The Effects of Astaxanthin on Ischemia-Reperfusion Induced Renal Functional and Histopathological Disturbances in Rats: Relevance to Its Antioxidant Effects DOI Creative Commons
Salma Naderi, Houshang Najafi, Fatemeh Abbaszadeh

et al.

Journal of Reports in Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: 13(1)

Published: April 27, 2025

Background: Ischemia-reperfusion (I/R) injury is a leading cause of acute renal failure, primarily driven by oxidative stress and inflammation, resulting in cell dysfunction damage. Objectives: This study aims to evaluate the effects astaxanthin (AST), potent antioxidant anti-inflammatory carotenoid, against I/R rat model. Methods: A total 30 male Wistar rats were randomly assigned five groups: sham group, an three groups treated with AST at doses 5, 10, 15 mg/kg after I/R. The group underwent surgery without ischemia received drug/AST solvent (5% DMSO) for seven days. experienced minutes followed days treatment drug solvent. AST-treated (AST mg/kg) subjected same ischemic conditions subsequently their respective AST. After period, kidney tissues harvested histological examination, serum samples analyzed function markers (urea creatinine) oxidative/antioxidant biomarkers, including catalase, glutathione (GSH), nitrite. Results: results indicated that administration significantly alleviated detrimental Biochemical analysis revealed marked reductions levels urea creatinine, alongside increases (catalase GSH) decreases nitrite groups. Notably, receiving exhibited substantial reduction tissue Conclusions: demonstrated significant protective model, as evidenced improvements function, histology, biomarker profiles.

Language: Английский

The Effects of Astaxanthin on Ischemia-Reperfusion Induced Renal Functional and Histopathological Disturbances in Rats: Relevance to Its Antioxidant Effects DOI Creative Commons
Salma Naderi, Houshang Najafi, Fatemeh Abbaszadeh

et al.

Journal of Reports in Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: 13(1)

Published: April 27, 2025

Background: Ischemia-reperfusion (I/R) injury is a leading cause of acute renal failure, primarily driven by oxidative stress and inflammation, resulting in cell dysfunction damage. Objectives: This study aims to evaluate the effects astaxanthin (AST), potent antioxidant anti-inflammatory carotenoid, against I/R rat model. Methods: A total 30 male Wistar rats were randomly assigned five groups: sham group, an three groups treated with AST at doses 5, 10, 15 mg/kg after I/R. The group underwent surgery without ischemia received drug/AST solvent (5% DMSO) for seven days. experienced minutes followed days treatment drug solvent. AST-treated (AST mg/kg) subjected same ischemic conditions subsequently their respective AST. After period, kidney tissues harvested histological examination, serum samples analyzed function markers (urea creatinine) oxidative/antioxidant biomarkers, including catalase, glutathione (GSH), nitrite. Results: results indicated that administration significantly alleviated detrimental Biochemical analysis revealed marked reductions levels urea creatinine, alongside increases (catalase GSH) decreases nitrite groups. Notably, receiving exhibited substantial reduction tissue Conclusions: demonstrated significant protective model, as evidenced improvements function, histology, biomarker profiles.

Language: Английский

Citations

0