Indian Journal of Pharmaceutical Sciences,
Journal Year:
2022,
Volume and Issue:
85(2)
Published: Jan. 1, 2022
To
investigate
the
effect
of
naringin
on
fibrosis
transforming
growth
factor-beta
1
induced
human
embryonic
lung
fibroblasts
MRC-5
and
its
potential
mechanism.
cells
were
treated
with
different
concentrations
naringin,
5
ng/ml
2
μmol/l
nuclear
factor
kappa
B
activator
phorbol
myristate
acetate.
The
experiment
was
divided
into
blank
group,
1+naringin
group
1+naringin+phorbol
acetate
group.
3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium
bromide,
flow
cytometry
scratch
experiments
used
to
analyze
cell
viability,
cycle
distribution
migration
ability.
Western
blot
examine
protein
levels.
With
increase
concentration,
viability
gradually
decreased.
Compared
cycle,
rate,
alpha-smooth
muscle
actin,
collagen
I
alpha
1,
fibronectin,
phosphorylatednuclear
p65
phosphorylated-nuclear
factor-kappa
inhibitor
expression
in
increased.
Naringin
inhibited
factorbeta
proliferation,
through
inactivating
pathway.
Besides,
could
reverse
naringinmediated
inhibition
compared
reduced
1-induced
by
inhibiting
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(2), P. 824 - 824
Published: Jan. 9, 2024
Transcription
factors
are
pivotal
regulators
in
the
cellular
life
process.
Activating
transcription
factor
3
(ATF3),
a
member
of
ATF/CREB
(cAMP
response
element-binding
protein)
family,
plays
crucial
role
as
cells
respond
to
various
stresses
and
damage.
As
factor,
ATF3
significantly
influences
signal
transduction
regulation,
orchestrating
variety
signaling
pathways,
including
apoptosis,
ferroptosis,
differentiation.
In
addition,
serves
an
essential
link
between
inflammation,
oxidative
stress,
immune
responses.
This
review
summarizes
recent
advances
research
on
activation
its
regulating
inflammatory
responses,
cell
ferroptosis
while
exploring
dual
functions
these
processes.
Additionally,
this
article
discusses
diseases
related
pathogenic
microbial
infections.
Our
may
be
helpful
better
understand
responses
disease
progression,
thus
promoting
advancements
clinical
treatments
for
inflammation
stress-related
diseases.
Cell Biochemistry and Biophysics,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 19, 2025
Abstract
Idiopathic
Pulmonary
Fibrosis
(IPF)
is
a
severe,
rapidly
advancing
disease
that
drastically
diminishes
life
expectancy.
Without
treatment,
it
can
progress
to
lung
cancer.
The
precise
etiology
of
IPF
remains
unknown,
but
inflammation
and
damage
the
alveolar
epithelium
are
widely
thought
be
pivotal
in
its
development.
Research
has
indicated
activating
NLRP3
inflammasome
crucial
mechanism
pathogenesis,
as
triggers
release
pro-inflammatory
cytokines
such
IL-1β,
IL-18,
TGF-β.
These
contribute
myofibroblast
differentiation
extracellular
matrix
(ECM)
accumulation.
Currently,
treatment
options
for
limited.
Only
two
FDA-approved
medications,
pirfenidone
nintedanib,
available.
While
these
drugs
decelerate
progression,
they
come
with
range
side
effects
do
not
cure
disease.
Additional
strategies
primarily
involve
supportive
care
therapy.
Emerging
research
highlighted
numerous
flavonoids
derived
from
traditional
medicines
inhibit
critical
regulators
responsible
inflammasome.
show
promise
potential
therapeutic
agents
managing
IPF,
offering
new
avenue
targets
core
inflammatory
processes
this
debilitating
condition.
Graphical
Phytotherapy Research,
Journal Year:
2024,
Volume and Issue:
38(9), P. 4406 - 4423
Published: July 10, 2024
Idiopathic
pulmonary
fibrosis
(IPF)
is
a
progressive
lung
disease
with
an
unknown
underlying
cause.
There
no
complete
cure
for
IPF;
however,
two
anti-fibrotic
agents
(Nintedanib
and
pirfenidone)
are
approved
by
the
USFDA
to
extend
patient's
life
span.
Therefore,
alternative
therapies
supporting
survival
of
fibrotic
patients
have
been
studied
in
recent
literature.
The
abundance
phenolic
compounds,
particularly
flavonoids,
has
gathered
attention
due
their
potential
health
benefits.
Various
like
naringin,
quercetin,
baicalin,
baicalein,
puerarin,
silymarin,
kaempferol,
exhibit
anti-inflammatory
anti-oxidant
properties,
which
help
decrease
fibrosis.
databases,
including
PubMed,
EBSCO,
ProQuest,
Scopus,
as
well
particular
websites,
such
World
Health
Organisation
National
Institutes
Health,
were
used
conduct
literature
search.
Several
mechanisms
action
flavonoids
reported
vivo
cell
line
studies
emphasizing
ability
modulate
oxidative
stress,
inflammation,
processes
lungs.
They
restoration
biomarkers
hydroxyproline,
cytokines,
superoxide
dismutase,
malondialdehyde
others
associated
IPF
modulating
various
pathways
responsible
progression
Yet,
some
drawbacks,
poor
solubility,
challenging
drug
loading,
stability
issues,
scarce
bioavailability.
novel
formulations
explored,
liposomes,
solid
lipid
microparticles,
polymeric
nanoparticles,
nanogels,
nanocrystals,
enhance
therapeutic
efficacy
This
review
focuses
on
role
mitigating
idiopathic
fibrosis,
mode
formulations.
Heliyon,
Journal Year:
2023,
Volume and Issue:
9(8), P. e19308 - e19308
Published: Aug. 1, 2023
Pulmonary
fibrosis
is
an
enduring
and
advancing
pulmonary
interstitial
disease
caused
by
multiple
factors
that
ultimately
lead
to
structural
changes
in
normal
lung
tissue.
Currently,
a
global
with
high
degree
of
heterogeneity
mortality
rate.
Nitidine
pirfenidone
have
been
approved
for
treating
fibrosis,
the
quest
effective
therapeutic
drugs
remains
unabated.
In
recent
years,
anti-pulmonary
properties
natural
flavonoids
garnered
heightened
attention,
although
further
research
needed.
this
paper,
resources,
characteristics,
mechanisms
were
reviewed.
We
hope
provide
potential
opportunities
application
fight
against
fibrosis.
Microorganisms,
Journal Year:
2024,
Volume and Issue:
12(2), P. 332 - 332
Published: Feb. 4, 2024
Coronavirus
disease
2019
(COVID-19)
caused
a
severe
epidemic
due
to
acute
respiratory
syndrome
coronavirus-2
(SARS-CoV-2).
Recent
studies
have
found
that
patients
do
not
completely
recover
from
infections,
but
instead,
suffer
variety
of
post-acute
sequelae
SARS-CoV-2
infection,
known
as
long
COVID.
The
effects
COVID
can
be
far-reaching,
with
duration
up
six
months
and
range
symptoms
such
cognitive
dysfunction,
immune
dysregulation,
microbiota
dysbiosis,
myalgic
encephalomyelitis/chronic
fatigue
syndrome,
myocarditis,
pulmonary
fibrosis,
cough,
diabetes,
pain,
reproductive
thrombus
formation.
However,
recent
shown
naringenin
naringin
palliative
on
various
COVID-19
sequelae.
Flavonoids
naringenin,
commonly
in
fruits
vegetables,
positive
effects,
including
reducing
inflammation,
preventing
viral
providing
antioxidants.
This
article
discusses
the
molecular
mechanisms
clinical
treating
above
diseases.
It
proposes
them
potential
drugs
for
treatment
COVID,
it
inferred
exhibit
extended
medications,
future
likely
serving
nutraceuticals
or
supplements
comprehensive
alleviation
manifestations
complications.
Archiv der Pharmazie,
Journal Year:
2024,
Volume and Issue:
357(10)
Published: July 3, 2024
Idiopathic
pulmonary
fibrosis
(IPF)
is
a
chronic
interstitial
lung
disease
of
unknown
etiology.
Currently,
drugs
used
to
treat
IPF
in
clinical
practice
exhibit
severe
side
effects
and
limitations.
To
address
these
issues,
this
paper
discusses
the
therapeutic
preclinical
targeted
(such
as
STAT3
TGF-β/Smad
pathway
inhibitors,
chitinase
PI3K
phosphodiesterase
etc.)
natural
products
on
IPF.
Through
summary
current
research
progress,
it
found
that
possess
multitarget
effects,
stable
efficacy,
low
nondrug
dependence.
Furthermore,
we
discuss
significant
prospects
product
molecules
combating
by
influencing
immune
system,
expecting
analytical
data
will
aid
development
new
or
investigation
active
ingredients
for
potential
treatments
future.
Biologics,
Journal Year:
2025,
Volume and Issue:
Volume 19, P. 15 - 29
Published: Feb. 1, 2025
Introduction:
ATF3,
a
stress-induced
transcription
factor,
has
been
implicated
in
the
injury
processes
of
various
cell
types,
including
neurons.
It
is
recognized
as
common
marker
for
neuronal
damage
following
neurotrauma.
However,
its
role
other
types
glial
cells,
particularly
astrocytes,
response
to
ischemic
remains
unclear.
Mitochondrial
dysfunction
key
factor
pathogenesis
stroke,
and
impaired
mitochondrial
function
astrocytes
associated
with
astrocyte
activation.
This
study
aimed
explore
relationship
between
stroke
investigate
how
ATF3
regulates
activation
context
injury.
Methods:
In
transient
middle
cerebral
artery
occlusion
(tMCAO)
mouse
model,
we
knocked
down
assessed
infarct
size,
motor
deficits,
activation,
damage.
vitro,
used
oxygen-glucose
deprivation
reoxygenation
(OGD-R)
simulate
ischemia
evaluated
impact
knockdown
on
function.
Results:
exacerbated
vivo,
increased
depletion
worsened
interacted
Drp1
via
Akt2,
inhibiting
fission
protecting
astrocytes.
Conclusion:
protects
highlighting
potential
therapeutic
target
recovery.
Keywords:
activating
3,
acute
AIS,
dysfunction,
dynamics-related
protein
1,
Drp1,
threonine/serine
kinase
2,
Akt2
Frontiers in Cell and Developmental Biology,
Journal Year:
2025,
Volume and Issue:
13
Published: March 31, 2025
Idiopathic
pulmonary
fibrosis
(IPF)
is
a
chronic
respiratory
disease
with
an
unknown
origin
and
complex
pathogenic
mechanisms.
A
deeper
understanding
of
these
mechanisms
essential
for
effective
treatment.
Pulmonary
associated
the
senescence
alveolar
type
II
epithelial
(ATⅡ)
cells.
Additionally,
ATⅡ
can
lead
to
senescence-associated
secretory
phenotype,
which
affects
cellular
communication
disrupts
lung
tissue
repair,
contributing
development
IPF.
The
role
mitochondrial
dysfunction
in
senescence-related
diseases
increasingly
recognized.
It
induce
through
apoptosis,
impaired
autophagy,
disrupted
energy
metabolism,
potentially
playing
key
IPF
progression.
This
article
explores
therapeutic
potential
targeting
dysfunction,
emphasizing
their
significant
roles
pathogenesis.
