Published: Jan. 1, 2025
Language: Английский
International Immunopharmacology, Journal Year: 2022, Volume and Issue: 104, P. 108516 - 108516
Published: Jan. 6, 2022
Language: Английский
Citations
158
Biomedicine & Pharmacotherapy, Journal Year: 2021, Volume and Issue: 138, P. 111518 - 111518
Published: March 18, 2021
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, China, December 2020 and disease 19 (COVID-19) was later announced as pandemic by the World Health Organization (WHO). Since then, several studies have been conducted on prevention treatment of COVID-19 potential vaccines drugs. Although, governments global population attracted some vaccine production projects, presence SARS-CoV-2-specific antiviral drugs would be an urge necessity parallel with efficient preventive vaccines. Various nonspecific produced previously against other bacterial, viral, parasite infections were recently evaluated for treating patients COVID-19. In addition to therapeutic properties these anti-COVID-19 compounds, adverse effects observed different human organs well. Not only attentions paid therapy COVID-19, but also nanomedicine, immunotherapy, cell this viral infection. review study, we planned introduce present future strategies define advantages disadvantages each strategy.
Language: Английский
Citations
61
Catalysts, Journal Year: 2022, Volume and Issue: 12(6), P. 667 - 667
Published: June 18, 2022
The COVID-19 pandemic has been transformed into one of the main worldwide challenges, in recent years. For controlling symptoms that are caused by this disease (e.g., chills or fever, shortness breath and/or difficulty breathing, cough, sore throat, fatigue, headache, muscle aches, new loss tastes smells, congestion runny nose, nausea, vomiting diarrhea), lots medicines including analgesics, mucolytics, and anti-biotic/viral/inflammatory drugs have frequently prescribed. As these finally contaminate terrestrial aquatic habitats entering surface waterways through pharmaceutical production excreting trace amounts waste after human usage, they negative impacts on wildlife’s health ecosystem. Residual water potential to harm creatures disrupt their food chain as well breeding cycle. Therefore, proper degradation broadly used is highly crucial. In work, use nanomaterials applicable photocatalytic degradations analgesics acetaminophen, aspirin, ibuprofen, naproxen), mucolytics ambroxol), antibiotics azithromycin quinolones hydroxychloroquine chloroquine phosphate), anti-inflammatory glucocorticoids dexamethasone cortisone acetate), antihistamines diphenhydramine), H2 blockers famotidine), anthelmintics praziquantel), antivirals ivermectin, acyclovir, lopinavir/ritonavir, favipiravir, nitazoxanide, remdesivir) which widely controlling/treating coronavirus reviewed discussed.
Language: Английский
Citations
61
Journal of Cleaner Production, Journal Year: 2022, Volume and Issue: 340, P. 130753 - 130753
Published: Feb. 1, 2022
Language: Английский
Citations
49
Clinical Pharmacology Advances and Applications, Journal Year: 2025, Volume and Issue: Volume 17, P. 1 - 11
Published: Jan. 1, 2025
Various repurposing drugs have been tested for their efficacy on coronavirus disease 2019 (COVID-19), including antimalarial drugs. During the pandemic, Chloroquine (CQ) and Hydroxychloroquine (HCQ) demonstrated good potential against COVID-19, but further studies showed both had side effects that were more dangerous than efficacy. This made World Health Organization (WHO) ban usage COVID-19 patients. In this context, there is a need to explore other as therapies COVID-19. study provides descriptive synthesis of clinical trials evaluating treatment conducted after withdrawal CQ HCQ. The method was literature using keywords "antimalarial", "COVID-19", "SARS-CoV-2", "clinical trial", "randomized controlled trial" MEDLINE, Scopus, Cochrane databases. Inclusion criteria published with randomized (RCTs) safety single in English excluding combination therapies. results 3 drugs, namely Quinine Sulfate (QS), Atovaquone (AQ), Artemisinin-Piperaquine (AP), gone through trial assess Out only AP significant primary outcome, which time required reach undetectable levels SARS-CoV-2. Furthermore, intervention group took 10.6 days, control 19.3 days (p=0.001). Based review, therapy fight
Language: Английский
Citations
1
Journal of Photochemistry and Photobiology A Chemistry, Journal Year: 2021, Volume and Issue: 419, P. 113453 - 113453
Published: July 21, 2021
Language: Английский
Citations
54
Biomedicine & Pharmacotherapy, Journal Year: 2021, Volume and Issue: 142, P. 111966 - 111966
Published: July 27, 2021
Since December 2019, the world was encountered a new disease called coronavirus 2019 (COVID-19), caused by severe acute respiratory syndrome 2 (SARS-CoV-2). Although SARS-CoV-2 initially causes lung damage, it also affects many other organs, including kidneys, and on average, 5-23% of people with COVID-19 develop symptoms kidney injury (AKI), elevated blood creatinine urea, hematuria, proteinuria, histopathological damages. The exact mechanism is unknown, but researchers believe that directly indirectly kidneys. direct pathway binding virus to ACE2 receptor in kidney, damage cells, renin-angiotensin system disturbances, activating coagulation pathways, damaging renal vascular endothelium. initial evidence from studying tissue postmortem patients more favor pathway. indirect created increased cytokines cytokine storm, sepsis, circulatory hypoxemia, as well using nephrotoxic drugs. Using biopsy autopsy COVID-19, recent studies found for predominant AKI induction SARS-CoV-2. Besides, some showed degree tubular (ATI) autopsies victims milder compared degree. We review side effects most common drugs used treat after overview latest findings pathogenicity.
Language: Английский
Citations
42
Environmental Science and Pollution Research, Journal Year: 2022, Volume and Issue: 29(42), P. 62887 - 62912
Published: July 14, 2022
Language: Английский
Citations
31
Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13
Published: March 11, 2022
Despite ongoing vaccination COVID-19 is a global healthcare problem because of the lack an effective targeted therapy. In severe manifesting as acute respiratory distress syndrome, uncontrolled innate immune system activation results in cytokine deregulation, damage-associated molecular patterns release upon tissue damage and high occurrence thrombotic events. These pathomechanisms are linked to neutrophil function dysfunction, particularly increased formation extracellular traps (NETs). While association NETs severity has been shown proved, causes unclear. The aim this review summarize potential inducers discuss treatment options targeting removal.
Language: Английский
Citations
30
International Journal of Biological Sciences, Journal Year: 2021, Volume and Issue: 17(6), P. 1538 - 1546
Published: Jan. 1, 2021
The outbreak of coronavirus disease-19 (COVID-19) caused by severe acute respiratory syndrome 2 (SARS-CoV-2) has rapidly evolved into a global pandemic.One major challenge in the battle against this deadly disease is to find effective therapy.Due availability and proven clinical record hydroxychloroquine (HCQ) chloroquine (CQ) various human diseases, there have been enormous efforts repurposing these two drugs as therapeutics for COVID-19.To date, substantial amount work at cellular, animal models trials performed verify their therapeutic potential COVID-19.However, neither lab-based studies nor provided consistent convincing evidence support value HCQ/CQ treatment COVID-19.In mini review we provide systematic summary on important topic aim reveal some truth covered mystery regarding COVID-19.
Language: Английский
Citations
38