Microorganisms,
Journal Year:
2021,
Volume and Issue:
9(7), P. 1357 - 1357
Published: June 23, 2021
More
recently,
increasing
attention
has
been
directed
to
exploring
the
function
of
global
virome
in
health
and
disease.
Currently,
by
new
molecular
techniques,
such
as
metagenomic
DNA
sequencing,
better
unveiled.
By
investigating
human
lung
virome,
we
could
provide
novel
insights
into
respiratory
diseases.
The
a
part
microbiome,
is
characterized
constant
change
composition
related
type
diet,
environment,
our
genetic
code,
other
incalculable
factors.
plays
substantial
role
modulating
immune
defenses
contributing
inflammatory
processes.
Anelloviruses
(AVs)
are
components
virome.
AVs
already
present
during
early
life
reproduce
without
apparently
causing
harm
host.
still
unknown,
but
several
reports
have
shown
that
activate
inflammasomes,
intracellular
multiprotein
oligomers
innate
system,
which
show
crucial
host
defense
pathogens.
In
this
narrative
revision,
summarize
epidemiological
data
possible
link
between
microbial
alterations
chronic
diseases
children.
Briefly,
also
describe
characteristics
most
frequent
viral
family
Anelloviridae.
Furthermore,
discuss
how
modulate
system
children,
affecting
development
diseases,
particularly
asthma,
common
disease
childhood.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(4), P. 4086 - 4086
Published: Feb. 17, 2023
The
wide
diversity
of
microbiota
at
the
genera
and
species
levels
across
sites
individuals
is
related
to
various
causes
observed
differences
between
individuals.
Efforts
are
underway
further
understand
characterize
human-associated
its
microbiome.
Using
16S
rDNA
as
a
genetic
marker
for
bacterial
identification
improved
detection
profiling
qualitative
quantitative
changes
within
population.
In
this
light,
review
provides
comprehensive
overview
basic
concepts
clinical
applications
respiratory
microbiome,
alongside
an
in-depth
explanation
molecular
targets
potential
relationship
microbiome
disease
pathogenesis.
paucity
robust
evidence
supporting
correlation
pathogenesis
currently
main
challenge
not
considering
novel
druggable
target
therapeutic
intervention.
Therefore,
studies
needed,
especially
prospective
studies,
identify
other
drivers
better
in
lung
along
with
association
medications.
Thus,
finding
unfolding
significance
would
be
crucial.
Allergy Asthma and Immunology Research,
Journal Year:
2023,
Volume and Issue:
15(6), P. 705 - 705
Published: Jan. 1, 2023
Allergic
diseases
are
a
major
public
health
problem
with
increasing
prevalence.These
immune-mediated
characterized
by
defective
epithelial
barriers,
which
explained
the
barrier
theory
and
continuously
emerging
evidence.Environmental
exposures
(exposome)
including
global
warming,
changes
loss
of
biodiversity,
pollution,
pathogens,
allergens
mites,
laundry
dishwasher
detergents,
surfactants,
shampoos,
body
cleaners
household
cleaners,
microplastics,
nanoparticles,
toothpaste,
enzymes
emulsifiers
in
processed
foods,
dietary
habits
responsible
for
mucosal
skin
disruption.Exposure
to
barrier-damaging
agents
causes
cell
injury
damage,
colonization
opportunistic
commensal
bacteria,
decreased
microbiota
diversity,
bacterial
translocation,
allergic
sensitization,
inflammation
periepithelial
area.Here,
we
review
scientific
evidence
on
environmental
components
that
impact
barriers
microbiome
composition
their
influence
asthma
diseases.We
also
discuss
historical
overview
evolution
hygiene
hypothesis
theoretical
evidence.
Briefings in Bioinformatics,
Journal Year:
2023,
Volume and Issue:
24(3)
Published: March 20, 2023
Abstract
Traditional
Chinese
medicine
(TCM)
has
accumulated
thousands
years
of
knowledge
in
herbal
therapy,
but
the
use
formulas
is
still
characterized
by
reliance
on
personal
experience.
Due
to
complex
mechanism
actions,
it
challenging
discover
effective
for
diseases
integrating
traditional
experiences
and
modern
pharmacological
mechanisms
multi-target
interactions.
In
this
study,
we
propose
a
formula
prediction
approach
(TCMFP)
combined
therapy
experience
TCM,
artificial
intelligence
network
science
algorithms
screen
optimal
efficiently,
which
integrates
herb
score
(Hscore)
based
importance
targets,
pair
(Pscore)
empirical
learning
predictive
(FmapScore)
intelligent
optimization
genetic
algorithm.
The
validity
Hscore,
Pscore
FmapScore
was
verified
functional
similarity
topological
evaluation.
Moreover,
TCMFP
used
successfully
generate
formulae
three
diseases,
i.e.
Alzheimer’s
disease,
asthma
atherosclerosis.
Functional
enrichment
analysis
indicates
efficacy
targets
predicted
formula.
proposed
may
provides
new
strategy
formula,
TCM
herbs
drug
development.
Dermatologic Therapy,
Journal Year:
2020,
Volume and Issue:
33(6)
Published: June 30, 2020
Face
masks
wearing
during
the
coronavirus
disease
2019
(COVID-19)
pandemic
became
ubiquitous.
The
aim
of
our
study
was
to
assess
use
face
among
young
adults
current
viral
pandemic.
survey
based
on
specially
created
Google
Forms
and
posted
numerous
Facebook
groups
for
people
in
Poland.
Seven
days
were
considered
as
a
recall
period.
A
total
2315
answers
obtained,
2307
finally
analysis,
eight
questionnaires
removed
because
data
incompleteness.
60.4%
responders
declared
using
masks.
Those
who
reported
an
atopic
predisposition
wore
significantly
(P
=
.007)
more
commonly
(65.5%
57.7%,
respectively).
Cloth
(46.2%)
appeared
be
most
popular
ones,
followed
by
surgical
(39.2%),
respirators
(N95
FFP)
(13.3%),
half-face
elastomeric
(0.8%)
full-face
(0.4%).
Females
frequently
.0001)
used
cloth
masks;
respirators,
males
<
.0001,
P
.001
.001,
23.9%
single-use
mask
it
again.
Moreover,
73.6%
participants
decontamination;
however,
procedures
not
always
appropriate.
We
suggest
that
results
may
help
construction
general
public
education
campaigns
proper
Dermatologic Therapy,
Journal Year:
2020,
Volume and Issue:
33(4)
Published: May 3, 2020
Coronavirus
disease
2019
(COVID-19)
is
a
pandemic
caused
by
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
with
high
morbidity
and
mortality.
There
are
very
limited
data
on
the
interference
of
immunomodulating
drugs
risk
infection
course
disease.
In
particular,
there
no
current
clinical
about
exerted
dupilumab,
biologic
blocking
IL-4
IL-13,
used
for
adult
atopic
dermatitis.
The
pathogenesis
COVID-19
complex,
characterized
an
immune
response
mainly
Th1/Th17.
hyper-activation
these
cells
may
cause
release
pro-inflammatory
cytokines
that
result
in
lung
impairment.
IL-13
Th2
cytokines,
thus
being
part
pathway
not
considered
implicated
host
defense
mechanism
against
viral
infections.
Indeed,
infections,
including
have
been
reported
as
significant
adverse
event
trials.
Furthermore,
dupilumab
has
proved
to
be
efficacious
also
exacerbations
asthma,
it
known
infections
can
worsen
asthma.
Therefore,
seem
suggest
treatment
should
stopped
during
pandemic.
Obviously,
careful
assessment
mandatory
each
individual
patient
further
studies
necessary
characterize
immunologic
responses
COVID-19.
Frontiers in Immunology,
Journal Year:
2020,
Volume and Issue:
11
Published: Sept. 25, 2020
Asthma
is
a
highly
prevalent,
chronic
respiratory
disease
that
impacts
millions
of
people
worldwide
and
causes
thousands
deaths
every
year.
Asthmatics
display
different
phenotypes
with
distinct
genetic
components,
environmental
causes,
immunopathologic
signatures,
are
broadly
characterized
into
type
2-high
or
2-low
(non-type
2)
endotypes
by
linking
clinical
characteristics,
steroid
responsiveness,
molecular
pathways.
Regardless
asthma
severity
adequate
management,
patients
may
experience
acute
exacerbations
symptoms
loss
control,
often
triggered
infections.
The
interferon
(IFN)
family
represents
group
cytokines
play
central
role
in
the
protection
against
exacerbation
various
infections
pathologies,
including
asthma.
Type
I
III
IFNs
particular
an
indispensable
host
immune
system
to
fight
off
pathogens,
which
seems
be
altered
both
pediatric
adult
asthmatics.
Impaired
IFN
production
leaves
asthmatics
susceptible
infection
uncontrolled
2
immunity,
promotes
airway
hyperresponsiveness
(AHR)
inflammation
can
lead
exacerbations.
However,
deficiency
not
observed
all
asthmatics,
alterations
expression
independent
immunity.
In
this
review,
we
discuss
link
between
general
specific
contexts,
during
viral
infection,
co-infection,
bacterial/fungal
infection.
We
also
highlight
several
studies
examine
potential
for
as
asthma-related
therapies.
Cells,
Journal Year:
2021,
Volume and Issue:
10(8), P. 2134 - 2134
Published: Aug. 19, 2021
Non-persistent
viruses
classically
cause
transient,
acute
infections
triggering
immune
responses
aimed
at
the
elimination
of
pathogen.
Successful
evolved
strategies
to
manipulate
and
evade
these
anti-viral
defenses.
Symptoms
during
phase
are
often
linked
dysregulated
that
disappear
once
patient
recovers.
In
some
patients,
however,
symptoms
persist
or
new
emerge
beyond
phase.
Conditions
resulting
from
previous
transient
infection
termed
post-acute
sequelae
(PAS)
were
reported
for
a
wide
range
non-persistent
such
as
rota-,
influenza-
polioviruses.
Here
we
provide
an
overview
viral
pathogens
be
associated
with
diverse
PAS,
among
them
chronic
fatigue,
auto-immune
disorders,
neurological
complications
highlight
known
mechanistic
details.
Recently,
emergence
COVID-19
(PASC)
long
COVID
highlighted
impact
PAS.
Notably,
PAS
resemble
persistent
infections,
defined
by
inflammation.
Inflammation
maintained
after
may
key
driver
viruses.
Therefore,
explore
current
insights
into
aberrant
activation
innate
signaling
pathways
in
Finally,
conclusions
drawn
future
perspectives
treatment
prevention
discussed.
Biomedicines,
Journal Year:
2022,
Volume and Issue:
10(8), P. 1861 - 1861
Published: Aug. 2, 2022
Monoclonal
antibodies
(mAbs),
the
new
revolutionary
class
of
medications,
are
fast
becoming
tools
against
various
diseases
thanks
to
a
unique
structure
and
function
that
allow
them
bind
highly
specific
targets
or
receptors.
These
specialized
proteins
can
be
produced
in
large
quantities
via
hybridoma
technique
introduced
1975
by
means
modern
technologies.
Additional
methods
have
been
developed
generate
mAbs
with
biological
properties
such
as
humanized,
chimeric,
murine.
The
inclusion
therapeutic
regimens
is
major
medical
advance
will
hopefully
lead
significant
improvements
infectious
disease
management.
Since
first
mAb,
muromonab-CD3,
was
approved
U.S.
Food
Drug
Administration
(FDA)
1986,
list
their
clinical
indications
applications
proliferating.
New
technologies
modify
mAbs,
thereby
increasing
efficacy
improving
delivery
routes.
Gene
technologies,
non-viral
synthetic
plasmid
DNA
messenger
RNA
vectors
(DMabs
mRNA-encoded
mAbs),
built
express
tailored
mAb
genes,
might
help
overcome
some
challenges
therapy,
including
production
restrictions,
cold-chain
storage,
transportation
requirements,
expensive
manufacturing
distribution
processes.
This
paper
reviews
recent
developments
discovery
viral
infections
illustrates
how
combat
outbreaks.
