Modulation of vigilance/alertness using beta (30 Hz) transcranial alternating current stimulation

Frontiers in Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: Feb. 13, 2025

Vigilance refers to the ability maintain alertness and sustain attention for prolonged periods detect respond subtle changes in environment. Previous research has explored use of transcranial alternating current stimulation (tACS) modulate brain oscillations enhance vigilance/alertness. In this study, we explore modulation effects different parameters on using an open-source dataset. The dataset includes within participant application High-Definition tES (HD-tES) types, targeting two cortical regions (frontal, motor) with one waveforms (30 Hz); combining human-participant high-density electroencephalography (EEG) continuous behavioral metrics. We only analyzed task performance data assess how vigilant states are acutely altered by specific types. Our findings indicate that (1) Both online offline tACS improve vigilance performance; (2) have greater effect than tACS; (3) frontal region stimulating motor region. These results align view theoretical accounts oscillatory nature contribute groundwork closed-loop interventions counteracting decrements.

Language: Английский

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μ‐Transcranial Alternating Current Stimulation Induces Phasic Entrainment and Plastic Facilitation of Corticospinal Excitability

European Journal of Neuroscience, Journal Year: 2025, Volume and Issue: 61(5)

Published: March 1, 2025

Transcranial alternating current stimulation (tACS) has been proposed to modulate neural activity through two primary mechanisms: entrainment and neuroplasticity. The study aimed probe both of these mechanisms in the context sensorimotor μ-rhythm using transcranial magnetic (TMS) electroencephalography (EEG) assess corticospinal excitability (CSE) during (i.e., online) immediately following stimulation, as well neuroplastic aftereffects on CSE μ EEG power. Thirteen participants received three sessions stimulation. Each session consisted 90 trials μ-tACS tailored each participant's individual frequency (IMF), with trial consisting 16 s tACS followed by 8 rest (for a total 24 min 12 per session). Motor-evoked potentials (MEPs) were acquired at start end (n = 41), additional MEPs across different phases epochs within for epoch): early online, late online offline echo. Resting was recorded start, throughout session. data then pooled participant maximise MEP sample size participant. We present preliminary evidence persisting beyond have also replicated plastic facilitation observed previous studies, thus supporting neuroplasticity which can activity.

Language: Английский

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Intensity-Dependent Tacs Entrainment Effects in a Cortical Microcircuit: A Computational Study

Published: Jan. 1, 2025

Language: Английский

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A Novel Program to Improve Cognitive Function in Individuals With Dementia Using Transcranial Alternating Current Stimulation (tACS) and Tutored Cognitive Exercises

Frontiers in Aging, Journal Year: 2021, Volume and Issue: 2

Published: March 12, 2021

The effects of cognitive exercises on the healthy aging population is controversial. Transcranial alternating current stimulation (tACS) considered a promising tool for modulating brain oscillation. Research lacking its long-lasting cognitive/therapeutic effect. This first pilot study to explore effect regimen with and without tACS older adults dementia. groups were 28 individuals (age 56-83 years) enrolled into two groups: Exr Group, who received only + Group at 40 Hz simultaneously period 4 consecutive weeks, 5 days/week, 30 min-sessions/day; all training sessions tutored. applied using MindTriggers app. They assessed pre post intervention also one month after end trial (follow-up) an independent assessment (WMS-IV) as primary outcome measure. results show significant improvement post-intervention in both groups, while protocol lead superior follow-up session. most important outcomes this are: 1) tutored repeated practice app does significantly improve functions dementia that lasts least intervention, 2) application increases positive lasting even longer time than alone; other words we speculate it may long-term potentiation.

Language: Английский

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What can neurofeedback and transcranial alternating current stimulation reveal about cross-frequency coupling?

Frontiers in Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: Feb. 12, 2025

In recent years, the dynamics and function of cross-frequency coupling (CFC) in electroencephalography (EEG) have emerged as a prevalent area investigation within research community. One possible approach studying CFC is to utilize non-invasive neuromodulation methods such transcranial alternating current stimulation (tACS) neurofeedback (NFB). this study, we address (1) potential applicability single multifrequency tACS NFB protocols research; (2) prevalence types, phase–amplitude or amplitude–amplitude CFC, studies; (3) factors that contribute inter- intraindividual variability ways them potentially. Here analyzed studies on tACS, neurofeedback. Based knowledge, types been reported studies. We hypothesize direct indirect effects can induce CFC. Several health status, age, fatigue, personality traits, eyes-closed (EC) vs. eyes-open (EO)condition may influence types. Modifying duration intervention selecting specific demographic experimental group could reduce these sources variability. Neurofeedback appear be promising tools for

Language: Английский

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Phase-locked transcranial electrical brain stimulation for tremor suppression in dystonic tremor syndromes

Clinical Neurophysiology, Journal Year: 2022, Volume and Issue: 140, P. 239 - 250

Published: April 7, 2022

To establish the causal role of cerebellum and motor cortex in dystonic tremor syndromes, explore therapeutic efficacy phase-locked transcranial alternating current stimulation (TACS). We applied TACS over ipsilateral (N = 14) contralateral 17) syndrome patients, while patients assumed a tremor-evoking posture. measured power using accelerometery during 30 s periods at 10 different phase-lags (36-degrees increments) between for each target. Post-hoc, TACS-effects were related to key clinical feature: jerkiness (regularity) tremor. Cerebellar modulated amplitude phase-dependent manner, such that was suppressed or enhanced opposite sides phase-cycle. This effect specific with non-jerky (sinusoidal) (n 10), but absent jerky (irregular) 4). Phase-locked did not modulate amplitude. study indicates plays generation (non-jerky) syndrome. Our findings suggest pathophysiologic heterogeneity syndrome, which mirrors variability. show phenotype dependent involvement Tremor may thus guide optimal intervention targets.

Language: Английский

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Individually tuned theta HD-tACS improves spatial performance

Brain stimulation, Journal Year: 2022, Volume and Issue: 15(6), P. 1439 - 1447

Published: Oct. 31, 2022

BackgroundUsing transcranial alternating current stimulation (tACS) to improve visuospatial working memory (vsWM) has received considerable attention over the past few years. However, fundamental issues remain, such as optimal frequency, generality of behavioral effects, and anatomical specificity stimulation.ObjectivesHere we examined effects two theory-driven tACS protocols for improving vsWM on electroencephalogram (EEG) measures.MethodsTwenty adults each completed 3 HD-tACS conditions (Tuned, Slow, Sham) separate days. The Tuned condition refers a situation in which frequency is tuned individual theta peak measured during task. By contrast, was fixed 4 Hz Slow condition. A high-definition deployed target smaller frontal parietal regions increasing their phase-locking values. During condition, participants performed vsWM, mental rotation (MR), arithmetic tasks. Resting-state EEG (rs-EEG) recorded before after condition.ResultsCompared with Sham, but not improved both MR arithmetics. rs-EEG recording showed an increased fronto-parietal synchrony Tuned, this increase synchronicity correlated improvement. follow-up study no improvement anti-phase setting.ConclusionWe provide first evidence that simulating right network increases interregional improves performance spatial results insight into structure abilities well suggestions stimulating network.

Language: Английский

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Transcranial Alternating Current Stimulation (tACS) and Its Role in Schizophrenia: A Scoping Review

Clinical Psychopharmacology and Neuroscience, Journal Year: 2023, Volume and Issue: 21(4), P. 634 - 649

Published: May 22, 2023

Transcranial alternating current stimulation (tACS) may modulate neuronal oscillations by applying sinusoidal current, thereby alleviating associated symptoms in schizophrenia. Considering its possible utility schizophrenia, we reviewed the literature for tACS protocols administered schizophrenia and their findings. A scoping review was conducted following Preferred Reporting Items Systematic reviews Meta-Analyses (PRISMA) guideline databases clinical trial registers. The search resulted 59 publications. After excluding articles unrelated to tACS, trials without published results or not involving patients with 14 studies were included. Among included studies/case reports only 5 randomized controlled therapeutic trials. investigated of neurobiological outcomes. All reported good tolerability transient mild side effects. It mostly during working memory task (such as computerized n-back task, dual back digit symbol substitution task) cognitive deficits resting state while targeting positive symptoms. reduction hallucinations delusions using alpha improvement negative theta gamma reported. Nevertheless, one rigorous large-sample are lacking other domains. evidence is preliminary though promising. In future, more sham assessing effect on various domains needed substantiate these early

Language: Английский

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The Role of Non-Invasive Brain Modulation in Identifying Disease Biomarkers for Diagnostic and Therapeutic Purposes in Parkinsonism

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(7), P. 695 - 695

Published: July 12, 2024

Over the past three decades, substantial advancements have occurred in non-invasive brain stimulation (NIBS). These developments encompass various techniques aimed at modulating function. Among most widely utilized methods today are transcranial magnetic (TMS) and electrical (TES), which include direct- or alternating-current (tDCS/tACS). In addition to these established techniques, newer modalities emerged, broadening scope of neuromodulation approaches available for research clinical applications movement disorders, particularly Parkinson’s disease (PD) and, a lesser extent, atypical Parkinsonism (AP). All NIBS offer opportunity explore wide range neurophysiological mechanisms exert influence over distinct regions implicated pathophysiology Parkinsonism. This paper’s first aim is provide brief overview historical background underlying physiological principles primary focusing on their translational relevance. It aims shed light potential identification biomarkers diagnostic therapeutic purposes, by summarising experimental data individuals with To date, despite promising findings indicating utility Parkinsonism, integration into routine protocols remains subject ongoing investigation scientific debate. this context, paper addresses current unsolved issues methodological challenges concerning use NIBS, importance future endeavours maximizing efficacy relevance strategies

Language: Английский

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Theta-gamma-coupling as predictor of working memory performance in young and elderly healthy people

Molecular Brain, Journal Year: 2024, Volume and Issue: 17(1)

Published: Oct. 16, 2024

Abstract The relationship between working memory (WM) and neuronal oscillations can be studied in detail using brain stimulation techniques, which provide a method for modulating these thus influencing WM. endogenous coupling the amplitude of gamma phase theta is crucial cognitive control. Theta/gamma peak-coupled transcranial alternating current (TGCp-tACS) modulate this influence WM performance. This study investigated effects TGCp-tACS on older adults compared their responses with those younger participants from our previous work who underwent same experimental design. Twenty-eight subjects both sham sessions at least 72 h apart. Resting-state electroencephalography (EEG) was recorded before after interventions, task battery five different tasks performed during interventions to assess various components. Outcomes measured included performance (e.g., accuracy, reaction time (RT)) changes power spectral density (PSD) frequency bands. significantly decreased accuracy RT 10- 14-point Sternberg increased Digit Symbol Substitution Test adults. In contrast, showed significant increase only 14-item task. Electrophysiological analysis revealed decrease delta PSD an high verum stimulation. conclusion, theta-gamma essential modulation affects vary age due natural changes. To better support adults, suggests several strategies improve function, including: Adjusting parameters, applying two sites, conducting multiple sessions, imaging techniques precise targeting.

Language: Английский

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