Probiotics for inflammatory bowel disease: Is there sufficient evidence?

Open Life Sciences, Journal Year: 2024, Volume and Issue: 19(1)

Published: Jan. 1, 2024

Abstract Inflammatory bowel disease (IBD) refers to chronic inflammatory disorders of the gut. Ulcerative colitis (UC) and Crohn’s (CD) are two subtypes IBD. Evidence suggests that intestinal microbiota plays a role in pathogenesis IBD, so probiotics have garnered lot interest as potential treatment or prevention for However, clinical evidence efficacy is still debatable. We performed literature review. An advanced search considered studies on probiotic IBD from inception 2023 PubMed, Embase, Cochrane Library, Web Science. In UC with probiotics, only Escherichia coli Nissle 1917 maintenance remission, Bifidobacterium VSL#3 induction remission patients mild moderately active shown strong evidence. Currently, there no definitive conclusions regarding effectiveness CD. The mechanism may be related reducing oxidative stress, repairing barrier, regulating flora balance, modulating immune response. Differences benefits between CD attributable different lesion extent immune-mediated pathophysiology. More robust randomized trials required validate safety diverse strains

Language: Английский

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Respiratory diseases and gut microbiota: relevance, pathogenesis, and treatment

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: July 16, 2024

Preclinical evidence has firmly established a bidirectional interaction among the lung, gut, and gut microbiome. There are many complex communication pathways between lung intestine, which affect each other's balance. Some metabolites produced by intestinal microorganisms, immune cells, factors enter tissue through blood circulation participate in function. Altered gut-lung-microbiome interactions have been identified rodent models humans of several diseases such as pulmonary fibrosis, chronic obstructive disease, cancer, asthma, etc. Emerging suggests that microbial therapies can prevent treat respiratory diseases, but it is unclear whether this association simple correlation with pathological mechanisms disease or result causation. In review, we summarize critical link microbiota well influence mechanism on discuss role interventions prebiotics fecal bacteria transplantation diseases. To provide reference for rational design large-scale clinical studies, direct application therapy to respiratory-related reduce incidence severity accompanying complications.

Language: Английский

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Exploring probiotics as a sustainable alternative to antimicrobial growth promoters: mechanisms and benefits in animal health

Frontiers in Sustainable Food Systems, Journal Year: 2025, Volume and Issue: 8

Published: Jan. 3, 2025

The extensive use of antimicrobial growth promoters (AGPs) in livestock has raised global concerns due to increasing resistance (AMR) among pathogenic microbes. This review examines probiotics as a sustainable alternative AGPs, offering safer approach for promoting animal and health. Probiotics enhance productivity immunity by producing compounds competing with pathogens nutrients. In addition, strengthen the gut barrier modulate microbiome, facilitating beneficial bacterial while suppressing species. Studies demonstrate efficacy probiotic strains genera Lactobacillus Bifidobacterium inhibiting such Clostridium perfringens Salmonella livestock. comprehensive evaluation highlights probiotics' potential advance practices, reduce reliance on antibiotics, mitigate AMR risks, underscoring need further research regulatory considerations their husbandry.

Language: Английский

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Impact of antibiotic usage in food-producing animals on food safety and possible antibiotic alternatives

The Microbe, Journal Year: 2024, Volume and Issue: 4, P. 100097 - 100097

Published: June 12, 2024

The increasing use of antibiotics in food animal production systems has contributed to the emergence antibiotic-resistant zoonotic bacteria that are transmissible humans via chain. Infection with a negative effect on public health due frequency treatment failure and severity disease. development resistant animals can come through chromosomal changes, but is more frequently related horizontal transmission resistance determinants carried by mobile genetic elements. Food may constitute dynamic habitat for continued transfer antibiotic among bacteria.Existing preservation strategies rely combination environmental factors inhibit bacterial growth exacerbate spread food-borne pathogens, resulting failure, increased mortality as well costs, decreased infection control efficacy, infections community.The rise microorganisms made rising global concern. Food-producing regarded reservoirs genes (ARGs) residual travel from farm consumer's plate.Antibiotic develop if leftover allowed build up environment. Consequently, possible impact usage food-producing safety, risk carrying spreading chain, assessed this review.This review also provides an in-depth analysis alternatives, including natural antibiotics, nano-antibiotics, lactic acid bacteria, bacteriocin, cyclopeptide, bacteriophage, synthetic biology, predatory bacteria.

Language: Английский

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Hands-on learning for probiotic quality assessment: enhancing microbiology education through applied microbial counting techniques

Journal of Microbiology and Biology Education, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 7, 2025

ABSTRACT The microbial plate count continues to be an essential technique in food microbiology research and quality control. In science education, this is often taught through traditional fact-based methods, requiring students follow pre-established protocols. This approach may not fully engage or enhance their problem-solving skills. Eighty-two final-year Food Science Technology bachelor’s at the University of Milan were asked combine knowledge on general physiology for assessment different probiotic products, including freeze-dried cells, fermented milk, bacterial spore suspension. They required select appropriate culture media, incubation conditions, treatments based flow cytometry cell quantification optimize counts selectively species present formulations. project aimed bridge theoretical with practical applications, emphasizing most procedure viable cultivable quantification, particularly relevant formulation. Survey feedback indicated high satisfaction relevance future careers, majority finding activity challenging yet engaging. demonstrated effectiveness combining microbiological techniques fostering a deeper understanding cultivability probiotics role selective agents.

Language: Английский

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Microbial Functional Foods and Nutraceuticals

Royal Society of Chemistry eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 206 - 226

Published: April 11, 2025

Bacteria, yeast, and microalgae serve as catalysts in producing several food components, such enzymes nutraceuticals. The current trend for natural ingredients has significantly increased the demand microbially-derived flavours, colours, their large-scale bioprocessing. It is, therefore, crucial that microbes are exploited bio-factories continuous production of metabolites like organic acids, enzymes, proteins, vitamins, antibiotics, hydrocolloids. been shown lactic acid bacteria, particular Lactococcus lactis, make best cell factories to manufacture these vital In recent years, researchers have discovered bacteria also a significant source terpenes, components many medications additives. Furthermore, diseases including protein energy malnutrition (PEM), anaemia, diarrhoea, cancer, obesity, ulcerative colitis, Crohn’s disease, irritable bowel syndrome, gluten-treatment-resistant celiac disease can all benefit from use microorganisms adjuvant therapy.

Language: Английский

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A comprehensive approach, based on the use of Caenorhabditis elegans, mouse, and human models, elucidates the impact of Lactiplantibacillus plantarum TWK10 on exercise performance and longevity

Current Research in Food Science, Journal Year: 2025, Volume and Issue: 10, P. 101015 - 101015

Published: Jan. 1, 2025

The functionality of probiotics is highly influenced by culture and processing conditions, making batch stability validation through human or mouse trials impractical. Here, we employed a comprehensive approach using Caenorhabditis elegans, models to elucidate the beneficial effects Lactiplantibacillus plantarum TWK10 (TWK10). In C. administration significantly prolonged lifespan 26.1 ± 11.9 % (p < 0.05), enhanced locomotion 0.01) muscle mass 0.001), elevated glycogen storage reduced lipid accumulation outperforming Lacticaseibacillus rhamnosus GG L. type strain ATCC 14917T. We also confirmed equivalence laboratory-prepared mass-produced in ergogenic efficacy elegans assay. mice, oral exercise performance liver dose-dependent manner. clinical study involving healthy male adults, significant improvements grip strength (1.1-fold, p exhaustion time (1.27-fold, 0.01), reductions circulating lactate ammonia levels were observed group (1 × 1010 colony-forming unit/day) compared control group. Both humans mice receiving showed improved body composition with increased fat mass. conclusion, demonstrates superior longevous reference strains. consistent across humans, highlights utility as reliable model for probiotic research industrial application.

Language: Английский

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Harnessing the Fish Gut Microbiome and Immune System to Enhance Disease Resistance in Aquaculture

Fish & Shellfish Immunology, Journal Year: 2025, Volume and Issue: unknown, P. 110394 - 110394

Published: May 1, 2025

Language: Английский

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Probiotics Supplementation during Pregnancy: Can They Exert Potential Beneficial Effects against Adverse Pregnancy Outcomes beyond Gestational Diabetes Mellitus?

Biology, Journal Year: 2024, Volume and Issue: 13(3), P. 158 - 158

Published: Feb. 28, 2024

Background: Probiotics, as supplements or food ingredients, are considered to exert promising healthy effects when administered in adequate quantity. Probiotics’ related with the prevention of many diseases, well decreasing symptom severity. Currently, most available data concerning their potential health associated metabolic disorders, including gestational diabetes mellitus. There is also clinical evidence supporting that they may beneficial against diverse adverse pregnancy outcomes. The purpose current narrative study extensively review and analyze existing studies probable positive impacts probiotics supplementation during a protective agent outcomes beyond Methods: comprehensive thorough literature search was conducted precise scientific databases, such PubMed, Scopus, Web Sciences, utilizing efficient, representative, appropriate keywords. Results: last few years, recent research has been several lipid metabolism dysregulation, hypertensive preterm birth, excessive weight gain, caesarean risk section, vaginal microbiota impairment, mental disturbances, others. Conclusion: up present day, there only preliminary not conclusive results for probiotics’ pregnancy, it remains questionable whether could be used supplementary treatment

Language: Английский

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Complete Genome Sequence and Probiotic Characterization of Lactobacillus delbrueckii subsp. Indicus DC-3 Isolated from Traditional Indigenous Fermented Milk

Probiotics and Antimicrobial Proteins, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 17, 2024

Language: Английский

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