SARS‐CoV‐2 infection and multi-organ system damage: a review

Bosnian Journal of Basic Medical Sciences, Journal Year: 2022, Volume and Issue: unknown

Published: Sept. 16, 2022

The SARS-CoV-2 infection causes COVID-19, which has affected approximately six hundred million people globally as of August 2022. Organs and cells harboring angiotensin-converting enzyme 2 (ACE2) surface receptors are the primary targets virus. However, once it enters body through respiratory system, virus can spread hematogenously to infect other organs. Therefore, COVID-19 affects many organs, causing severe long-term complications, even after disease ended, thus worsening quality life. Although is known that system most by infection, organs/systems in short long term. Since simultaneously redesigning diagnostic therapy policies fit damaged organs strongly recommended. Even though pathophysiology problems unknown, frequency cases rises with age existence preexisting symptoms. This study aims update our knowledge multi-organ dysfunction interaction based on clinical theoretical evidence. For this purpose, comprehensively elucidates recent studies effects multiple systems, including respiratory, cardiovascular, gastrointestinal, renal, nervous, endocrine, reproductive, immune, parts integumentary system. Understanding range atypical symptoms could improve surveillance, limit transmission, avoid additional multi-organ-system problems.

Language: Английский

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Vascular Implications of COVID-19: Role of Radiological Imaging, Artificial Intelligence, and Tissue Characterization: A Special Report

Journal of Cardiovascular Development and Disease, Journal Year: 2022, Volume and Issue: 9(8), P. 268 - 268

Published: Aug. 15, 2022

The SARS-CoV-2 virus has caused a pandemic, infecting nearly 80 million people worldwide, with mortality exceeding six million. average survival span is just 14 days from the time symptoms become aggressive. present study delineates deep-driven vascular damage in pulmonary, renal, coronary, and carotid vessels due to SARS-CoV-2. This special report addresses an important gap literature understanding (i) pathophysiology of role medical imaging visualization by SARS-CoV-2, (ii) further severity COVID-19 using artificial intelligence (AI)-based tissue characterization (TC). PRISMA was used select 296 studies for AI-based TC. Radiological techniques such as magnetic resonance (MRI), computed tomography (CT), ultrasound were selected vasculature infected COVID-19. Four kinds hypotheses are presented showing radiological images Three AI models, namely, machine learning, deep transfer Further, presents recommendations improving architectures studies. We conclude that process similarities across vessel types, even though it results multi-organ dysfunction. Although rate ~2% those infected, long-term effect needs monitoring avoid deaths. seems be penetrating health care industry at warp speed, we expect see emerging patient care, reduce morbidity rate.

Language: Английский

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TCM “medicine and food homology” in the management of post-COVID disorders

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Aug. 31, 2023

The World Health Organization declared that COVID-19 is no longer a public health emergency of global concern on May 5, 2023. Post-COVID disorders are, however, becoming more common. Hence, there lies growing need to develop safe and effective treatment measures manage post-COVID disorders. Investigating the use TCM medicinal foods in long-term therapy illnesses may be beneficial given contemporary research's emphasis development foods.The for highlighted this review. Following discussion history "Medicine Food Homology" theory, pathophysiological effects will briefly reviewed. An analysis their functions treating then provided before offering some insight into potential directions future research application.TCM can different aspects management efficient choice because they are typically milder nature than chronic drug use. These findings also applied post-disease similar respiratory

Language: Английский

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Iron and ferroptosis in kidney disease: molecular and metabolic mechanisms

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 5, 2025

Maintaining iron homeostasis is necessary for kidney functioning. There more and research indicating that disease often caused by imbalance. Over the past decade, ferroptosis’ role in mediating development progression of renal disorders, such as acute injury (renal ischemia-reperfusion injury, drug-induced severe pancreatitis induced sepsis-associated injury), chronic (diabetic nephropathy, fibrosis, autosomal dominant polycystic disease) cell carcinoma, has come into focus. Thus, knowing metabolism ferroptosis regulation may enhance therapy. In this review, we discuss metabolic molecular mechanisms signaling disease. We also explore possible targets therapy illness, well their existing limitations future strategies.

Language: Английский

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Hemoglobin-Polyvinyl Alcohol (Hb-PVA) Macroporous Cryogels As Swelling-Controlled Drug Delivery System Optimization and Release Kinetics of Vancomycin

Journal of Pharmaceutical Innovation, Journal Year: 2025, Volume and Issue: 20(1)

Published: Feb. 1, 2025

Language: Английский

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The Efficacy and Tolerability of Colistin Versus Non-Colistin Antimicrobial Regimens Among Hospitalized COVID-19 Patients with Multidrug-Resistant Bacterial Superinfection: An Observational Multicenter Study

Medicina, Journal Year: 2025, Volume and Issue: 61(5), P. 884 - 884

Published: May 13, 2025

Background and Objectives: Bacterial infections amongst COVID-19 patients could be associated with worsened outcomes. This study aimed to investigate the efficacy of colistin antibiotic in multidrug-resistant (MDR) Gram-negative (-ve) secondary bacterial among hospitalized patients. Materials Methods: In this multicentered retrospective study, we analyzed data from medical records 116 diagnosed infection MDR respiratory infections. Results: We compared those assigned versus non-colistin-based antimicrobial therapy. The two arms were similar baseline clinical features, demographics, pathogens’ distribution. Acinetobacter baumannii (51.7%) was major pathogen, followed by Klebsiella pneumonia (26.7%). Patients who received colistin-based regimen showed a non-significant difference non-colistin (NCA) therapy (p > 0.05) main Nephrotoxicity significantly higher IV group, control (34.1% 15.3%, p = 0.018). There substantial differences observed levels serum creatinine urea 0.029 <0.001, respectively). Conclusions: combination other agents comparable results that NCA regimens superinfections isolates; however, there notably elevated incidence nephrotoxicity Further randomized controlled trials are needed assess therapeutic benefits tolerability

Language: Английский

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Acute Kidney Injury among Hospital-Admitted COVID-19 Patients: A Study from Jordan

International Journal of General Medicine, Journal Year: 2022, Volume and Issue: Volume 15, P. 4475 - 4482

Published: April 1, 2022

During the COVID-19 pandemic, many patients have been admitted to hospitals with severe respiratory disease and suffered complications. Acute kidney injury (AKI) is among more dangerous complications contributing morbidity mortality patients.This retrospective study focused on all hospital-admitted between September December 2020. A total of 1,044 were enrolled. Patient demographics, medical records, laboratory data gathered. Patients split into two groups: AKI non-AKI. Comparisons comprised labs, ICU transfer, need for ventilation oxygen therapy, medications, hospital stay, deaths.AKI incidence in cohort was 25.3%, a majority stage 1 (53.3%). Among these, hemodialysis started 1.8%. Higher age (P<0.001), diabetes mellitus (P=0.001), hypertension ACEI/ARB use (P=0.008), erythrocyte-sedimentation rate (P=0.002), CRP (P<0.0001), ferritin (P=0.01) predictors AKI. patients, 30.2% died hospital. those AKI, 75.9% comparison 24.1% non-AKI (P<0.001). ICU, 80.5% died: 70.5% from group 29.5% (P<0.001).High associated infection, significantly outcomes hospitalized infection. Early recognition treatment will decrease hospitalization COVID-19.

Language: Английский

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Intervention effect of Lycium barbarum polysaccharide on lead-induced kidney injury mice and its mechanism: A study based on the PI3K/Akt/mTOR signaling pathway

Journal of Ethnopharmacology, Journal Year: 2023, Volume and Issue: 319, P. 117197 - 117197

Published: Sept. 16, 2023

Language: Английский

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Shortening the long-COVID: An exploratory review on the potential of Unani medicines in mitigating post-Covid-19 sequelae

Phytomedicine Plus, Journal Year: 2024, Volume and Issue: 4(2), P. 100570 - 100570

Published: April 16, 2024

Since the early days of coronavirus disease-2019 (COVID-19) pandemic, a number persistent symptoms have been observed in patients, continuing for weeks or even months after recovery, now named as post-COVID-19 condition, long-COVID. The commonest are neurological (cognitive decline, headache, insomnia etc.), cardiovascular afflictions (thromboembolism, hypertension respiratory problems, and general like fatigue, malaise etc. In this context, traditional medicine systems being explored their holistic multi-dimensional effects, often not attainable synthetic drugs. This review is done to explore potential medicaments (single raw/ natural ingredients only) Unani system which may be beneficial condition. We four important textbooks medications conditions similar COVID-19, light guidelines post-febrile phase medicine. After following inclusion exclusion criteria, total 159 herbal, animal mineral origin were identified. It was that 57.23% herbs (e.g. Pistacia vera L., Pimpinella anisum L.) had efficacy various conditions, while 38.36% Crocus sativus Borago officinalis effective conditions. Besides, many other described ailments gastro-intestinal tract, vital-organ tonics, nutritive, An observation most more than one Some include C. sativus, honey, Cichorium intybus Aucklandia costus Falc., B. officinalis, Cordia dichotoma G.Forst. Pre-clinical clinical studies on drugs corroborate classical literature. Several can potentially utilized due therapeutic protective actions. Hence, research direction provide practical solution overcome sequelae COVID-19.

Language: Английский

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Comparative analysis of the glomerular filtration rate effect on the course of COVID-19 in patients with coronary heart disease with and without concomitant coronavirus disease

International Journal of Medicine and Medical Research, Journal Year: 2023, Volume and Issue: 9(1), P. 15 - 23

Published: April 21, 2023

The research relevance is determined by the COVID-19 pandemic, which has led to serious medical consequences, including high levels of infectiousness, development diseases accompanied complications kidney and cardiovascular system function, increased mortality. Therefore, aims study compare impact glomerular filtration rate on course in patients with without coronary heart disease. A retrospective analysis 410 coronavirus was conducted, who were divided into 2 groups: those chronic disease this During hospital period (14.7 ± 5.3 days), composite endpoint all-cause deaths combination major adverse events assessed. thresholds for associated an increase incidence determined: COVID-19, less than 35 mL/min×1.73 m2 (p<0.01); 60 (p<0.01). Independent predictors decreased renal capacity group 1 were: age over 65 years, type diabetes mellitus, cholesterol, D-dimer, C-reactive protein, ferritin. Patients adversely affected arterial hypertension, D-dimer protein (p < 0.05). difference explained influence applied therapy anticoagulant renin-angiotensin systems. This will allow stratify terms impairment risk factors, as well identify effective strategies their management depending

Language: Английский

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