Digestive Diseases and Sciences, Journal Year: 2024, Volume and Issue: 69(6), P. 2026 - 2043
Published: April 15, 2024
Gastrointestinal transit (GIT) is influenced by factors including diet, medications, genetics, and gut microbiota, with slow GIT potentially indicating a functional disorder linked to conditions, such as constipation. Although studies have utilized various animal models, few effectively model spontaneous GIT.
Language: Английский
Journal of Agricultural and Food Chemistry, Journal Year: 2023, Volume and Issue: 71(44), P. 16568 - 16580
Published: Oct. 24, 2023
Constipation, a common gastrointestinal dysfunction, damages patients' life quality and predisposes them to other serious diseases. Current strategies against constipation often cause drug dependency side effects. Here, we demonstrated that broccoli-derived exosome-like nanoparticles (BENs), natural product with high stability, ameliorated LOP-induced in mice. Specifically, orally administered BENs (17.5 mg/kg/d) effectively shortened defecation time, sped up intestinal propulsion rate, increased feces amount constipated also raised excitatory neurotransmitters SP MTL reduced inhibitory VIP ET-1. Mechanistically, were taken by gut microbes, restored LOP-disordered microbiota, altered microbial metabolism of SCFAs tryptophan, as evidenced the results fluorescence microscopy, 16S rRNA gene sequencing, nontargeted metabolomics. Thereinto, BEN-enriched SCFA-producing microorganisms are closely associated levels BEN-elevated indole-3-pyruvic acid 3-indoleacetic highly linked ET-1, SP, levels. Conclusively, BENs, mitigating regulating microbiota tryptophan metabolism, showed potential be developed alternative regimens for constipation.
Language: Английский
Citations
24
Gut Microbes, Journal Year: 2023, Volume and Issue: 15(2)
Published: Nov. 27, 2023
Our previous work revealed that unbalanced dietary intake was an important independent factor associated with constipation and gastrointestinal (GI) symptoms in children autism spectrum disorder (ASD). Growing evidence has shown the alterations gut microbiota microbiota-derived metabolites ASD. However, how altered might affect associations between diets GI ASD remains unknown. We analyzed microbiome metabolomics data 90 typically developing (TD) based on 16S rRNA untargeted metabolomics, together assessment. found there existed 11 (FDR-corrected P-value <0.05) 397 (P-value compared TD children. Among microbiota, Turicibacter, Coprococcus 1, Lachnospiraceae FCS020 group were positively correlated <0.25). The Eggerthellaceae total More importantly, three increased including modulated of symptoms, decreased Clostridium sp. BR31 negatively their <0.05). Together, strengthens relationship symptoms. metabolites, ten derived from (Turicibacter, Eggerthellaceae, BR31) screened out, enriched eight metabolic pathways, identified to correlate These findings further support modulating role Collectively, our research provides insights into diet,
Language: Английский
Citations
17
Journal of Functional Foods, Journal Year: 2024, Volume and Issue: 116, P. 106158 - 106158
Published: April 7, 2024
Disruptions in the gut microbiota can impede gene expression and metabolic enzyme activity, thereby precipitating onset of diverse ailments. Spirulina polysaccharides, which are characterized by their high molecular weight composed multiple monosaccharides connected glycosidic bonds, demonstrate notable biological activity. Gut possesses ability to break down polysaccharides into butyrate, short-chain fatty acids, other metabolites that be readily absorbed utilized human body. Furthermore, have capacity modulate composition products microbiota, thus fostering general well-being averting diseases. This study reviews summarizes critically examines consolidates significant regulatory impacts on elucidating structural attributes potential mechanisms operation. These findings offer a valuable point reference for subsequent advancement prebiotic foods preparations based polysaccharides.
Language: Английский
Citations
6
Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15
Published: July 17, 2024
Constipation is a prevalent gastrointestinal disorder affecting approximately 15% of the global population, leading to significant healthcare burdens. Emerging evidence suggests that gut microbiota plays pivotal role in pathogenesis constipation, although causality remains uncertain due potential confounding factors observational studies. This study aims clarify causal relationships between and constipation using bidirectional Mendelian Randomization (MR) approach, which helps overcome issues reverse causality.
Language: Английский
Citations
6
BMC Gastroenterology, Journal Year: 2024, Volume and Issue: 24(1)
Published: Aug. 19, 2024
Constipation is one of the most common gastrointestinal disorders afflicting population, with recent observational studies implicating dysfunction gut microbiota in constipation. Despite indicating a relationship, clear causality remains unclear. This study aims to use two-sample Mendelian randomization (MR) establish clearer causal relationship between two.
Language: Английский
Citations
5
Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14
Published: Sept. 17, 2024
Background The relationship between dysbiosis of the gastrointestinal microbiota and gastric cancer (GC) has been extensively studied. However, alterations in GC patients vary widely across studies, reproducible diagnostic biomarkers for early are still lacking multiple populations. Thus, this study aimed to characterize microbial communities involved carcinogenesis through a meta-analysis published open datasets. Methods We analyzed 16S rRNA sequencing data from 1,642 biopsy samples 394 stool 11 independent studies. VSEARCH, QIIME R packages such as vegan, phyloseq, cooccur, random forest were used processing analysis. PICRUSt software was employed predict functions. Results α-diversity results indicated significant differences intratumoral compared non-cancer patients, while no observed fecal microbiota. Network analysis showed that positive correlation with GC-enriched bacteria increased, GC-depleted decreased healthy individuals. Functional analyses pathways related carbohydrate metabolism significantly enriched GC, biosynthesis unsaturated fatty acids diminished. Additionally, we investigated non- Helicobacter pylori (HP) commensals, which crucial both HP -negative -positive GC. Random models, constructed using specific taxa associated identified LEfSe analysis, revealed combination Lactobacillus Streptococcus included alone could effectively discriminate individuals (area under curve (AUC) = 0.7949). This finding also validated an cohort (AUC 0.7712). Conclusions examined dual microecological perspective Lactobacillus, Streptococcus, Roseburia, Faecalibacterium Phascolarctobacterium intestinal-specific co-differential bacteria. Furthermore, it confirmed validity GC-specific markers populations, may aid non-invasive diagnosis
Language: Английский
Citations
5
Postgraduate Medical Journal, Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 16, 2024
Abstract Chronic constipation is a prevalent clinical condition. Its etiology and pathogenesis have not yet been fully understood. In recent years, mounting evidence suggests close association between chronic intestinal dysbiosis, including alterations in the colony structure metabolites, as well modulation of bowel movements via brain–gut–microbiota axis. With deepening related research, probiotic-related therapies are expected to become potential first-line treatment for future. this review, we summarize current research insights into intricate relationships gut microbiota briefly discuss several different approaches treating constipation. The findings from review may advance our understanding pathological mechanisms underlying and, ultimately, translate them improvements patient care.
Language: Английский
Citations
4
Journal of Inflammation Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 565 - 572
Published: Jan. 1, 2025
Sleep disturbance is an immune-related disease, and the gut-brain axis important regulatory pathway. This cross-sectional study was designed to address these associations between complement C4, habitual constipation, sleep presents a reference for prevention treatment of disturbance. Based on China Hainan Centenarian Cohort Study, Pittsburgh Quality Index (PSQI) used evaluate following standard procedure. Complement C4 constipation were assessed groups with without by enzyme colorimetry Intestinal Health Questionnaire, respectively. A total 1621 participants included prevalence being 30.41%. significantly lower (24 mg/dL versus 25 mg/dL, P < 0.05) higher (19.88% 14.27%, in group than Multiple linear regression models detected negative association PSQI (β: -0.030, 95% confidence interval [CI]: -0.052--0.008, positive 0.610, CI: 0.145-1.074, 0.05). In multiple logistic models, negatively associated (odds ratio: 0.978, 0.963-0.993, 0.05), positively 1.609, 1.194-2.168, The present provides epidemiological evidence that oldest-old centenarian Chinese adults, which expands knowledge elderly population new insights pathways regulating immune factors intestinal function.
Language: Английский
Citations
0
Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16
Published: March 12, 2025
Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by difficulties in social interaction and communication, repetitive stereotyped behaviors, restricted interests, sensory abnormalities. Its etiology influenced both genetic environmental factors, with no definitive cause identified specific pharmacological treatments available, posing significant burden on patients’ families society. In recent years, research has discovered that gut microbiota dysbiosis plays crucial role the pathogenesis of ASD. The can influence brain function behavior through gut-brain axis via nervous system, immune metabolic pathways. On one hand, microbes such as Clostridium Prevotella species are found to be abnormal ASD patients, their products, like short-chain fatty acids, serotonin, GABA, also involved pathological process other patients exhibit system dysfunction, cells related cytokines affecting neural activities brain. Currently, intervention methods targeting microbiota, probiotics, prebiotics, fecal transplantation, have shown some potential improving symptoms. However, more studies needed explore long-term effects optimal treatment protocols. This paper reviews mechanisms interrelationships among discusses challenges future directions existing research, aiming provide new insights for prevention
Language: Английский
Citations
0
Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12
Published: March 31, 2025
Objective To examine the potential association between dietary index of gut microbiota (DI-GM) scores and constipation in adult women United States. Methods This cross-sectional study used data from participants 2005–2010 US National Health Survey (NHANES). The missing values covariables were filled by multiple interpolation. Multivariate logistic regression models to determine odds ratios (OR) 95% confidence intervals (CI) for DI-GM constipation. Subgroup analyses also performed possible interactions Results Of 7,325 subjects, 887 reported constipations, with a prevalence 12.1%. After adjustment multivariate modeling, score was significantly associated (0.92 [95% CI 0.87–0.96]; p = 0.001). Similar results found beneficial (OR 0.89 0.84 0.95]; 0. 001). revealed that relationship remained stable ( > 0.05). Conclusion negatively incidence female population. Clinicians should consider influence structure on treatment women. Dietary intervention can be an important strategy comprehensive
Language: Английский
Citations
0