The effects of light in children: A systematic review DOI Creative Commons
Emily Westwood, Simon S. Smith, D Mann

et al.

Journal of Environmental Psychology, Journal Year: 2023, Volume and Issue: 89, P. 102062 - 102062

Published: June 28, 2023

Light affects human health and behaviour. Research has demonstrated that children are more susceptible to the effects of light than adults, however this population remains underrepresented in literature. This systematic review reports evidence objectively measured exposure on development outcomes (0–12 years old). Study (n = 59) were categorised into five thematic domains. Heterogeneity measurement summarisation techniques identified. Light's melatonin activity patterns relatively robust, while research sleep was sparse. Mixed findings suggest a protective effect myopia, vision improvements under cooler, brighter lighting. Increased during daytime broadly associated with beneficial social-emotional, cognitive, physical outcomes. Timing, colour, intensity exposures important understanding developmental light. methods limits comparability across studies should be carefully considered. Greater about could inform novel approaches support children's health, sleep, development.

Language: Английский

The circadian immune system DOI
Chen Wang, Lydia K. Lutes, Coline Barnoud

et al.

Science Immunology, Journal Year: 2022, Volume and Issue: 7(72)

Published: June 3, 2022

The immune system is highly time-of-day dependent. Pioneering studies in the 1960s were first to identify responses be under a circadian control. Only last decade, however, have molecular factors governing rhythms been identified. These revealed complex picture of interconnectivity rhythmicity within cells with that their environment. Here, we provide global overview system, focusing on recent advances rapidly expanding field immunology.

Language: Английский

Citations

122
Circadian tumor infiltration and function of CD8+ T cells dictate immunotherapy efficacy DOI Creative Commons
Chen Wang, Qun Zeng,

Zeynep Melis Gül

et al.

Cell, Journal Year: 2024, Volume and Issue: 187(11), P. 2690 - 2702.e17

Published: May 1, 2024

The quality and quantity of tumor-infiltrating lymphocytes, particularly CD8+ T cells, are important parameters for the control tumor growth response to immunotherapy. Here, we show in murine human cancers that these exhibit circadian oscillations, driven by both endogenous clock leukocytes rhythmic leukocyte infiltration, which depends on endothelial cells microenvironment. To harness rhythms therapeutically, demonstrate efficacy chimeric antigen receptor cell therapy immune checkpoint blockade can be improved adjusting time treatment during day. Furthermore, time-of-day-dependent signatures models predict overall survival patients with melanoma correlate anti-PD-1 therapy. Our data functional significance dynamics microenvironment suggest importance leveraging features improving future clinical trial design patient care.

Language: Английский

Citations

61
Circadian rhythm regulates the function of immune cells and participates in the development of tumors DOI Creative Commons

Yuen Zeng,

Zichan Guo, Mengqi Wu

et al.

Cell Death Discovery, Journal Year: 2024, Volume and Issue: 10(1)

Published: April 27, 2024

Abstract Circadian rhythms are present in almost all cells and play a crucial role regulating various biological processes. Maintaining stable circadian rhythm is essential for overall health. Disruption of this can alter the expression clock genes cancer-related genes, affect many metabolic pathways factors, thereby affecting function immune system contributing to occurrence progression tumors. This paper aims elucidate regulatory effects BMAL1, other on cells, reveal molecular mechanism rhythm’s involvement tumor its microenvironment regulation. A deeper understanding has potential provide new strategies treatment cancer immune-related diseases.

Language: Английский

Citations

35
Biological rhythms in COVID-19 vaccine effectiveness in an observational cohort study of 1.5 million patients DOI Creative Commons
Guy Hazan, Or Duek, Hillel Alapi

et al.

Journal of Clinical Investigation, Journal Year: 2023, Volume and Issue: 133(11)

Published: April 13, 2023

BACKGROUND. Circadian rhythms are evident in basic immune processes, but it is unclear if exist clinical endpoints like vaccine protection. Here, we examined associations between COVID-19 vaccination timing and effectiveness.

Language: Английский

Citations

25
Why does circadian timing of administration matter for immune checkpoint inhibitors’ efficacy? DOI Creative Commons
Abdoulaye Karaboué, Pasquale F. Innominato,

Nicholas I. Wreglesworth

et al.

British Journal of Cancer, Journal Year: 2024, Volume and Issue: 131(5), P. 783 - 796

Published: June 4, 2024

Abstract Background Tolerability and antitumour efficacy of chemotherapy radiation therapy can vary largely according to their time administration along the 24-h scale, due moderation molecular cellular mechanisms by circadian rhythms. Recent clinical data have highlighted a striking role dosing for cancer immunotherapy, thus calling critical evaluation. Methods Here, we review analyse through which rhythms influence outcomes on ICI therapies. We examine how rhythm disorders affect tumour immune microenvironment, as main mechanism linking clock cycles in ICIs efficacy. Results Real-life from 18 retrospective studies revealed that early time-of-day (ToD) infusion checkpoint inhibitors (ICIs) could enhance progression-free and/or overall survival up fourfold compared late ToD dosing. The involved total 3250 patients with metastatic melanoma, lung, kidney, bladder, oesophageal, stomach or liver 9 countries. Such large consistent differences effects only result previously ignored robust chronobiological mechanism. timing system coordinates cellular, tissue whole-body physiology timescale. Circadian are generated at level involves 15 specific genes. disruption trigger accelerate carcinogenesis, contribute treatment failure, possibly evasion resulting immunosuppressive microenvironment. Conclusions perspective emerging understanding regulation immunity now calls randomised trials establish recommendations personalised chrono-immunotherapies current forthcoming drugs.

Language: Английский

Citations

14
Complex gene-dependent and-independent mechanisms control daily rhythms of hematopoietic cells DOI Open Access
Francesca Sciarra, Edoardo Franceschini, Gabriella Palmieri

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 183, P. 117803 - 117803

Published: Jan. 2, 2025

Language: Английский

Citations

1
Bidirectional and persistent immunomodulation of Astragalus polysaccharide as an adjuvant of influenza and recombinant SARS-CoV-2 vaccine DOI Creative Commons

Dan-Ping Zhao,

Xiuhong Chen,

Linyuan Wang

et al.

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 234, P. 123635 - 123635

Published: Feb. 16, 2023

Respiratory viral infections, such as coronavirus disease of 2019 (COVID-19) and influenza, cause significant morbidity mortality have become a worldwide public health concern with tremendous economic societal burdens. Vaccination is major strategy for preventing infections. However, some new vaccines an unmet need impairing responses in certain individuals, especially COVID-19 vaccines, despite ongoing vaccine adjuvant research. Here, we evaluated the effectiveness Astragalus polysaccharide (APS), bioactive extracted from traditional Chinese herb membranaceus immune to regulate efficacy influenza split (ISV) recombinant severe acute respiratory syndrome (SARS)-Cov-2 mice. Our data indicated that APS can facilitate induction high levels hemagglutination inhibition (HAI) titer specific antibody immunoglobulin G (IgG) confer protection against lethal challenge A viruses, including increased survival amelioration weight loss mice immunized ISV. RNA sequencing (RNA-seq) analysis revealed NF-κB Fc gamma R-mediated phagocytosis signaling pathways are essential response SARS-Cov-2 (RSV). Another important finding was bidirectional immunomodulation on cellular humoral immunity observed, APS-adjuvant-induced antibodies persisted at level least 20 weeks. These findings suggest potent has advantages immunoregulation persistent immunity.

Language: Английский

Citations

19
Circadian rhythm regulation in the immune system DOI Open Access
Jun Ding, Pengyu Chen, Chunjian Qi

et al.

Immunology, Journal Year: 2023, Volume and Issue: 171(4), P. 525 - 533

Published: Dec. 30, 2023

Abstract Circadian rhythms are a ubiquitous feature in nearly all living organisms, representing oscillatory patterns with 24‐h cycle that widespread across various physiological processes. regulate multitude of systems, including the immune system. At molecular level, most cells autonomously express clock‐regulating genes, which play critical roles regulating cell functions. These functions encompass migration, phagocytic activity, metabolism (such as mitochondrial structural function and metabolism), signalling pathway activation, inflammatory responses, innate recognition, adaptive processes (including vaccine responses pathogen clearance). The endogenous circadian clock orchestrates multifaceted rhythmicity within system, optimizing surveillance responsiveness; this bears significant implications for maintaining homeostasis resilience against diseases. This work provides an overview rhythm regulation

Language: Английский

Citations

17
Crosstalk between circadian clocks and pathogen niche DOI Creative Commons
Helene Borrmann, Filipa Rijo‐Ferreira

PLoS Pathogens, Journal Year: 2024, Volume and Issue: 20(5), P. e1012157 - e1012157

Published: May 9, 2024

Circadian rhythms are intrinsic 24-hour oscillations found in nearly all life forms. They orchestrate key physiological and behavioral processes, allowing anticipation response to daily environmental changes. These manifest across entire organisms, various organs, through intricate molecular feedback loops that govern cellular oscillations. Recent studies describe circadian regulation of pathogens, including parasites, bacteria, viruses, fungi, some which have their own while others influenced by the rhythmic environment hosts. Pathogens target specific tissues organs within host optimize replication. Diverse compositions interplay among cell types create unique microenvironments different tissues, distinctive biology. Hence, residing pathogens exposed cyclic conditions, can profoundly impact host–pathogen interactions. This review explores influence mammalian tissue-specific interactions on dynamics pathogen–host relationships. Overall, this demonstrates between body’s internal timekeeping system its susceptibility has implications for future infectious disease research treatment.

Language: Английский

Citations

7
Chronic Inflammation Disrupts Circadian Rhythms in Splenic CD4+ and CD8+ T Cells in Mice DOI Creative Commons
Misa Hirose, Alexei Leliavski, Leonardo Vinícius Monteiro de Assis

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(2), P. 151 - 151

Published: Jan. 13, 2024

Internal circadian clocks coordinate 24 h rhythms in behavior and physiology. Many immune functions show daily oscillations, cellular can impact disease outcome. Inflammation may disrupt peripheral tissues innate cells. However, it remains elusive if chronic inflammation impacts adaptive cell clock, e.g., CD4+ CD8+ T lymphocytes. We studied this the experimental autoimmune encephalomyelitis (EAE), a mouse model for multiple sclerosis, as an established paradigm inflammation. analyzed splenic clock gene expression mice with late-stage EAE, CFA/PTx-treated, untreated mice. In both treatment groups, were altered differential effects baseline peak phase compared control Most marker genes tested study did not oscillations either of three but time-of-day- independent alterations observed EAE CFA/PTx to Notably, likely central function behavioral remained intact. Together, induced by immunization has lasting on

Language: Английский

Citations

5