Rheumatology International,
Journal Year:
2024,
Volume and Issue:
44(10), P. 2185 - 2196
Published: Aug. 27, 2024
Abstract
Since
the
introduction
of
mRNA
vaccines
against
SARS-CoV-2,
induction
autoimmunity
by
vaccination
has
been
discussed.
Several
cases
dermatomyositis
(DM)
associated
with
SARS-CoV-2
infection
have
reported.
The
question
is
whether
there
a
common
pathomechanism
for
DM
this
vaccination.
aim
review
to
analyse
sample
previously
published
case
reports
following
COVID-19
indicators
possible
immune
pathomechanism.
In
review,
we
summarised
COVID-19.
We
considered
report
landscape
as
cumulative
(
n
=
32)
and
identified
clinical
molecular
parameters
in
intersection
statistically
analysed
effect
these
on
development
DM.
MDA-5
antibodies
seem
play
role
autoantibody
signature
after
MDA-5-positive
more
strongly
interstitial
lung
disease/rapidly
progressive
disease
(ILD/RP-ILD)
than
MDA-5-negative
seems
not
be
an
increased
risk
malignancy,
whereas
malignancy.
Our
findings
emphasize
potential
innate
antiviral
signalling
pathways
connecting
autoantibodies
appear
predictive
severe
progression
There
association
between
paraneoplastic
post-vaccination.
Further
studies
are
required
uncover
underlying
mechanisms
triggered
Immunologic Research,
Journal Year:
2023,
Volume and Issue:
71(4), P. 537 - 546
Published: March 16, 2023
Abstract
Several
cases
of
vaccine-associated
manifestations
have
been
published
including
inflammatory
myositis.
Herein,
we
comprehensively
review
the
literature
on
occasion
case
a
woman
with
myositis
following
COVID-19
vaccination.
A
67-year-old
presented
left
arm
edema,
rash,
and
weakness
after
2
nd
dose
BTN162b2
vaccine.
Raised
muscle
enzymes
markers
edema
MRI
findings
electromyogram
established
diagnosis.
She
was
successfully
treated
methylprednisolone
pulses,
intravenous
immunoglobulin,
methotrexate,
hydroxychloroquine.
Cases
myositis,
dermatomyositis,
or
interstitial
lung
disease
myositis-specific
autoantibodies
myositis-associated
within
12
weeks
from
SARS-CoV-2
vaccination
were
included.
malignancy,
prior
subsequent
infection,
preexisting
myositis/interstitial
(ILD)/dermatomyositis
(DM),
other
connective
tissue
diseases
excluded.
From
our
search,
49
identified
(mean
age:
56.55
+
17.17
years),
59%
women,
while
patients
received
ChAdOx1
vaccine,
27
BNT162b2,
8
mRNA-1273,
1
DB15806,
Ad26.COV2.S
(overall,
70%
mRNA
vaccines).
Muscle
involvement
most
common
manifestation
(79.5%),
followed
by
skin
(53%)
ILD
(34.6%),
which
more
in
m-RNA
vaccinees.
biopsy,
findings,
autoantibody
profile
varied
significantly,
successful
immunosuppressive
treatment
applied
cases.
Inflammatory
has
well
documented
worldwide.
Current
evidence
support
pathogenic
link
is
challenging
due
to
significant
variation
clinical
manifestations,
radiological,
histopathological,
immunological
features.
Proceedings of the National Academy of Sciences,
Journal Year:
2024,
Volume and Issue:
121(16)
Published: April 8, 2024
Anti-melanoma
differentiation-associated
gene
5
(MDA5)
antibody-positive
dermatomyositis
(DM)
is
characterized
by
amyopathic
DM
with
interstitial
lung
disease
(ILD).
Patients
anti-MDA5
antibody-associated
ILD
frequently
develop
rapidly
progression
and
present
high
mortality
rate
in
the
acute
phase.
Here,
we
established
a
murine
model
of
mediated
autoimmunity
against
MDA5.
Mice
immunized
recombinant
MDA5
whole
protein,
accompanied
complete
Freund's
adjuvant
once
week
for
four
times,
developed
MDA5-reactive
T
cells
antibodies.
After
injury
induced
intranasal
administration
polyinosinic-polycytidylic
acid
[poly
(I:C)]
mimicking
viral
infection,
MDA5-immunized
mice
fibrotic
representing
prolonged
respiratory
inflammation
changes
2
wk
after
poly
(I:C)-administration,
while
control
had
quickly
completely
recovered
from
inflammation.
Treatment
anti-CD4
depleting
antibody,
but
not
anti-CD8
suppressed
severity
MDA5-induced
ILD.
Upregulation
interleukin
(IL)-6
mRNA,
which
was
temporarily
observed
(I:C)-treated
mice,
mice.
anti-IL-6
receptor
antibody
ameliorated
These
results
suggested
that
exacerbates
toll-like
3-mediated
injury,
prolongs
resulting
development
IL-6
may
play
key
role
initiating
this
model.
Rheumatology International,
Journal Year:
2023,
Volume and Issue:
43(7), P. 1221 - 1243
Published: Feb. 14, 2023
A
literature
review
on
new-onset
autoimmune
connective
tissue
diseases
(ACTDs)
following
COVID-19
is
lacking.
We
evaluated
potential
associations
between
and
the
development
of
ACTDs.
The
"population"
was
adults
with
disease
terms
for
ACTDs,
including
systemic
lupus
erythematosus
(SLE),
Sjogren's
syndrome,
sclerosis
(SSc),
idiopathic
inflammatory
myositis
(IIM),
anti-synthetase
mixed
CTD
undifferentiated
CTD,
"intervention"
as
related
terms.
Databases
were
searched
English-language
articles
published
until
September
2022.
identified
2236
28
ultimately
included.
Of
included
patients,
64.3%
female,
a
mean
age
51.1
years.
USA
reported
most
cases
(9/28).
ACTD
diagnoses
comprised:
11
(39.3%)
IIM
(including
four
dermatomyositis);
7
(25%)
SLE;
(14.3%)
syndrome;
SSc;
two
(7.1%)
other
(one
lupus/MCTD
overlap).
eight,
patients
that
lupus/MCTD)
had
nephritis.
average
time
from
to
diagnosis
23.7
days.
third
admitted
critical
care,
one
treatment
haemophagocytic
lymphohistiocytosis
in
SLE
(14
sessions
plasmapheresis,
rituximab
intravenous
corticosteroids)
nine
due
COVID-19.
80%
went
into
remission
treatment,
while
three
(10%)
died-one
macrophage
activation
syndrome
unreported
causes.
Our
results
suggest
association
notably
young
females,
reflecting
more
comprehensive
epidemiology.
common
our
cohort
IIM.
aetiology
mechanisms
by
which
ACTDs
emerge
remain
unknown
require
further
research.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: April 10, 2024
Juvenile
dermatomyositis
(JDM)
is
the
most
common
inflammatory
myopathy
affecting
children,
being
marked
by
chronic
inflammation
which
mostly
impacts
on
both
skin
and
skeletal
muscles;
diagnostic
criteria
of
JDM
include
an
unforeseeable
mixture
clinical
features,
while
treatment
modalities
commonly
require
corticosteroids
or
immunosuppressant
agents.
Although
pathogenesis
not
completely
understood,
several
infectious
triggers
have
been
linked
to
its
priming
via
anecdotal
reports
related
children.
Pediatric
cases
recent-onset
temporally
associated
disease
power
increased
titers
circulating
antibodies
a
putative
agent,
including
parasites,
and/or
detectable
viral
RNA
bacterial
DNA.
With
this
narrative
review
we
offer
update
about
association
with
host
infections,
namely
parvovirus
B19,
Epstein-Barr
virus,
Coxsackie
human
immune
deficiency
severe
acute
respiratory
syndrome
coronavirus
2,
Vaccines,
Journal Year:
2023,
Volume and Issue:
11(10), P. 1571 - 1571
Published: Oct. 8, 2023
A
comprehensive,
up-to-date
systematic
review
(SR)
of
the
new-onset
rheumatic
immune-mediated
inflammatory
diseases
(R-IMIDs)
following
COVID-19
vaccinations
is
lacking.
Therefore,
we
investigated
demographics,
management,
and
prognosis
new
R-IMIDs
in
adults
SARS-CoV-2
vaccinations.
literature
search
Medline,
Embase,
Google
Scholar,
LitCovid,
Cochrane
was
conducted.
We
included
any
English-language
study
that
reported
R-IMID
post-COVID-19
vaccination.
total
271
cases
were
from
39
countries
between
January
2021
May
2023.
The
mean
age
patients
56
(range
18-90),
most
females
(170,
62.5%).
Most
(153,
56.5%)
received
Pfizer
BioNTech
vaccine.
Nearly
50%
developed
after
second
dose
Vasculitis
prevalent
clinical
presentation
(86,
31.7%),
followed
by
connective
tissue
disease
(66,
24.3%).
duration
vaccine's
'trigger'
11
days.
(220,
81.2%)
corticosteroids;
however,
42%
(115)
DMARDs
such
as
methotrexate,
cyclophosphamide,
tocilizumab,
anakinra,
IV
immunoglobulins,
plasma
exchange,
or
rituximab.
Complete
remission
achieved
75
(27.7%),
137
(50.6%)
improved
treatment.
Two
died
due
to
myositis.
This
SR
highlights
vaccines
may
trigger
R-IMID;
further
epidemiology
studies
are
required.
Mediterranean Journal of Rheumatology,
Journal Year:
2024,
Volume and Issue:
35(1), P. 179 - 179
Published: March 1, 2024
Vaccination
against
Sars-CoV-2
has
been
proven
to
significantly
reduce
COVID-19
morbidity
and
mortality
is
therefore
recommended
for
the
general
population,
especially
seniors
with
impaired
immunity.However,
it
currently
postulated
that
vaccines
could
rarely
induce
autoimmune
diseases
in
previously
healthy
individuals.We
report
a
case
of
new-onset
anti-melanoma
differentiation-associated
protein
5
(anti-MDA5)
antibody-positive
dermatomyositis
patient
presenting
rash
fever
following
third
dose
vaccine.The
laboratory
testing
revealed
high
titres
anti-MDA-5
antibody
chest
computed
tomography
showed
micronodular
lesions
ground
glass
opacities
bilaterally.The
was
promptly
treated
corticosteroids,
methotrexate,
azathioprine,
later
started
on
rituximab
due
exacerbation
along
newly
formed,
diffuse
skin
ulcers.Our
highlights
potential
immunogenicity
need
further
reporting
rare
rheumatic
syndromes
possibly
related
disease
vaccination.
PLoS ONE,
Journal Year:
2025,
Volume and Issue:
20(2), P. e0317319 - e0317319
Published: Feb. 10, 2025
Objective
The
coronavirus
disease
pandemic
brought
unknown
challenges
to
patients
with
idiopathic
inflammatory
myopathy,
who
are
often
heavily
immunosuppressed
and
have
comorbidities.
We
aimed
investigate
the
outcomes
risk
factors
of
in
Chinese
myopathy
during
Omicron
wave.
Methods
This
observational
study
included
visited
China-Japan
Friendship
Hospital.
Data
on
baseline
characteristics
disease-related
information
were
collected
through
medical
records
surveys,
subsequently
analysed.
Results
Overall,
204
identified;
dermatomyositis
was
most
common
subtype.
from
185
tested
positive
for
severe
acute
respiratory
syndrome
2
via
polymerase
chain
reaction
or
antigen
tests;
these,
20
experienced
a
course
disease,
9
died.
All
had
myopathy-associated
interstitial
lung
antibodies
observed
mortality
anti-aminoacyl
tRNA
synthetase
anti-MDA-5
antibodies.
Furthermore,
45.0%
group
took
>
15.0
mg
prednisone
daily
before
infection,
significantly
higher
proportion
than
that
non-severe
group.
Advanced
age,
mechanics’
hands,
dyspnoea,
chronic
cough
fever
myositis,
low
lymphocyte
count,
serum
albumin
level,
high
D-dimer
ferritin
levels
infection
prominent
disease.
Albumin
below
35.0
g/L
above
306.8
ng/mL
independent
Conclusion
did
not
worsen
overall
myopathy;
however,
specific
identified,
highlighting
need
targeted
management
strategies.