Overview of the Efficacy of Using Probiotics for Neurosurgical and Potential Neurosurgical Patients DOI Creative Commons
Sabina Fijan, Tomaž Šmigoc

Microorganisms, Journal Year: 2024, Volume and Issue: 12(7), P. 1361 - 1361

Published: July 2, 2024

This review delves into the emerging field of gut microbiota-brain axis, emphasizing its bidirectional communication and implications for neurological health, particularly in trauma neurosurgery. While disruptions this axis can lead to dysbiosis hinder recovery, recent studies have highlighted therapeutic potential interventions like probiotics targeting axis. aims focus on efficacy probiotic supplementation support trauma, neurosurgery, or pain based current clinical trials assess complex interplays among probiotics, microbiota, central nervous system (CNS). comprehensive literature identified 10 relevant publications various neurosurgical conditions across multiple countries. These demonstrated diverse outcomes, with significant improvements observed gastrointestinal mobility, inflammatory responses, infection rates, post-traumatic brain injury spinal surgery. Probiotics also showed promise mitigating antibiotic-associated diarrhea modulating cytokines. Despite promising findings, (CNS) call cautious interpretation. Conflicting outcomes emphasize need better-designed understand strain-specific disease-specific effects accurately. In conclusion, offer a adjuvant therapy patients, traumatic injuries, post-spinal However, further well-designed randomized controlled are essential elucidate intricate relationship between microbiome-modulating CNS via

Language: Английский

Gut microbial metabolites in lung cancer development and immunotherapy: Novel insights into gut-lung axis DOI
Xinpei Li,

Shijie Shang,

Meng Wu

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: 598, P. 217096 - 217096

Published: July 4, 2024

Language: Английский

Citations

11
Microbiome and pancreatic cancer: time to think about chemotherapy DOI Creative Commons
Juliana de Castilhos,

Katharina Tillmanns,

J. A. BLESSING

et al.

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: July 18, 2024

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer characterized by late diagnosis, rapid progression, and high mortality rate. Its complex biology, dense, stromal tumor environment with an immunosuppressive milieu, contributes to resistance against standard treatments like chemotherapy radiation. This comprehensive review explores the dynamic role of microbiome in modulating efficacy outcomes PDAC. It delves into microbiome's impact on drug metabolism resistance, interaction between microbial elements, drugs, human biology. We also highlight significance specific bacterial species enzymes influencing action immune response microenvironment. Cutting-edge methodologies, including artificial intelligence, low-biomass analysis patient-derived organoid models, are discussed, offering insights nuanced interactions microbes cells. The potential microbiome-based interventions as adjuncts conventional PDAC paving way for personalized therapy approaches. synthesizes recent research provide in-depth understanding how affects efficacy. focuses elucidating key mechanisms identifying existing knowledge gaps. Addressing these gaps crucial enhancing medicine refining treatment strategies, ultimately improving patient outcomes.

Language: Английский

Citations

9
Inulin extracted from burdock root (Arctium lappa L.) incorporated alginate/chitosan hydrogel beads for probiotics encapsulation DOI Creative Commons
Korlid Thinkohkaew,

Nichapa Aumphaiphensiri,

Thakorn Tangamornsiri

et al.

Journal of Agriculture and Food Research, Journal Year: 2024, Volume and Issue: 18, P. 101405 - 101405

Published: Sept. 10, 2024

Language: Английский

Citations

9
Dysbiosis–NK Cell Crosstalk in Pancreatic Cancer: Toward a Unified Biomarker Signature for Improved Clinical Outcomes DOI Open Access
Sara Fanijavadi, Lars Henrik Jensen

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 730 - 730

Published: Jan. 16, 2025

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with poor prognosis, primarily due to its immunosuppressive tumor microenvironment (TME), which contributes treatment resistance. Recent research shows that the microbiome, including microbial communities in oral cavity, gut, bile duct, and intratumoral environments, plays a key role PDAC development, imbalances (dysbiosis) promoting inflammation, progression, therapy resistance, side effects. Microbial metabolites can also affect immune cells, especially natural killer (NK) are vital for surveillance, response treatment-related Dysbiosis NK cell function, leading resistance We propose combined biomarker approach, integrating microbiome composition profiles, help predict effects, enabling more personalized therapies. This review examines how dysbiosis dysfunction discusses strategies (e.g., antibiotics, probiotics, vaccines) modulate enhance function. Targeting could activity, improve effectiveness of treatments, reduce However, further needed develop unified cell–microbiome interaction-based biomarkers precise effective patient outcomes.

Language: Английский

Citations

1
A comprehensive review of synbiotics: an emerging paradigm in health promotion and disease management DOI
Sulhee Lee, Sang-Pil Choi, Hak‐Jong Choi

et al.

World Journal of Microbiology and Biotechnology, Journal Year: 2024, Volume and Issue: 40(9)

Published: July 27, 2024

Language: Английский

Citations

5
Decoding the potential microbiome modulation strategies from bugs to drugs in pancreatic cancer: Insights from clinical trials DOI
Yuning Wang, Wang Shuhang,

Ning Li

et al.

Cancer Letters, Journal Year: 2025, Volume and Issue: unknown, P. 217465 - 217465

Published: Jan. 1, 2025

Language: Английский

Citations

0
The role of nutrition in cancer prevention: the effect of dietary patterns, bioactive compounds, and metabolic pathways on cancer development DOI Creative Commons
Sebastián Chapela,

Julieta Locatelli,

Facundo Saettone

et al.

Food and Agricultural Immunology, Journal Year: 2025, Volume and Issue: 36(1)

Published: April 17, 2025

Language: Английский

Citations

0
Overview of the Efficacy of Using Probiotics for Neurosurgical and Potential Neurosurgical Patients DOI Creative Commons
Sabina Fijan, Tomaž Šmigoc

Microorganisms, Journal Year: 2024, Volume and Issue: 12(7), P. 1361 - 1361

Published: July 2, 2024

This review delves into the emerging field of gut microbiota-brain axis, emphasizing its bidirectional communication and implications for neurological health, particularly in trauma neurosurgery. While disruptions this axis can lead to dysbiosis hinder recovery, recent studies have highlighted therapeutic potential interventions like probiotics targeting axis. aims focus on efficacy probiotic supplementation support trauma, neurosurgery, or pain based current clinical trials assess complex interplays among probiotics, microbiota, central nervous system (CNS). comprehensive literature identified 10 relevant publications various neurosurgical conditions across multiple countries. These demonstrated diverse outcomes, with significant improvements observed gastrointestinal mobility, inflammatory responses, infection rates, post-traumatic brain injury spinal surgery. Probiotics also showed promise mitigating antibiotic-associated diarrhea modulating cytokines. Despite promising findings, (CNS) call cautious interpretation. Conflicting outcomes emphasize need better-designed understand strain-specific disease-specific effects accurately. In conclusion, offer a adjuvant therapy patients, traumatic injuries, post-spinal However, further well-designed randomized controlled are essential elucidate intricate relationship between microbiome-modulating CNS via

Language: Английский

Citations

1