Nature Communications,
Journal Year:
2020,
Volume and Issue:
11(1)
Published: Feb. 18, 2020
Abstract
Cognitive
decline
is
one
of
the
complications
type
2
diabetes
(T2D).
Intermittent
fasting
(IF)
a
promising
dietary
intervention
for
alleviating
T2D
symptoms,
but
its
protective
effect
on
diabetes-driven
cognitive
dysfunction
remains
elusive.
Here,
we
find
that
28-day
IF
regimen
diabetic
mice
improves
behavioral
impairment
via
microbiota-metabolites-brain
axis:
enhances
mitochondrial
biogenesis
and
energy
metabolism
gene
expression
in
hippocampus,
re-structures
gut
microbiota,
microbial
metabolites
are
related
to
function.
Moreover,
strong
connections
observed
between
affected
genes,
microbiota
metabolites,
as
assessed
by
integrative
modelling.
Removing
with
antibiotics
partly
abolishes
neuroprotective
effects
IF.
Administration
3-indolepropionic
acid,
serotonin,
short
chain
fatty
acids
or
tauroursodeoxycholic
acid
shows
similar
terms
improving
Together,
our
study
purports
axis
mechanism
can
enable
therapeutic
strategies
against
metabolism-implicated
pathophysiologies.
Frontiers in Nutrition,
Journal Year:
2022,
Volume and Issue:
9
Published: March 25, 2022
Acrylamide
(ACR),
a
potential
neurotoxin,
is
produced
by
the
Maillard
reaction
between
reducing
sugars
and
free
amino
acids
during
food
processing.
Over
past
decade,
neurotoxicity
of
ACR
has
caused
increasing
concern,
prompting
many
related
studies.
This
review
summarized
relevant
literature
published
in
recent
years
discussed
exposure
to
occupational,
environmental,
daily
contamination
food.
Moreover,
metabolism
mechanism
ACR-induced
were
discussed,
with
particular
focus
on
axonal
degeneration
nervous
system,
nerve
cell
apoptosis,
oxidative
stress,
inflammatory
response,
gut-brain
axis
homeostasis.
Additionally,
limitations
existing
knowledge,
as
well
new
perspectives,
examined,
specifically
regarding
connection
neurodegenerative
diseases,
NOD-like
receptor
protein
3
(NLRP3)
inflammasome-related
neuroinflammation,
microbiota-gut-brain
signaling.
might
provide
systematic
information
for
developing
an
alternative
pathway
approach
assess
risk.
Journal of Food Protection,
Journal Year:
2024,
Volume and Issue:
87(9), P. 100338 - 100338
Published: Aug. 3, 2024
Advanced
glycation
end
products
(AGEs),
heterocyclic
aromatic
amines
(HAAs),
acrylamide
(AA),
5-hydroxymethylfurfural
(5-HMF),
and
polycyclic
hydrocarbons
(PAHs)
are
toxic
substances
that
produced
in
certain
foods
during
thermal
processing
by
using
common
high-temperature
unit
operations
such
as
frying,
baking,
roasting,
grill
cooking,
extrusion,
among
others.
Understanding
the
formation
pathways
of
these
potential
risk
factors,
which
can
cause
cancer
or
contribute
to
development
many
chronic
diseases
humans,
is
crucial
for
reducing
their
occurrence
thermally
processed
foods.
During
processing,
food
rich
carbohydrates,
proteins,
lipids
undergoes
a
Maillard
reaction,
leading
production
highly
active
carbonyl
compounds.
These
compounds
then
react
with
other
form
harmful
substances,
ultimately
affect
negatively
health
human
body.
Although
differ
various
forms
formation,
they
all
partake
pathway.
This
review
primarily
summarizes
occurrence,
pathways,
reduction
measures
food,
based
on
independent
studies
each
specific
contaminant
its
corresponding
matrix.
Finally,
it
provides
several
approaches
simultaneous
multiple
Journal of Agricultural and Food Chemistry,
Journal Year:
2019,
Volume and Issue:
67(31), P. 8510 - 8519
Published: July 11, 2019
Acrylamide,
mainly
formed
in
Maillard
browning
reaction
during
food
processing,
causes
defects
liver
circadian
clock
and
mitochondrial
function
by
inducing
oxidative
stress.
Resveratrol
is
a
polyphenol
that
has
powerful
antioxidant
anti-inflammatory
activity.
However,
the
preventive
effects
of
resveratrol
on
acrylamide-triggered
damage
rhythm
disorders
are
unclear
at
current
stage.
The
present
research
revealed
pretreatment
prevented
acrylamide-induced
cell
death,
dysfunction,
inflammatory
responses
HepG2
cells.
Acrylamide
significantly
triggered
genes
transcription
protein
expressions
including
Bmal1
Cry
1
primary
hepatocytes,
which
were
pretreatment.
Moreover,
we
found
beneficial
stimulating
Nrf2/NQO-1
pathway
respiration
complex
acrylamide-treated
cells
Bmal1-dependent.
Similarly,
inhibitory
inflammation
signaling
NF-κB
Cry1-dependent.
In
conclusion,
these
results
demonstrated
could
be
promising
compound
suppressing
hepatotoxicity
balancing
clock.
Ecotoxicology and Environmental Safety,
Journal Year:
2020,
Volume and Issue:
208, P. 111543 - 111543
Published: Nov. 9, 2020
Acrylamide
(ACR)
is
generated
during
thermal
processing
of
carbohydrate-rich
foods
at
high
temperature
and
can
directly
enter
the
body
through
ingestion,
inhalation
skin
contact.
The
toxicity
ACR
has
been
widely
studied.
main
results
these
studies
show
that
exposure
to
cause
neurotoxicity
in
both
animals
humans,
reproductive
carcinogenicity
rodent
animal
models.
However,
mechanism
not
studied
by
metabolomics
approaches,
effect
on
autophagy
remains
unknown.
Here,
U2OS
cell
were
treated
with
6
24
h
collected
for
further
study.
We
have
demonstrated
inhibited
autophagic
flux,
increased
ROS
content.
Accumulation
resulted
increase
apoptosis
rates
secretion
inflammatory
factors.
In
addition,
significant
differences
metabolic
profiles
observed
between
control
cells
according
multiple
analysis
A
total
73
key
differential
metabolites
identified.
They
involved
pathways.
Among
them,
caused
glycolysis/gluconeogenesis
attenuation
decreasing
levels
glycolytic
intermediates,
reduced
rate
TCA
cycle,
while
elevating
several
amino
acid
lipid
metabolites.
summary,
our
study
provides
useful
evidence
cytotoxicity
via
bioanalytic
methods.
