Probiotics in reducing obesity by reconfiguring the gut microbiota. DOI

Yunuo Zhang,

Wei Wang

PubMed, Journal Year: 2024, Volume and Issue: 49(7), P. 1042 - 1051

Published: July 28, 2024

Obesity, as a global health crisis, is increasingly linked to intestinal microecology. Probiotics colonise the body, effectively regulating balance of flora, while strengthening barrier, activating immune response, releasing beneficial substances, and maintaining micro-ecological balance. This process not only enhances defence against pathogens, but also reduces production inflammatory factors lowers level chronic inflammation. However, specific mechanism by which probiotics influence microecology through improve metabolic disorders caused obesity, participate in weight management are clear. Through multiple neural pathways including 'gut-brain axis' their direct interaction with intestine, increase number bacteria intestine inhibit growth harmful bacteria, thus restructuring flora. can optimise environment enhance efficiency food digestion nutrient absorption. show positive effects on obesity reducing fat accumulation, providing individuals new way control body prevent obesity. Therefore, application great significance promoting gut management.

Language: Английский

Caenorhabditis elegans as a Screening Model for Probiotics with Properties against Metabolic Syndrome DOI Open Access

Ignacio Goyache,

Deyan Yavorov-Dayliev, Fermı́n I. Milagro

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(2), P. 1321 - 1321

Published: Jan. 22, 2024

There is a growing need to develop new approaches prevent and treat diseases related metabolic syndromes, including obesity or type 2 diabetes, that focus on the different factors involved in pathogenesis of these diseases. Due role gut microbiota regulation glucose insulin homeostasis, probiotics with beneficial properties have emerged as an alternative therapeutic tool ameliorate diseases-related disturbances, fat excess inflammation. In last few years, strains bacteria, mainly lactic acid bacteria (LAB) species from genus Bifidobacterium, potential due their anti-obesogenic and/or anti-diabetic properties. However, vivo studies are needed demonstrate mechanisms probiotic features. this context, Caenorhabditis elegans has very powerful simple model study physiological molecular effects applications regarding pathologies syndrome. This review aims summarize main describing anti-obesogenic, anti-diabetic, anti-inflammatory using C. research model, well providing description activities.

Language: Английский

Citations

11
Pediococcus acidilactici CECT 9879 (pA1c®) and heat inactivated pA1c® (pA1c® HI) ameliorate gestational diabetes mellitus in mice DOI Creative Commons
Deyan Yavorov-Dayliev, Fermı́n I. Milagro, Josune Ayo

et al.

Life Sciences, Journal Year: 2025, Volume and Issue: 362, P. 123359 - 123359

Published: Jan. 4, 2025

Language: Английский

Citations

1
Inter- and Transgenerational Effects of In Ovo Stimulation with Bioactive Compounds on Cecal Tonsils and cecal Mucosa Transcriptomes in a Chicken Model DOI Open Access
Mariam Ibrahim, Marek Bednarczyk, Katarzyna Stadnicka

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1174 - 1174

Published: Jan. 29, 2025

Exploring how early-life nutritional interventions may impact future generations, this study examines the inter- and transgenerational effects of in ovo injection bioactive compounds on gene expression cecal tonsils mucosa using a chicken model. Synbiotic PoultryStar® (Biomin) choline were injected 12th day egg incubation. Three experimental groups established generation F1: (1) control group (C) receiving 0.9% physiological saline (NaCl), (2) synbiotic (SYN) 2 mg/embryo, (3) combined (SYNCH) mg 0.25 per embryo. For generations F2 F3, SYN SYNCH each divided into two subgroups: (A) those solely F1 (SYNs SYNCHs) (B) (SYNr SYNCHr). At 21 weeks posthatching, tonsil samples collected from F1, F2, F3 birds for transcriptomic analysis. Gene profiling revealed distinct intergenerational patterns both tissues. In tonsils, significant was noted following drop F2. contrast, showed more changes indicating effects. While some carried they less pronounced, except SYNs group, which experienced an increase compared to The highlights that epigenetic modifications are dynamic unpredictable, with potentially re-emerging later under certain conditions or fading intensifying over time. This provides valuable insights stimulation during embryonic development regulate processes across multiple generations. Our findings provide evidence supporting phenomenon dynamics

Language: Английский

Citations

1
Screening model in Caenorhabditis elegans for radioprotective natural products DOI
Yang Wenxi, Zhihui Li, Xiaojuan Chen

et al.

International Journal of Radiation Biology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 10

Published: Jan. 2, 2025

Purpose Ionizing radiation (IR) could induce damage such as DNA and oxidative stress. Natural products, like tea, have been demonstrated potential in mitigating these damages. However, the lack of efficient rapid screening methods for natural products hinders their widespread application. To address this challenge, study utilized Caenorhabditis elegans (C. elegans) an vivo model to investigate radioprotective products.

Language: Английский

Citations

0
Benefits of inulin and fructo-oligosaccharides on high fat diet-induced type 2 diabetes mellitus by regulating the gut microbiota in mice DOI

Xiaoqin Ding,

Qingyan Chen, Lanlan Du

et al.

The Journal of Nutritional Biochemistry, Journal Year: 2025, Volume and Issue: unknown, P. 109908 - 109908

Published: March 1, 2025

Language: Английский

Citations

0
Matrine Inhibits High-Glucose-Diet-Induced Fat Accumulation and Aβ-Mediated Lipid Metabolic Disorder via AAK-2/NHR-49 Pathway in Caenorhabditis elegans DOI Open Access

Aimin Qiao,

Meiqing Pan,

Yue Zeng

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3048 - 3048

Published: March 26, 2025

Matrine, a quinoline alkaloid, possesses lipid-regulating effects, but the underlying mechanisms are rarely characterized in vivo. With fat-accumulating Caenorhabditis elegans model, we show that matrine reduces fat content and DHS-3::GFP-labeled lipid droplets high-glucose-diet N2 transgenic LIU1 nematodes, respectively. Based on RNA-seq, this study demonstrates loss of AAK-2 function suppresses fat-lowering effects matrine, hyperactivated strain has relatively lower than N2. The involvement NHR-49 matrine's further suggests impacts breakdown storage via AAK-2/NHR-49-governed pathway. Using SJ4143 (ges-1::GFP(mit)) VS10 (vha-6p::mRFP-PTS1), activates AAK-2/NHR-49 pathway, coupling alteration mitochondrial peroxisomal functions. Studies aak-2 nhr-49 mutants reveal modulate metabolic homeostasis; meanwhile, increases physical fitness lifespan through activating pathway nematodes. Surprisingly, found β-amyloid (Aβ) induces disorder an Alzheimer's disease (AD) C. not only Aβ aggregation also alleviates Aβ-mediated disorder. Our data suggest promise as agent, offer new insights into its therapeutic potential for AD.

Language: Английский

Citations

0
Application of prebiotic stachyose on metabolic diseases and other human diseases through regulation of gut microbiota DOI Creative Commons
Ziheng Zhang, Jiajing Wu, Zhaodong Zhang

et al.

Journal of Functional Foods, Journal Year: 2025, Volume and Issue: 127, P. 106778 - 106778

Published: April 1, 2025

Language: Английский

Citations

0
Pediococcus acidilactici (pA1c®) alleviates obesity-related dyslipidemia and inflammation in Wistar rats by activating beta-oxidation and modulating the gut microbiota DOI Creative Commons
Deyan Yavorov-Dayliev, Fermı́n I. Milagro, Miguel Lópeź‐Yoldi

et al.

Food & Function, Journal Year: 2023, Volume and Issue: 14(24), P. 10855 - 10867

Published: Jan. 1, 2023

pA1c® prevents obesity-related disturbances including hypercholesterolemia and hypertriglyceridemia by reducing inflammation, activating beta-oxidation reverting gut microbiota dysbiosis.

Language: Английский

Citations

9
Synbiotic supplementation with Xylooligosaccharide derived probiotic Lactobacillus gasseri and prebiotic mixture exerts antidiabetic effects via collaborative action DOI
Chenwei Li, Dongyao Li, Hongjie Liu

et al.

Food Bioscience, Journal Year: 2024, Volume and Issue: 61, P. 104948 - 104948

Published: Aug. 23, 2024

Language: Английский

Citations

2
Antimicrobial effects and metabolomics analysis of cell-free supernatant produced by Pediococcus acidilactici LWX 401 isolated from Yunnan traditional pickles DOI Creative Commons
Weixin Liu, Jiajia Wang,

Xian-Kang Xiao

et al.

LWT, Journal Year: 2023, Volume and Issue: 191, P. 115626 - 115626

Published: Dec. 8, 2023

Foodborne pathogens pose a significant risk to human health via the food chain. Here, we evaluated antibacterial effects of cell-free supernatant (CFS) Pediococcus acidilactici (P. acidilactici) LWX 401 isolated from food-grade Chinese traditional pickles and found that it exhibited broad activity against multidrug-resistant gram-negative Escherichia coli (E. coli) O157:H7 yogurt-derived gram-positive Staphylococcus aureus (S. aureus), with inhibition zone sizes 23.10 ± 0.80 20.53 0.07 mm, respectively (all P < 0.001 compared controls). Moreover, CFS strong thermostability pH tolerance was capable inhibiting formation biofilms these foodborne pathogens. Notably, inhibited both E. S. contamination in milk samples under different storage temperatures (4 °C, 25 35 °C), considerable bacterial reduction by 1–7 log CFU/mL untreated controls. Additionally, potential metabolites (VIP >1, adjusted 0.05, fold-change >2; n = 56) were identified UHPLC-QE-MS metabolomic analysis, mostly lipids (25.73%) organic acids (23.30%). Our results provide insights for development bio-preservatives industry.

Language: Английский

Citations

6