Advances in Flavonoid Research: Sources, Biological Activities, and Developmental Prospectives

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(4), P. 2884 - 2925

Published: March 26, 2024

At present, the occurrence of a large number infectious and non-communicable diseases poses serious threat to human health as well drug development for treatment these diseases. One most significant challenges is finding new candidates that are therapeutically effective have few or no side effects. In this respect, active compounds in medicinal plants, especially flavonoids, potentially useful with wide range pharmacological activities. They naturally present nature valuable many Flavonoids divided into fourteen categories mainly derived from plant extraction, chemical synthesis structural modification, biosynthesis. The modification flavonoids an important way discover drugs, but biosynthesis currently considered promising research direction potential revolutionize production pipeline flavonoids. However, relevant problems such metabolic pathway analyses cell protocols need be addressed on urgent basis. review, techniques assessing biological activities mechanisms their elucidated modes interaction other drugs described. Moreover, novel delivery systems, nanoparticles, bioparticles, colloidals, etc., gradually becoming means addressing issues poor hydrophilicity, lipophilicity, stability, low bioavailability review summarizes latest progress existing therapeutic efficacy, how can solved

Language: Английский

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Therapeutic potential of natural flavonoids in pulmonary arterial hypertension: A review

Phytomedicine, Journal Year: 2024, Volume and Issue: 128, P. 155535 - 155535

Published: March 12, 2024

Language: Английский

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Modulating NLRP3 Inflammasomes in Idiopathic Pulmonary Fibrosis: A Comprehensive Review on Flavonoid-Based Interventions

Cell Biochemistry and Biophysics, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

Abstract Idiopathic Pulmonary Fibrosis (IPF) is a severe, rapidly advancing disease that drastically diminishes life expectancy. Without treatment, it can progress to lung cancer. The precise etiology of IPF remains unknown, but inflammation and damage the alveolar epithelium are widely thought be pivotal in its development. Research has indicated activating NLRP3 inflammasome crucial mechanism pathogenesis, as triggers release pro-inflammatory cytokines such IL-1β, IL-18, TGF-β. These contribute myofibroblast differentiation extracellular matrix (ECM) accumulation. Currently, treatment options for limited. Only two FDA-approved medications, pirfenidone nintedanib, available. While these drugs decelerate progression, they come with range side effects do not cure disease. Additional strategies primarily involve supportive care therapy. Emerging research highlighted numerous flavonoids derived from traditional medicines inhibit critical regulators responsible inflammasome. show promise potential therapeutic agents managing IPF, offering new avenue targets core inflammatory processes this debilitating condition. Graphical

Language: Английский

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A review on current advancement in zebrafish models to study chronic inflammatory diseases and their therapeutic targets

Heliyon, Journal Year: 2024, Volume and Issue: 10(11), P. e31862 - e31862

Published: May 24, 2024

Chronic inflammatory diseases are caused due to prolonged inflammation at a specific site of the body. Among other diseases, bacterial meningitis, chronic obstructive pulmonary disease (COPD), atherosclerosis and bowel (IBD) primarily focused on because their adverse effects fatality rates around globe in recent times. In order come up with novel strategies eradicate these clear understanding mechanisms is needed. Similarly, detailed insight into commercially available drugs potent lead compounds from natural sources also important establish efficient therapeutic effects. Zebrafish widely accepted as model study drug toxicity pharmacokinetic drug. Moreover, researchers use various inducers trigger cascades stimulate physiological changes zebrafish. The effect contrasts type zebrafish used investigation. Hence, thorough analysis required current advancements for suppression. This review presents most common drugs, therapeutics, action provides description models diseases. Finally, future prospects challenges same described, which can help understand potency its further exploration attenuation.

Language: Английский

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Therapeutic effects of flavonoids on pulmonary fibrosis: A preclinical meta-analysis

Phytomedicine, Journal Year: 2024, Volume and Issue: 132, P. 155807 - 155807

Published: June 7, 2024

The efficacy of flavonoid supplementation in animal models pulmonary fibrosis has been demonstrated.

Language: Английский

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The Effect of Physalis angulata L. Administration on Gene Expressions Related to Lung Fibrosis Resolution in Mice-Induced Bleomycin

Journal of Experimental Pharmacology, Journal Year: 2024, Volume and Issue: Volume 16, P. 49 - 60

Published: Feb. 1, 2024

Purpose: To explore the potential therapeutic effects of Physalis angulata L . (Ciplukan) extract on lung fibrosis resolution in a Bleomycin-induced mouse model, researchers conducted comprehensive study. The study focused key genes associated with progression, including Nox4, Mmp8, Klf4, and FAS, assessed their mRNA expression levels following administration Ciplukan extract. Methods: A mice model was divided into seven groups to investigate ciplukan fibrosis-related gene expressions. Mice were induced subcutaneously injected Bleomycin generate given different doses for four weeks. Lung analyzed by semi-quantitative PCR FAS. Results: resulted significant decrease Nox4 p -value=0.000, Mmp8 -value =0.002, Klf4 =0.007, indicating antifibrotic effects. However, FAS remained unchanged ( -value=0.127). Conclusion: exhibited promising expressions, particularly Klf4. This suggests that has intervene offering avenue strategies. Keywords: ciplukan, fibrosis, pulmonary

Language: Английский

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Integrating metabolomics and network pharmacology analysis to explore mechanism of Pueraria lobata against pulmonary fibrosis: involvement of arginine metabolism pathway

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 332, P. 118346 - 118346

Published: May 21, 2024

Language: Английский

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Molecular mechanism of Dang-Shen-Yu-Xing decoction against Mycoplasma bovis pneumonia based on network pharmacology, molecular docking, molecular dynamics simulations and experimental verification

Frontiers in Veterinary Science, Journal Year: 2024, Volume and Issue: 11

Published: Sept. 24, 2024

Mycoplasma bovis pneumonia is a highly contagious respiratory infection caused by . It particularly prevalent in calves, posing significant threat to animal health and leading substantial economic losses. Dang-Shen-Yu-Xing decoction often used treat this condition veterinary clinics. exhibits robust anti-inflammatory effects can alleviate pulmonary fibrosis. However, its mechanism of action remains unclear. Therefore, study aimed preliminarily explore the molecular for treating mycoplasma calves through combination network pharmacology, docking, dynamics simulation methods, experimental validation. The active components related targets were extracted from several public databases. Additionally, complex interactions between drugs explored topology, Gene Ontology, Kyoto Encyclopedia Genes Genomes enrichment analyses. Subsequently, binding affinity drug disease-related was verified docking simulation. Finally, pharmacodynamics via experiments. primary topology analysis revealed two core 10 key against pneumonia. showed that involved multiple signaling pathways, with main pathways including PI3K-Akt IL17 pathways. Moreover, predicted conformation decoction, IL6, IL10, associated ingredients. results strong ingredients hub target. Further, three IL10 induced experiments confirmed pharmacodynamics, suggesting it holds potential as an alternative therapy

Language: Английский

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The role of epithelial-mesenchymal transition in pulmonary fibrosis: lessons from idiopathic pulmonary fibrosis and COVID-19

Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)

Published: Nov. 13, 2024

Despite the tremendous advancements in knowledge of pathophysiology and clinical aspects SARS-CoV-2 infection, still many issues remain unanswered, especially long-term effects. Mounting evidence suggests that pulmonary fibrosis (PF) is one most severe complications associated with COVID-19. Therefore, understanding molecular mechanisms behind its development helpful to develop successful therapeutic strategies. Epithelial mesenchymal transition (EMT) cell specific variants endothelial (EndMT) mesothelial (MMT) are physio-pathologic cellular reprogramming processes induced by several infectious, inflammatory biomechanical stimuli. Cells undergoing EMT acquire invasive, profibrogenic proinflammatory activities secreting extracellular mediators. Their activity has been implicated pathogenesis PF a variety lung disorders, including idiopathic (IPF) Aim this article provide an updated survey mechanisms, emphasis on EMT-related processes, genesis IFP

Language: Английский

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Regulatory effects of natural products on N6-methyladenosine modification: A novel therapeutic strategy for cancer

Drug Discovery Today, Journal Year: 2024, Volume and Issue: 29(2), P. 103875 - 103875

Published: Jan. 3, 2024

Language: Английский

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