Characterization of the first antimicrobial peptide from Sea Seal with potent therapeutic effect in septic mice
Biochemical Pharmacology,
Journal Year:
2025,
Volume and Issue:
unknown, P. 116891 - 116891
Published: March 1, 2025
Language: Английский
Marsupial cathelicidins: characterization, antimicrobial activity and evolution in this unique mammalian lineage
Emma Peel,
No information about this author
Adele Gonsalvez,
No information about this author
Carolyn J. Hogg
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et al.
Frontiers in Immunology,
Journal Year:
2025,
Volume and Issue:
16
Published: April 4, 2025
Cathelicidins
are
a
family
of
antimicrobial
peptides
well-known
for
their
and
immunomodulatory
functions
in
eutherian
mammals
such
as
humans.
However,
cathelicidins
marsupials,
the
other
major
lineage
mammals,
have
received
little
attention
despite
lineage-specific
gene
expansions
resulting
large
diverse
peptide
repertoire.
We
characterized
across
marsupial
tree
investigated
genomic
organisation
evolutionary
relationships
amongst
mammals.
Ancestral
sequence
reconstruction
was
used
to
predict
ancestral
cathelicidins,
which,
alongside
extant
peptides,
were
synthesized
screened
activity.
identified
130
cathelicidin
genes
14
species
representing
10
families,
with
all
species.
Cathelicidin
encoded
highly
syntenic
region
genome
although
number
clusters
differed
lineages
(eutherians
one,
marsupials
two,
monotremes
three).
32
displayed
rapid,
potent,
and/or
broad-spectrum
antibacterial
antifungal
Phylogenetic
analysis
revealed
that
monotreme
repertoires
may
reflect
both
birds,
they
encode
non-classical
found
only
well
multiple
copies
neutrophil
granule
protein
classic
This
study
sheds
light
on
history
mammalian
highlights
potential
wildlife
novel
bioactive
discovery.
Language: Английский
Targeting siRNA Nanoparticles with ApoB Peptide: Formulation, Biodistribution, and Bioactivity in Pancreatic Tumor-bearing Mice
Majd Agbaria,
No information about this author
Doaa Jbara-Agbaria,
No information about this author
Gershon Golomb
No information about this author
et al.
Journal of Drug Delivery Science and Technology,
Journal Year:
2025,
Volume and Issue:
unknown, P. 106900 - 106900
Published: April 1, 2025
Language: Английский
Structure, Function, and Regulation of LytA: The N-Acetylmuramoyl-l-alanine Amidase Driving the “Suicidal Tendencies” of Streptococcus pneumoniae—A Review
Microorganisms,
Journal Year:
2025,
Volume and Issue:
13(4), P. 827 - 827
Published: April 5, 2025
Streptococcus
pneumoniae
(pneumococcus)
is
a
significant
human
pathogen
responsible
for
range
of
diseases
from
mild
infections
to
invasive
pneumococcal
diseases,
particularly
affecting
children,
the
elderly,
and
immunocompromised
individuals.
Despite
conjugate
vaccines
having
reduced
disease
incidence,
challenges
persist
due
serotype
diversity,
vaccine
coverage
gaps,
antibiotic
resistance.
This
review
highlights
role
LytA,
key
autolysin
(N-acetylmuramoyl-l-alanine
amidase),
in
biology.
LytA
regulates
autolysis,
contributes
inflammation,
biofilm
formation,
impairs
bacterial
clearance.
It
also
modulates
complement
activation,
aiding
immune
evasion.
expression
influenced
by
environmental
signals
genetic
regulation
tied
competence
transformation,
which
an
important
virulence
trait,
meningitis.
With
increase
resistance,
has
emerged
as
potential
therapeutic
target.
Current
research
explores
its
use
bacteriolytic
therapies,
development,
synergistic
strategies.
Various
compounds,
including
synthetic
peptides,
plant
extracts,
small
molecules,
have
been
investigated
their
ability
trigger
LytA-mediated
lysis.
Future
directions
include
development
novel
anti-pneumococcal
interventions
leveraging
LytA’s
properties
while
overcoming
efficacy
resistance-related
challenges.
Human
challenge
models
animal
studies
continue
deepen
our
understanding
pathogenesis
treatment
Language: Английский
The Role of Antimicrobial Peptides in Overcoming Antibiotic Resistance
The Microbe,
Journal Year:
2025,
Volume and Issue:
unknown, P. 100337 - 100337
Published: April 1, 2025
Language: Английский
PMAP-37: A versatile cathelicidin for neutralizing bacteria and viruses
Fatemeh Pashaie,
No information about this author
Naomi Benne,
No information about this author
Philippa I.P. Holzapfel
No information about this author
et al.
Microbial Pathogenesis,
Journal Year:
2025,
Volume and Issue:
unknown, P. 107568 - 107568
Published: April 1, 2025
Language: Английский
Nanogel encapsulation improves pharmacokinetics and biodistribution of antimicrobial peptide LL37 upon lung deposition: In vivo evaluation by SPECT/CT
Journal of Controlled Release,
Journal Year:
2025,
Volume and Issue:
unknown, P. 113817 - 113817
Published: May 1, 2025
Language: Английский
The application and prospects of antimicrobial peptides in antiviral therapy
Amino Acids,
Journal Year:
2024,
Volume and Issue:
56(1)
Published: Dec. 4, 2024
Antimicrobial
peptides
(AMPs)
have
broad-spectrum
antimicrobial
activity,
enabling
them
to
rapidly
detect
and
eliminate
targets.
In
addition,
many
AMPs
are
natural
peptides,
making
promising
candidates
for
therapeutic
drugs.
This
review
discusses
the
basic
properties
mechanisms
of
action
AMPs,
highlighting
their
ability
disrupt
microbial
membranes
modulate
host
immune
responses.
It
also
reviews
current
state
research
into
using
against
various
viral
infections,
focusing
on
potential
viruses
that
contribute
global
health
crisis.
Despite
developments,
therapies
based
still
face
challenges
such
as
stability,
toxicity,
production
costs.
this
text,
we
will
discuss
these
latest
technological
advances
aimed
at
overcoming
them.
The
combination
nanotechnology
bioengineering
approaches
offers
new
ways
enhance
delivery,
efficacy,
safety
AMPs.
We
emphasize
importance
further
fully
exploit
in
antiviral
therapy,
advocating
a
multifaceted
approach
includes
optimizing
clinical
use
exploring
synergies
with
existing
Language: Английский