Surface Functionalization of Nanocarriers with Anti-EGFR Ligands for Cancer Active Targeting
Nanomaterials,
Journal Year:
2025,
Volume and Issue:
15(3), P. 158 - 158
Published: Jan. 21, 2025
Active
cancer
targeting
consists
of
the
selective
recognition
overexpressed
biomarkers
on
cell
surfaces
or
within
tumor
microenvironment,
enabled
by
ligands
conjugated
to
drug
carriers.
Nanoparticle
(NP)-based
systems
are
highly
relevant
for
such
an
approach
due
their
large
surface
area
which
is
amenable
a
variety
chemical
modifications.
Over
past
decades,
several
studies
have
debated
efficiency
passive
targeting,
highlighting
active
as
more
specific
and
approach.
The
choice
conjugation
chemistry
attaching
nanocarriers
critical
ensure
stable
robust
system.
Among
panel
biomarkers,
epidermal
growth
factor
receptor
(EGFR)
stands
one
most
frequently
receptors
in
different
types.
design
development
with
surface-bound
anti-EGFR
vital
targeted
therapy,
relying
facilitated
capture
EGFR-overexpressing
cells
enabling
receptor-mediated
endocytosis
improve
accumulation
microenvironment.
In
this
review,
we
examine
examples
recent
significant
explore
various
strategies
NP
functionalization
biomolecules
small
molecular
ligands.
addition,
also
describe
some
common
characterization
techniques
confirm
analyze
patterns.
Language: Английский
Trends in nanobody radiotheranostics
Xingbo Long,
No information about this author
Sixuan Cheng,
No information about this author
Xiaoli Lan
No information about this author
et al.
European Journal of Nuclear Medicine and Molecular Imaging,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 13, 2025
Language: Английский
Development and evaluation of Hsp90-targeting nanobodies for visualisation of extracellular Hsp90 in tumours using PET imaging
EJNMMI Radiopharmacy and Chemistry,
Journal Year:
2025,
Volume and Issue:
10(1)
Published: Feb. 21, 2025
Language: Английский
Nanoscale warriors against viral invaders: a comprehensive review of Nanobodies as potential antiviral therapeutics
Vaishali Verma,
No information about this author
N. D. Sinha,
No information about this author
A. Raja
No information about this author
et al.
mAbs,
Journal Year:
2025,
Volume and Issue:
17(1)
Published: April 9, 2025
Viral
infections
remain
a
significant
global
health
threat,
with
emerging
and
reemerging
viruses
causing
epidemics
pandemics.
Despite
advancements
in
antiviral
therapies,
the
development
of
effective
treatments
is
often
hindered
by
challenges,
such
as
viral
resistance
emergence
new
strains.
In
this
context,
novel
therapeutic
modalities
essential
to
combat
notorious
viruses.
While
traditional
monoclonal
antibodies
are
widely
used
for
treatment
several
diseases,
nanobodies
derived
from
heavy
chain-only
have
emerged
promising
"nanoscale
warriors"
against
infections.
Nanobodies
possess
unique
structural
properties
that
enhance
their
ability
recognize
diverse
epitopes.
Their
small
size
also
imparts
properties,
improved
bioavailability,
solubility,
stability,
proteolytic
resistance,
making
them
an
ideal
class
therapeutics
review,
we
discuss
role
antivirals
various
Techniques
developing
nanobodies,
delivery
strategies
covered,
challenges
opportunities
associated
use
therapies
discussed.
We
offer
insights
into
future
nanobody-based
research
support
managing
Language: Английский
Development and evaluation of albumin binder-conjugated heterodimeric radiopharmaceuticals targeting integrin αvβ3 and CD13 for cancer therapy
Biao Yang,
No information about this author
Changyu Shan,
No information about this author
Xiangming Song
No information about this author
et al.
European Journal of Nuclear Medicine and Molecular Imaging,
Journal Year:
2024,
Volume and Issue:
51(11), P. 3334 - 3345
Published: May 24, 2024
Language: Английский
Metal-based nanomedicine systems for the diagnosis and treatment of colorectal cancer: Current advances and future perspectives
Jie Gou,
No information about this author
Lu Chen,
No information about this author
Tianyu Liu
No information about this author
et al.
Materials Today Chemistry,
Journal Year:
2025,
Volume and Issue:
45, P. 102702 - 102702
Published: April 1, 2025
Language: Английский
Framework Nucleic Acid-Nanobody Fusion Probe-Based Pharmacokinetics Modulation and Analysis for Efficient Positron Emission Tomography Imaging
Yani Yang,
No information about this author
Zhiqiang Ren,
No information about this author
Dan Wang
No information about this author
et al.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 23, 2024
Nanobodies
are
promising
for
immunoPET
imaging
due
to
their
excellent
antigen
recognition
and
tumor
targeting,
yet
rapid
clearance
limits
accumulation.
Although
multimerization
albumin
binding
can
extend
circulation
time
improve
a
simple
universal
method
creating
protein
multimers
is
still
needed.
Here,
we
leveraged
the
facile
synthesis,
controllable
size,
precise
assembly
of
DNA
nanotechnology
construct
CD47-targeted
framework
nucleic
acid-nanobody
fusion
probes
with
multiple
valences
sizes.
Following
comprehensive
structural
characterization,
in
vitro
specificity
assessment
vivo
PET/CT
analysis
were
conducted
on
colorectal
cancer
LS174T
mouse
model.
Furthermore,
pharmacokinetic
model
was
developed
fitted
considerable
data
prove
its
rationality,
followed
by
testing
effects
uptake
prediction
changing
different
parameters.
Indeed,
manipulating
size
acid
scaffolding
number
attached
nanobodies,
could
precisely
modulate
accumulation
at
site.
Overall,
this
study
not
only
an
efficient
strategy
constructing
nanobody
but
also
provided
model,
allowing
profound
insight
into
multidimensional
obtained
experimentally
informing
design
future
predictable
delivery
efficacies.
Language: Английский