Nano-Drug Delivery Systems in Oral Cancer Therapy: Recent Developments and Prospective

Pharmaceutics, Journal Year: 2023, Volume and Issue: 16(1), P. 7 - 7

Published: Dec. 19, 2023

Oral cancer (OC), characterized by malignant tumors in the mouth, is one of most prevalent malignancies worldwide. Chemotherapy a commonly used treatment for OC; however, it often leads to severe side effects on human bodies. In recent years, nanotechnology has emerged as promising solution managing OC using nanomaterials and nanoparticles (NPs). Nano-drug delivery systems (nano-DDSs) that employ various NPs nanocarriers have been extensively developed enhance current therapies achieving controlled drug release targeted delivery. Through searching analyzing relevant research literature, was found certain nano-DDSs can improve therapeutic effect drugs enhancing accumulation tumor tissues. Furthermore, they achieve through adjustments particle size, surface functionalization, encapsulation technology nano-DDSs. The application provides new tool strategy therapy, offering personalized options patients delivery, reducing toxic effects, improving outcomes. However, use therapy still faces challenges such toxicity, precise targeting, biodegradability, satisfying drug-release kinetics. Overall, this review evaluates potential limitations different focusing their components, mechanisms action, laboratory aiming provide insights into understanding, designing, developing more effective safer Future studies should focus addressing these issues further advance development therapy.

Language: Английский

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Therapeutic potential of ursolic acid (UA) and their derivatives with nanoformulations to combat nosocomial pathogens

Future Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: 11(1)

Published: March 11, 2025

Abstract Background Ursolic acid (UA) is a natural pentacyclic triterpene derived from fruit, herbs, and other plants of the terpenoid category. UA has multi-dynamic antimicrobial activity against various pathogens. However, its poor water solubility, low intestinal mucosal absorption, bioavailability restrict clinical application. Nanotechnology can overcome these deficiencies with nanoformulations: nanoemulsion, nanoparticles, nanoemulgels, liposomes, supramolecular gel. derivatives are used as therapeutic agents have immunomodulatory functions. The main body abstract Nanoformulations popularly known promising delivery system for several drugs to increase their efficacy. act on many cellular targets such bacterial cell envelop, efflux pump, enzymatic inhibition, microbial (fungal virus) virulence factors, demonstrating that it be potential biomedicinal agent antibacterial, antifungal, antiviral activity. Various nanoformulations been reported decrease MIC available nosocomial pathogens Staphylococcus aureus, Escherichia coli, Streptococcus pneumoniae, Klebsiella Pseudomonas aeruginosa. Short conclusion This review highlights traditional modern extraction purification techniques. also focuses pharmaceutical uses treat different types infections. Further, UA’s comprehensive molecular mechanism discussed.

Language: Английский

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Effects of ursolic acid on growth performance, serum biochemistry, antioxidant capacity, and intestinal health of broilers

animal, Journal Year: 2024, Volume and Issue: 19(1), P. 101385 - 101385

Published: Nov. 28, 2024

Previous studies have shown that adding 450 mg/kg of ursolic acid (UA) can improve the growth performance broilers. However, specific mechanism is still unclear. Therefore, purpose this study was to further explore whether UA promotes broilers by affecting intestinal environment We randomly divided 120 with similar BW (46.53 ± 0.05 g) into two groups. Each group had six replicates, 10 per replicate. The were fed either corn-soybean meal-basal diet (CON group) or supplemented (UA group). This lasted 42 days. Adding increased daily weight gain and feed conversion ratio (P < 0.05). exhibited reduced aspartate aminotransferase, total cholesterol, interleukin 6 1, triacylglycerol levels, high-density lipoprotein cholesterol in serum supplementation improved antioxidant capacity, superoxide dismutase, glutathione peroxidase activity 0.05), these levels jejunum It malondialdehyde concentration ileum jejunal morphology increasing villus height villus-to-crypt ratio, decreased crypt depth Gene expression zona occludens 1 Claudin-1 higher, while lower Additionally, gene mucosa higher Significant differences observed abundance Bacteroides, proteobacteria, desulfurisation bacteria Barnesiella Clostridia_UCG-014, Romboutsia negatively correlated 6, triacylglycerol, but positively In conclusion, broiler reduce ileal inflammation, morphology, regulate caecal microbiota structure composition, promoting growth.

Language: Английский

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Ursolic Acid-Loaded Chitosan Nanoparticles Modulate the Expression Pattern of Apoptotic Markers Towards Oral Tumour Inhibition in Golden Syrian Hamsters

Tropical Journal of Natural Product Research, Journal Year: 2023, Volume and Issue: 7(11)

Published: Dec. 1, 2023

Apoptosis, a systematic and harmonized sequential process, eliminates cells that contain potentially dangerous mutations. Cancer evade apoptosis by interfering with the functions of pro-apoptotic anti-apoptotic proteins. The efficiency ursolic acid-loaded chitosan nanoparticles (UACNP) in modulating markers’ expression towards tumor inhibition was assessed using immunohistochemistry 7,12- dimethylbenz(a)anthracene (DMBA)-induced oral carcinoma golden Syrian hamsters. An developed buccal pouch hamsters painting DMBA, three times perweek for 14 weeks. While mucosa mutant p53 Bcl-2 proteins were overexpressed, Bax, Bid, Bad, caspase-3 9 downregulated tumor-bearing UACNP administration (12.5 mg/Kg b.w) to hamsters, on alternative days DMBA exposure reverted immunoexpression pattern apoptotic markers formation. present investigation also observed can improve marker chemotherapeutic phase (DMBA → UACNP) as evidenced reduction number tumors well size. findings thus highlight UACNP, which could probably be attributed its tumor-preventing efficacy DMBA-induced carcinogenesis. 

Language: Английский

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