Salvia miltiorrhiza in osteoporosis: a review of its phytochemistry, traditional clinical uses and preclinical studies (2014–2024) DOI Creative Commons
Lili Wang, Shan Wang, Xuan Dai

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 3, 2024

Osteoporosis becomes a global public health concern due to its rising prevalence and substantial impact on life quality. Salvia miltiorrhiza Bunge (Salviae Miltiorrhizae Radix et Rhizoma, SM) has been firstly recorded in Shen Nong's Herbal Classic, is frequently prescribed conjunction with other herbs for the management of osteoporosis. This systematic review aims comprehensively analyze recent advances SM osteoporosis traditional Chinese clinical uses preclinical investigations. Literature encompassing pertinent studies were systematically retrieved across multiple databases, including PubMed, Web Science, National Knowledge Infrastructure, VIP Database, Biomedical Database. Original investigations spanning from February 2014 March 2024, medicine (TCM) trials studies, employed effects actions Thirty-eight TCM identified employ combination primary secondary The overall efficacy was between 77% 96.67%. Forty investigate and/or ingredients anti-osteoporosis this herb may be attributed inhibit osteoclastogenesis/bone resorption promote osteoblastogenesis/osteogenesis. ethanol extracts (tanshinones) by inhibiting MAPK/NF-κB/NFATc1 signaling pathway cathepsin K-induced collagen degradation. Both water (Sal B tanshinol) contribute osteoblastogenesis promoting osteogenesis angiogenesis via activation Wnt/β-catenin/VEGF ERK/TAZ pathways, eliminating ROS production targeting Nrf2/ARE/HO-1 pathway. In conclusions, offer novel strategy management. Well-designed are still needed evaluate bone remodeling.

Language: Английский

Systematic review and meta-analysis of the effects of sodium tanshinone IIA sulfonate injection on essential hypertension DOI

Li Chen,

Shuang Shen,

Jiadong Liang

et al.

Journal of the Renin-Angiotensin-Aldosterone System, Journal Year: 2025, Volume and Issue: 26

Published: April 1, 2025

Introduction Recent studies suggest that sodium tanshinone IIA sulfonate (STS) may offer therapeutic benefits in managing essential hypertension (EH). This study systematically evaluates the efficacy and safety of STS EH treatment. Materials methods A comprehensive search was conducted across seven databases: PubMed, Cochrane Library, Embase, Wanfang, China Biomedical Literature Service System, VIP Chinese Sci-tech Journal Database, National Knowledge Infrastructure from their inception through February 4, 2025. Methodological quality evaluated using Handbook guidelines. Meta-analysis performed Stata 14.0. Results Twenty-two involving 2347 patients were included. Combining with conventional therapy significantly reduced systolic blood pressure (WMD: −8.37, 95% CI: −10.28 to −6.45), diastolic −5.68, −6.67 −4.68), serum creatinine −16.89, −21.37 −12.41), total cholesterol −2.45, −2.58 −2.32), endothelin-1 −9.13, −13.64 −4.63). Nitric oxide increased 8.98, 6.38 11.58). Conclusions The combination demonstrates significant improvements pressure, vascular endothelial function, renal function. serve as an adjunctive treatment for EH.

Language: Английский

Citations

0
MicroRNAs modulation by curcumin, catalpol, and other natural products in Alzheimer’s disease: a review DOI
Amir Modarresi Chahardehi, Reza Arefnezhad,

Alireza Pourbafrani

et al.

Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)

Published: May 6, 2025

Language: Английский

Citations

0
Salvia miltiorrhiza in osteoporosis: a review of its phytochemistry, traditional clinical uses and preclinical studies (2014–2024) DOI Creative Commons
Lili Wang, Shan Wang, Xuan Dai

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 3, 2024

Osteoporosis becomes a global public health concern due to its rising prevalence and substantial impact on life quality. Salvia miltiorrhiza Bunge (Salviae Miltiorrhizae Radix et Rhizoma, SM) has been firstly recorded in Shen Nong's Herbal Classic, is frequently prescribed conjunction with other herbs for the management of osteoporosis. This systematic review aims comprehensively analyze recent advances SM osteoporosis traditional Chinese clinical uses preclinical investigations. Literature encompassing pertinent studies were systematically retrieved across multiple databases, including PubMed, Web Science, National Knowledge Infrastructure, VIP Database, Biomedical Database. Original investigations spanning from February 2014 March 2024, medicine (TCM) trials studies, employed effects actions Thirty-eight TCM identified employ combination primary secondary The overall efficacy was between 77% 96.67%. Forty investigate and/or ingredients anti-osteoporosis this herb may be attributed inhibit osteoclastogenesis/bone resorption promote osteoblastogenesis/osteogenesis. ethanol extracts (tanshinones) by inhibiting MAPK/NF-κB/NFATc1 signaling pathway cathepsin K-induced collagen degradation. Both water (Sal B tanshinol) contribute osteoblastogenesis promoting osteogenesis angiogenesis via activation Wnt/β-catenin/VEGF ERK/TAZ pathways, eliminating ROS production targeting Nrf2/ARE/HO-1 pathway. In conclusions, offer novel strategy management. Well-designed are still needed evaluate bone remodeling.

Language: Английский

Citations

1