Journal of Personalized Medicine,
Journal Year:
2023,
Volume and Issue:
13(12), P. 1632 - 1632
Published: Nov. 22, 2023
Stem
cells
are
undifferentiated
presenting
extensive
self-renewal
features
and
the
ability
to
differentiate
"in
vitro"
vivo"
into
a
range
of
lineage
cells,
like
chondrogenic,
osteogenic
adipogenic
lineages
when
cultured
in
specific
inducing
media.
Two
major
domains
clinical
applications
stem
thoracic
surgery
have
been
investigated:
regenerative
medicine,
which
is
section
translational
research
tissue
engineering
focusing
on
replacement,
renewal
or
regeneration
tissues
organs
re-establish
damaged
physiologic
functions;
drug
loading
delivery,
representing
new
branch
proposing
as
carriers
provide
selected
districts
with
anti-cancer
agents
for
targeted
treatments.
The
production
of
nanoparticles
has
recently
surged
due
to
their
varied
applications
in
biomedical,
pharmaceutical,
textile,
and
electronic
sectors.
However,
this
rapid
increase
nanoparticle
manufacturing
raised
concerns
about
environmental
pollution,
particularly
potential
adverse
effects
on
human
health.
Among
the
various
concerns,
inhalation
exposure
poses
significant
risks,
especially
affecting
respiratory
system.
Airway
epithelial
cells
play
a
crucial
role
as
primary
defense
against
inhaled
particulate
matter
pathogens.
Studies
have
shown
that
can
disrupt
airway
barrier,
triggering
inflammatory
responses,
generating
reactive
oxygen
species,
compromising
cell
viability.
our
understanding
how
different
types
specifically
impact
barrier
remains
limited.
To
investigate
nanoparticle-induced
cellular
responses
dysfunction,
both
vitro
culture
models
vivo
murine
are
commonly
utilized.
In
review,
we
discuss
methodologies
frequently
employed
assess
toxicity
disruption.
Furthermore,
analyze
compare
distinct
barrier.
By
elucidating
diverse
elicited
by
nanoparticles,
aim
provide
insights
guide
future
research
endeavors
assessing
mitigating
risks
associated
with
exposure.
ACS Pharmacology & Translational Science,
Journal Year:
2024,
Volume and Issue:
7(8), P. 2280 - 2305
Published: July 18, 2024
Rheumatoid
arthritis
(RA)
is
a
complex
condition
that
influenced
by
various
causes,
including
immunological,
genetic,
and
environmental
factors.
Several
studies
using
animal
models
have
documented
immune
system
dysfunction
described
the
clinical
characteristics
of
disease.
These
provided
valuable
insights
into
pathogenesis
inflammatory
identification
new
targets
for
treatment.
Nevertheless,
none
these
successfully
replicated
all
RA.
Additionally,
numerous
experimental
medications,
which
were
developed
based
on
our
enhanced
comprehension
system's
function
in
RA,
shown
potential
research
but
ultimately
proved
ineffective
during
different
stages
trials.
There
been
several
novel
therapy
alternatives,
do
not
achieve
consistently
outstanding
therapeutic
outcome
patients.
This
underscores
importance
employing
progress
ACS Omega,
Journal Year:
2024,
Volume and Issue:
9(39), P. 40358 - 40367
Published: Sept. 20, 2024
In
the
field
of
regenerative
medicine,
umbilical
cord-derived
mesenchymal
stem
cells
(UC-MSCs)
have
a
plausible
potential.
However,
traditional
two-dimensional
(2D)
culture
systems
remain
limited
in
replicating
complex
Journal of Functional Biomaterials,
Journal Year:
2023,
Volume and Issue:
14(11), P. 543 - 543
Published: Nov. 8, 2023
Male
germline
stem
cells
(mGSCs),
also
known
as
spermatogonial
(SSCs),
are
the
fundamental
seed
of
male
animal
reproductive
physiology.
However,
environmental
influences,
drugs,
and
harmful
substances
often
pose
challenges
to
SSCs,
such
population
reduction
quality
decline.
With
advancements
in
bioengineering
technology
biomaterial
technology,
an
increasing
number
novel
cell
culture
methods
techniques
have
been
employed
for
studying
proliferation
differentiation
SSCs
vitro.
This
paper
provides
a
review
on
recent
progress
3D
vitro;
we
summarize
microenvironment
spermatocyte
development,
with
focus
scaffold-based
printing
SSCs.
Additionally,
decellularized
testicular
matrix
(DTM)
other
biological
substrates
utilized
through
various
combinations
approaches
construct
vitro
suitable
SSC
growth.
Finally,
present
some
perspectives
current
research
trends
potential
opportunities
within
three
areas:
niche
environment,
alternative
options
DTM
utilization,
advancement
system.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(14), P. 7885 - 7885
Published: July 18, 2024
The
production
of
nanoparticles
has
recently
surged
due
to
their
varied
applications
in
the
biomedical,
pharmaceutical,
textile,
and
electronic
sectors.
However,
this
rapid
increase
nanoparticle
manufacturing
raised
concerns
about
environmental
pollution,
particularly
its
potential
adverse
effects
on
human
health.
Among
various
concerns,
inhalation
exposure
poses
significant
risks,
especially
affecting
respiratory
system.
Airway
epithelial
cells
play
a
crucial
role
as
primary
defense
against
inhaled
particulate
matter
pathogens.
Studies
have
shown
that
can
disrupt
airway
barrier,
triggering
inflammatory
responses,
generating
reactive
oxygen
species,
compromising
cell
viability.
our
understanding
how
different
types
specifically
impact
barrier
remains
limited.
Both
vitro
culture
vivo
murine
models
are
commonly
utilized
investigate
nanoparticle-induced
cellular
responses
dysfunction.
This
review
discusses
methodologies
frequently
employed
assess
toxicity
disruption.
Furthermore,
we
analyze
compare
distinct
barrier.
By
elucidating
diverse
elicited
by
nanoparticles,
aim
provide
insights
guide
future
research
endeavors
assessing
mitigating
risks
associated
with
exposure.
Russian Journal of Transplantology and Artificial Organs,
Journal Year:
2024,
Volume and Issue:
26(3), P. 183 - 194
Published: May 20, 2024
Lung
transplantation
(LT)
is
the
only
treatment
for
many
end-stage
lung
diseases.
Despite
significant
progress
in
transplantology
and
surgery,
LT
remains
a
high-tech
surgical
procedure
performed
at
select
research
centers.
Primary
graft
dysfunction,
acute
rejection,
chronic
allograft
dysfunction
are
serious
problems
that
can
worsen
transplant
outcomes
significantly.
Using
animal
models
experimental
studies
to
investigate
these
pathologic
conditions
one
of
more
rational
approaches.
A
literature
review
was
conducted
order
suitable
model
reproduces
processes
developing
after
LT.
The
searched
ana-
lyzed
MEDLINE
Elibrary
databases,
US
National
Institute
Health
guidelines
period
up
December
2023
were
reviewed.
It
found
most
frequently
used
small
laboratory
(without
LT)
large
(with
LT).
Journal of clinical practice,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 20, 2024
Lung-on-a-Chip
(LoC)
is
a
microfluidic
device
that
simulates
the
gas-liquid
interface
of
human
pulmonary
alveoli
and
intended
for
pathophysiological,
pharmacological
molecular
biological
studies
blood-air
barrier
in
vitro.
The
LoC
includes
system
liquid
gas
microchannels
separated
by
semipermeable
elastic
membrane
containing
polymer
base
cellular
elements
alveoli.
Depending
on
type
(single-channel,
two-channel
three-channel),
may
contain
only
alveolocytes,
or
alveolocytes
combination
with
other
cells:
endothelial
cells,
fibroblasts,
alveolar
macrophages,
tumor
etc.
Some
models
also
include
hydrogel
stroma
interstitium.
first
LoC,
which
there
monolayer
cells
one
side
other,
was
developed
2010
group
Ingber
et
al.
at
Wyss
Institute
Harvard
University
order
to
reproduce
microenvironment
biomechanics
Modern
modifications
same
differ
design
system,
biomaterial,
composition
stromal
special
tasks
being
solved.
In
addition
barrier,
are
studying
specific
pathophysiological
processes,
screening
drugs,
modeling
particular
diseases,
such
as
lung
cancer,
COPD
asthma.
this
review,
we
analyzed
existing
varieties
biomaterials
used,
methods
detecting
processes
devices
main
areas
research
using
"Lung-on-a-chip"
technology.
Journal of Personalized Medicine,
Journal Year:
2023,
Volume and Issue:
13(12), P. 1632 - 1632
Published: Nov. 22, 2023
Stem
cells
are
undifferentiated
presenting
extensive
self-renewal
features
and
the
ability
to
differentiate
"in
vitro"
vivo"
into
a
range
of
lineage
cells,
like
chondrogenic,
osteogenic
adipogenic
lineages
when
cultured
in
specific
inducing
media.
Two
major
domains
clinical
applications
stem
thoracic
surgery
have
been
investigated:
regenerative
medicine,
which
is
section
translational
research
tissue
engineering
focusing
on
replacement,
renewal
or
regeneration
tissues
organs
re-establish
damaged
physiologic
functions;
drug
loading
delivery,
representing
new
branch
proposing
as
carriers
provide
selected
districts
with
anti-cancer
agents
for
targeted
treatments.
