Activity of protegrin-1 against mouse Ehrlich ascites carcinoma <i>in vitro</i> and <i>in vivo</i> DOI
Alena E. Rudel, Т. А. Филатенкова, Maria S. Zharkova

et al.

Medical academic journal, Journal Year: 2024, Volume and Issue: 24(2), P. 117 - 124

Published: Oct. 29, 2024

BACKGROUND: The problem of multidrug resistance in cancer treatment creates an urgent demand for developing new effective antitumor agents. Due to the unusual mechanism recognizing and damaging tumor cells, antimicrobial peptides are considered as possible prototypes designing such therapeutics. AIM: This work was aimed compare potential promising membranolytic peptide protegrin-1 vitro vivo Ehrlich ascites carcinoma mice model. MATERIALS AND METHODS: We used two variants model by inducing a solid or form. In first case, were injected with twice week three weeks, second injections provided every other day six days. activity against isolated cells analyzed using MTT-test. RESULTS: Protegrin-1 demonstrated high vitro, but had no significant effect on lifespan bearing form at dosing administration regimens we used. However, caused decrease volume number fluid. CONCLUSIONS: retains its properties vivo, it may be presumed, that effectively suppress growth requires more frequent prolonged compared conventional antibiotics, which adopted regimen this study.

Language: Английский

Recent advances in the therapeutic potential of cathelicidins DOI Creative Commons
Maria Eduarda Souza Guerra, Brenda Vieira,

Ana Paula Carvalho Thiers Calazans

et al.

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: June 26, 2024

The alarming increase in antimicrobial resistance the last decades has prompted search for alternatives to control infectious diseases. Antimicrobial peptides (AMPs) represent a heterogeneous class of molecules with ample antibacterial, antiviral, and antifungal effects. They can be found many organisms, including all classes vertebrates, providing valuable source new agents. unique properties AMPs make it harder microbes develop resistance, while their immunomodulatory target diversity reinforce translational use multiple diseases, from autoimmune disorders different types cancer. latest years have witnessed vast number studies evaluating therapy, progressing clinical trials. present review explores recent developments medicinal cathelicidins, family potent Cathelicidins several organisms been tested disease models viral bacterial infections, inflammatory tumors, encouraging results. Combining nanomaterials active, natural peptides, LL-37 synthetic analogs like ceragenins, leads creation innovative nanoagents significant promise. However, there are still important limitations, such as toxicity cathelicidins healthy host cells low stability

Language: Английский

Citations

8
Dual-Action Therapeutics: DNA Alkylation and Antimicrobial Peptides for Cancer Therapy DOI Open Access
Celia María Curieses Andrés, José Manuel Pérez de la Lastra, Elena Bustamante Munguira

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(18), P. 3123 - 3123

Published: Sept. 10, 2024

Cancer remains one of the most difficult diseases to treat, requiring continuous research into innovative therapeutic strategies. Conventional treatments such as chemotherapy and radiotherapy are effective a certain extent but often have significant side effects carry risk resistance. In recent years, concept dual-acting therapeutics has attracted considerable attention, particularly combination DNA alkylating agents antimicrobial peptides. alkylation, well-known mechanism in cancer therapy, involves attachment alkyl groups DNA, leading damage subsequent cell death. Antimicrobial peptides, on other hand, been shown be anticancer due their ability selectively disrupt membranes modulate immune responses. This review aims explore synergistic potential these two modalities. It examines mechanisms action, current findings, promise they offer improve efficacy specificity treatments. By combining cytotoxic power alkylation with unique properties dual-action may new more approach fighting cancer.

Language: Английский

Citations

6
Unraveling the role of the P2X7 receptor in cancer radioresistance: Molecular insights and therapeutic implications DOI

Seyedeh Nasibeh Mousavikia,

Maryam Moghaddam Matin,

Mohammad Taghi Bahreyni Tossi

et al.

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Journal Year: 2025, Volume and Issue: 1872(3), P. 119910 - 119910

Published: Jan. 29, 2025

Language: Английский

Citations

0
Fluorescence-based multimodal imaging for in vivo tracking of magnetic Janus nanoparticles as potential carriers for DOX under the alternating magnetic field: Enhancing tumor penetration DOI
Samideh Khoei, Sepideh Khoee,

Elahe Sadri

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106730 - 106730

Published: Feb. 1, 2025

Language: Английский

Citations

0
Glioblastoma Multiforme: Sensitivity to Antimicrobial Peptides LL-37, PG-1 and Its Combinations with Chemotherapy for Prediction of Overall Survival of the Patients DOI Open Access
Alexander N. Chernov,

Sofia S. Skliar,

Alexander Kim

et al.

Published: Aug. 5, 2024

Glioblastomas (GBMs) are the most malignant and intractable of all cancers, with an unfavourable clinical prognosis for affected patients. The objective was analysis sensitivity GBM cells to antimicrobial peptides (AMPs) cathelicidin (LL-37) protegrin-1 (PG-1), both alone in combination chemotherapy, predict overall survival (OS) study conducted on 27 patients treated neurosurgical departments Almazov Medical Research Centre (Saint-Petersburg, Russia) from 2021 2024. cytotoxic effects chemo-therapy, AMPs their combinations brain tumor were assessed by MTT assay using 50%-inhibitory concentration (IC50). In patients, LL-37 PG-1 exhibited strong anticancer effects, surpassing those chemotherapy drugs. These anti-cancer associated a statistically significant increase life expectancy OS findings confirmed experiments rats C6 glioma, where intranasal administration (300 μM) (600 increased animals 69 55 days, respectively, compared 24 days control group (HR=4.139, p=0.0005; HR=2.542, p=0.0759). Additionally, chemo-therapy drugs showed that high IC50 cisplatin (cutoff &gt;800 (19 vs 5 months, HR=4.708, p=0.0101) could be used future treatments.

Language: Английский

Citations

2
RECENT ADVANCES IN THE THERAPEUTIC POTENTIAL OF CATHELICIDINS DOI Open Access
Thiago Rojas Converso, Maria Eduarda Souza Guerra, Brenda Vieira

et al.

Authorea (Authorea), Journal Year: 2024, Volume and Issue: unknown

Published: May 2, 2024

Antimicrobial peptides (AMPs) are part of the innate immunity, aiding in defense against pathogens. Cathelicidins represent a class cationic AMPs distributed across various organisms, including mammals, birds, reptiles, amphibians, and fish. These perform several important functions for host, contributing to direct elimination pathogens by their microbicidal activities, while also promoting immune modulation, wound healing, anti-tumor effects. Based on versatility, cathelicidins have been investigated as therapeutic agents infections, inflammatory autoimmune diseases, tumors. The present review summarizes most recent discoveries regarding use therapy, addressing challenges such cytotoxicity, production costs, bacterial resistance. Additionally, combining nanomaterials with active, natural antimicrobial peptides, LL-37 synthetic analogs like ceragenins, leads creation innovative nanoagents significant clinical promise. Despite vast number pre-clinical studies, very few progressed trials. Nevertheless, advances biology may help overcome current limitations, enabling future therapeutics.

Language: Английский

Citations

0
Cocrystal of Naringenin and Norfloxacin: Crystal Transformation, Solubility, and Antibacterial and Anticancer Activities DOI

Xin Zeng,

Chupei Zheng,

Shouliang Qiu

et al.

Crystal Growth & Design, Journal Year: 2024, Volume and Issue: 24(11), P. 4416 - 4427

Published: May 25, 2024

Drug cocrystals can modulate the physical and chemical properties of drugs, even complement each other's strengths, have a synergistic enhancement effect. Here, we reported drug cocrystal prepared by norfloxacin (NOR) naringenin (NAR), comprising an antibacterial antitumor active pharmaceutical ingredient. The hydrate obtained crystal transformation methods enhanced activity NOR against one Gram-positive bacterium (Staphylococcus aureus), three Gram-negative bacteria (Escherichia coli, Dysentery bacillus, Pseudomonas aeruginosa), fungus (Candida albicans), improved solubility NAR, reduced hygroscopicity NOR, anticancer NAR human breast cancer cells MDA-MB-231. This combination has potential therapeutic synergy in clinical terms.

Language: Английский

Citations

0
Glioblastoma Multiforme: Sensitivity to Antimicrobial Peptides LL-37 and PG-1, and Their Combination with Chemotherapy for Predicting the Overall Survival of Patients DOI Creative Commons
Alexander N. Chernov,

Sofia S. Skliar,

Alexander Kim

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(9), P. 1234 - 1234

Published: Sept. 22, 2024

Glioblastomas (GBMs) are the most malignant and intractable of all cancers, with an unfavorable clinical prognosis for affected patients. The objective was to analyze sensitivity GBM cells antimicrobial peptides (AMPs) cathelicidin (LL-37) protegrin-1 (PG-1), both alone in combination chemotherapy, predict overall survival (OS)

Language: Английский

Citations

0
Activity of protegrin-1 against mouse Ehrlich ascites carcinoma <i>in vitro</i> and <i>in vivo</i> DOI
Alena E. Rudel, Т. А. Филатенкова, Maria S. Zharkova

et al.

Medical academic journal, Journal Year: 2024, Volume and Issue: 24(2), P. 117 - 124

Published: Oct. 29, 2024

BACKGROUND: The problem of multidrug resistance in cancer treatment creates an urgent demand for developing new effective antitumor agents. Due to the unusual mechanism recognizing and damaging tumor cells, antimicrobial peptides are considered as possible prototypes designing such therapeutics. AIM: This work was aimed compare potential promising membranolytic peptide protegrin-1 vitro vivo Ehrlich ascites carcinoma mice model. MATERIALS AND METHODS: We used two variants model by inducing a solid or form. In first case, were injected with twice week three weeks, second injections provided every other day six days. activity against isolated cells analyzed using MTT-test. RESULTS: Protegrin-1 demonstrated high vitro, but had no significant effect on lifespan bearing form at dosing administration regimens we used. However, caused decrease volume number fluid. CONCLUSIONS: retains its properties vivo, it may be presumed, that effectively suppress growth requires more frequent prolonged compared conventional antibiotics, which adopted regimen this study.

Language: Английский

Citations

0