Comparison of “hock-a-loogie” saliva versus nasopharyngeal and oropharyngeal swabs for detecting common respiratory pathogens DOI Creative Commons

Renke Chen,

Jiaqi Bao, Xiaojuan Huang

et al.

Heliyon, Journal Year: 2023, Volume and Issue: 9(10), P. e20965 - e20965

Published: Oct. 1, 2023

Self-collection of saliva samples has attracted considerable attention in recent years, particularly during the coronavirus disease 2019 pandemic. However, studies investigating detection other common respiratory pathogens are limited. In this study, nasopharyngeal swabs (NPS), oropharyngeal (OPS), and "hock-a-loogie" (HLS) were collected from 469 patients to detect 13 pathogens. Overall positivity rates for NPS (66.1 %), HLS (63.5 OPS (57.8 %) statistically different (P = 0.028), with an overall concordance 72.7 %. Additionally, (85.9 (83.2 all much higher than (73.3 %). Coronavirus human rhinovirus most frequently detected < 0.001). Mycoplasma pneumoniae was significantly more prevalent group 0.008). conclusion, a reliable sample type detecting easily can be used emergencies or specific conditions. Mixed NPS/OPS NPS/HLS specimens have potential improve rates, although testing alone relatively high risk missed detection.

Language: Английский

Exploring the role of noncoding RNAs in cancer diagnosis, prognosis, and precision medicine DOI Creative Commons
Basmah Eldakhakhny,

Abdulaziz M. Sutaih,

Moaaz A. Siddiqui

et al.

Non-coding RNA Research, Journal Year: 2024, Volume and Issue: 9(4), P. 1315 - 1323

Published: July 1, 2024

This review article studies the complex field of noncoding RNAs (ncRNAs) in cancer biology, focusing on their potential use as biomarkers and therapeutic targets. NcRNAs include circular (circRNAs), long (lncRNAs), microRNAs (miRNAs). We discuss how ncRNAs affect gene expression cancerous cells, spread cancer, metastasis. The illustrates pathways through which can oncogenesis, tumor suppression, resistance. It also assesses clinical uses non-coding (ncRNAs), including utility diagnosis, prognosis. Besides, for personalized therapy is documented. Finally, it concluded that understanding role ncRNA importance regarding carcinogenesis, therapy.

Language: Английский

Citations

5
Diagnostic value of miR-193a-5p in severe pneumonia and its correlation with prognosis DOI Creative Commons

Xiaoji Su,

Lijuan Zhu, Jian Zhuo

et al.

Journal of Cardiothoracic Surgery, Journal Year: 2025, Volume and Issue: 20(1)

Published: Jan. 23, 2025

Language: Английский

Citations

0
Biomarkers associated with the diagnosis and prognosis of Mycoplasma pneumoniae pneumonia in children: a review DOI Creative Commons

Lele Ding,

Yonghong Jiang

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: March 18, 2025

Community-acquired pneumonia (CAP) is a major cause of death in children, and Mycoplasma pneumoniae (MP) the main pathogen CAP children China. Although (MPP) usually self-limiting disease, many develop multiple complications due to drug resistance or untimely diagnosis treatment, may even progress severe MPP refractory with poor prognosis. It important explore value biomarkers that can be used clinical practice assess severity assist decision making. In this article, we searched literature last four years review roles various types associated predictive models, aim helping pediatricians understand evaluation indexes related other than microbiology.

Language: Английский

Citations

0
Predictive clinical indicators of refractory Mycoplasma pneumoniae pneumonia in children: A retrospective cohort study DOI Creative Commons
Hong Pei, Hongli Luo

Medicine, Journal Year: 2024, Volume and Issue: 103(34), P. e39375 - e39375

Published: Aug. 23, 2024

To determine the clinical indicators predictive of refractory Mycoplasma pneumoniae pneumonia (RMPP) in children and develop a robust model to aid early identification management. A retrospective cohort study was conducted on 338 diagnosed with RMPP out total 1500 cases at single tertiary hospital from May 2021 November 2023. Clinical demographic data analyzed included age, gender, parents’ educational level, household income, body mass index, allergic constitution, laboratory findings such as white blood cell count, neutrophil lymphocyte counts, platelet levels C-reactive protein (CRP), D-dimer, procalcitonin. Univariate multivariate logistic regression analyses were performed identify significant predictors RMPP, developed. Among cohort, 52.4% female, mean age 6.07 ± 2.78 years. Multivariate analysis identified several poor prognosis, including higher longer duration fever, elevated levels, increased ratio ratio. The demonstrated outstanding diagnostic performance, an area under receiver operating characteristic curve 0.963 (95% confidence interval: 0.946–0.981). Our identifies key accuracy for predicting children. established offers valuable tool clinicians, potentially improving outcomes through timely intervention.

Language: Английский

Citations

2
Overview of the epidemic characteristics of Mycoplasma pneumoniae infection around COVID pandemic DOI Creative Commons
Hongmei Sun, Li Xiao

iLABMED, Journal Year: 2023, Volume and Issue: 1(3), P. 148 - 157

Published: Dec. 1, 2023

Abstract Mycoplasma pneumoniae ( M. ) is a cell wall‐less respiratory pathogen causing community‐acquired pneumonia and extrapulmonary manifestations. It transmitted through close contact shows periodic regional outbreaks. The coronavirus disease (COVID‐19) pandemic interfered with the global spread of . A large‐scale post‐COVID outbreak currently ongoing in China. To help physicians better understand manage this epidemic, we provide review summarizing current knowledge on pathogenesis, epidemic characteristics, macrolide resistance, diagnostic methods, clinical treatment strategies for pathogen.

Language: Английский

Citations

4
LINC02605 involved in paediatric Mycoplasma pneumoniae pneumonia complicated with diarrhoea via miR‐539‐5p/CXCL1 axis DOI
Yang Zhang, Zeming Wu

European Journal of Clinical Investigation, Journal Year: 2024, Volume and Issue: 54(9)

Published: April 25, 2024

To investigate the involvement of LINC02605 in progression paediatric Mycoplasma pneumoniae pneumonia (MPP).

Language: Английский

Citations

0
Long non-coding RNA MMTP mediates necroptosis in alveolar macrophages during Mycoplasma hyopneumoniae infection by enhancing TNF-α transcription DOI
Zhenzhen Zhang,

Xiuzhen Mei,

Hui Wang

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 288, P. 138649 - 138649

Published: Dec. 14, 2024

Language: Английский

Citations

0
Comparison of “hock-a-loogie” saliva versus nasopharyngeal and oropharyngeal swabs for detecting common respiratory pathogens DOI Creative Commons

Renke Chen,

Jiaqi Bao, Xiaojuan Huang

et al.

Heliyon, Journal Year: 2023, Volume and Issue: 9(10), P. e20965 - e20965

Published: Oct. 1, 2023

Self-collection of saliva samples has attracted considerable attention in recent years, particularly during the coronavirus disease 2019 pandemic. However, studies investigating detection other common respiratory pathogens are limited. In this study, nasopharyngeal swabs (NPS), oropharyngeal (OPS), and "hock-a-loogie" (HLS) were collected from 469 patients to detect 13 pathogens. Overall positivity rates for NPS (66.1 %), HLS (63.5 OPS (57.8 %) statistically different (P = 0.028), with an overall concordance 72.7 %. Additionally, (85.9 (83.2 all much higher than (73.3 %). Coronavirus human rhinovirus most frequently detected < 0.001). Mycoplasma pneumoniae was significantly more prevalent group 0.008). conclusion, a reliable sample type detecting easily can be used emergencies or specific conditions. Mixed NPS/OPS NPS/HLS specimens have potential improve rates, although testing alone relatively high risk missed detection.

Language: Английский

Citations

1