Pathophysiology of sarcopenia: Genetic factors and their interplay with environmental factors

Metabolism, Journal Year: 2023, Volume and Issue: 149, P. 155711 - 155711

Published: Oct. 21, 2023

Language: Английский

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Restoration of epigenetic impairment in the skeletal muscle and chronic inflammation resolution as a therapeutic approach in sarcopenia

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 96, P. 102267 - 102267

Published: March 9, 2024

Language: Английский

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Urinary odor molecules in the Otassha Study can distinguish patients with sarcopenia: A pilot study

Geriatrics and gerontology international/Geriatrics & gerontology international, Journal Year: 2025, Volume and Issue: 25(2), P. 307 - 315

Published: Jan. 19, 2025

To identify sarcopenia markers in urinary odor. We performed solid-phase microextraction from the headspace and gas chromatography-mass spectrometry analysis of volatile organic compounds (VOCs) 71 healthy individuals 68 patients diagnosed with according to Asian Working Group on Sarcopenia 2019 criteria. The mass-to-charge ratios (m/z) 10 VOCs a significant difference total ion chromatogram 220 detected this study were compared by U-test. calculate predictive values for sarcopenia, binomial logistic regression analyses conducted (0, 1) as dependent variable m/z each all independent variables. Receiver operating characteristic (ROC) curves generated evaluate diagnostic accuracy. correlations between value handgrip strength, usual gait speed, skeletal muscle mass assessed using Pearson's r. identified (p-xylene, 1-butanol, d-limonene, nonanal, pyrrole, γ-butyrolactone, texanol isomer, octanoic acid, nonanoic diisobutyl phthalate) candidate biomarkers urine. ROC curve showed high accuracy (area under = 0.866, 95% confidence interval: 0.829-0.942; sensitivity, 80.9%; specificity, 81.7%). Additionally, significantly correlated strength (male: r -0.505, P < 0.0001; female: -0.568, 0.0001). This possible non-invasive offering insights into its onset mechanism potential therapeutic targets. Geriatr Gerontol Int 2025; 25: 307-315.

Language: Английский

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Molecular and Structural Alterations of Skeletal Muscle Tissue Nuclei during Aging

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(3), P. 1833 - 1833

Published: Feb. 2, 2024

Aging is accompanied by a progressive loss of skeletal muscle mass and strength. The mechanisms underlying this phenomenon are certainly multifactorial still remain to be fully elucidated. Changes in the cell nucleus structure function have been considered among possible contributing causes. This review offers an overview current knowledge on nuclei aging, focusing impairment nuclear pathways potentially involved age-related decline. In two types cells present: fiber cells, constituting contractile containing hundreds myonuclei, satellite i.e., myogenic mononuclear stem occurring at periphery fibers responsible for growth repair. Research conducted different experimental models with methodological approaches demonstrated that both myonuclei aged muscles undergo several structural molecular alterations, affecting chromatin organization, gene expression, transcriptional post-transcriptional activities. These alterations play key role homeostasis regeneration, thus decrease function.

Language: Английский

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Age-related and cancer-related sarcopenia: is there a difference?

Current Opinion in Clinical Nutrition & Metabolic Care, Journal Year: 2024, Volume and Issue: 27(5), P. 410 - 418

Published: March 15, 2024

The aim of this review is the attempt to differentiating pathophysiologic and clinical features aging-related sarcopenia from cancer-related sarcopenia. In fact, there some controversy among experts mainly regarding two points: always sarcopenia, even that one, expression a generalized disease or may exist independently without major alteration muscle function? Are completely separated entities?

Language: Английский

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Circulating inflammatory biomarker responses in intervention trials in frail and sarcopenic older adults: A systematic review and meta-analysis

Experimental Gerontology, Journal Year: 2023, Volume and Issue: 177, P. 112199 - 112199

Published: May 8, 2023

Consistent with the inflammaging concept, cross-sectional associations have been established between inflammatory biomarkers, frailty and sarcopenia. Less certain is value of markers in monitoring potential anti-inflammatory effects therapeutic interventions targeted at The aims this systematic review meta-analysis are to determine if there a measurable change or immune biomarkers that improve sarcopenia 2. To specific greater sensitivity change. In total, 3051 articles were scanned 16, primarily exercise nutrition interventions, included 11 meta-analysis. At least one C reactive protein (CRP), interleukin-6 (IL-6) tumour necrosis factor alpha (TNF-α) was reduced 10 16 studies but only 3/13 reported reductions multiple markers. CRP, IL-6 TNF-α individually sensitive 5/11, 3/12 5/12 respectively. meta-analyses, positive effect favouring intervention conditions for CRP (SMD = −0.28, p 0.05) not TNF- α −0.12, 0.48). There issues quality these which designed an marker as primary outcome. conclusion, can also reduce literature lacks consistency. We unable conclude any being superior others.

Language: Английский

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Muscle mass, creatinine, cystatin C and selective glomerular hypofiltration syndromes

Clinical Kidney Journal, Journal Year: 2023, Volume and Issue: 16(8), P. 1206 - 1210

Published: April 13, 2023

ABSTRACT In this issue of Clinical Kidney Journal, Stehlé and colleagues demonstrate that estimation glomerular filtration rate (GFR) by use creatinine a measure, total lumbar muscle cross-sectional area, reflecting the mass an individual, is superior to GFR-estimating equations based upon demographic variables. The report et al. demonstrates one solution interference in estimate GFR. This was identified already at start, 1959, using for Different ways taking into account when creatinine-based estimations GFR have been used generally include controversial race sex coefficients. A new marker GFR, cystatin C, introduced 1979, has shown be virtually uninfluenced mass. editorial, simultaneous C selective hypofiltration syndromes described.

Language: Английский

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Sarcopenia as a Little-Recognized Comorbidity of Type II Diabetes Mellitus: A Review of the Diagnosis and Treatment

Nutrients, Journal Year: 2023, Volume and Issue: 15(19), P. 4149 - 4149

Published: Sept. 26, 2023

Background: Type II diabetes mellitus (T2DM) is one of the most widespread metabolic diseases worldwide, with a significant impact on morbi-mortality. Sarcopenia has high risk in this population (two times more risk) and at functional level, especially older adults. In addition, it poses enormous challenges diagnosis, prevention, treatment disease concomitantly. The objective to review current knowledge state muscle mass pathogenesis, sarcopenia people T2DM. Methods: A bibliographic search was conducted PubMed-Medline databases for articles from 2015 previously defined terms. Results: loss diabetic patients who are malnourished or malnutrition proven negative their autonomy closely related as high-impact disease, also frailty, an associated multidimensional syndrome. Notably, we found that protein deficiency often underdiagnosed obese overweight T2DM patients. Biochemical markers could help future approaches managing four essential elements which form basis care pharmacological treatment, nutrition management, regular physical exercise, correct daily regime. Conclusions: increasing prevalence among impacts quality life public health concern. Effective diagnosis management require multidisciplinary approach involving nutrition, regime, research needed understand underlying mechanisms improve diagnostic strategies.

Language: Английский

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Towards a core outcome set (COS) for intrinsic capacity (IC) intervention studies in adults in midlife and beyond: a scoping review to identify frequently used outcomes and measurement tools

Aging Clinical and Experimental Research, Journal Year: 2024, Volume and Issue: 36(1)

Published: March 5, 2024

Abstract This scoping review was conducted to identify the outcomes and measurement tools used in IC intervention studies, as first step towards development of a core outcome set (COS) for trials. PRISMA-ScR COS-STAD were followed. The considered randomized controlled trials targeting published Medline, Scopus, Embase, Cochrane Central Register Controlled Trials, clinicaltrials.gov, until June 2023. Of 699 references, 534 studies screened once duplicates removed, 15 assessed eligibility, 7 (4 articles 3 protocols) met eligibility criteria. Twenty-eight identified (19 related its domains 9 unrelated). most reported primary change levels postintervention (5 over studies) (either and/or secondary) changes physical performance depressive symptoms (6 studies). Fifty-five construct domains’ z -scores assess effect interventions (47 8 tool an Z -score, calculated by 4 -scores: locomotor, vitality, cognitive, psychological differed among (10 locomotor related, 6 vitality 16 cognitive sensorial unrelated tools). vast heterogeneity (28 55 within highlighted need COS. These will be presented experts future step, select ones that should taken into consideration

Language: Английский

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Neurofilament-light chains (NF-L), a biomarker of neuronal damage, is increased in patients with severe sarcopenia: results of the SarcoPhAge study

Aging Clinical and Experimental Research, Journal Year: 2023, Volume and Issue: 35(10), P. 2029 - 2037

Published: Aug. 15, 2023

Abstract Background As clinical tests, such as gait speed, require nervous system integrity to be performed properly, sarcopenia shares features with neurological diseases. Neurofilament light chains (NF-L) are now used a blood-biomarker of neuronal damage, and its expression might altered in sarcopenia. We aimed assess NF-L concentrations large cohort older individuals screened for Methods The SarcoPhAge is Belgian 534 community-dwelling adults an ongoing 10-year follow-up. Sarcopenia diagnosis was established at inclusion according the European Working Group on Older People 2 (EWGSOP2) criteria. Muscle strength evaluated hydraulic hand dynamometer, appendicular lean mass by Dual-Energy X-ray Absorptiometry (DXA) physical performance Short Physical Performance Battery (SPPB). measured all available sera collected time ( n = 409) using SiMoA technology (Quanterix°). Results In multivariate model, associated tests speed p < 0.0001) SPPB scores 0.0004). An association also observed muscle 0.0123) 0.0279). logistic regression independent predictor severe 0.0338; OR 20.0; 95% CI 1.39–287.7) satisfactory diagnostic accuracy (AUC: 0.828) subjects score ≤ 8 had higher odds having increased 0.0001; 23.9; 5.5–104). Conclusions These data highlight potential investigate pathophysiology severity tests. However, these results need confirmed other cohorts different settings.

Language: Английский

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