Clinical Nutrition, Journal Year: 2024, Volume and Issue: 43(7), P. 1725 - 1735
Published: May 31, 2024
Language: Английский
Frontiers in Public Health, Journal Year: 2023, Volume and Issue: 11
Published: Oct. 13, 2023
Aging is a progressive and irreversible pathophysiological process that manifests as the decline in tissue cellular functions, along with significant increase risk of various aging-related diseases, including metabolic diseases. While advances modern medicine have significantly promoted human health extended lifespan, diseases such obesity type 2 diabetes among older adults pose major challenge to global public societies age. Therefore, understanding complex interaction between factors crucial for promoting well-being healthy aging. This review article explores environmental behavioral associated their impact on The environment, an obesogenic environment exposure toxins, strongly correlated rising prevalence its comorbidities. Behavioral factors, diet, physical activity, smoking, alcohol consumption, sleep patterns, influence throughout Public interventions targeting modifiable can effectively promote healthier lifestyles prevent Collaboration government agencies, healthcare providers community organizations essential implementing these creating supportive environments foster
Language: Английский
Citations
58
Nature Reviews Endocrinology, Journal Year: 2023, Volume and Issue: 19(5), P. 272 - 284
Published: Feb. 1, 2023
Language: Английский
Citations
39
Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14
Published: Oct. 11, 2023
The biological clock system is an intrinsic timekeeping device that integrates internal physiology and external cues. Maintaining a healthy crucial for life. Disruptions to the body’s can lead disturbances in sleep-wake cycle abnormalities hormone regulation, blood pressure, heart rate, other vital processes. Long-term have been linked development of various common major diseases, including cardiovascular metabolic disorders, tumors, neuropsychiatric conditions, so on. External factors, such as diurnal rhythm light, significant impact on clock. Additionally, important non-photic zeitgeber, exercise regulate rhythms certain extent, making it possible become non-drug intervention preventing treating circadian disorders. This comprehensive review encompasses behavioral, physiological, molecular perspectives provide deeper understanding how influences its association with related diseases.
Language: Английский
Citations
27
Journal of Pineal Research, Journal Year: 2024, Volume and Issue: 76(4)
Published: May 1, 2024
Abstract The circadian timing system controls glucose metabolism in a time‐of‐day dependent manner. In mammals, the consists of main central clock bilateral suprachiasmatic nucleus (SCN) anterior hypothalamus and subordinate clocks peripheral tissues. oscillations produced by these different with period approximately 24‐h are generated transcriptional‐translational feedback loops set core genes. Glucose homeostasis is one daily rhythms controlled this system. pacemaker SCN through its neural projections to hypothalamic hubs that control feeding behavior energy metabolism. Using hormones such as adrenal glucocorticoids melatonin autonomic nervous system, modulates critical processes production insulin sensitivity. Peripheral tissues, liver, muscle, adipose tissue serve enhance sustain signals. optimal situation all synchronized aligned environmental light/dark cycle. A negative impact on becomes apparent when internal disturbed, also known desynchrony or misalignment. Circadian may occur at several levels, mistiming light exposure sleep will especially affect clock, whereas food intake physical activity involve clocks. review, we summarize literature investigating how it result development resistance. addition, discuss potential strategies aimed reinstating synchrony improve sensitivity contribute prevention type 2 diabetes.
Language: Английский
Citations
15
Biomolecules, Journal Year: 2025, Volume and Issue: 15(1), P. 130 - 130
Published: Jan. 15, 2025
Proteomics accelerates diagnosis and research of muscular diseases by enabling the robust analysis proteins relevant for manifestation neuromuscular in following aspects: (i) evaluation effect genetic variants on corresponding protein, (ii) prediction underlying defect based proteomic signature muscle biopsies, (iii) pathophysiologies different entities diseases, key definition new intervention concepts, (iv) patient stratification according to biochemical fingerprints as well (v) monitoring success therapeutic interventions. This review presents—also through exemplary case studies—the various advantages mass proteomics investigation discusses technical limitations, provides an outlook possible future application concepts. Hence, is excellent large-scale analytical tool diagnostic workup (hereditary) warrants systematic profiling pathophysiological processes. The steady development may allow overcome existing limitations including a quenched dynamic range quantification protein isoforms. Future directions include targeted settings using not only biopsies but also liquid address need minimally invasive procedures.
Language: Английский
Citations
1
Metabolites, Journal Year: 2023, Volume and Issue: 13(6), P. 694 - 694
Published: May 26, 2023
Exercise has many benefits for physical and mental well-being. Metabolomics research allowed scientists to study the impact of exercise on body by analyzing metabolites released tissues such as skeletal muscle, bone, liver. Endurance training increases mitochondrial content oxidative enzymes, while resistance muscle fiber glycolytic enzymes. Acute endurance affects amino acid metabolism, fat cellular energy cofactor vitamin metabolism. Subacute alters lipid nucleotide Chronic improves metabolism changes several metabolic pathways, including anaerobic processes muscular strength. resulting in adaptations. Combined endurance–resistance carbohydrate increasing capacity fatigue resistance. Studying exercise-induced is a growing field, further can uncover underlying mechanisms help tailor programs optimal health performance.
Language: Английский
Citations
19
The Journal of Physiology, Journal Year: 2023, Volume and Issue: 601(11), P. 2165 - 2188
Published: Feb. 23, 2023
Exercise-induced perturbation of skeletal muscle metabolites is a probable mediator long-term health benefits in older adults. Although specific have been identified to be impacted by age, physical activity and exercise, the depth coverage metabolome still limited. Here, we investigated resting exercise-induced metabolite distribution from well-phenotyped adults who were active or sedentary, group young Percutaneous biopsies vastus lateralis obtained before, immediately after 3 h following bout endurance cycling. Metabolite profile was determined tandem mass spectrometry. Mitochondrial energetics permeabilized fibre bundles assessed high resolution respirometry type proportion immunohistology. We found that kynurenine/tryptophan pathway age activity. Specifically, kynurenine elevated adults, whereas downstream (kynurenic acid NAD
Language: Английский
Citations
18
Molecular Metabolism, Journal Year: 2024, Volume and Issue: 86, P. 101980 - 101980
Published: June 29, 2024
In this investigation, we addressed the contribution of core circadian clock factor, BMAL1, in skeletal muscle to both acute transcriptional responses exercise and remodeling response training. Additionally, adopted a systems biology approach investigate how loss BMAL1 altered peripheral tissue homeostasis as well training adaptations iWAT, liver, heart, lung male mice.
Language: Английский
Citations
7
Journal of Molecular and Cellular Cardiology, Journal Year: 2024, Volume and Issue: 188, P. 79 - 89
Published: Feb. 15, 2024
Language: Английский
Citations
6
Sports Medicine, Journal Year: 2023, Volume and Issue: 53(10), P. 1951 - 1961
Published: July 17, 2023
Language: Английский
Citations
14