Metabolites in the Dance: Deciphering Gut-Microbiota-Mediated Metabolic Reprogramming of the Breast Tumor Microenvironment DOI Open Access
Afaf Altrawy,

Maye M. Khalifa,

Asmaa Abdelmaksoud

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(24), P. 4132 - 4132

Published: Dec. 11, 2024

Breast cancer (BC), a major cause of death among women worldwide, has traditionally been linked to genetic and environmental factors. However, emerging research highlights the gut microbiome’s significant role in shaping BC development, progression, treatment outcomes. This review explores intricate relationship between microbiota breast tumor microenvironment, emphasizing how these microbes influence immune responses, inflammation, metabolic pathways. Certain bacterial species either contribute or hinder progression by producing metabolites that affect hormone metabolism, system pathways, cellular signaling. An imbalance bacteria, known as dysbiosis, associated with heightened risk BC, like short-chain fatty acids (SCFAs) enzymes such β-glucuronidase playing key roles this process. Additionally, can impact effectiveness chemotherapy, certain bacteria degrade drugs gemcitabine irinotecan, leading reduced efficacy. Understanding complex interactions may pave way for innovative approaches, including personalized microbiome-targeted therapies, probiotics fecal transplants, offering new hope more effective prevention, diagnosis, BC.

Language: Английский

Microbes Saving Lives and Reducing Suffering DOI Creative Commons
Kenneth N. Timmis, Zeynep Ceren Karahan, Juan L. Ramos

et al.

Microbial Biotechnology, Journal Year: 2025, Volume and Issue: 18(1)

Published: Jan. 1, 2025

Language: Английский

Citations

3
Alcohol, the gut microbiome, and liver disease DOI Creative Commons
Michael Jew, Cynthia L. Hsu

Journal of Gastroenterology and Hepatology, Journal Year: 2023, Volume and Issue: 38(8), P. 1205 - 1210

Published: April 25, 2023

Abstract The microorganisms inhabiting our gastrointestinal tract are critical for human health. Chronic heavy alcohol use can modulate the composition and function of gut microbiota, thereby exacerbating end‐organ damage via gut–brain axis gut–liver axis. In this review, we summarize bacterial, fungal, viral microbial compositional changes associated with alcohol‐associated liver disease discuss mechanisms action by which dysbiosis reinforces behavior inflammation injury. We also highlight important pre‐clinical clinical trials that target microbial‐specific treatment disorder disease.

Language: Английский

Citations

23
Fecal microbiota transplantation repairs intestinal permeability and regulates the expression of 5-HT to influence alcohol-induced depression-like behaviors in C57BL/6J mice DOI Creative Commons
Dezhi Li,

Wei Liang,

Wentong Zhang

et al.

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 5, 2024

The epidemic of alcohol abuse affects millions people worldwide. Relevant evidence supports the notion that gut microbiota (GM) plays a crucial role in central nervous system (CNS) function, and its composition undergoes changes following consumption. Therefore, purpose this study was to investigate effect reconstructing by fecal transplantation (FMT) on dependence. Here, we established an dependence model with C57BL/6J mice proved FMT treatment improved anxiety-like behavior alcohol-seeking alcohol-dependent mice. Additionally, found expression intestinal intercellular tight junction structure proteins ZO-1 occludin significantly increased after FMT. repaired permeability decreased levels lipopolysaccharide (LPS) proinflammatory factors. Moreover, serotonin (5-hydroxytryptamine, 5-HT) content mouse brain tissues receiving microbiome from healthy 16S rRNA sequencing demonstrated markedly reshaped elicited barrier 5-HT levels. Collectively, our results revealed has palliative explored underlying mechanisms, which provides new strategies for

Language: Английский

Citations

12
The Potential Impact of the Gut Microbiota on Neonatal Brain Development and Adverse Health Outcomes DOI Creative Commons
Maria Tzitiridou‐Chatzopoulou,

Jannis Kountouras,

Γεωργία Ζουρνατζίδου

et al.

Children, Journal Year: 2024, Volume and Issue: 11(5), P. 552 - 552

Published: May 5, 2024

Over the past decade, microbiome research has significantly expanded in both scope and volume, leading to development of new models treatments targeting gut–brain axis mitigate effects various disorders. Related suggests that interventions during critical period from birth three years old may yield greatest benefits. Investigating substantial link between gut brain this crucial developmental phase raises fundamental issues about role microorganisms human health development. This underscores importance focusing on prevention rather than treatment neurodevelopmental neuropsychiatric The present review examines microbiota age 3, with a particular focus its potential relationship neurodevelopment. emphasizes immunological mechanisms underlying relationship. Additionally, study investigates impact cognitive neurobehavioral such as anxiety autism. Importantly, it highlights need integrate mechanistic studies animal epidemiological across diverse cultures better understand healthy early life implications dysbiosis. Furthermore, summarizes factors contributing transmission microbiome-targeted therapies their Recent environmental toxins known neurodevelopment are also reviewed, exploring whether or modulate these effects.

Language: Английский

Citations

12
A gut (microbiome) feeling about addiction: Interactions with stress and social systems DOI Creative Commons
Rubén García‐Cabrerizo, John F. Cryan

Neurobiology of Stress, Journal Year: 2024, Volume and Issue: 30, P. 100629 - 100629

Published: March 18, 2024

In recent years, an increasing attention has given to the intricate and diverse connection of microorganisms residing in our gut their impact on brain health central nervous system disease. There been a shift mindset understand that drug addiction is not merely condition affects brain, it now being recognized as disorder also involves external factors such intestinal microbiota, which could influence vulnerability development addictive behaviors. Furthermore, stress social interactions, are closely linked powerful modulators addiction. This review delves into mechanisms through microbiota-stress-immune axis may shape work integrates preclinical clinical evidence demonstrate bidirectional communication between stress, behaviors, substance use disorders suggesting microbes might modulate having significance

Language: Английский

Citations

11
Gut–brain axis and neuropsychiatric health: recent advances DOI Creative Commons
Ceymi Doenyas, Gerard Clarke, Renáta Cserjési

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 27, 2025

The gut–brain axis, a bidirectional communication pathway, permits the central nervous system (CNS) to exert influence over gastrointestinal function in response stress, while gut microbiota regulates CNS via immune, neuroendocrine, and vagal pathways. Current research highlights importance of stress-related disorders need for further into mechanisms communication, with potential therapeutic implications wide range health conditions. This is challenge taken on this Scientific Reports Collection Gut-Brain Axis. axis has significant neurodegenerative, psychiatric, metabolic disorders. Recent studies have underscored role microbiome conditions such as Parkinson's disease (PD), evidence indicating that dysfunction pathological features can precede motor symptoms by decades. use vivo animal models demonstrated preformed α-synuclein fibrils (PFFs) travel from brain dosage-dependent manner, thereby supporting "gut-first" theory context PD, explored using vitro approaches. There also plays obesity machine learning algorithms may assist differentiating between obese overweight individuals based their data. growing interest at interface post-traumatic stress disorder (PTSD), sleep disturbances, irritable bowel syndrome (IBS). described support expand observations previous preclinical clinical investigations, providing essential novel insights drive discovery previously unexplored avenues brain-gut-microbiome interactions disease.

Language: Английский

Citations

1
MetALD: Does it require a different therapeutic option? DOI
George Marek, Harmeet Malhi

Hepatology, Journal Year: 2024, Volume and Issue: 80(6), P. 1424 - 1440

Published: May 31, 2024

New guidelines for the definitions of steatotic liver disease have named entity metabolic dysfunction and alcohol-associated (MetALD) as an overlap condition dysfunction–associated (MASLD) disease. There is a broad range therapeutics in all stages development MASLD, but these therapeutics, general, not been studied patients with significant ongoing alcohol use. In this review, we discuss current understanding endogenous exogenous risks MASLD MetALD. Rational strategies therapeutic intervention MetALD include biopsychosocial interventions, use cessation strategies, including medications disorder, judicious Therapeutics promise incretin-based therapies, FGF21 agonists, thyroid hormone receptor beta sodium-glucose co-transporter 2 inhibitors, agents to modify de novo lipogenesis. Currently, glucagon-like peptide 1 agonists peroxisome proliferator–activated γ largest body literature supporting their there paucity trials From existing studies, it clear if unique or combinatorial approach are needed Further elucidation safety benefits MASLD-related therapies paramount importance advancing carefully designed inclusive clinical trials.

Language: Английский

Citations

8
Neurolaw: Revisiting Huberty v. McDonald’s through the Lens of Nutritional Criminology and Food Crime DOI Creative Commons

Alan Logan,

Jeffrey J. Nicholson,

Stephen J. Schoenthaler

et al.

Laws, Journal Year: 2024, Volume and Issue: 13(2), P. 17 - 17

Published: March 21, 2024

Recent studies have illuminated the potential harms associated with ultra-processed foods, including poor mental health, aggression, and antisocial behavior. At same time, human gut microbiome has emerged as an important contributor to cognition behavior, disrupting concepts of biopsychosocial ‘self’ raising questions related free will. Since is undeniably connected dietary patterns components, topics nutrition microbes are heightened interest neuroscience psychiatry. Research spanning epidemiology, mechanistic bench science, intervention trials brought legitimacy nutritional criminology idea that relevance criminal justice system. The individual community-level relationships between behavior also salient torts relatively new field food crime—that which examines vast harms, grand-scale non-communicable diseases behavioral outcomes, caused by manufacturers, distributors, marketers products. Here in this essay, we will synthesize various strands research, reflecting emergent using a notable case straddled both neurolaw crime, Huberty v. McDonald’s (1987). It our contention legalome—microbiome omics science applied forensics—will play increasing role 21st-century courtroom discourse, policy, decision-making.

Language: Английский

Citations

7
Adolescence, the Microbiota-Gut-Brain Axis, and the Emergence of Psychiatric Disorders DOI

Sadie F. McVey Neufeld,

Matthew Ahn,

Wolfgang Kunze

et al.

Biological Psychiatry, Journal Year: 2023, Volume and Issue: 95(4), P. 310 - 318

Published: Oct. 13, 2023

Language: Английский

Citations

15
Gut microbiome in alcohol use disorder: Implications for health outcomes and therapeutic strategies-a literature review DOI Open Access
Ilias Koutromanos, Evangelia Legaki, Maria Gazouli

et al.

World Journal of Methodology, Journal Year: 2024, Volume and Issue: 14(1)

Published: March 7, 2024

Alcohol use disorder (AUD) represents a major public health issue which affects millions of people globally and consist chronic relapsing condition associated with substantial morbidity mortality. The gut microbiome plays crucial role in maintaining overall has emerged as significant contributor to the pathophysiology various psychiatric disorders. Recent evidence suggests that is intimately linked development progression AUD, alcohol consumption directly impacting its composition function. This review article aims explore intricate relationship between focusing on implications for mental outcomes potential therapeutic strategies. We discuss bidirectional communication brain, highlighting microbiota-derived metabolites neuroinflammation, neurotransmission, mood regulation. Furthermore, we examine influence AUD-related factors, such alcohol-induced dysbiosis increased intestinal permeability, outcomes. Finally, emerging avenues targeting management including prebiotics, probiotics, fecal microbiota transplantation. Understanding complex interplay AUD holds promise developing novel interventions could improve individuals AUD.

Language: Английский

Citations

5