Chemotherapy-Mediated Complications of Wound Healing: An Understudied Side Effect

Advances in Wound Care, Journal Year: 2024, Volume and Issue: 13(4), P. 187 - 199

Published: Jan. 6, 2024

Chemotherapy is a primary method to treat cancer. While chemotherapeutic drugs are designed target rapidly dividing cancer cells, they can also affect other cell types. In the case of dermal cells and macrophages involved in wound healing, cytotoxicity often leads development chronic wounds. The situation becomes even more severe when chemotherapy combined with surgical tumor excision.

Language: Английский

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Patient-Specific Nanoparticle Targeting in Human Leukemia Blood

ACS Nano, Journal Year: 2024, Volume and Issue: 18(42), P. 29021 - 29035

Published: Oct. 9, 2024

Antibody-directed targeting of chemotherapeutic nanoparticles to primary human cancers holds promise for improving efficacy and reducing off-target toxicity. However, clinical responses targeted nanomedicines are highly variable. Herein, we prepared examined a matrix 9 particles (organic inorganic three surface chemistries with without antibody functionalization) developed an

Language: Английский

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Targeted delivery and controlled release of polymeric nanomedicines for tumor therapy

Fundamental Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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Exosomes derived from syncytia induced by SARS-2-S promote the proliferation and metastasis of hepatocellular carcinoma cells

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 14

Published: Jan. 8, 2025

Coronavirus disease 2019 (COVID-19) is characterized by fever, fatigue, dry cough, dyspnea, mild pneumonia and acute lung injury (ALI), which can lead to respiratory distress syndrome (ARDS), SARS-CoV-2 accelerate tumor progression. However, the molecular mechanism for increased mortality in cancer patients infected with COVID-19 unclear. Colony formation wound healing assays were performed on Huh-7 cells cocultured syncytia. Exosomes purified from cell supernatant verified nanoparticle tracking analysis (NTA), Western blot (WB) scanning electron microscopy (SEM). Differentially expressed proteins syncytia-derived exosomes (Syn-Exos) their functions was analyzed Proteomic sequencing. Syn-Exo-mediated promotion of hepatocellular carcinoma measured CCK-8 Transwell migration assays. The Syn-Exos promote growth blotting. A patient-derived xenotransplantation (PDX) mouse model constructed evaluate pathological role spike protein (SARS-2-S). number syncytia tissue sections determined immunofluorescence analysis. Syncytium promoted proliferation cells. sequencing revealed that regulate metastasis significantly upregulated. Animal experiments showed a pseudotyped lentivirus bearing SARS-2-S (SARS-2-Spp) development PDX mice. More found SARS-2-Spp mice than VSV-Gpp induced

Language: Английский

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Nobiletin reduces 5-FU-induced lung injury with antioxidative, anti-inflammatory and anti-apoptotic activities

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 17, 2025

Abstract Like other chemotherapeutic agents, 5-fluorouracil (5-FU) targets cancerous cells, but it also causes many unwanted side effects on healthy tissues and cells. Based the undesirable of 5-FU, aim this study was to determine how 5-FU affects lung tissue whether nobiletin has any protective effect. The consisted negative control, Nobiletin, Nobiletin + groups. groups received 10 mg/kg i.g. for 7 days. On day 8, 100 administered i.p. Biochemical immunohistochemical analyses were performed dissected at end study. caused growth retardation, disturbed oxidant-antioxidant balance by increasing MDA levels decreasing GSH levels, triggered cellular apoptosis Bax caspase-3 Bcl-2, increased inflammation damage NFκB IL-1β levels. However, determined that prevented disruption balance, showed significant anti-apoptotic effects, especially reducing partially modulating Bcl-2 exhibited anti-inflammatory supported normal development animals. Our results pretreatment activity inhibiting pathway in 5-FU-induced injury, suppressed oxidative stress with its antioxidant effective activity. In conclusion, been shown have an important potential fluorouracil-induced acting through multiple pathways. Graphical

Language: Английский

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Home Environment as a Therapeutic Target for Prevention and Treatment of Chronic Diseases: Delivering Restorative Living Spaces, Patient Education and Self-Care by Bridging Biophilic Design, E-Commerce and Digital Health Technologies

International Journal of Environmental Research and Public Health, Journal Year: 2025, Volume and Issue: 22(2), P. 225 - 225

Published: Feb. 5, 2025

A high prevalence of chronic diseases exposes diverse healthcare pain points due to the limited effectiveness pharmaceutical drugs and biologics, sedentary lifestyles, insufficient health literacy, stress, unsatisfactory patient experience, environmental pollution competition with commercial determinants health. To improve care long-term outcomes, impact home environment is overlooked underutilized by healthcare. This cross-disciplinary work describes perspectives on (1) as a therapeutic target for prevention treatment (2) transforming health-centric household goods e-commerce platforms into digital interventions. We provide rationale creating environments grounded in biophilic design (multisensory, enrichment) supporting physical activities, quality sleep, nutrition, music, stress reduction, self-efficacy, social support education, hence providing clinical benefits through modulation autonomic nervous system, neuroplasticity behavior change. These pleiotropic "active non-pharmacological ingredients" can be personalized people living depression, anxiety, migraine, pain, cancer, cardiovascular other conditions. discuss prospects integrating create "therapeutic environment" interventions delivered therapeutics their combinations prescription drugs. multimodal approach enhance engagement while bridging consumer spending outcomes.

Language: Английский

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Magnetic–Plasmonic Core–Shell Nanoparticles: Properties, Synthesis and Applications for Cancer Detection and Treatment

Nanomaterials, Journal Year: 2025, Volume and Issue: 15(4), P. 264 - 264

Published: Feb. 10, 2025

Nanoparticles have been widely used in cancer diagnostics and treatment research due to their unique properties. Magnetic nanoparticles are popular imaging techniques ability alter the magnetization field around them. Plasmonic mainly applied treatments like photothermal therapy convert light into heat. While these among respective fields, magnetic–plasmonic core–shell (MPNPs) gained popularity recent years combined magnetic optical properties from core shell. MPNPs stood out theranostics as a multimodal platform capable of serving contrast agent for imaging, guidable drug carrier, causing cellular ablation through energy conversion. In this review, we summarize different most common synthesis approaches. We particularly discuss applications diagnosis based on mechanisms using particles. Lastly, look current challenges they face clinical future perspectives detection therapy.

Language: Английский

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Study on the Mechanism and Dose-Effect Relationship of Flavonoids in Different Extracts of Hedysarum Hedysari Against Gastrointestinal Injury Induced by Chemotherapy

Published: Jan. 1, 2025

Language: Английский

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Impact of Nutritional Changes on the Prognosis in Pancreatic Cancer Patients Underwent Curative Surgery After Neoadjuvant Chemotherapy

Nutrients, Journal Year: 2025, Volume and Issue: 17(4), P. 647 - 647

Published: Feb. 11, 2025

Background: Pancreatic cancer is a highly aggressive malignancy with poor prognosis. Neoadjuvant chemotherapy (NAC) increasingly used to improve survival in patients pancreatic cancer; however, it often results nutritional deterioration, which may negatively impact patient outcomes. Therefore, this study aimed assess the effect of changes status on long-term outcomes who underwent curative surgery after NAC. Methods: This retrospective single-center included 148 NAC between 2010 and 2020. The Controlled Nutritional Status (CONUT) score was determine patients. Patients were categorized into worsened, maintained, improved groups based their CONUT scores before We compared differences overall (OS) disease-free (DFS) groups. Results: worsened group exhibited shortest median OS (28 months) maintained (39 66 months, respectively; p = 0.01). Additionally, demonstrated DFS other two (13, 22, 39 0.02). Multivariate analysis identified deterioration as an independent prognostic factor for (hazard ratios (HR), 2.11; 95% confidence intervals (CI), 1.31–3.40; < Conclusions: significant cancer. These findings indicate that serial assessments treatment during are crucial improving

Language: Английский

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Evaluating the risk of comorbidity onset in elderly patients after a cancer diagnosis

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 17, 2025

Abstract Background Cancer is a critical disease that affects person physically, mentally, socially, and in many other aspects. During the treatment stage of cancer, patients suffer from various health complexities, especially elderly people, which might result onset diseases development comorbid condition. Several studies have shown comorbidity plays crucial role cancer survival. However, there remains lack comprehensive statistical techniques at national level to assess significance comorbidities cancer. Our research aims address this gap by comparing non-cancer individuals over four years’ time period. Methods The Health Retirement Study (HRS) data was used extract information 6651 participants aged more than 50. Within 4-year span, cross-sectional observations were created whether or not based on such as high blood pressure, diabetes, heart disease, stroke, lung psychological disease. Results In multivariable regression model, we observed higher chances developing (OR = 1.321, p-value 0.0051) among group compared group, adjusting socio-economic factors. Moreover, factors found be significantly associated with leading applying propensity score matching (1:3 matching). Finally, balanced also showed 1.294, 0.0207) patients. Conclusions above findings demonstrated imperative enhanced protocols, prioritize overall patients, thereby reducing their susceptibility additional illnesses.

Language: Английский

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