Association of Zinc with Anemia DOI Open Access
Sen-Shyong Jeng, Yen‐Hua Chen

Nutrients, Journal Year: 2022, Volume and Issue: 14(22), P. 4918 - 4918

Published: Nov. 20, 2022

Zinc is an essential trace element, and anemia the most common blood disorder. The association of zinc with may be divided into three major forms: (1) deficiency contributing to anemia, (2) excess intake leading (3) abnormal blood–zinc levels in body. In cases, coexists iron deficiency, especially pregnant women preschool-age children. To a lesser extent, cooperate other factors lead anemia. It seems that alone does not result it need Excess rare. However, interferes uptake copper results leads Animal model studies indicate redistributed from plasma bones bone marrow produce new red cells. Inadequate status (zinc or excess) could have effects on anemia; at same time, render handling needs observed carefully, supplementation preventive curative effects.

Language: Английский

Arbuscular mycorrhizal fungi and its major role in plant growth, zinc nutrition, phosphorous regulation and phytoremediation DOI
Parashuram Bhantana,

Muhammad Shoaib Rana,

Xuecheng Sun

et al.

Symbiosis, Journal Year: 2021, Volume and Issue: 84(1), P. 19 - 37

Published: April 12, 2021

Language: Английский

Citations

186
Natural Compounds and Products from an Anti-Aging Perspective DOI Creative Commons
Geir Bjørklund, Mariia Shanaida, Roman Lysiuk

et al.

Molecules, Journal Year: 2022, Volume and Issue: 27(20), P. 7084 - 7084

Published: Oct. 20, 2022

Aging is a very complex process that accompanied by degenerative impairment in many of the major functions human body over time. This inevitable influenced hereditary factors, lifestyle, and environmental influences such as xenobiotic pollution, infectious agents, UV radiation, diet-borne toxins, so on. Many external internal signs symptoms are related with aging senescence, including skin dryness wrinkles, atherosclerosis, diabetes, neurodegenerative disorders, cancer, etc. Oxidative stress, consequence imbalance between pro- antioxidants, one main provoking factors causing aging-related damages concerns, due to generation highly reactive byproducts oxygen nitrogen species during metabolism, which result cellular damage apoptosis. Antioxidants can prevent these processes extend healthy longevity ability inhibit formation free radicals or interrupt their propagation, thereby lowering level oxidative stress. review focuses on supporting antioxidant system organism balancing diet through consumption necessary amount natural ingredients, vitamins, minerals, polyunsaturated fatty acids (PUFA), essential amino acids, probiotics, plants’ fibers, nutritional supplements, polyphenols, some phytoextracts, drinking water.

Language: Английский

Citations

113
The Role of Zinc in Bone Tissue Health and Regeneration—a Review DOI Creative Commons
Magda Molenda, Joanna Kolmas

Biological Trace Element Research, Journal Year: 2023, Volume and Issue: 201(12), P. 5640 - 5651

Published: March 31, 2023

Zinc is a micronutrient of key importance for human health. An increasing number studies indicate that zinc plays significant role in bone tissue's normal development and maintaining homeostasis. not only component tissue but also involved the synthesis collagen matrix, mineralization, turnover. It has been demonstrated can stimulate runt-related transcription factor 2 (Runx2) promote differentiation osteoblasts. On other hand, found to inhibit osteoclast-like cell formation decrease resorption by stimulating osteoclasts' apoptosis. Moreover, regulates RANKL/RANK/OPG pathway, thereby facilitating remodeling. To date, all mechanisms Zn activity on are well understood documented. The review aimed present current state research tissue, its beneficial properties, effects regeneration. Since calcium phosphates as substitute materials increasingly enriched ions, paper included an overview potential such filling

Language: Английский

Citations

82
Mechanistic Impact of Zinc Deficiency in Human Development DOI Creative Commons
Azhar Hussain,

Wenting Jiang,

Xiukang Wang

et al.

Frontiers in Nutrition, Journal Year: 2022, Volume and Issue: 9

Published: March 9, 2022

Zinc (Zn) deficiency in humans is an emerging global health issue affecting approximately two billion people across the globe. The situation prevails due to intake of Zn deficient grains and vegetables worldwide. Clinical identification remains problematic because symptoms do not appear until impair vital organs, such as gastrointestinal track, central nervous system, immune skeletal, system. Lower body levels are also responsible for multiple physiological disorders, apoptosis, organs destruction, DNA injuries, oxidative damage cellular components through reactive oxygen species (ROS). causes chronic inflammation lead toward several diseases, heart cancers, alcohol-related malady, muscular contraction, neuro-pathogenesis. present review focused on growth-related changes under conditions, mechanisms adopted by human proper functioning systems, importance nutritional nutraceutical approaches overcome concluded that biofortified food best source compared chemical supplementation avoid their negative impacts human.

Language: Английский

Citations

78
A comprehensive review on water pollution, South Asia Region: Pakistan DOI
Rabeea Noor,

Aarish Maqsood,

Azhar Baig

et al.

Urban Climate, Journal Year: 2023, Volume and Issue: 48, P. 101413 - 101413

Published: Jan. 25, 2023

Language: Английский

Citations

68
Metal‐Organic Framework Functionalized Bioceramic Scaffolds with Antioxidative Activity for Enhanced Osteochondral Regeneration DOI Creative Commons

Chaoqin Shu,

Qin Chen, Lei Chen

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 10(13)

Published: Feb. 24, 2023

Osteoarthritis (OA) is a degenerative disease that often causes cartilage lesions and even osteochondral damage. Osteochondral defects induced by OA are accompanied an inflammatory arthrosis microenvironment with overproduced reactive oxygen species (ROS), resulting in the exacerbation of difficulty regenerating tissues. Therefore, it urgently needed to develop scaffolds can not only promote integrated regeneration subchondral bone, but also possess ROS-scavenging ability protect tissues from oxidative stress. Herein, zinc-cobalt bimetallic organic framework (Zn/Co-MOF) functionalized bioceramic designed for repairing under environment. By functionalizing Zn/Co-MOF on 3D-printed beta-tricalcium phosphate (β-TCP) scaffolds, β-TCP (MOF-TCP) broad-spectrum successfully developed. Benefiting its catalytic active sites degradation products, endows excellent antioxidative anti-inflammatory properties cells ROS invasion, as well dual-bioactivities simultaneously inducing osteogenic chondrogenic differentiation vitro. Furthermore, vivo results confirm MOF-TCP accelerate bone severe defects. This study offers promising strategy treating other diseases.

Language: Английский

Citations

59
Functional electrospun nanofibers: fabrication, properties, and applications in wound-healing process DOI Creative Commons
Qianlan Zheng, Y.X. Xi, Yunxuan Weng

et al.

RSC Advances, Journal Year: 2024, Volume and Issue: 14(5), P. 3359 - 3378

Published: Jan. 1, 2024

Electrostatic spinning as a technique for producing nanoscale fibers has recently attracted increasing attention due to its simplicity, versatility, and loadability.

Language: Английский

Citations

33
ROS: Executioner of regulating cell death in spinal cord injury DOI Creative Commons
Zhaoyang Yin, Bowen Wan,

Ge Gong

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Jan. 23, 2024

The damage to the central nervous system and dysfunction of body caused by spinal cord injury (SCI) are extremely severe. pathological process SCI is accompanied inflammation nerve cells. Current evidence suggests that oxidative stress, resulting from an increase in production reactive oxygen species (ROS) imbalance its clearance, plays a significant role secondary during SCI. transcription factor nuclear erythroid 2-related 2 (Nrf2) crucial regulatory molecule for cellular redox. This review summarizes recent advancements regulation ROS-Nrf2 signaling focuses on interaction between ROS different modes neuronal cell death after SCI, such as apoptosis, autophagy, pyroptosis, ferroptosis. Furthermore, we highlight pathways through which materials science, including exosomes, hydrogels, nanomaterials, can alleviate modulating clearance. provides valuable insights directions reducing alleviating stress.

Language: Английский

Citations

30
Improving acid mine drainage treatment by combining treatment technologies: A review DOI
Alseno K. Mosai,

Gebhu Ndlovu,

Hlanganani Tutu

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 919, P. 170806 - 170806

Published: Feb. 12, 2024

Language: Английский

Citations

28
Cellular Trojan Horse initiates bimetallic Fe-Cu MOF-mediated synergistic cuproptosis and ferroptosis against malignancies DOI Creative Commons
Kerong Chen, Anwei Zhou, X Zhou

et al.

Science Advances, Journal Year: 2024, Volume and Issue: 10(15)

Published: April 10, 2024

Disruptions in metal balance can trigger a synergistic interplay of cuproptosis and ferroptosis, offering promising solutions to enduring challenges oncology. Here, we have engineered Cellular Trojan Horse, named MetaCell, which uses live neutrophils stably internalize thermosensitive liposomal bimetallic Fe-Cu MOFs (Lip@Fe-Cu-MOFs). MetaCell instigate thereby enhancing treatment efficacy. Mirroring the characteristics neutrophils, evade immune system not only infiltrate tumors but also respond inflammation by releasing therapeutic components, surmounting traditional barriers. Notably, Lip@Fe-Cu-MOFs demonstrate notable photothermal effects, inciting targeted release Fe-Cu-MOFs within cancer cells amplifying action ferroptosis. has demonstrated outcomes tumor-bearing mice, effectively eliminating solid forestalling recurrence, leading extended survival. This research provides great insights into complex between copper iron homeostasis malignancies, potentially paving way for innovative approaches treatment.

Language: Английский

Citations

28