Psychopharmacological treatment of depression and anxiety and their different drug delivery targets DOI
Aditya Sharma, Md. Aftab Alam, Awaneet Kaur

et al.

Current Psychiatry Research and Reviews, Journal Year: 2023, Volume and Issue: 20(4), P. 297 - 322

Published: Aug. 23, 2023

Abstract: General practitioners observe a high prevalence of anxiety and depression symptoms. Depressed or anxious patients frequently develop both conditions. The symptoms diseases may be present at the same time. There has been numerous studies on higher levels depression, bipolar disorder II, mixed depression. So, we ended up reviewing different drug delivery targets. Even low dosages, antidepressants were better absorbed more effective when given by nose. In this review, focused cutting-edge methods for intranasal antidepressant vehicles. Consequently, it seems that drugs are sufficiently effective, have fewer side effects, less expensive. researchers in metaanalysis set out to determine whether not they used successfully traditional medicine treat human animal studies.

Language: Английский

PI3K/AKT signaling pathway: Molecular mechanisms and therapeutic potential in depression DOI Creative Commons
Ningning Guo, Xin Wang,

Muran Xu

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: 206, P. 107300 - 107300

Published: July 9, 2024

Depression is a serious global mental disorder. Numerous studies have found that depression may be closely related to decreased neurogenesis, neuroinflammation, neurotransmitter imbalance, and synaptic plasticity dysfunction. The pathogenesis of complex involves multiple signal transduction pathways molecular changes. PI3K/AKT pathway an essential signaling in neurons, which widely expressed emotion-related regions the brain. Therefore, play moderating role mood disorders. However, mechanism not been fully described. This review systematically summarized discussed its potential treatment depression. will help development antidepressants.

Language: Английский

Citations

27
Network pharmacology to unveil the blood components and mechanisms of Tongmai Yangxin Pills in treating elderly coronary heart disease DOI Creative Commons
Y. Zhang, Chaohui Li,

Yi-Zhi Yan

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 12

Published: Feb. 13, 2025

Background Tongmai Yangxin Pills (TMYXP) is a well-known traditional Chinese medicine compound to treat coronary heart disease (CHD). Aging key immutable independent risk factor for CHD. Currently, there are few gene expression profiles of patients treated with (TCM) or TCM compound. However, the chemical composition and underlying mechanisms TMYXP against elderly CHD need be elucidated. Objective Exploring mechanism in treating based on human profiles, find pharmacodynamic ingredients plasma pharmacochemistry network pharmacology. Methods A strength this study use pharmacology analysis before after treatment. This focused peripheral blood mononuclear cell samples from 6 over 60 years old (GSE142008). total 40 components identified by UPLC/Q-TOF-MS method SD rats. Then, we collected literature-validated component targets further analysis. Results All exhibited non-toxic properties. By retrieving validated components's targets, 15 correspond 4,789 targets. Genistein, emodin, isoliquiritigenin, glycyrrhizic acid, gallic verbascoside, calycosin, rhein, formononetin ephedrine were most potential anti-CHD TMYXP. The above 10 mainly regulate hub genes CASP3, TGFB1, PTGS2, CXCL8, FAS JAK2 , mediating multiple exerts effects TNF signaling pathway, PI3K-Akt p53 MAPK lipid atherosclerosis, NOD-like receptor diabetic cardiomyopathy cytokine-cytokine interaction. We used molecular docking technology verify direct interaction its target Conclusion builds bridge connecting confirmed clinical efficacy, identifies series lead compounds, analyzes their possible research strategy has promote modernization transformation drug development.

Language: Английский

Citations

1
Unraveling the Role of the Blood-Brain Barrier in the Pathophysiology of Depression: Recent Advances and Future Perspectives DOI

Shamili Mariya Varghese,

Shashikant Patel,

Amritasree Nandan

et al.

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: 61(12), P. 10398 - 10447

Published: May 10, 2024

Language: Английский

Citations

6
Novel insights into dietary bioactive compounds and major depressive disorders: evidence from animal studies and future perspectives DOI
Chwan‐Li Shen,

Taha Hassan,

Peyton Presto

et al.

Journal of Nutrition, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Neuroprotective effects of total phenolics from Hemerocallis citrina Baroni leaves through the PI3K/AKT pathway DOI Creative Commons

Yanjun Jia,

Yanping Wang,

Zixia Wang

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: July 12, 2024

Neurological injury, as a major pathogenic mechanism in depression, holds significant importance the research and development of antidepressant drugs. Hemerocallis citrina Baroni ( H. ), referred to “Forgetting Sadness Grass,” has been confirmed possess remarkable neuroprotective effects. Studies have identified that total phenolics leaves (HLTP) consist flavonoids phenolic acids numerous studies substantiated effects them. Based on this, we propose HLTP may properties. To confirm this hypothesis, initially employed network pharmacology techniques predict potential targets for based Swiss Target Prediction database. GO KEGG analyses were conducted pathways, component-target-pathway was constructed. Molecular docking experiments then performed analyze binding abilities selected active components with main targets. Furthermore, validated key through using corticosterone-induced PC12 neuronal cell damage model. Network HLTP, Quercetin, Rutin, Apigenin, Isoquercitrin are exert by modulating such AKT1, TNF, TP53, CASP3 crucial pathways including PI3K/AKT apoptosis. revealed 4-O-Caffeoylquinic acid, 5-O-Caffeoylshikimic 4-p-Coumaroylquinic 5-O-Feruloylquinic acid exhibit low energies Particularly, forms stable hydrogen bonding residues LYS389, GLU49, GLN47, LYS30, ASP44, GLU40 AKT1. cells stimulated 200 μmol/L Corticosterone (Cort) 24 h, treated 50, 100 μg/mL h. The viability damaged significantly increased dose-dependent manner 9.50%, 10.42% 21.25%, respectively P < 0.01). Western blot analysis 0.01) protein expression PI3K AKT 15.24%, 30.44%, 41.03%, 21.78%, 43.63%, 12.86%, respectively. In addition, biochemical method, flow cytometry WB analysis, found different concentrations can all improve reducing ROS, MDA, Ca 2+ , Cyt-C, Caspase-3, TNF-α IL-1β, increasing SOD, CAT, MMP, Bcl-2/Bax IL-10. particular, at μg/mL, compared Model group, decreased 140.2%, 54.66%, 51.34%, 65.26%, 40.32%, 63.87%, 55.38%, 39.65%, 35.45%, 38.38%, 28.54%, 39.98%, Through above experiments, verified mediating signaling pathway counteract oxidative stress damage, mitochondrial dysfunction, alleviate inflammatory injury.

Language: Английский

Citations

1
Phytochemical characterization, toxicity and pharmacological profile of the central effects of the fixed fruit pulp oil of Mauritia flexuosa L.F. (buriti) DOI
Isaac Moura Araújo, Andressa de Alencar Silva, Luís Pereira-de-Morais

et al.

Fitoterapia, Journal Year: 2024, Volume and Issue: 180, P. 106303 - 106303

Published: Nov. 17, 2024

Language: Английский

Citations

1
Flaxseed Oil (Linum usitatissimum) Prevents Cognitive and Motor Damage in Rats with Hyperammonemia DOI Open Access
Marcos Fernando Ocaña Sánchez, Gabriel Arturo Soto Ojeda, Yolanda Cocotle‐Ronzón

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(21), P. 4550 - 4550

Published: Oct. 27, 2023

Hyperammonemia is characterized by the excessive accumulation of ammonia in body as a result loss liver detoxification, leading to development hepatic encephalopathy (HE). These metabolic alterations carry cognitive and motor deficits cause neuronal damage, with no effective treatment at present. In this study, we aimed evaluate effect two subacute oral administrations flaxseed oil (0.26 0.52 mL/kg) on short- long-term memory, visuospatial locomotor activity, coordination, morphology prefrontal cortex (PFC) via tests Wistar rats hyperammonemia. The goal was identify its role regulation cerebral edema, without damage causing failure. contrast an ammonium-rich diet, normal foods did not impairment or alterations, evidenced short-term memory tests. Furthermore, maintained regular cortex, which represents neuroprotective effect. We conclude that administration prevents impairments well hyperammonemia, supports potential use ameliorate changes occur encephalopathy.

Language: Английский

Citations

2
Co-Morbidity of Insomnia and Depression from a Chinese Perspective DOI

涛 高

Advances in Clinical Medicine, Journal Year: 2024, Volume and Issue: 14(10), P. 509 - 520

Published: Jan. 1, 2024

Language: Английский

Citations

0
Psychopharmacological treatment of depression and anxiety and their different drug delivery targets DOI
Aditya Sharma, Md. Aftab Alam, Awaneet Kaur

et al.

Current Psychiatry Research and Reviews, Journal Year: 2023, Volume and Issue: 20(4), P. 297 - 322

Published: Aug. 23, 2023

Abstract: General practitioners observe a high prevalence of anxiety and depression symptoms. Depressed or anxious patients frequently develop both conditions. The symptoms diseases may be present at the same time. There has been numerous studies on higher levels depression, bipolar disorder II, mixed depression. So, we ended up reviewing different drug delivery targets. Even low dosages, antidepressants were better absorbed more effective when given by nose. In this review, focused cutting-edge methods for intranasal antidepressant vehicles. Consequently, it seems that drugs are sufficiently effective, have fewer side effects, less expensive. researchers in metaanalysis set out to determine whether not they used successfully traditional medicine treat human animal studies.

Language: Английский

Citations

0