Smart Design of Targeted Drug Delivery System for Precise Drug Delivery and Visual Treatment of Brain Gliomas DOI Open Access

Baoqin Song,

Mengru Wu,

Lijing Qin

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 14(4)

Published: Dec. 20, 2024

Abstract In the treatment of glioma, which is one malignant tumors, although chemotherapy used as most common method, it often suffers from low bioavailability. Therefore, improving precision and efficiency drugs crucial in treating gliomas a great challenge. Here, an advanced drug delivery system reported for (CZQD@HA@DOX), aggregates multiple features such susceptible imaging tracer property due to use CZQD targeting HA receptor cluster 44 (CD44) glioma cells, provides with functions targeted enrichment precise at tumor site. The pH‐responsive has not only excellent encapsulation rate but also high loading capacity, doxorubicin loaded on can be released centrally microenvironment site causes increase reactive oxygen species mitochondria trigger oxidative stress, leads expression Bax apoptotic proteins, ultimately activating mitochondrial pathway‐mediated process cells. Overall, this potential application therapy visual gliomas.

Language: Английский

Biodegradable and Stimuli-Responsive Nanomaterials for Targeted Drug Delivery in Autoimmune Diseases DOI Creative Commons
Nargish Parvin, Sang Woo Joo, Tapas Kumar Mandal

et al.

Journal of Functional Biomaterials, Journal Year: 2025, Volume and Issue: 16(1), P. 24 - 24

Published: Jan. 14, 2025

Autoimmune diseases present complex therapeutic challenges due to their chronic nature, systemic impact, and requirement for precise immunomodulation avoid adverse side effects. Recent advancements in biodegradable stimuli-responsive nanomaterials have opened new avenues targeted drug delivery systems capable of addressing these challenges. This review provides a comprehensive analysis state-of-the-art nanocarriers such as polymeric nanoparticles, liposomes, hydrogels engineered autoimmune therapies. These are designed degrade safely the body while releasing agents response specific stimuli, including pH, temperature, redox conditions, enzymatic activity. By achieving localized controlled release anti-inflammatory immunosuppressive agents, minimize toxicity enhance efficacy. We discuss underlying mechanisms nanomaterials, recent applications treating rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, design considerations essential clinical translation. Additionally, we address current challenges, biocompatibility, scalability, regulatory hurdles, well future directions integrating advanced nanotechnology with personalized medicine treatment. highlights transformative potential presenting them promising strategy advance precision improve patient outcomes disease management.

Language: Английский

Citations

2
Zwitterionic Poly(ethylene glycol) Nanoparticles Minimize Protein Adsorption and Immunogenicity for Improved Biological Fate DOI
Yuan Tian,

Huiyuan Lv,

Yi Ju

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 17, 2025

We report the assembly of poly(ethylene glycol) nanoparticles (PEG NPs) and optimize their surface chemistry to minimize formation protein coronas immunogenicity for improved biodistribution. PEG NPs cross-linked with disulfide bonds are synthesized utilizing zeolitic imidazolate framework-8 as templates, which subsequently modified molecules different end groups (carboxyl, methoxy, or amino) vary chemistry. Among modifications, amino residual carboxyl form a pair zwitterionic structures on NPs, adsorption proteins (e.g., immunoglobulin, complement proteins) maximize blood circulation time. The influence preexisting antibodies in mice pharmacokinetics is negligible, demonstrates resistance anti-PEG inhibition accelerated clearance phenomenon. This research highlights importance PEGylated design delivery systems reveals translational potential cancer therapy.

Language: Английский

Citations

2
Approaching Two Decades: Biomolecular Coronas and Bio–Nano Interactions DOI
Shiyao Li, Christina Cortez‐Jugo, Yi Ju

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 27, 2024

It has been nearly two decades since the term "protein corona" was coined. This evolved to "biomolecular or "biocorona" capture diverse biomolecules that spontaneously form on surface of nanoparticles upon exposure biological fluids and drive nanoparticle interactions with systems. In this Perspective, we highlight significant progress in field, including studies nonprotein corona components, lipid nanoparticles, role endogenous organ targeting. We also discuss research opportunities particularly need for improved characterization standardization analysis how recent advances artificial intelligence ex vivo models can improve our understanding biomolecular guiding nanomedicine design.

Language: Английский

Citations

4
Hydrogen Bonding-Driven Adaptive Coacervates as Protocells DOI
D.J. Wang, Peiyu Zhang, Qi‐Zhi Zhong

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

Coacervation based on liquid-liquid phase separation (LLPS) has been widely used for the preparation of artificial protocells and to mimic dynamic organization membrane-free organelles. Most complex synthetic coacervates are formed through electrostatic interactions but cannot withstand high ionic strength conditions (>0.1 M). Alternative components driving forces highly desired formation natural organelles overcome drawbacks traditional coacervates. Herein, hydrogen bonding-driven adaptive reported via complexation poly(ethylene glycol) (PEG) tannic acid (TA). The LLPS behavior these is dependent concentration mass ratio PEG TA, which can be tune size ranging from 70 nm 10 μm as well morphology isotropic particles hollow capsules. Coacervates stable at concentrations up 1 M serve cellular behaviors including metabolism (e.g., nutrient uptake), phagocytosis, membrane fusion. approach provides a platform rational design with controllable morphology, offering potential applications in protocell construction therapeutic delivery.

Language: Английский

Citations

0
Nanovesicles for Lipid Metabolism Reprogram-Enhanced Ferroptosis and Magnetotherapy of Refractory Tumors and Inhibiting Metastasis with Activated Innate Immunity DOI
Xue-Qing Cheng, Jinshun Xu, Yongsheng Cui

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 10, 2025

Castration-resistant prostate cancer (CRPC) is an intractable disease, but approaches for eradicating primary tumors and inhibiting metastasis are limited. Considering that lipid metabolism plays key roles in ferroptosis tumor progression treatment resistance, here we developed a biomimetic nanovesicle (FiFe@RBM) encapsulating fatty acid synthetase inhibitors iron oxide nanoparticles synergistic therapy of CRPC the metastasis. FiFe@RBM with superior magnetic properties efficiently delivered drugs into cells, where it can release Fe ions to induce reactive oxygen species mitochondrial dysfunction inhibit AKT-mTOR pathway, which synergistically causes apoptosis enhances by rewired through increasing polyunsaturated acids (PUFAs), PUFA-enriched phosphatidylcholine (PUFA-PC), phosphatidylethanolamine (PUFA-PE), etc. By intravenous injection, high accumulation PC-3 enabled precision T1/T2-weighted resonance imaging-guided effective eradication human hyperthermia (MHT) ferroptosis, further inhibited liver activated recruited rates natural killer cells nude mice model. This work presents strategy reprogramming enhance synergy MHT effectively treating refractory cancers.

Language: Английский

Citations

0
Anthracycline-induced cardiotoxicity: emerging mechanisms and therapies DOI Creative Commons
Guanjing Ling, Fei Ge, Weili Li

et al.

Medicine Plus, Journal Year: 2025, Volume and Issue: unknown, P. 100074 - 100074

Published: Feb. 1, 2025

Language: Английский

Citations

0
Modular Layer-by-Layer Nanoparticle Platform for Hematopoietic Progenitor and Stem Cell Targeting DOI
Tamara G. Dacoba,

Namita Nabar,

Paula T. Hammond

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: March 13, 2025

Effective delivery of drug and gene cargos to hematopoietic stem progenitor cells (HSPCs) is a major challenge. Current therapeutic strategies in genetic disorders or hematological malignancies are hindered by high costs, low accessibility, off-target toxicities. Layer-by-layer nanoparticles (LbL NPs) modular systems with tunable surface properties enable highly specific targeting. In this work, we developed LbL NPs that target HSPCs via antibody functionalization reduced uptake circulating myeloid cells. layered poly(acrylic acid), bioinert polymer, provided more stealth vivo than other tested bioactive polyanions. The additional conjugation anti-cKit anti-CD90 antibodies improved NP 2- 3-fold nondifferentiated bone marrow vitro. By contrast, anti-CD105 functionalized showed the highest association vivo, ranging from 3.0 8.5% subpopulations. This platform was then adapted human HSPC receptors, similar targeting trends healthy CD34+ anti-CXCR4 demonstrated greatest B-cell lymphoma leukemia Taken together, these results underscore potential capacity disease-dependent context.

Language: Английский

Citations

0
Nanoengineering of Phosphate/Phosphonate Drugs via Competitive Replacement with Metal‐Phenolic Networks to Overcome Breast Tumor with Lung and Bone Metastasis DOI Creative Commons

Wanrui Shi,

Dashuai Liu,

Wenjie Feng

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 12(2)

Published: Nov. 18, 2024

Abstract Phosphate and phosphonate drugs are vital in building organisms, regulating physiological processes, exhibiting diverse biological activities, including antiviral, antibacterial, antineoplastic, enzyme‐inhibitory effects. However, their therapeutic potential is limited by the lack of advanced nanoengineering technologies. Herein, a competitive coordination strategy for phosphate/phosphonate introduced. By leveraging difference capabilities between polyphenols phosphates/phosphonates with metal ions, various phosphate/phosphonate‐based nanodrugs using metal‐phenolic networks (MPNs) as templates agents constructed. The dynamic nature these bonds imparts stimuli‐responsiveness to nanodrugs, allowing targeted release therapy. As proof concept, Fe 3+ galangin used form MPN template, zoledronic acid cGAMP agents, DOX loaded drug construct DOX@Fe‐galangin@Fe‐zoledronic acid‐cGAMP nanodrugs. results demonstrate that, triggering pyroptosis activating cGAS‐STING pathway, exhibit potent cytotoxicity accurate selectivity eradicating orthotopic breast tumors, activate an antitumor immune response against lung bone metastases. Because applicable variety it holds significant enhancing clinical efficacy advancing nanodrug development complex applications.

Language: Английский

Citations

1
Smart Design of Targeted Drug Delivery System for Precise Drug Delivery and Visual Treatment of Brain Gliomas DOI Open Access

Baoqin Song,

Mengru Wu,

Lijing Qin

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 14(4)

Published: Dec. 20, 2024

Abstract In the treatment of glioma, which is one malignant tumors, although chemotherapy used as most common method, it often suffers from low bioavailability. Therefore, improving precision and efficiency drugs crucial in treating gliomas a great challenge. Here, an advanced drug delivery system reported for (CZQD@HA@DOX), aggregates multiple features such susceptible imaging tracer property due to use CZQD targeting HA receptor cluster 44 (CD44) glioma cells, provides with functions targeted enrichment precise at tumor site. The pH‐responsive has not only excellent encapsulation rate but also high loading capacity, doxorubicin loaded on can be released centrally microenvironment site causes increase reactive oxygen species mitochondria trigger oxidative stress, leads expression Bax apoptotic proteins, ultimately activating mitochondrial pathway‐mediated process cells. Overall, this potential application therapy visual gliomas.

Language: Английский

Citations

1