Thioredoxin Reductase Is Involved in Development and Pathogenicity in Fusarium graminearum DOI Creative Commons

Xinyue Fan,

Fang He,

Mingyu Ding

et al.

Frontiers in Microbiology, Journal Year: 2019, Volume and Issue: 10

Published: March 7, 2019

Fusarium graminearum is one of the causal agents head blight and produces trichothecene mycotoxin, deoxynivalenol (DON). Thioredoxin reductases (TRRs) play critical roles in recycling oxidized thioredoxin. However, their functions are not well known plant pathogenic fungi. In this study, we characterized a TRR orthologue FgTRR F. graminearum. The FgTRR-GFP fusion protein localized to cytoplasm. gene deletion demonstrated that involved hyphal growth, conidiation, sexual reproduction, DON production, virulence. ΔTRR mutants also exhibited defect pigmentation, expression level aurofusarin biosynthesis-related genes was significantly decreased mutant. Furthermore, were more sensitive oxidative stress aggravated apoptosis-like cell death compared with wild type strain. Taken together, these results indicate important development pathogenicity

Language: Английский

Entomopathogenic Fungi DOI
Tariq M. Butt, Christopher J. Coates, Ivan M. Dubovskiy

et al.

Advances in genetics, Journal Year: 2016, Volume and Issue: unknown, P. 307 - 364

Published: Jan. 1, 2016

Language: Английский

Citations

353
Ecology of aspergillosis: insights into the pathogenic potency of Aspergillus fumigatus and some other Aspergillus species DOI Creative Commons

Caroline Paulussen,

John E. Hallsworth, Sergio Álvarez‐Pérez

et al.

Microbial Biotechnology, Journal Year: 2016, Volume and Issue: 10(2), P. 296 - 322

Published: June 7, 2016

Fungi of the genus Aspergillus are widespread in environment. Some species, most commonly fumigatus, may lead to a variety allergic reactions and life-threatening systemic infections humans. Invasive aspergillosis occurs primarily patients with severe immunodeficiency, has dramatically increased recent years. There several factors at play that contribute aspergillosis, including both fungus host-related such as strain virulence host pulmonary structure/immune status, respectively. The environmental tenacity Aspergilllus, its dominance diverse microbial communities/habitats, ability navigate ecophysiological biophysical challenges infection attributable, large part, robust stress-tolerance biology exceptional capacity generate cell-available energy. Aspects stress metabolism, ecology, interactions animal hosts, clinical presentations treatment regimens have been well-studied over past Here, we synthesize these findings relation way which some species become successful opportunistic pathogens human- other hosts. We focus on capabilities pathogens, key aspects their ecophysiology flexibility undergo sexual cycle or form cryptic species. Additionally, advances diagnosis disease discussed well implications questions yet be resolved.

Language: Английский

Citations

285
Aflatoxin Biosynthesis and Genetic Regulation: A Review DOI Creative Commons
Isaura Caceres,

Anthony Al Khoury,

Rhoda El Khoury

et al.

Toxins, Journal Year: 2020, Volume and Issue: 12(3), P. 150 - 150

Published: Feb. 28, 2020

The study of fungal species evolved radically with the development molecular techniques and produced new evidence to understand specific mechanisms such as production toxic secondary metabolites. Taking advantage these technologies improve food safety, toxinogenic can help elucidate underlying toxin enable effective strategies control toxicity. Numerous studies have been made on genes involved in aflatoxin B1 (AFB1) production, one most hazardous carcinogenic toxins for humans animals. current review presents roles different their possible impact AFB1 production. We focus strains Aspergillus flavus A. parasiticus, primary contaminants major producers crops. However, genetic reports nidulans are also included because capacity this fungus produce sterigmatocystin, penultimate stable metabolite during aim is provide a general overview enzymatic biosynthesis pathway its link belonging cluster. It aims illustrate role global environmental factors recent data that demonstrate an interconnection between regulated by signals biosynthetic pathway.

Language: Английский

Citations

251
The Toxins of Beauveria bassiana and the Strategies to Improve Their Virulence to Insects DOI Creative Commons
Haiyang Wang, Hui Peng, Wenjuan Li

et al.

Frontiers in Microbiology, Journal Year: 2021, Volume and Issue: 12

Published: Aug. 26, 2021

The long-term and excessive usage of pesticides is an enormous burden on the environment, which also increases pest resistance. To overcome this problem, research application entomopathogenic fungi, are both environmentally friendly cause lower resistance, have gained great momentum. Entomopathogenic fungi a wide range prospects. Apart from Bacillus thuringiensis, Beauveria bassiana most studied biopesticide. After invading insect hosts, B. produces variety toxins, secondary metabolites such as beauvericin, bassianin, bassianolide, beauverolides, tenellin, oosporein, oxalic acid. These toxins help to parasitize kill hosts. This review unequivocally considers beauveria highly promising summarizes their attack mechanism(s) host immune system. Genetic engineering strategies improve toxin principles, genes, or virulent molecules been discussed. Lastly, we discuss future perspective research, including newly discovered toxins.

Language: Английский

Citations

134
Concomitant osmotic and chaotropicity-induced stresses in Aspergillus wentii: compatible solutes determine the biotic window DOI

Flávia de Lima Alves,

Andrew Stevenson,

Esther Baxter

et al.

Current Genetics, Journal Year: 2015, Volume and Issue: 61(3), P. 457 - 477

Published: June 8, 2015

Language: Английский

Citations

121
Molecular interactions between entomopathogenic fungi (Hypocreales) and their insect host: Perspectives from stressful cuticle and hemolymph battlefields and the potential of dual RNA sequencing for future studies DOI
Nicolás Pedríni

Fungal Biology, Journal Year: 2017, Volume and Issue: 122(6), P. 538 - 545

Published: Oct. 23, 2017

Language: Английский

Citations

98
Glycerol enhances fungal germination at the water‐activity limit for life DOI Creative Commons
Andrew Stevenson, Philip Hamill, Ángel Medina

et al.

Environmental Microbiology, Journal Year: 2016, Volume and Issue: 19(3), P. 947 - 967

Published: Sept. 15, 2016

Summary For the most‐extreme fungal xerophiles, metabolic activity and cell division typically halts between 0.700 0.640 water (approximately 70.0–64.0% relative humidity). Here, we investigate whether glycerol can enhance xerophile germination under acute water‐activity regimes, using an experimental system which represents biophysical limit of Earth's biosphere. Spores from a variety species, including Aspergillus penicillioides , Eurotium halophilicum Xerochrysium xerophilum (formerly Chrysosporium ) Xeromyces bisporus were produced by cultures growing on media supplemented with (and contained up to 189 mg g dry spores −1 ). The ability these germinate, kinetics germination, then determined range designed recreate stresses experienced in microbial habitats or anthropogenic systems (with water‐activities 0.765 0.575). A. amstelodami E. X. occurred at lower than previously recorded (0.640, 0.685, 0.651, 0.664 0.637 respectively). In addition, low substantially faster those reported previously. Extrapolations indicated theoretical minima below values; as 0.570 for . Glycerol is present high concentrations (up molar levels) many types habitat. We discuss likely role expanding function relation temporal constraints location findings here have also critical implications understanding extremes biosphere; potency disease‐causing microorganisms; biotechnologies that operate limits function.

Language: Английский

Citations

66
Fungal strategies for dealing with environment- and agriculture-induced stresses DOI Creative Commons
Drauzio E.N. Rangel, Roger D. Finlay, John E. Hallsworth

et al.

Fungal Biology, Journal Year: 2018, Volume and Issue: 122(6), P. 602 - 612

Published: Feb. 16, 2018

Language: Английский

Citations

63
Outcome of blue, green, red, and white light on Metarhizium robertsii during mycelial growth on conidial stress tolerance and gene expression DOI Creative Commons

Luciana P. Dias,

Nicolás Pedríni, Gilberto Úbida Leite Braga

et al.

Fungal Biology, Journal Year: 2019, Volume and Issue: 124(5), P. 263 - 272

Published: May 10, 2019

Language: Английский

Citations

44
The effect of type and combination of fertilizers on eukaryotic microbiome of date palm rhizosphere DOI Creative Commons
Sara H. Al-Hadidi, Dana A. Abumaali, Talaat Ahmed

et al.

Plant Growth Regulation, Journal Year: 2024, Volume and Issue: 103(2), P. 439 - 451

Published: Jan. 30, 2024

Abstract The date palm ( Phoenix dactylifera ) is an important cultivated crop in arid areas. Here, we studied the effect of plant genotype and type fertilizers on eukaryotic community structures rhizosphere. Samples were collected from one wild population, five cultivars two farms, a factorial fertilizer experiment (organic, chemical, biofertilizer) Qatar. communities sequenced using next-generation sequencing method. A total 2422 Operational Taxonomic Units (OTUs) identified as belonging to 15 phyla, Chlorophyta , Streptophyta Imbricatea Chytridiomycota Ascomycota Olpidiomycota being dominant. wild-type palms showed low number OTUs compared palms, potentially due strong influence soil salinity moisture level. However, hosted highest unique OTUs. PCA revealed that microbiome was separated microbial diversity varied between similar environments. Using amounts biofertilizer chemical decreased species within samples. high concentration combined with enhanced We conclude cultivar (biotic factor), fertilizer, dosage (abiotic factor) play significant roles determining population could host salt drought-tolerating eukaryotes should be further investigated for future development biofertilizers suitable drylands.

Language: Английский

Citations

5