Involvement of LaeA and Velvet Proteins in Regulating the Production of Mycotoxins and Other Fungal Secondary Metabolites
Xuwen Hou,
No information about this author
Liyao Liu,
No information about this author
Dan Xu
No information about this author
et al.
Journal of Fungi,
Journal Year:
2024,
Volume and Issue:
10(8), P. 561 - 561
Published: Aug. 8, 2024
Fungi
are
rich
sources
of
secondary
metabolites
agrochemical,
pharmaceutical,
and
food
importance,
such
as
mycotoxins,
antibiotics,
antitumor
agents.
Secondary
play
vital
roles
in
fungal
pathogenesis,
growth
development,
oxidative
status
modulation,
adaptation/resistance
to
various
environmental
stresses.
LaeA
contains
an
S-adenosylmethionine
binding
site
displays
methyltransferase
activity.
The
members
velvet
proteins
include
VeA,
VelB,
VelC,
VelD
VosA
for
each
member
with
a
domain.
can
form
multimeric
complexes
VosA-VelB
VelB-VeA-LaeA.
They
belong
global
regulators
mainly
impacted
by
light.
One
their
most
important
functions
is
regulate
gene
expressions
that
responsible
metabolite
biosynthesis.
aim
this
mini-review
represent
the
newest
cognition
biosynthetic
regulation
mycotoxins
other
proteins.
In
cases,
positively
production
metabolites.
regulated
species
toxigenic
fungi
from
genera
Alternaria,
Aspergillus,
Botrytis,
Fusarium,
Magnaporthe,
Monascus,
Penicillium
mycotoxins.
We
control
inhibit
harmful
while
promoting
useful
fungi.
Furthermore,
should
be
practical
strategy
activating
silent
clusters
(BGCs)
obtain
previously
undiscovered
Language: Английский
Regulation of LaeA and Velvet Proteins on the Production of Mycotoxins and Other Fungal Secondary Metabolites
Xuwen Hou,
No information about this author
Liyao Liu,
No information about this author
Dan Xu
No information about this author
et al.
Published: July 16, 2024
Fungi
are
rich
sources
of
secondary
metabolites
agrochemical,
pharmaceutical
and
food
importances,
such
as
mycotoxins,
antibiotics
antitumor
agents.
Secondary
play
vital
roles
in
fungal
pathogenesis,
growth
development,
oxidative
status
modulation,
adaptation/resistance
to
various
environmental
stresses.
LaeA
contains
an
S-adenosylmethionine
binding
site
displays
methyltransferase
activity.
The
members
velvet
proteins
include
VeA,
VelB,
VelC,
VelD
VosA,
for
each
member
with
a
domain.
can
form
multimeric
complexes
VosA-VelB
VelB-VeA-LaeA.
They
belong
global
regulators
mainly
impacted
by
light.
One
their
most
important
functions
is
regulate
gene
expression
that
responsible
metabolite
biosynthesis.
aim
this
mini-review
represent
the
newest
cognition
on
biosynthetic
regulation
mycotoxins
other
proteins.
In
cases,
positively
regulated
production
metabolites.
species
toxigenic
fungi
from
genera
Alternaria,
Aspergillus,
Botrytis,
Fusarium,
Magnaporthe,
Monascus,
Penicillium
mycotoxins.
We
control
inhibit
harmful
while
promoting
useful
fungi.
Furthermore,
should
be
practical
strategy
activating
silent
clusters
(BGCs)
obtain
previously
undiscovered
Language: Английский
Leveraging endophytic fungi and multiomics integration for targeted drug discovery
Elsevier eBooks,
Journal Year:
2025,
Volume and Issue:
unknown, P. 277 - 293
Published: Jan. 1, 2025
Language: Английский
Genome mining of an endophytic natural yeast isolate Rhodotorula sp. Y090 and production of the antioxidant ergothioneine
Yu-Zhen Li,
No information about this author
Qi Wang,
No information about this author
Cheng Cheng
No information about this author
et al.
Journal of Biotechnology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 1, 2025
Language: Английский
l‐Asparaginase Bio‐Betters: Insight Into Current Formulations, Optimization Strategies and Future Bioengineering Frontiers in Anti‐Cancer Drug Development
Advanced Therapeutics,
Journal Year:
2024,
Volume and Issue:
7(10)
Published: Aug. 19, 2024
Abstract
Cancer
remains
a
persistent
global
health
concern,
representing
significant
challenge
in
medical
science
and
patient
care.
In
this
context,
l
‐asparaginase
has
emerged
as
promising
therapeutic
agent
due
to
its
unique
ability
deplete
circulating
asparagine,
thereby
selectively
targeting
cancer
cells.
However,
despite
potential,
current
formulations
of
are
not
without
limitations.
Issues
such
immunogenicity,
short
half‐life,
variable
efficacy
present
hurdles
widespread
clinical
application.
To
overcome
these
hurdles,
researchers
focusing
on
developing
bio‐better
versions
‐asparaginase.
These
bio‐betters
aim
enhance
stability,
reduce
optimize
enzyme
kinetics,
thus
improving
treatment
outcomes.
This
review
critically
assesses
the
landscape
bio‐betters,
offering
insights
into
ongoing
advancements,
optimization
strategies,
future
bio‐engineering
frontiers.
It
discusses
modifications
properties
explores
innovative
approaches
like
in‐silico
engineering
artificial
intelligence,
highlighting
their
potential
improve
profile
Challenges
debates
surrounding
mechanism
also
addressed.
By
addressing
challenges
outlining
directions,
aims
contribute
advancement
anti‐cancer
therapeutics,
particularly
context
research.
Language: Английский
Beauvericin Reverses Epithelial-to-Mesenchymal Transition in Triple-Negative Breast Cancer Cells through Regulation of Notch Signaling and Autophagy
ACS Pharmacology & Translational Science,
Journal Year:
2024,
Volume and Issue:
7(9), P. 2878 - 2893
Published: Sept. 3, 2024
Metastasis
stands
as
a
prime
contributor
to
triple-negative
breast
cancer
(TNBC)
associated
mortality
worldwide,
presenting
heightened
severity
and
significant
challenges
due
limited
treatment
options.
Addressing
TNBC
metastasis
necessitates
innovative
approaches
novel
therapeutics
specifically
target
its
propensity
for
dissemination
distant
organs.
Targeted
therapies
capable
of
reversing
epithelial-to-mesenchymal
transition
(EMT)
play
crucial
role
in
suppressing
enhancing
the
response.
Beauvericin,
promising
fungal
secondary
metabolite,
exhibits
potential
diminishing
viability
EMT-induced
cells
by
triggering
intracellular
oxidative
stress,
evidenced
an
enhanced
reactive
oxygen
species
level
reduced
mitochondrial
transmembrane
potential.
In
monolayer
cultures,
it
has
exhibited
IC
Language: Английский