IntechOpen eBooks,
Journal Year:
2024,
Volume and Issue:
unknown
Published: June 13, 2024
Quercetin,
a
naturally
occurring
flavonoid,
has
gained
significant
attention
in
recent
years
due
to
its
potential
health
benefits
and
versatile
applications.
This
book
chapter
explores
the
chemistry
of
quercetin,
shedding
light
on
molecular
structure,
biosynthesis,
extraction
methods.
The
delves
into
extensive
research
effects
highlighting
antioxidant,
anti-inflammatory,
anticancer,
neuroprotective,
cardioprotective
properties.
Moreover,
risks
toxicity
associated
with
quercetin
consumption
are
thoroughly
examined,
emphasizing
importance
proper
dosage
drug
interactions.
concludes
by
providing
an
overview
advances
development,
including
nanoformulations,
targeted
delivery
systems,
combination
therapies,
that
hold
promise
for
enhancing
therapeutic
efficacy
bioavailability.
comprehensive
exploration
aims
provide
researchers,
scientists,
healthcare
professionals
valuable
insights
multifaceted
nature
applications
human
health.
Heliyon,
Journal Year:
2024,
Volume and Issue:
10(11), P. e31925 - e31925
Published: May 24, 2024
BackgroundBreast
cancer
is
a
major
global
cancer,
for
which
radiation
and
chemotherapy
are
the
main
treatments.
Natural
remedies
being
studied
to
reduce
side
effects.
Etoposide
(ETO),
chemo-drug,
quercetin
(QC),
phytochemical,
considered
potential
factors
adaptation
conventional
treatments.ObjectivesThe
anticancer
effect
of
synergy
between
ETO
Quercetin-loaded
solid
lipid
nanoparticles
(QC-SLNs),
was
investigated
in
MDA-MB-231
cells.MethodsWe
developed
QC-SLNs
efficient
cellular
delivery,
characterizing
their
morphology,
particle
size,
zeta
potential.
We
assessed
cytotoxicity
on
breast
cells
via
MTT
assay.
Effects
apoptosis
intensity
have
been
detected
utilizing
annexin
V-FITC,
PI,
caspase
activities.
Real-time
PCR
Bax
gene
Bcl-2
fold
change
expression,
while
Western
blot
analysis
determined
p53
p21
protein
levels.ResultsSpherical,
negatively
charged
QC-SLNs,
when
combined
with
ETO,
significantly
enhanced
inhibition
cell
proliferation
compared
or
alone.
The
treatment
also
notably
increased
pathway.
+
Bax/Bcl-2
ratio,
elevated
proteins,
activated
3
9
enzymes.
These
results
indicate
as
strategy
treatment,
potentially
overcoming
ETO-resistant
chemoresistance.ConclusionThese
suggest
that
QC-SLN
has
substantial
impact
cure
by
improving
efficacy
ETO.
This
enhancement
could
help
overcome
chemoresistance
observed
cancer.
Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(7), P. 775 - 775
Published: June 27, 2024
Rheumatoid
arthritis
(RA)
is
a
persistent
autoimmune
disorder
that
characterized
by
joint
inflammation,
discomfort,
and
impairment.
Despite
the
existence
of
several
therapeutic
approaches,
their
effectiveness
often
restricted
may
be
linked
to
unfavorable
side
effects.
Consequently,
there
has
been
growing
interest
in
investigating
naturally
derived
compounds
as
plausible
agents
for
RA
disease.
The
objective
this
review
summarize
existing
preclinical
clinical
evidence
regarding
efficacy
extracted
plant
extracts
treatment
RA,
focusing
on
anti-inflammatory,
anti-oxidative,
immunomodulatory
properties.
Some
problems
with
using
natural
chemicals
are
uneven
quality
commercially
available
preparations
poor
bioavailability
these
compounds.
Future
investigations
should
focus
improving
formulations,
conducting
thorough
trials,
exploring
different
techniques
fully
utilize
intrinsic
potential
treating
RA.
Molecules,
Journal Year:
2023,
Volume and Issue:
28(22), P. 7530 - 7530
Published: Nov. 10, 2023
Flavopiridol
is
a
flavone
synthesized
from
the
natural
product
rohitukine,
which
derived
an
Indian
medicinal
plant,
namely
Dysoxylum
binectariferum
Hiern.
A
deeper
understanding
of
biological
mechanisms
by
such
molecules
act
may
allow
scientists
to
develop
effective
therapeutic
strategies
against
variety
life-threatening
diseases,
as
cancer,
viruses,
fungal
infections,
parasites,
and
neurodegenerative
diseases.
Mechanistic
insight
flavopiridol
reveals
its
potential
for
kinase
inhibitory
activity
CDKs
(cyclin-dependent
kinases)
other
kinases,
leading
inhibition
various
processes,
including
cell
cycle
progression,
apoptosis,
tumor
proliferation,
angiogenesis,
metastasis,
inflammation
process.
The
synthetic
derivatives
have
overcome
few
demerits
parent
compound.
Moreover,
these
much
improved
CDK-inhibitory
abilities
treating
severe
human
It
appears
that
has
candidate
formulation
integrated
strategy
combat
alleviate
This
review
article
aims
unravel
effectiveness
possible
mechanism
action.
Pharmaceutical Development and Technology,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 19
Published: Jan. 7, 2025
In
this
paper,
the
pH-sensitive
targeting
functional
material
NGR-poly(2-ethyl-2-oxazoline)-cholesteryl
methyl
carbonate
(NGR-PEtOz-CHMC,
NPC)
modified
quercetin
(QUE)
liposomes
(NPC-QUE-L)
was
constructed.
The
structure
of
NPC
confirmed
by
infrared
spectroscopy
(IR)
and
nuclear
magnetic
resonance
hydrogen
spectrum
(1H-NMR).
Pharmacokinetic
results
showed
that
accumulation
QUE
in
plasma
NPC-QUE-L
group
1.28
times
2.43
Solution
QUE-L
groups,
respectively.
release
amount
an
acidic
environment
significantly
higher
than
physiological
pH
value.
order
tumor
cell
inhibition
rate
different
environments
>
PC-QUE-L
QUE-L.
addition,
cellular
uptake
NPC-modified
PC-modified
unmodified
liposomes,
indicating
had
good
pH-sensitivity
targeting.
triple-negative
breast
cancer
(TNBC)
model,
relative
proliferation
is
about
73%,
which
better
solution
group.
Western
blot
show
can
effectively
reduce
expression
α-smooth
actin
transforming
growth
factor-β1
tissues,
improve
degree
fibrosis.
study,
could
endow
with
stability,
pH-sensitivity,
targeting,
provides
a
reference
for
improving
solubility
poorly
soluble
natural
drug
components.
Discover Oncology,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: Feb. 15, 2025
Abstract
Harmine
is
a
β-carboline
alkaloid
derived
from
Peganum
harmala
,
showing
solid
antitumor
potential
in
different
types
of
human
cancer
cells.
Unfortunately,
the
clinical
application
this
natural
has
been
impeded
till
now
by
severe
toxic
side
effects,
especially
neurotoxicity,
besides
its
poor
water
solubility.
Therefore,
over
recent
years,
several
semisynthetic
derivatives
harmine
have
prepared
and
studied
concerning
their
abilities
to
inhibit
tumor
cell
proliferation,
survival,
angiogenesis,
migration,
invasion
diverse
preclinical
models.
This
review
article
summarizes
anticancer
effects
synthetic
derivatives,
demonstrating
high
be
developed
as
novel
drugs
supplement
our
current
therapeutic
arsenal
fight
against
globally
increasing
rate
malignant
disorders.
