Epidemiology of diabetes among South Asians in the United States: lessons from the MASALA study DOI
Unjali P. Gujral, Alka M. Kanaya

Annals of the New York Academy of Sciences, Journal Year: 2020, Volume and Issue: 1495(1), P. 24 - 39

Published: Nov. 20, 2020

Abstract South Asian individuals in the United States are at an increased risk of type 2 diabetes (T2DM); however, mechanisms behind this not well understood. The Mediators Atherosclerosis Asians Living America (MASALA) study is only longitudinal cohort and provides key insights as to epidemiology T2DM Asians. Evidence from MASALA suggests that experience a disproportionately high burden prevalent incident compared with members other race/ethnic groups. Higher insulin resistance Asians, even low body mass index (BMI), more impairment secretion, greater deposition ectopic fat likely play role etiology. Furthermore, migrants range factors related acculturation, social networks, religious beliefs, which may impact physical activity dietary practices. Interventions prevent should include focus on cultural health consider complete mechanistic pathway relative contributions resistance, β cell dysfunction, development particularly those lower BMI.

Language: Английский

Metabolic non-communicable disease health report of India: the ICMR-INDIAB national cross-sectional study (ICMR-INDIAB-17) DOI Open Access
Ranjit Mohan Anjana, Ranjit Unnikrishnan,

Mohan Deepa

et al.

The Lancet Diabetes & Endocrinology, Journal Year: 2023, Volume and Issue: 11(7), P. 474 - 489

Published: June 8, 2023

Language: Английский

Citations

309
Pathophysiology, phenotypes and management of type 2 diabetes mellitus in Indian and Chinese populations DOI Open Access
Calvin Ke, K.M. Venkat Narayan, Juliana C.N. Chan

et al.

Nature Reviews Endocrinology, Journal Year: 2022, Volume and Issue: 18(7), P. 413 - 432

Published: May 4, 2022

Language: Английский

Citations

149
Epidemiology of Diabetes and Atherosclerotic Cardiovascular Disease Among Asian American Adults: Implications, Management, and Future Directions: A Scientific Statement From the American Heart Association DOI Open Access
Tak Kwan,

Sally S. Wong,

Yuling Hong

et al.

Circulation, Journal Year: 2023, Volume and Issue: 148(1), P. 74 - 94

Published: May 8, 2023

Asian American individuals make up the fastest growing racial and ethnic group in United States. Despite substantial variability that exists type 2 diabetes atherosclerotic cardiovascular disease risk among different subgroups of Americans, current literature, when available, often fails to examine these individually. The purpose this scientific statement is summarize latest disaggregated data, possible, on demographics, prevalence, biological mechanisms, genetics, health behaviors, acculturation lifestyle interventions, pharmacological therapy, complementary alternative their impact disease. On basis available evidence date, we noted prevalences stroke mortality are higher all compared with non-Hispanic White adults. Data also showed highest South Filipino adults but lowest Chinese, Japanese, Korean This discusses pathway possible role genetics Challenges provide evidence-based recommendations included limited data prediction models, national surveillance surveys, clinical trials, leading significant research disparities population. large disparity within population a call for action public care community, whom opportunities inclusion should be priority. Future studies need adequately powered, incorporate multiple ancestries, include multigenerational cohorts. With advances epidemiology analysis availability larger, representative cohorts, furthering refining Pooled Cohort Equations, addition enhancers, would allow better estimation segments Last, provides individual- community-level intervention suggestions professionals who interact

Language: Английский

Citations

55
Disparities in diabetes prevalence and management by race and ethnicity in the USA: defining a path forward DOI
Saria Hassan, Unjali P. Gujral, Rakale C. Quarells

et al.

The Lancet Diabetes & Endocrinology, Journal Year: 2023, Volume and Issue: 11(7), P. 509 - 524

Published: June 25, 2023

Language: Английский

Citations

52
Multi-ancestry polygenic mechanisms of type 2 diabetes DOI
Kirk Smith, Aaron J. Deutsch,

Carolyn McGrail

et al.

Nature Medicine, Journal Year: 2024, Volume and Issue: 30(4), P. 1065 - 1074

Published: March 5, 2024

Language: Английский

Citations

31
Visceral Adipose Tissue: The Hidden Culprit for Type 2 Diabetes DOI Open Access

Sneha Dhokte,

Krzysztof Czaja

Nutrients, Journal Year: 2024, Volume and Issue: 16(7), P. 1015 - 1015

Published: March 30, 2024

Type 2 diabetes (T2D) is a chronic metabolic disorder characterized by insulin resistance in various tissues. Though conventionally associated with obesity, current research indicates that visceral adipose tissue (VAT) the leading determining factor, wielding more influence regardless of individual body mass. The heightened activity VAT encourages circulation free fatty acid (FFA) molecules, which induce surrounding Individuals most vulnerable to this preferential fat deposition are older males ancestral ties Asian countries because genetics and sex hormones pivotal factors for accumulation. However, interventions one's diet lifestyle have potential strategically discourage growth VAT. This illuminates possibility expansion and, subsequently, risk T2D development preventable. Therefore, reducing amount accumulated an preventing it from building up, one can effectively control prevent T2D.

Language: Английский

Citations

27
Possible sarcopenia, Sarcopenic obesity phenotypes and their association with diabetes: Evidence from LASI wave-1 (2017-18) DOI
Inderdeep Kaur, Subrat Das,

Shivangi Chandel

et al.

Diabetes & Metabolic Syndrome Clinical Research & Reviews, Journal Year: 2025, Volume and Issue: 19(2), P. 103185 - 103185

Published: Jan. 11, 2025

Language: Английский

Citations

2
Young-onset diabetes in Asian Indians is associated with lower measured and genetically determined beta cell function DOI Creative Commons
Moneeza K. Siddiqui, Ranjit Mohan Anjana, Adem Y. Dawed

et al.

Diabetologia, Journal Year: 2022, Volume and Issue: 65(6), P. 973 - 983

Published: March 5, 2022

Abstract Aims/hypothesis South Asians in general, and Asian Indians particular, have higher risk of type 2 diabetes compared with white Europeans, a younger age onset. The reasons for the onset relation to obesity, beta cell function insulin sensitivity are under-explored. Methods Two cohorts Indians, ICMR-INDIAB cohort (Indian Council Medical Research-India Diabetes Study) DMDSC (Dr Mohan’s Specialties Centre), one ESDC (East Scotland Cohort), were used. Using cross-sectional design, we examined comparative prevalence healthy, overweight obese participants young-onset diabetes, classified according their BMI. We explored role clinically measured Indians. Finally, distribution partitioned polygenic score (pPS) due poor was examined. Replication genetic findings sought using data from UK Biobank. Results normal BMI 9.3% amongst Europeans 24–39% In after adjustment family history sex, HDL-cholesterol, stimulated C-peptide 492 pmol/ml (IQR 353–616, p <0.0001) lower lean individuals. our study, Biobank, had number alleles than Europeans. After weighting pPS function, genetically determined ( <0.0001). associated diagnosis but not explained 2% variation 1.2%, 0.97%, 0.36% variance BMI, or as respectively. Conclusions/interpretation is over two times This phenotype lean, appears driven part by function. demonstrate that also Graphical abstract

Language: Английский

Citations

62
Subgroups of patients with young-onset type 2 diabetes in India reveal insulin deficiency as a major driver DOI Creative Commons
Rashmi B. Prasad, Olof Asplund, Sharvari Shukla

et al.

Diabetologia, Journal Year: 2021, Volume and Issue: 65(1), P. 65 - 78

Published: Oct. 23, 2021

Five subgroups were described in European diabetes patients using a data driven machine learning approach on commonly measured variables. We aimed to test the applicability of this phenotyping Indian individuals with young-onset type 2 diabetes.

Language: Английский

Citations

57
Associations between accurate measures of adiposity and fitness, blood proteins, and insulin sensitivity among South Asians and Europeans DOI Creative Commons
Pik Fang Kho, Laurel Stell,

Shirin Jimenez

et al.

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 20, 2025

Objective South Asians (SAs) may possess a unique predisposition to insulin resistance (IR). We explored this possibility by investigating the relationship between ‘gold standard’ measures of adiposity, fitness, selected proteomic biomarkers, and sensitivity among cohort SAs Europeans (EURs). Methods A total 46 41 EURs completed ‘conventional’ (lifestyle questionnaires, standard physical exam) as well (dual energy X-ray absorptiometry scan, cardiopulmonary exercise test, suppression test) assessments sensitivity. In subset 28 36 EURs, we also measured blood-levels eleven IR-related proteins. conducted Spearman correlation identify correlates steady-state plasma glucose (SSPG) derived from followed multivariable linear regression analyses SSPG, adjusting for age, sex ancestral group. Results Sixteen 30 significantly associated with including one conventional eight gold measure five Multivariable regressions revealed that proteins attenuated group differences in IR, suggesting their potential utility assessing especially SAs. Conclusion Ancestral IR be explained accurate adiposity specific possibly serving useful surrogates these measures, particularly

Language: Английский

Citations

1