Advanced Materials Technologies,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 11, 2024
Abstract
Nasopharyngeal
cancer
(NPC)
is
a
challenging
malignancy
with
poor
prognosis
due
to
late
diagnosis
and
resistance
conventional
treatments.
Nanotechnology
offers
promising
solutions
address
these
limitations
by
enabling
targeted
drug
delivery,
enhancing
therapeutic
efficacy,
facilitating
multimodal
treatment
strategies.
By
leveraging
the
unique
properties
of
nanomaterials
nanocarrier
systems,
innovative
approaches
for
early
detection,
treatment,
therapy
can
be
developed,
paving
way
more
effective
personalized
management
NPC.
This
review
provides
comprehensive
overview
recent
developments
applications
nanotechnology
in
NPC
therapy,
focusing
on
improving
stability,
biodistribution,
delivery
tumors.
Journal of Hematology & Oncology,
Journal Year:
2024,
Volume and Issue:
17(1)
Published: Aug. 16, 2024
Cuproptosis
is
a
newly
identified
form
of
cell
death
induced
by
excessive
copper
(Cu)
accumulation
within
cells.
Mechanistically,
cuproptosis
results
from
Cu-induced
aggregation
dihydrolipoamide
S-acetyltransferase,
correlated
with
the
mitochondrial
tricarboxylic
acid
cycle
and
loss
iron–sulfur
cluster
proteins,
ultimately
resulting
in
proteotoxic
stress
triggering
death.
Recently,
has
garnered
significant
interest
tumor
research
due
to
its
potential
as
crucial
therapeutic
strategy
against
cancer.
In
this
review,
we
summarized
cellular
molecular
mechanisms
relationship
other
types
Additionally,
reviewed
current
drugs
or
strategies
available
induce
cells,
including
Cu
ionophores,
small
compounds,
nanomedicine.
Furthermore,
targeted
metabolism
specific
regulatory
genes
cancer
therapy
enhance
sensitivity
cuproptosis.
Finally,
discussed
feasibility
targeting
overcome
chemotherapy
immunotherapy
resistance
suggested
future
directions.
This
study
that
could
open
new
avenues
for
developing
therapy.
Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 9, 2025
Abstract
Anti‐tumor
theranostic
radionuclide
nanosystems
have
gained
significant
attention
as
an
emerging
therapeutic
strategy.
This
review
systematically
elucidates
the
concept
and
recent
advances
of
anti‐tumor
nanotheranostic
systems
with
radionuclides,
a
focus
on
design
nanocarriers,
precise
selection
their
advantages
limitations
in
clinical
translation.
also
explores
integration
imaging
various
treatment
modalities,
including
photodynamic
therapy,
photothermal
sonodynamic
immunotherapy.
Furthermore,
combination
therapy
fluorescence
magnetic
resonance
technologies,
which
broadens
application
nanotheranostics,
is
discussed.
Finally,
outlooks
future
development
nanotheranostics
radionuclides
proposes
key
research
focus.
Cell Death and Disease,
Journal Year:
2024,
Volume and Issue:
15(11)
Published: Nov. 20, 2024
Abstract
Copper
(Cu),
an
indispensable
micronutrient
for
the
sustenance
of
living
organisms,
contributes
significantly
to
a
vast
array
fundamental
metabolic
processes.
The
human
body
maintains
relatively
low
concentration
copper,
which
is
mostly
found
in
bones,
liver,
and
brain.
Despite
its
concentration,
Cu
plays
crucial
role
as
element
progression
pathogenesis
central
nervous
system
(CNS)
diseases.
Extensive
studies
have
been
conducted
recent
years
on
copper
homeostasis
copper-induced
cell
death
CNS
disorders,
including
glioma,
Alzheimer’s
disease,
Amyotrophic
lateral
sclerosis,
Huntington’s
stroke.
Cuproptosis,
novel
pathway
distinct
from
apoptosis,
necrosis,
pyroptosis,
ferroptosis,
has
identified
potentially
intricately
linked
pathogenic
mechanisms
underlying
various
Therefore,
systematic
review
cuproptosis
their
relationship
with
disorders
could
deepen
our
understanding
these
In
addition,
it
may
provide
new
insights
strategies
treatment
disorders.
Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 10, 2025
Abstract
Disturbances
in
intracellular
copper
(Cu)
homeostasis
can
trigger
cuproptosis,
a
new
form
of
cell
death,
which,
when
combined
with
photothermal
therapy
(PTT),
offers
promising
solution
to
the
persistent
challenges
colorectal
cancer
(CRC)
treatment.
In
this
study,
“three‐level
nanoparticle
rocket”
strategy
is
developed
by
engineering
Cu
5.4
O,
multifunctional
Cu‐based
nanoenzyme
that
and
has
electron
transfer
properties
antioxidant
efficiency.
O
effectively
remodels
inflammatory
environment
scavenging
reactive
oxygen
species,
thereby
overcoming
traditional
limitations
PTT.
Concurrently,
releases
substantial
amounts
+
into
malignant
cells,
disrupting
homeostasis,
inducing
ultimately
inhibiting
tumor
progression.
vivo
vitro
experiments
demonstrate
operates
through
multiple
successive
interlocking
stages
significantly
eradicate
tumors,
prevent
relapse,
prolong
survival.
This
study
provides
profound
insights
synergistic
effects
PTT,
regulation,
cuproptosis
within
complex
microenvironment,
presenting
innovative
approaches
for
future
CRC
therapy.
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
15
Published: Jan. 10, 2025
Breast
cancer
is
the
most
commonly
diagnosed
worldwide.
Metal
metabolism
pivotal
for
regulating
cell
fate
and
drug
sensitivity
in
breast
cancer.
Iron
copper
are
essential
metal
ions
critical
maintaining
cellular
function.
The
accumulation
of
iron
triggers
distinct
death
pathways,
known
as
ferroptosis
cuproptosis,
respectively.
Ferroptosis
characterized
by
iron-dependent
lipid
peroxidation,
while
cuproptosis
involves
copper-induced
oxidative
stress.
They
increasingly
recognized
promising
targets
development
anticancer
drugs.
Recently,
compelling
evidence
demonstrated
that
interplay
between
plays
a
crucial
role
progression.
This
review
elucidates
converging
pathways
Moreover,
we
examined
value
genes
associated
with
clinical
diagnosis
treatment
cancer,
mainly
outlining
potential
co-targeting
approach.
Lastly,
delve
into
current
challenges
limitations
this
strategy.
In
general,
offers
an
overview
interaction
offering
valuable
perspectives
further
research
treatment.
The
designability
and
high
reactivity
of
nanotechnology
provide
strategies
for
antitumor
therapy
by
regulating
the
redox
state
in
tumor
cells.
Here,
we
synthesize
a
kind
vanadium
dioxide
nanoparticle
encapsulated
bovine
serum
albumin
containing
disulfide
bonds
(VSB
NPs)
photothermal-enhanced
ferroptosis
pyroptosis
effects.
Mechanism
studies
show
that
can
effectively
consume
overexpressed
glutathione
(GSH)
microenvironment,
leading
to
decrease
peroxidase
4
(GPX4)
activity.
Simultaneously,
tetravalent
induce
catalytic
reaction
H2O2,
producing
plenty
toxic
hydroxyl
radicals
(·OH)
singlet
oxygen
(1O2),
cell
ferroptosis.
In
addition,
consumption
also
lead
degradation
nanoparticles
into
high-valent
vanadates,
activating
thermal
protein
domain-associated
3
(NLRP3)
inflammasomes
causing
pyroptosis.
It
is
worth
mentioning
VSB
NPs
not
only
ablate
cells
under
near-infrared
light
irradiation
but
further
disrupt
homeostasis
thereby
enhancing
induced
biodegradable
vanadium-based
nanomaterials.
This
strategy,
based
on
biological
effects
regulate
cells,
provides
possibilities
cancer
treatment.
Exploration,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 6, 2025
ABSTRACT
Nanozyme‐based
immunogenic
cell
death
(ICD)
inducers
that
effectively
induce
a
strong
immune
response
via
enzyme‐like
process
have
attracted
great
attention,
but
how
to
ensure
controllable
active
sites
and
maximize
site
utilization
remains
problem.
Here,
we
report
structurally
well‐defined
highly
functional
single‐site
copper(I)
nanomodulators
termed
CuNTD,
constructed
by
precisely
anchoring
atomically
dispersed
self‐assembly
S‐Cu(I)‐S
onto
two‐dimensional
Ti
3
C
2
surface.
Leveraging
Cu
+
with
higher
catalytic
efficiency
than
2+
,
CuNTD
generates
reactive
oxygen
species
(ROS)
storms
through
photothermal‐enhanced
cascade
catalysis,
further
inducing
mitochondrial
dysfunction,
ferroptosis
cuproptosis.
Multifunctional
triggers
ICD
cascade‐regulatory
pathways
of
photothermal‐amplified
ROS
storms,
cuproptosis
ferroptosis,
promoting
dendritic
maturation
while
reducing
monotherapies
side
effects
resistance.
In
vivo,
combined
FDA‐approved
immunoadjuvants
significantly
prolong
the
survival
mice.
With
its
demonstrated
biosafety
high
as
an
inducer,
this
study
provides
promising
framework
for
advancing
augmented
tumor
immunotherapy
significant
clinical
potential.
