Pleiotropic Signaling by Reactive Oxygen Species Concerted with Dietary Phytochemicals and Microbial-Derived Metabolites as Potent Therapeutic Regulators of the Tumor Microenvironment DOI Creative Commons
Toshiyuki Murai, Satoru Matsuda

Antioxidants, Journal Year: 2023, Volume and Issue: 12(5), P. 1056 - 1056

Published: May 6, 2023

The excessive generation of reactive oxygen species (ROS) plays a pivotal role in the pathogenesis diseases. ROS are central to cellular redox regulation and act as second messengers activate redox-sensitive signals. Recent studies have revealed that certain sources can be beneficial or harmful human health. Considering essential pleiotropic roles basic physiological functions, future therapeutics should designed modulate state. Dietary phytochemicals, microbiota, metabolites derived from them expected developed drugs prevent treat disorders tumor microenvironment.

Language: Английский

Mushrooms as future generation healthy foods DOI Creative Commons
Victoria Bell,

Cídia Rosália Pinho Guina Silva,

José Guina

et al.

Frontiers in Nutrition, Journal Year: 2022, Volume and Issue: 9

Published: Dec. 6, 2022

The potential of edible mushrooms as an unexploited treasure trove, although rarely included in known food guidelines, is highlighted. Their role shielding people against the side effects unhealthy stylish diet reviewed. Mushrooms complement human with various bioactive molecules not identified or deficient foodstuffs plant and animal sources, being considered a functional for prevention several diseases. have been widely used medicinal products more than 2,000 years, but globally field use wild has untapped. There broad range which remain poorly even unreported valuable pool sources compounds biopharma utilization new dietary supplements. Some unique elements their preventative healthcare are emphasized, through positive impact on immune system. antiviral, anti-inflammatory, anti-neoplastic, other health concerns discussed. incorporate top non-digestible oligosaccharides, ergothioneine, humans unable to synthesize, later antioxidant, cytoprotective, anti-inflammatory element, therapeutic potential, approved by world agencies. prebiotic activity beneficially affects gut homeostasis performance balance microbiota enhanced. Several recent studies neurological contribution growth nerve brain cells mentioned. Indeed, foods' nutraceuticals presently regarded next-generation foods, supporting wellness, promising prophylactic agents.

Language: Английский

Citations

91
A Review of Ganoderma Triterpenoids and Their Bioactivities DOI Creative Commons
Mahesh C. A. Galappaththi, Nimesha M. Patabendige, Bhagya M. Premarathne

et al.

Biomolecules, Journal Year: 2022, Volume and Issue: 13(1), P. 24 - 24

Published: Dec. 22, 2022

For centuries,

Language: Английский

Citations

84
Fungi as a Source of Edible Proteins and Animal Feed DOI Creative Commons
Amro Abd Al Fattah Amara, Nawal Abd El‐Baky

Journal of Fungi, Journal Year: 2023, Volume and Issue: 9(1), P. 73 - 73

Published: Jan. 3, 2023

It is expected that the world population will reach 9 billion by 2050. Thus, meat, dairy or plant-based protein sources fail to meet global demand. New solutions must be offered find innovative and alternative sources. As a natural gift, edible wild mushrooms growing in wet shadow places can picked hand have been used as food. From searching forests producing single cell proteins (SCP) small scales mega production, academia, United Nations Organizations, industries, political makers others, play significant roles. Fermented traditional foods also reinvestigated. For example, kefir, miso, tempeh, are an excellent source for fungal isolates production. Fungi unique criteria of consuming various inexpensive wastes carbon energy biomass, concentrate amino acids with minimal requirement other environmental resources (e.g., light water). Fungal fermented SCP consumed either intentionally unintentionally our daily meals many applications food feed industries. This review addresses fungi animal feed, focusing mainly on SCP, mushrooms, foods, safety their consumption.

Language: Английский

Citations

79
Endophytic fungi: hidden treasure chest of antimicrobial metabolites interrelationship of endophytes and metabolites DOI Creative Commons
Priyanka Jha,

Tamanna Kaur,

Ishita Chhabra

et al.

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14

Published: July 11, 2023

Endophytic fungi comprise host-associated fungal communities which thrive within the tissues of host plants and produce a diverse range secondary metabolites with various bioactive attributes. The such as phenols, polyketides, saponins, alkaloids help to mitigate biotic abiotic stresses, fight against pathogen attacks enhance plant immune system. We present an overview association endophytic discuss molecular mechanisms induced during their symbiotic interaction. focuses on (especially those terpenoid nature) secreted by respective function. recent advancement in multi-omics approaches paved way for identification these characterization via comparative analysis extensive omics datasets. This study also elaborates role associated key agricultural crops hence important sustainability agriculture.

Language: Английский

Citations

65
Phylogenomics, divergence times and notes of orders in Basidiomycota DOI
Mao-Qiang He, Bin Cao, Fei Liu

et al.

Fungal Diversity, Journal Year: 2024, Volume and Issue: 126(1), P. 127 - 406

Published: July 9, 2024

Language: Английский

Citations

24
OMICS and Other Advanced Technologies in Mycological Applications DOI Creative Commons
Nalin N. Wijayawardene, Nattawut Boonyuen, C. B. Ranaweera

et al.

Journal of Fungi, Journal Year: 2023, Volume and Issue: 9(6), P. 688 - 688

Published: June 19, 2023

Fungi play many roles in different ecosystems. The precise identification of fungi is important aspects. Historically, they were identified based on morphological characteristics, but technological advancements such as polymerase chain reaction (PCR) and DNA sequencing now enable more accurate taxonomy, higher-level classifications. However, some species, referred to "dark taxa", lack distinct physical features that makes their challenging. High-throughput metagenomics environmental samples provide a solution identifying new lineages fungi. This paper discusses approaches including PCR amplification rDNA, multi-loci phylogenetic analyses, the importance various omics (large-scale molecular) techniques for understanding fungal applications. use proteomics, transcriptomics, metatranscriptomics, metabolomics, interactomics provides comprehensive These advanced technologies are critical expanding knowledge Kingdom Fungi, its impact food safety security, edible mushrooms foodomics, secondary metabolites, mycotoxin-producing fungi, biomedical therapeutic applications, antifungal drugs drug resistance, data novel development. also highlights exploring from extreme environments understudied areas identify dark taxa.

Language: Английский

Citations

32
Natural Compounds of Fungal Origin with Antimicrobial Activity—Potential Cosmetics Applications DOI Creative Commons
Katarzyna Sułkowska‐Ziaja,

Monika Trepa,

Aldona Olechowska‐Jarząb

et al.

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(9), P. 1200 - 1200

Published: Aug. 23, 2023

The phenomenon of drug resistance in micro-organisms necessitates the search for new compounds capable combating them. Fungi emerge as a promising source such they produce wide range secondary metabolites with bacteriostatic or fungistatic activity. These can serve alternatives commonly used antibiotics. Furthermore, fungi also accumulate antiviral This review focuses on filamentous and macrofungi sources antimicrobial compounds. article describes both individual isolated extracts that exhibit antibacterial, antifungal, are produced by fruiting bodies mycelium, well biomass mycelial cultures. Additionally, this characterizes chemical extracted from mushrooms realm cosmetology; specifically, their

Language: Английский

Citations

31
Sickle Cell Disease Update: New Treatments and Challenging Nutritional Interventions DOI Open Access
Victoria Bell, Theodoros Varzakas, Θεοδώρα Ψαλτοπούλου

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(2), P. 258 - 258

Published: Jan. 15, 2024

Sickle cell disease (SCD), a distinctive and often overlooked illness in the 21st century, is congenital blood disorder characterized by considerable phenotypic diversity. It comprises group of disorders, with sickle anemia (SCA) being most prevalent serious genotype. Although there have been some systematic reviews global data, worldwide statistics regarding SCD prevalence, morbidity, mortality remain scarce. In developed countries lower number patients, cutting-edge technologies led to development new treatments. However, developing settings where (SCD) more prevalent, medical management, rather than cure, still relies on use hydroxyurea, transfusions, analgesics. This that affects red cells, consequently affecting organs diverse manners. We discuss its etiology advent technologies, but aim this study understand various types nutrition-related studies involving individuals suffering from SCD, particularly Africa. The interplay environment, food, gut microbiota, along their respective genomes collectively known as microbiome, host metabolism responsible for mediating metabolic phenotypes modulating microbiota. addition, it serves purpose providing essential nutrients. Moreover, engages direct interactions homeostasis immune system, well indirect via metabolites. Nutrition interventions nutritional care are mechanisms addressing increased nutrient expenditures important aspects supportive management patients SCD. Underprivileged areas Sub-Saharan Africa should be accompanied efforts define promote Their importance key maintaining well-being quality life, especially because products limited, while native medicinal plant resources acknowledged.

Language: Английский

Citations

15
Biologically active secondary metabolites from white-rot fungi DOI Creative Commons
Orkun Pinar, Susana Rodríguez‐Couto

Frontiers in Chemistry, Journal Year: 2024, Volume and Issue: 12

Published: March 13, 2024

In recent years, there has been a considerable rise in the production of novel metabolites derived from fungi compared to ones originating bacteria. These organic substances are utilized various sectors such as farming, healthcare, and pharmaceutical. Since all dividing living cells contain primary metabolites, secondary synthesized by utilizing intermediate compounds or by-products generated metabolic pathways. Secondary not critical for growth development an organism; however, they exhibit variety distinct biological characteristics. White-rot only microorganisms able decompose wood components. Hence, play important role both carbon nitrogen cycles decomposing non-living substrates. They ubiquitous nature, particularly hardwood (e.g., birch aspen) forests. fungi, besides ligninolytic enzymes, produce different bioactive during their metabolism including some with antimicrobial anticancer properties. Such properties could be potential interest pharmaceutical industries. Considering importance untapped biologically active white-rot present paper reviews produced interesting bioactivities.

Language: Английский

Citations

13
Improving the Proteome-Mining of Schizophyllum commune to Enhance Medicinal Mushroom Applications DOI Creative Commons

Anthea Desiderio,

Lorenzo Goppa, Carlo Santambrogio

et al.

Journal of Fungi, Journal Year: 2025, Volume and Issue: 11(2), P. 120 - 120

Published: Feb. 5, 2025

This study presents the first comprehensive proteomic profile of an Italian strain Schizophyllum commune, a highly heterogeneous white-rot fungal species with significant potential for industrial, nutraceutical, cosmeceutical, and clinical applications. Three protein extraction methods their impact on yield resulting composition have been compared. Results revealed that combination Tris–Cl urea increases total variety enzymatic related to pivotal pathways. Notably, over 2000 proteins were identified, including enzymes involved in growth development mycelium, trehalose biosynthesis, different types carbohydrate-active (CAZymes). These are crucial nutraceutical agro-industrial applications S. commune. The multiple-step approach used could be model investigating other species.

Language: Английский

Citations

1