Journal of Clinical Medicine,
Journal Year:
2024,
Volume and Issue:
14(1), P. 112 - 112
Published: Dec. 28, 2024
Background:
Atopic
dermatitis
(AD)
is
a
chronic
skin
condition
that
weakens
the
barrier,
leading
to
increased
trans-epidermal
water
loss
and
reduced
moisture.
Understanding
how
these
changes
in
barrier
relate
AD
severity
Mongolian
children
may
offer
insights
could
apply
other
regions
facing
similar
environmental
challenges.
Methods:
A
cross-sectional
study
was
conducted
at
National
Dermatology
Center
of
Mongolia,
involving
103
with
AD.
Severity
assessed
using
SCORAD
index,
function
measured
through
TEWL,
moisture,
pH.
Linear
regression
analyses
were
conducted,
adjusting
for
age,
physiological
parameters,
characteristics,
total
IgE
levels.
Results:
Among
participants,
48.54%
classified
as
having
moderate
AD,
while
34.95%
had
severe
The
mean
index
43.19
±
17.11.
In
final
adjusted
analysis,
higher
TEWL
significantly
associated
greater
(non-lesional:
B
=
0.328,
p
0.004;
lesional:
0.272,
0.007),
moisture
showed
an
inverse
association
−0.771,
<
0.001;
−0.218,
0.001).
level
group
(p
0.013).
Although
pH
initially
correlated
severity,
it
did
not
remain
significant
multivariate
analysis.
Conclusions:
This
emphasizes
role
function,
particularly
among
children.
Chemico-Biological Interactions,
Journal Year:
2024,
Volume and Issue:
394, P. 111002 - 111002
Published: April 9, 2024
Lung
inflammatory
disorders
are
a
major
global
health
burden,
impacting
millions
of
people
and
raising
rates
morbidity
death
across
many
demographic
groups.
An
industrial
chemical
common
environmental
contaminant,
formaldehyde
(FA)
presents
serious
concerns
to
the
respiratory
system,
including
onset
aggravation
lung
disorders.
Epidemiological
studies
have
shown
significant
associations
between
FA
exposure
levels
incidence
severity
several
diseases.
causes
inflammation
in
tract
via
immunological
activation,
oxidative
stress,
airway
remodelling,
aggravating
pre-existing
pulmonary
compromising
function.
Additionally,
functions
as
sensitizer,
causing
allergic
responses
hypersensitivity
pneumonitis
sensitive
people.
Understanding
complicated
processes
behind
formaldehyde-induced
is
critical
for
directing
targeted
strategies
aimed
at
minimizing
exposures
alleviating
burden
formaldehyde-related
illnesses
on
health.
This
abstract
explores
intricate
relationship
diseases,
asthma,
bronchitis,
inflammation,
injury
fibrosis.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(13), P. 6913 - 6913
Published: June 24, 2024
Chronic
exposure
to
harmful
pollutants,
chemicals,
and
pathogens
from
the
environment
can
lead
pathological
changes
in
epithelial
barrier,
which
increase
risk
of
developing
an
allergy.
During
allergic
inflammation,
cells
send
proinflammatory
signals
group
2
innate
lymphoid
cell
(ILC2s)
eosinophils,
require
energy
resources
mediate
their
activation,
cytokine/chemokine
secretion,
mobilization
other
cells.
This
review
aims
provide
overview
metabolic
regulation
asthma,
atopic
dermatitis
(AD),
rhinitis
(AR),
highlighting
its
underlying
mechanisms
phenotypes,
potential
regulatory
roles
eosinophils
ILC2s.
Eosinophils
ILC2s
regulate
inflammation
through
lipid
mediators,
particularly
cysteinyl
leukotrienes
(CysLTs)
prostaglandins
(PGs).
Arachidonic
acid
(AA)-derived
metabolites
Sphinosine-1-phosphate
(S1P)
are
significant
markers
that
indicate
immune
dysfunction
barrier
Notably,
promoters
symptoms
exhibit
greater
plasticity
compared
ILC2s,
directly
involved
promoting
symptoms.
Our
findings
suggest
metabolomic
analysis
provides
insights
into
complex
interactions
between
cells,
environmental
factors.
Potential
therapeutic
targets
have
been
highlighted
further
understand
Future
research
metabolomics
facilitate
development
novel
diagnostics
therapeutics
for
future
application.
Diseases,
Journal Year:
2024,
Volume and Issue:
12(8), P. 176 - 176
Published: Aug. 2, 2024
The
exposome
encompasses
all
endogenous
and
exogenous
exposure
individuals
encounter
throughout
their
lives,
including
biological,
chemical,
physical,
psychological,
relational,
socioeconomic
factors.
It
examines
the
duration
intensity
of
these
types
complex
interactions
over
time.
This
interdisciplinary
approach
involves
various
scientific
disciplines,
particularly
toxicology,
to
understand
long-term
effects
toxic
on
health.
Factors
like
air
pollution,
racial
background,
status
significantly
contribute
diseases
such
as
metabolic,
cardiovascular,
neurodegenerative
diseases,
infertility,
cancer.
Advanced
analytical
methods
measure
contaminants
in
biofluids,
food,
air,
water,
soil,
but
often
overlook
cumulative
risk
multiple
chemicals.
An
analysis
necessitates
sophisticated
tools
methodologies
health
integrate
findings
into
precision
medicine
for
better
disease
diagnosis
treatment.
Chronic
environmental
biological
stimuli
can
lead
persistent
low-grade
inflammation,
which
is
a
key
factor
chronic
non-communicable
(NCDs),
obesity,
cardiometabolic
disorders,
cancer,
respiratory
autoimmune
conditions,
depression.
These
NCDs
are
influenced
by
smoking,
unhealthy
diets,
physical
inactivity,
alcohol
abuse,
shaped
genetic,
environmental,
social
Dietary
patterns,
especially
ultra-processed
foods,
exacerbate
inflammation
alter
gut
microbiota.
study
investigates
exposome’s
role
prevention,
development,
progression
NCDs,
focusing
Advances in Dermatology and Allergology,
Journal Year:
2025,
Volume and Issue:
42(1), P. 105 - 109
Published: Jan. 1, 2025
An
impaired
skin
barrier
has
been
reported
in
allergic
diseases.
In
this
study,
we
aimed
to
evaluate
dermis
thickness
children
with
house
dust
allergy
without
symptoms.
This
cross-sectional
study
included
aged
4-18
years
asthma
and/or
rhinitis.
Participants
were
divided
into
three
groups:
healthy
controls
(n
=
50),
patients
sensitized
mites
60),
and
negative
mite
tests
48).
The
of
the
layers
was
measured
at
cubital
fossa
using
an
ultrasound.
median
age
gender
distribution
similar
across
mite-positive
-negative
groups
control
group.
There
no
significant
difference
between
terms
(p
0.053).
Absolute
eosinophils
eosinophil
percentage
significantly
negatively
correlated
<
0.05).
correlation
total
IgE,
specific
IgE
test
values
>
findings
highlight
impact
sensitization
on
thickness,
offering
potential
contributions
management
treatment
strategies
Allergy Asthma and Immunology Research,
Journal Year:
2025,
Volume and Issue:
17(2), P. 181 - 181
Published: Jan. 1, 2025
Immunoglobulin
E
(IgE)
induces
mast
cell/basophil
activation
by
binding
with
FcεRIα
and
contributes
to
the
development
of
allergic
disease,
in
which
targeting
IgE
has
been
considered
an
effective
therapeutic
strategy.
YH35324
(YH)
is
a
new
hybrid
protein
extracellular
domain
consisting
FcεRIα,
its
pharmacodynamic
effect
safety
were
validated.
This
study
aimed
evaluate
potential
YH
as
anti-IgE
immunomodulator
compared
omalizumab
(Oma).
To
vitro
efficacy
human
cells,
was
treated
various
methods,
changes
confirmed
through
flow
cytometry,
immunoblot
analysis,
immunocytochemistry.
ex
vivo
YH,
expression
on
surface
blood
basophils
measured
64
subjects
diseases
cytometry.
Serum
soluble
CD23,
Mas-Related
G-Protein
Coupled
Receptor
Member
X2
levels
enzyme-linked
immunosorbent
assay.
The
YH-administered
group
exhibited
significantly
lower
peripheral
Oma-administered
up
14
days
post-administration.
directly
suppressed
LAD2
it
bound
IgE-unbound
migrated
into
cells
actin-dependent
endocytosis,
then
recycled
FcRn
lysosome
vitro.
increased
other
groups
showed
positive
correlation
serum-free
IgE.
represents
agent
for
IgE-mediated
disease.
Further
studies
are
needed
additional
effects
FcεRIα-mediated
autoimmune
mechanism.
Nutrients,
Journal Year:
2025,
Volume and Issue:
17(8), P. 1355 - 1355
Published: April 16, 2025
Eosinophilic
esophagitis
(EoE)
is
a
chronic
disease
which
clinically
presents
with
symptoms
related
to
esophageal
dysfunction,
while
pathologically
it
characterized
by
eosinophilic
infiltration
of
epithelium.
Most
patients
EoE
present
food
and/or
inhalant
allergy
symptoms.
The
results
animal
model
studies
and
genetic
studies,
as
well
the
efficacy
elimination
diets
in
managing
symptoms,
suggest
an
atopic
background
disease.
aim
this
study
was
evaluate
prevalence
group
upper
gastrointestinal
allergies
assess
influence
drugs
used
type
I
on
endoscopic,
histopathological,
immunohistochemical
tests.
Methods:
This
prospective
observational
study.
Patients
inhalant/food
constituted
without
who
were
diagnosed
dyspepsia
or
irritable
bowel
syndrome
control
group.
All
subjects
underwent
testing,
including
prick
testing
blood
participants
gastroscopy
specimen
collection.
Esophageal
specimens
stained
for
eotaxin-1
desmoglein-1.
Results:
Based
histopathology
results,
found
9
73
from
presented
multimorbidity
at
least
one
allergic
addition
EoE.
Positive
staining
CCL-11
56
(78%)
group,
all
only
3
(17%)
individuals
showed
positive
staining.
presence
DSG-1
detected
6
(7%)
contrast
14
not
any
Conclusions:
rare
disease,
usually
accompanied
multimorbidity.
negative
desmoglein-1
but
did
meet
diagnostic
criteria
could
be
indicative
subclinical
course
masking
effect
corticosteroids.
It
now
vitally
important
both
researchers
practicing
clinicians
recognize
that
homogeneous
rather
consists
multiple
subtypes
(phenotypes).
so-called
“classic”
form
EoE—defined
current
more
than
15
eosinophils
per
high
power
field
histopathological
examination—appears
represent
tip
iceberg.
There
urgent
need
further
research
order
refine
endoscopic
techniques,
expand
scope
assessments,
identify
novel
biomarkers
better
define
distinct
phenotypes
esophagitis.
