenesis transcription factors peroxisome proliferator-activated receptor (PPAR)γ, CCAAT/enhancer-binding protein-alpha (C/EBPα), sterol regulatory element-binding protein-1 (SREBP-1) were ameliorated through AMP-activated protein kinase (AMPK) pathway by EEB in differentiated cells. attenuated mitotic clonal expansion upregulating cyclin-dependent inhibitors (CDKIs) while downregulating cyclins CDKs. In HFD-fed mice, significantly decreased total body weight, fat tissue tissue. The expression PPARγ, C/EBPα, SREBP-1 was increased subcutaneous tissues, levels these factors. also inhibited lipogenesis acetyl-CoA carboxylase (ACC) acid synthase (FAS) tissues. Moreover, phosphorylation AMPK ACC downregulated HFD-induced mouse group, whereas administration improved phosphorylation; thus, may be related pathway. Histological analysis showed that reduced adipocyte size accumulation respectively. promotes thermogenesis brown adipose improves insulin leptin blood lipid profiles. Our results suggest could used as agent prevent obesity.

Language: Английский

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Polymorphism of tmprss2 (rs12329760) but not ace2 (rs4240157), tmprss11a (rs353163) and cd147 (rs8259) is associated with the severity of COVID-19 in the Ukrainian population.

PubMed, Journal Year: 2023, Volume and Issue: 94(1), P. e2023030 - e2023030

Published: Feb. 13, 2023

Angiotensin-converting enzyme 2 (ACE2), transmembrane serine and 11A proteases (TMPRSS2, TMPRSS11A), a cell surface cluster of differentiation 147 (CD147) might be gene candidate that exerts the susceptibility to mortality from coronavirus disease 19 (COVID-19). The aim this study was investigate associations between ace2, tmprss2, tmprss11a, cd147 polymorphic variants severity COVID-19 in Ukrainian population.The population consisted with COVID-19: patients without oxygen therapy (n=62), non-invasive (n=92) invasive (n=35) therapy, as well control subjects (n=92). Allelic polymorphisms ace2 rs4240157, tmprss2 rs12329760, tmprss11a rs353163 were determined by real-time PCR, rs8259 polymorphism detected PCR subsequent restrictase analysis. We compared investigated distribution other populations meta-analysis.Our is first obtain data about population: rs12329760 - CC 60.9%, CT 35.9%, TT 3.2%; 46.7%, 40.2%, 13.1%; rs4240157 7.6%, C 18.5%, 22.8%, 19.6%, T 31.5%; AT 32.6%, AA 6.5%. This similar Northern, Western Southern European populations. There statistically significant difference frequency genotypes 57.1%, 28.6%, 14.3% (P<0.05) comparison therapy. mutation occurs scavenger receptor cysteine-rich (SRCR) domain important for protein-protein interaction calcium-dependent manner.Our indicated presence an association population.

Language: Английский

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Determinants of COVID-19 Severity: A Retrospective Analysis of Clinical and Epidemiological Factors in Durango, Mexico

Epidemiology Biostatistics and Public Health, Journal Year: 2025, Volume and Issue: 19(2)

Published: Jan. 8, 2025

Background: The COVID-19 pandemic, caused by SARS-CoV-2, has had a devastating global impact, with millions of confirmed cases and deaths. This study focused on analyzing 63,252 patient records from the state Durango, Mexico, to identify clinical epidemiological factors associated disease severity. Methods: employed descriptive, observational, retrospective approach, based open data SISVER platform. A descriptive analysis was conducted summarize demographic characteristics. multivariate performed using graph relative inertias assess how covariates (comorbidities) were hospitalization, intubation, death in patients. Subsequently, odds ratios tests calculated evaluate associations between specific variables, such as pneumonia, obesity, other comorbidities, intubation.Results: We found that majority (93.8%) treated an outpatient basis, while 6.2% required hospitalization. Hypertension, diabetes, obesity most prevalent comorbidities. mortality rate population 2.1%, particularly Jurisdiction I, corresponding capital city. Pneumonia strongly intubation (OR = 9.03, 95% CI 1.0232 – 44.3230, p 0.03), also showed increased risk 2.64, 1.0021 22.4210, 0.02). These findings underscore importance identifying managing comorbidities patients infected SARS-CoV-2. Conclusion: results highlight relevance social determinants health need for public policies address inequalities context appropriately reduce morbidity Mexico.

Language: Английский

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Obesity Aggravates the Clinical Profile of COVID-19 Patients Hospitalized in the North of Mato Grosso, Brazil: A Cohort Study

Obesities, Journal Year: 2025, Volume and Issue: 5(1), P. 4 - 4

Published: Jan. 15, 2025

COVID-19, caused by the SARS-CoV-2 coronavirus, has significantly impacted global health, particularly among patients with obesity. This study evaluates prevalence and effects of overweight obesity on clinical profiles complications COVID-19 admitted to a hospital in Northern Mato Grosso. We conducted retrospective cohort analyzing medical records hospitalized from March 2020 2021. Patients were classified into normal body weight, overweight, groups. Data statistically analyzed using Kruskal–Wallis’s test Dunn’s post-test (continuous variables) or chi-square (χ2) (categorical variables). Among 145 ward records, 24.1% 46.2% 29.7% obese. In intensive care unit, data 243 indicated that 17.3% 37.9% 44.9% obese, highlighting concerning overweight/obesity. Chest computed tomography revealed moderate pulmonary involvement (25–50%) was most frequent group, while severe (>50%) predominant group. The group experienced more complications, including increased use mechanical ventilation. Notably, both settings, mortality rates higher concludes worsen outcomes.

Language: Английский

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Lithium and the risk of severe COVID-19 infection: A retrospective population-based register study

Journal of Psychosomatic Research, Journal Year: 2025, Volume and Issue: 190, P. 112053 - 112053

Published: Feb. 13, 2025

Language: Английский

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Assessment of COVID-19 Vaccine Effectiveness Against SARS-CoV-2 Infection, Hospitalization and Death in Mexican Patients with Metabolic Syndrome from Northeast Mexico: A Multicenter Study

Vaccines, Journal Year: 2025, Volume and Issue: 13(3), P. 244 - 244

Published: Feb. 27, 2025

Background/Objectives: Metabolic syndrome (MetS) is a predisposing factor for severe COVID-19. The effectiveness of COVID-19 vaccines in patients with MetS has been poorly investigated. aim this study was to evaluate the vaccination before (BO) and after Omicron (AO) SARS-CoV-2 variant MetS. Methods: This retrospective observational carried out total 3194 PCR or rapid antigen test. main outcomes were vaccine against infection, hospitalization death resulting from Results: BO, only two doses BNT162b2 effective lost AO. Also, doses, BNT162b2, ChAdOx1 CoronaVac BO; however, AO, effective. Regarding as an outcome COVID-19, whereas 100% BO presentation sore throat increased regardless type, dyspnea diminished CoronaVac. Conclusions: impacted vaccines’ A tailored scheme should be implemented due varying rates observed our study.

Language: Английский

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Review of the relationship between growth hormone and SARS-CoV-2 infection

Future Virology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 15

Published: April 11, 2025

Language: Английский

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