Metabolomics in Psychiatric Disorders: What We Learn from Animal Models DOI Creative Commons
Elke Humer, Thomas Probst, Christoph Pieh

et al.

Metabolites, Journal Year: 2020, Volume and Issue: 10(2), P. 72 - 72

Published: Feb. 17, 2020

Biomarkers are a recent research target within biological factors of psychiatric disorders. There is growing evidence for deriving biomarkers disorders in serum or urine samples humans, however, few studies have investigated this differentiation brain cerebral fluid As from humans only available at autopsy, animal models commonly applied to determine the pathogenesis diseases and test treatment strategies. The aim review summarize on For depression, anxiety addiction studies, brains available. Furthermore, several medication, e.g., antipsychotics, antidepressants, mood stabilizers, animals. most notable changes depressed were related glutamate-γ-aminobutyric acid-glutamine-cycle. In models, alterations amino acid energy metabolism (i.e., mitochondrial regulation) observed. Addicted animals showed according induced drugs. summary, provide some direct insights into cellular metabolites that produced during processes. addition, influence due short- long-term medication noticeable finding. Further should combine representative human improve insight mental advance development novel

Language: Английский

The rising crisis of illicit fentanyl use, overdose, and potential therapeutic strategies DOI Creative Commons
Ying Han, Wei Yan, Yongbo Zheng

et al.

Translational Psychiatry, Journal Year: 2019, Volume and Issue: 9(1)

Published: Nov. 11, 2019

Abstract Fentanyl is a powerful opioid anesthetic and analgesic, the use of which has caused an increasing public health threat in United States elsewhere. was initially approved used for treatment moderate to severe pain, especially cancer pain. However, recent years have seen growing concern that fentanyl its analogs are widely synthesized laboratories adulterated with illicit supplies heroin, cocaine, methamphetamine, counterfeit pills, contributing exponential growth number drug-related overdose deaths. This review summarizes epidemic evolution use, pharmacological mechanisms side effects, potential clinical management prevention fentanyl-related overdoses. Because social, economic, problems related growing, there urgent need implement large-scale safe effective harm reduction strategies prevent

Language: Английский

Citations

175
Cross-talks between gut microbiota and tobacco smoking: a two-sample Mendelian randomization study DOI Creative Commons

Jiayao Fan,

Yuan Zhou, Ran Meng

et al.

BMC Medicine, Journal Year: 2023, Volume and Issue: 21(1)

Published: April 28, 2023

Considerable evidence has been reported that tobacco use could cause alterations in gut microbiota composition. The microbiota-gut-brain axis also turn hinted at a possible contribution of the to smoking. However, population-level studies with higher level for causality are lacking.

Language: Английский

Citations

74
Alterations in microbiome composition and metabolic byproducts drive behavioral and transcriptional responses to morphine DOI Open Access
Rebecca S. Hofford,

Nicholas L. Mervosh,

Tanner J. Euston

et al.

Neuropsychopharmacology, Journal Year: 2021, Volume and Issue: 46(12), P. 2062 - 2072

Published: June 14, 2021

Language: Английский

Citations

60
The role of the probiotic Akkermansia muciniphila in brain functions: insights underpinning therapeutic potential DOI Creative Commons
Ruiling Xu, Yuxuan Zhang, Shurui Chen

et al.

Critical Reviews in Microbiology, Journal Year: 2022, Volume and Issue: 49(2), P. 151 - 176

Published: March 11, 2022

The role of Akkermansia muciniphila, one the most abundant microorganisms intestinal microbiota, has been studied extensively in metabolic diseases, such as obesity and diabetes. It is considered a next-generation probiotic microorganism. Although its mechanism action not fully elucidated, accumulating evidence indicates important A. muciniphila brain functions via gut-brain axis potential therapeutic target various neuropsychiatric disorders. However, only limited number studies, particularly clinical have directly assessed effects interventions these This first review to discuss comprehensive protection mucosal barrier modulation immune system metabolites, short-chain fatty acids, amino acid derivatives. Additionally, disorders, including Alzheimer's disease cognitive deficit, amyotrophic lateral sclerosis, Parkinson's disease, multiple discussed. suggests healthy functions.

Language: Английский

Citations

56
Gut colonization by Proteobacteria alters host metabolism and modulates cocaine neurobehavioral responses DOI Creative Commons
Santiago Cuesta, Paula Burdisso,

Amir Segev

et al.

Cell Host & Microbe, Journal Year: 2022, Volume and Issue: 30(11), P. 1615 - 1629.e5

Published: Nov. 1, 2022

Gut-microbiota membership is associated with diverse neuropsychological outcomes, including substance use disorders (SUDs). Here, we mice colonized Citrobacter rodentium or the human γ-Proteobacteria commensal Escherichia coli HS as a model to examine mechanistic interactions between gut microbes and host responses cocaine. We find that cocaine exposure increases intestinal norepinephrine levels are sensed through bacterial adrenergic receptor QseC promote colonization of γ-Proteobacteria. Colonized show enhanced cocaine-induced behaviors. The neuroactive metabolite glycine, nitrogen source, depleted in cerebrospinal fluid mice. Systemic glycine repletion reversed, mutated for uptake did not alter response modulated linked transcriptional plasticity nucleus accumbens glutamatergic transmission. mechanism outline here could potentially be exploited modulate reward-related brain circuits contribute SUDs.

Language: Английский

Citations

42
The Microbiome-Gut-Brain axis regulates social cognition & craving in young binge drinkers DOI Creative Commons
Carina Carbia, Thomaz F. S. Bastiaanssen, Luigi Francesco Iannone

et al.

EBioMedicine, Journal Year: 2023, Volume and Issue: 89, P. 104442 - 104442

Published: Feb. 2, 2023

Language: Английский

Citations

35
The impact of aging-induced gut microbiome dysbiosis on dendritic cells and lung diseases DOI Creative Commons
Jonaid Ahmad Malik, Mohammad Adeel Zafar,

Taruna Lamba

et al.

Gut Microbes, Journal Year: 2023, Volume and Issue: 15(2)

Published: Dec. 12, 2023

Aging is an inevitable natural process that impacts every individual, and understanding its effect on the gut microbiome dendritic cell (DC) functionality in elderly subjects crucial. DCs are vital antigen-presenting cells (APCs) orchestrate immune response, maintaining tolerance to self-antigens bridging innate adaptive immunity. With aging, there a shift toward nonspecific immunity, resulting decline responses. This alteration raises significant concerns about managing health of population. However, precise impact aging changes DC function their implications lung-associated diseases remain relatively understudied. To illuminate this subject, we will discuss recent advancements connections between dysbiosis, DCs, lung diseases. Emphasizing key concepts linking age-related functions, focus relevance overall response individuals. article aims improve our intricate relationship microbiome, potentially benefiting management age-associated promoting healthy aging.

Language: Английский

Citations

28
Bridging the gap: associations between gut microbiota and psychiatric disorders DOI Creative Commons
Gellan K. Ahmed, Haidi Karam‐Allah Ramadan, Khaled Elbeh

et al.

Middle East Current Psychiatry, Journal Year: 2024, Volume and Issue: 31(1)

Published: Jan. 15, 2024

Abstract Background Gut microbiota plays a pivotal role in the gut-brain axis and can influence neurodevelopment mental health outcomes. This review summarizes current evidence on associations between gut alterations various psychiatric illnesses. Main body The composition of microbiome evolves from birth through old age, disruptions during critical periods may increase disease risk. Factors like diet, medications, stress, infections disturb microenvironment lead to dysbiosis. Dysbiosis has been linked conditions depression, anxiety, autism, ADHD, schizophrenia. Proposed mechanisms involve microbial regulation neurotransmitters, inflammation, oxidative blood-brain barrier permeability, immune system. Therapeutic strategies probiotics, prebiotics, faecal transplantation modulate ecosystem. However, more research is needed elucidate causal microbiota-psychiatry relationship. Understanding interactions uncover new possibilities for preventing managing disorders. Conclusion A growing points close relationship health. While field still emerging, dysbiosis ecosystem associated with neuropsychiatric conditions. underlying likely microbiota-gut-brain signalling pathways. Additional larger samples required establish links specific changes

Language: Английский

Citations

11
A gut (microbiome) feeling about addiction: Interactions with stress and social systems DOI Creative Commons
Rubén García‐Cabrerizo, John F. Cryan

Neurobiology of Stress, Journal Year: 2024, Volume and Issue: 30, P. 100629 - 100629

Published: March 18, 2024

In recent years, an increasing attention has given to the intricate and diverse connection of microorganisms residing in our gut their impact on brain health central nervous system disease. There been a shift mindset understand that drug addiction is not merely condition affects brain, it now being recognized as disorder also involves external factors such intestinal microbiota, which could influence vulnerability development addictive behaviors. Furthermore, stress social interactions, are closely linked powerful modulators addiction. This review delves into mechanisms through microbiota-stress-immune axis may shape work integrates preclinical clinical evidence demonstrate bidirectional communication between stress, behaviors, substance use disorders suggesting microbes might modulate having significance

Language: Английский

Citations

11
Gut microbiota signatures of vulnerability to food addiction in mice and humans DOI Creative Commons
S. Samulenaite, Alejandra García‐Blanco, Jordi Mayneris‐Perxachs

et al.

Gut, Journal Year: 2024, Volume and Issue: 73(11), P. 1799 - 1815

Published: June 26, 2024

Food addiction is a multifactorial disorder characterised by loss of control over food intake that may promote obesity and alter gut microbiota composition. We have investigated the potential involvement in mechanisms underlying addiction.

Language: Английский

Citations

11