Mung Bean Peptides Alleviate Dextran-Sulfate-Sodium-Induced Colitis Symptoms in Mice by Protecting the Intestinal Mechanical Barrier and Regulating Gut Microbiota

Foods, Journal Year: 2025, Volume and Issue: 14(8), P. 1363 - 1363

Published: April 15, 2025

Ulcerative colitis (UC), an idiopathic and recurrent ailment, substantially influences a patient’s health. Mung bean peptides (MBPs) are bioactive substances derived from mung protein that possess notable anti-inflammatory properties. However, their efficacy underlying mechanisms in UC treatment remain unclear. In this study, the structural characteristics of MBPs were examined by determining various parameters, such as amino acid composition, molecular weight distribution, peptide sequences, thereby structurally demonstrating potential. The therapeutic effectiveness was evaluated assessing its influence on colon length, histological damage to colonic tissue, disease activity index mice suffering induced dextran sulfate sodium (DSS). Additionally, study explored potential mechanism action analyzing intestinal microbiota, inflammatory cytokines serum, tight junction (TJ) proteins tissue mice. results revealed significantly increased reduced damage, decreased with UC. restored barrier function upregulating expression ZO-1 claudin-1 within DSS-induced colitis, treating exerted effects downregulating amplification improving gut microbiota structure regulating immune-related signaling pathways. Therefore, there is experimental basis for use adjunctive therapy

Language: Английский

Multi-omics reveals the alleviating effect of berberine on ulcerative colitis through modulating the gut microbiome and bile acid metabolism in the gut-liver axis

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 24, 2024

The dysfunction of gut microbiome and bile acid metabolism might cause the incidence relapse ulcerative colitis (UC). Thus, natural products have been considered effective for UC through regulation acid. In this study, we evaluated regulatory effect berberine on in UC. Results showed that relative abundances beneficial bacteria a decreasing trend model, taurine conjugated acids increased from liver tissue to colon tissue. Berberine inhibited colonization harmful promoted primary metabolism. Moreover, used multi-omics technology (metagenomics, metabolomics, transcriptomics technology) reveal restored intestinal barrier function acid/S1PR2/RhoA/ROCK pathway. result transmission electron microscopy directly damaged mucosal was repaired treatment. This study revealed treatment influence

Language: Английский