Current Opinion in Clinical Nutrition & Metabolic Care,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 27, 2024
Purpose
of
review
The
impact
vitamin
D
on
improving
insulin
resistance
in
prediabetes
remains
controversial.
purpose
this
is
to
examine
whether
supplementation
improves
adults
with
prediabetes,
and
if
so,
identify
the
mechanisms
specific
populations.
Recent
findings
Global
prevalence
increasing,
prevention
a
critical
issue
because
these
people
will
develop
type
2
diabetes
soon,
which
put
pressure
healthcare
costs.
evidence
effectiveness
administration
preventing
onset
has
been
accumulating.
2024
updated
clinical
practice
guideline
American
Diabetes
Association
states
that
patients
potentially
benefits
incidence
There
are
also
reports
via
increased
serum
osteocalcin
levels,
marker
bone
turnover.
Summary
Vitamin
likely
improve
resistance,
already
present
at
time
prediabetes.
However,
may
vary
depending
ethnic
differences
blood
levels
start
administration.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(9), P. 4827 - 4827
Published: April 28, 2024
Obesity,
type
2
diabetes
mellitus
(T2DM)
and
osteoporosis
are
serious
diseases
with
an
ever-increasing
incidence
that
quite
often
coexist,
especially
in
the
elderly.
Individuals
obesity
T2DM
have
impaired
bone
quality
elevated
risk
of
fragility
fractures,
despite
higher
and/or
unchanged
mineral
density
(BMD).
The
effect
on
fracture
is
site-specific,
reduced
for
several
fractures
(e.g.,
hip,
pelvis,
wrist)
increased
others
humerus,
ankle,
upper
leg,
elbow,
vertebrae,
rib).
Patients
a
greater
foot,
total
fractures.
A
chronic
pro-inflammatory
state,
falls,
secondary
complications,
pharmacotherapy
can
contribute
to
pathophysiology
aforementioned
Bisphosphonates
denosumab
significantly
vertebral
patients
both
T2DM.
Teriparatide
lowered
non-vertebral
subjects.
It
important
recognize
obese
patients,
as
they
currently
considered
low
tend
be
underdiagnosed
undertreated.
implementation
better
diagnostic
tools,
including
trabecular
score,
lumbar
spine
BMD/body
mass
index
(BMI)
ratio,
microRNAs
predict
fragility,
could
improve
prevention
this
patient
group.
Hypertension,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 12, 2025
BACKGROUND:
The
mediating
role
of
inflammatory
biomarkers
in
the
causal
relationship
between
body
composition
and
hypertension
remains
unclear
requires
further
investigation.
METHODS:
This
study
used
a
combination
retrospective
observational
analysis
Mendelian
randomization
approaches.
Observational
data
were
derived
from
4717
Chinese
children
adolescents
aged
6
to
18
years
who
underwent
dual-energy
X-ray
absorptiometry
assess
composition.
analyses
utilized
summary
statistics
large-scale
sets,
including
UK
Biobank,
deCODE2021,
International
Consortium
Blood
Pressure,
FinnGen,
other
consortia.
included
leptin,
insulin,
adiponectin,
osteocalcin,
FGF23
(fibroblast
growth
factor
23),
PTH
(parathyroid
hormone).
RESULTS:
revealed
that
increased
fat
mass
positively
influenced
diastolic
blood
pressure
through
while
fat-free
had
an
inverse
effect.
Insulin
mediated
association
systolic
pressure,
hypertension,
with
additional
indirect
effects
observed
for
(all
P
<0.05).
demonstrated
childhood
index
by
insulin
(indirect
effect:
odds
ratio,
0.87
[95%
CI,
0.78–0.97])
adiponectin
(odds
1.13
1.04–1.23]).
Adiponectin
0.81
0.71–0.93])
1.30
1.11–1.51])
on
hypertension.
Leptin,
also
CONCLUSIONS:
These
findings
indicate
influences
distinct
biomarkers.
Targeting
may
provide
tailored
strategies
managing
Diabetes Obesity and Metabolism,
Journal Year:
2024,
Volume and Issue:
26(11), P. 5444 - 5454
Published: Sept. 4, 2024
Abstract
Objective
The
aim
was
to
investigate
the
mediating
role
of
inflammatory
biomarkers
in
causal
effect
body
composition
on
glycaemic
traits
and
type
2
diabetes.
Methods
A
retrospective
observational
study
a
Mendelian
randomization
(MR)
were
used.
Observational
analyses
performed
using
data
from
4717
Chinese
children
adolescents
aged
6–18
years
who
underwent
dual‐energy
X‐ray
absorptiometry
for
composition.
MR
based
summary
statistics
UK
Biobank,
deCODE2021,
Meta‐Analysis
Glucose
Insulin‐Related
Traits
Consortium
(MAGIC)
other
large
consortiums.
Inflammatory
included
leptin,
adiponectin,
osteocalcin,
fibroblast
growth
factor
23
(FGF23)
parathyroid
hormone
(PTH).
Results
In
study,
increased
fat
mass
had
positive
homeostasis
model
assessment
insulin
resistance
(HOMA‐IR)
pancreatic
beta
cell
function
(HOMA‐β)
through
FGF23,
whereas
fat‐free
produced
opposite
effects.
PTH
osteocalcin
played
significant
roles
association
with
fasting
glucose,
HOMA‐IR
(all
p
<
0.05).
Mediation
results
indicated
that
childhood
index
affected
leptin
adiponectin.
There
existed
diabetes
via
FGF23
(indirect
effect:
OR
[odds
ratio]:
1.14
[95%
CI,
confidence
interval:
1.01–1.28])
adiponectin
(OR:
0.85
CI:
0.77–0.93]).
Leptin
mediated
β:
−0.05
−0.07,
−0.02])
(β:
0.03
0.01,
0.04])
glucose.
Conclusions
Our
findings
suggest
different
compositions
have
differential
influences
distinct
biomarkers.
may
be
helpful
tailoring
management
statuses.
Frontiers in Endocrinology,
Journal Year:
2025,
Volume and Issue:
15
Published: Jan. 13, 2025
Background
Osteocalcin
has
attracted
attention
for
its
potential
role
in
diabetes
management.
However,
there
been
no
bibliometric
assessment
of
scientific
progress
this
field.
Methods
We
analysed
1680
articles
retrieved
from
the
Web
Science
Core
Collection
(WoSCC)
between
1
January
1986
and
10
May
2024
using
various
online
tools.
Result
These
papers
accumulated
42,714
citations,with
an
average
25.43
citations
per
paper.
Publication
output
increased
sharply
1991
onwards.
The
United
States
China
are
at
forefront
research
area.
Discussion
keywords
were
grouped
into
four
clusters:
‘Differential
functional
osteocalcin
genes’,
expression
genes
relation
to
mellitus’,
‘Role
osteoporosis
‘Indirect
involvement
metabolic
processes’.
Analysis
VoS
viewer
suggests
a
shift
focus
towards
correlation
levels
diabetic
complications,
clinical
efficacy
therapeutic
agents
or
vitamins
treatment
patients,
mechanisms
by
which
modulates
insulin
action.
proposed
areas
“osteocalcin
genes”,
“insulin
regulation
“,
“different
populations”,
“diabetes-related
complications”
“type
2
mellitus”,“effect
on
sensitivity
as
well
secretion”,“osteocalcin
different
populations
patients
treatment-related
studies”.
Gynecological Endocrinology,
Journal Year:
2025,
Volume and Issue:
41(1)
Published: Jan. 21, 2025
Gestational
diabetes
mellitus
(GDM)
affects
9–25%
of
pregnancies.
Undiagnosed
or
poorly
managed
GDM
is
associated
with
both
short-
and
long-term
complications
in
the
fetus
mother.
The
pathogenesis
complex
has
not
yet
been
fully
elucidated.
Several
biomarkers
found
maternal
serum
have
potential
for
early
diagnosis
GDM.
aim
this
narrative
review
was
to
explore
novel
that
comprehensively
described
previous
reviews.
We
believe
these
may
allow
detection
stages
pregnancy,
enabling
timely
proper
treatment
potentially
preventing
mother
fetus.
Journal of the International Society of Sports Nutrition,
Journal Year:
2025,
Volume and Issue:
22(1)
Published: Jan. 23, 2025
Objective
The
aim
of
this
study
was
to
identify
the
key
regulatory
mechanisms
cartilage
injury
and
osteoporosis
through
bioinformatics
methods,
provide
a
new
theoretical
basis
molecular
targets
for
diagnosis
treatment
disease.
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 20, 2025
Abstract
Malignant
bone
tumor
defects
are
difficult
to
treat
because
of
the
simultaneous
need
for
treatment
and
bone‐repair
promotion.
This
study
presents
a
bioactive
composite
scaffold
(T‐rGO@Au)
personalized
defect
repair
treatment.
The
T‐rGO@Au
has
porous
structure,
its
mechanical
properties
close
those
human
cancellous
bone.
can
induce
upregulation
osteopontin
(OPN),
RUNX‐2,
osteocalcin
(OCN)
gene
expression.
In
vivo
experiments
showed
that
volume/total
volume
(BV/TV)
ratio
with
was
highest.
new
tightly
integrated
implant,
demonstrating
effective
osseointegration.
locally
generated
high
temperatures
reactive
oxygen
species
under
near‐infrared
excitation,
AuNPs
enhanced
photothermal
performance
rGO
through
“antenna
effect.”
Furthermore,
in
vitro
cell
nuclei
were
destroyed,
late‐stage
apoptotic
cells
increased,
morphology
severely
damaged.
Additionally,
RNA‐seq
revealed
destruction
mediated
signaling
pathways,
such
as
MAPK
pathway.
antitumor
also
demonstrated
significantly
inhibited
growth
within
2
weeks.
Thus,
provides
strategy
development
implantable
scaffolds
defects.
Journal of Reproductive Healthcare and Medicine,
Journal Year:
2025,
Volume and Issue:
6, P. 2 - 2
Published: Feb. 24, 2025
Conventionally,
bone
was
considered
a
static
organ
that
only
serves
the
protective
and
locomotive
functions.
However,
our
understanding
of
has
evolved
significantly
during
past
few
decades.
From
an
uninteresting
scaffold,
become
fascinating
regulates
various
local
systemic
Recent
research
suggests
skeleton
is
important
endocrine
organ,
with
osteocalcin
being
most
prominent
hormone
produced
by
bone-forming
osteoblast
cells.
Osteocalcin
controls
several
physiological
functions,
such
as
glucose
homeostasis,
energy
expenditure,
brain
development.
Another
intriguing
role
it
male
fertility
enhancing
testosterone
biosynthesis
independently
hypothalamus-pituitary
axis.
This
demonstrates
regulator
reproduction
expands
functional
repertoire
osteocalcin.
Furthermore,
interconnects
bone,
metabolism,
to
form
novel
pancreas-bone-testis
review
summarizes
current
knowledge
osteocalcin-mediated
regulation
different
biological
functions
special
reference
its
in
regulating
reproduction.
will
provide
deep
insights
into
underlying
mechanisms
involved
improve
relationship
between
