Exercise timing influences multi-tissue metabolome and skeletal muscle proteome profiles in type 2 diabetic patients – A randomized crossover trial

Metabolism, Journal Year: 2022, Volume and Issue: 135, P. 155268 - 155268

Published: July 28, 2022

Aims/hypothesisMetabolic effects of exercise may partly depend on the time-of-day when is performed. We tested hypothesis that timing affects adaptations in multi-tissue metabolome and skeletal muscle proteome profiles men with type 2 diabetes.MethodsMen fitting inclusion (type diabetes, age 45–68 years body mass index 23–33 kg/m2) exclusion criteria (insulin treatment, smoking, concurrent systemic disease, regular training) were included a randomized crossover trial (n = 15). Participants this metabolomics proteomics analysis fully completed all sessions 8). The consisted two weeks high-intensity interval training (HIT) (three sessions/week) either morning (08:00, n 5) or afternoon (16:45, 3), two-week wash-out period, an additional HIT at opposing time. researchers not blinded to group allocation. Blood, subcutaneous adipose tissue obtained before first, after each period. Broad-spectrum, untargeted proteomic was performed muscle, metabolomic biosamples. Differential content assessed by linear regression pathway set enrichment analyses Coordinated metabolic changes across tissues identified Spearman correlation analysis.ResultsMetabolic remained stable HIT, individual metabolites proteins altered, irrespective time day which However, coordinated relevant pathways protein categories identified. Morning similarly increased plasma diacylglycerols, acyl-carnitines, sphingomyelins lysophospholipids. Acyl-carnitines central training-induced cross-talk tissues. Plasma carbohydrates, via penthose phosphate pathway, lipids decreased compared HIT. Skeletal lipoproteins higher, mitochondrial complex III abundance lower HIT.Conclusions/interpretationWe provide comprehensive responses different times diabetes. Increased circulating lipid composition common between greater degree than training. Thus, there diurnal component response clinical relevance warrants further investigation.

Language: Английский

---

Setting your clock: associations between timing of objective physical activity and cardiovascular disease risk in the general population

European Journal of Preventive Cardiology, Journal Year: 2022, Volume and Issue: 30(3), P. 232 - 240

Published: Nov. 14, 2022

Abstract Aims Little is known about the impact of daily physical activity timing (here referred to as ‘chronoactivity’) on cardiovascular disease (CVD) risk. We aimed examined associations between chronoactivity and multiple CVD outcomes in UK Biobank. Methods results data were collected UK-Biobank through triaxial accelerometer over a 7-day measurement period. used K-means clustering create clusters participants with similar irrespective mean intensity activity. Multivariable-adjusted Cox-proportional hazard models estimate ratios (HRs) comparing different adjusted for age sex (model 1), baseline risk factors 2). Additional stratified analyses done by sex, level, self-reported sleep chronotype. included 86 657 individuals (58% female, age: 61.6 [SD: 7.8] years, BMI: 26.6 [4.5] kg/m2). Over follow-up period 6 3707 incident events reported. Overall, tendency late morning had lower coronary artery (HR: 0.84, 95%CI: 0.77, 0.92) stroke 0.83, 0.70, 0.98) compared midday pattern These effects more pronounced women (P-value interaction = 0.001). did not find evidence favouring effect modification total level Conclusion Irrespective activity, was associated risks diseases, highlighting potential importance prevention.

Language: Английский

---

Metabolism and exercise: the skeletal muscle clock takes centre stage

Nature Reviews Endocrinology, Journal Year: 2023, Volume and Issue: 19(5), P. 272 - 284

Published: Feb. 1, 2023

Language: Английский

---

Association of Timing of Moderate-to-Vigorous Physical Activity With Changes in Glycemic Control Over 4 Years in Adults With Type 2 Diabetes From the Look AHEAD Trial

Diabetes Care, Journal Year: 2023, Volume and Issue: 46(7), P. 1417 - 1424

Published: May 25, 2023

OBJECTIVE We aimed to determine the association of time-of-day bout-related moderate-to-vigorous physical activity (bMVPA) with changes in glycemic control across 4 years adults overweight/obesity and type 2 diabetes. RESEARCH DESIGN AND METHODS Among 2,416 participants (57% women; mean age, 59 years) 7-day waist-worn accelerometry recording at year 1 or 4, we assigned bMVPA timing groups based on participants’ temporal distribution recategorized them 4. The time-varying exposure (≥10-min bout) was defined as ≥50% occurring during same time period (morning, midday, afternoon, evening), <50% any (mixed), ≤1 day per week (inactive). RESULTS HbA1c reduction varied among (P = 0.02), independent weekly volume intensity. afternoon group had greatest versus inactive (−0.22% [95%CI −0.39%, −0.06%]), magnitude which 30–50% larger than other groups. odds discontinuation maintaining initiating glucose-lowering medications differed by 0.04). highest (odds ratio 2.13 [95% CI 1.29, 3.52]). For all year-4 groups, there were no significant between CONCLUSIONS performed is associated improvements diabetes, especially within initial 12 months an intervention. Experimental studies are needed examine causality.

Language: Английский

---

Effects of exercise on circadian rhythms in humans

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: Oct. 11, 2023

The biological clock system is an intrinsic timekeeping device that integrates internal physiology and external cues. Maintaining a healthy crucial for life. Disruptions to the body’s can lead disturbances in sleep-wake cycle abnormalities hormone regulation, blood pressure, heart rate, other vital processes. Long-term have been linked development of various common major diseases, including cardiovascular metabolic disorders, tumors, neuropsychiatric conditions, so on. External factors, such as diurnal rhythm light, significant impact on clock. Additionally, important non-photic zeitgeber, exercise regulate rhythms certain extent, making it possible become non-drug intervention preventing treating circadian disorders. This comprehensive review encompasses behavioral, physiological, molecular perspectives provide deeper understanding how influences its association with related diseases.

Language: Английский

---