Is Pulmonary Involvement a Distinct Phenotype of Post-COVID-19? DOI Creative Commons
Krystian Bartczak, Joanna Miłkowska-Dymanowska, Małgorzata Pietrusińska

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 11(10), P. 2694 - 2694

Published: Oct. 2, 2023

(1) Background: COVID-19 infection often provokes symptoms lasting many months: most commonly fatigue, dyspnea, myalgia and mental distress symptoms. In this study, we searched for clinical features of post-COVID-19 condition (PCC) differences between patients with without pulmonary involvement. (2) Methods: A total 282 a mean age 57 years (SD +/− 12 years) underwent assessment up to weeks after recovery. The course acute disease, past medical history were gathered; function tests performed; radiographic studies assessed follow-up examinations conducted. Patients detectable lesions divided into separate groups. (3) Results: within the group more older (59 vs. 51 y.o.; p < 0.001) males (p = 0.002) that COVID-19-related hospitalization either ex- or active smokers median 20 pack-years. We also managed find correlations hypertension 0.01), liver failure 0.03), such as dyspnea 0.001), 0.04), headache 0.009), sleeplessness 0.046), (such FVC, TLCO, RV TLC; several basic laboratory (D-dimer, cardiac troponin, WBC, creatinine others). (4) Conclusions: Our results indicate initial involvement alters PCC, it can be used individualize approaches.

Language: Английский

Interplay between Comorbidities and Long COVID: Challenges and Multidisciplinary Approaches DOI Creative Commons
Rasha Ashmawy, Esraa Abdellatif Hammouda, Yousra A. El‐Maradny

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(7), P. 835 - 835

Published: July 11, 2024

Long COVID, a name often given to the persistent symptoms following acute SARS-CoV-2 infection, poses multifaceted challenge for health. This review explores intrinsic relationship between comorbidities and autoimmune responses in shaping trajectory of long COVID. Autoantibodies have emerged as significant players COVID-19 pathophysiology, with implications disease severity progression. Studies show immune dysregulation persisting months after marked by activated innate cells high cytokine levels. The presence autoantibodies against various autoantigens suggests their potential comorbid factors Additionally, formation complexes may lead severe progression, highlighting urgency early detection intervention. Furthermore, COVID is highly linked cardiovascular complications neurological symptoms, posing challenges diagnosis management. Multidisciplinary approaches, including vaccination, tailored rehabilitation, pharmacological interventions, are used mitigating COVID’s burden. However, numerous persist, from evolving diagnostic criteria addressing psychosocial impact predicting outcomes. Leveraging AI-based applications holds promise enhancing patient management improving our understanding As research continues unfold, unravelling complexities remains paramount effective intervention care.

Language: Английский

Citations

11
Coronavirus disease 2019 (COVID-19) pandemic and autoimmune rheumatic diseases: Outcomes and prospects DOI Creative Commons
Е. Л. Насонов

Rheumatology Science and Practice, Journal Year: 2024, Volume and Issue: 62(1), P. 32 - 54

Published: Feb. 29, 2024

The pandemic of coronavirus disease 2019 (COVID-19), etiologically related to the SARS-CoV-2 virus (severe acute respiratory syndrome coronavirus-2), has drawn attention new clinical and fundamental problems in immunopathology human diseases associated with virus-induced autoimmunity autoinflammation. provision that “the experience gained rheumatology process studying pathogenetic mechanisms pharmacotherapy immunoinflammatory rheumatic as most common severe forms autoimmune autoinflammatory pathology humans will be demand for deciphering nature pathological processes underlying COVID-19 developing approaches effective pharmacotherapy” was confirmed numerous studies conducted over next 3 years midst pandemic. main focus on a critical analysis data regarding role inflammation, which basis pathogenesis immune-mediated context COVID-19.

Language: Английский

Citations

9
The relationship between infectious agents and juvenile dermatomyositis: a narrative update from the pediatric perspective DOI Creative Commons
Chiara Sassetti,

Claudia Borrelli,

Martha Mazuy

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: April 10, 2024

Juvenile dermatomyositis (JDM) is the most common inflammatory myopathy affecting children, being marked by chronic inflammation which mostly impacts on both skin and skeletal muscles; diagnostic criteria of JDM include an unforeseeable mixture clinical features, while treatment modalities commonly require corticosteroids or immunosuppressant agents. Although pathogenesis not completely understood, several infectious triggers have been linked to its priming via anecdotal reports related children. Pediatric cases recent-onset temporally associated disease power increased titers circulating antibodies a putative agent, including parasites, and/or detectable viral RNA bacterial DNA. With this narrative review we offer update about association with host infections, namely parvovirus B19, Epstein-Barr virus, Coxsackie human immune deficiency severe acute respiratory syndrome coronavirus 2,

Language: Английский

Citations

8
Paraneoplastic Dermatoses: A Clue for Underlying Malignancies DOI Open Access
Dario Didona,

Alessandra Rallo,

Andrea Carugno

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(3), P. 1014 - 1014

Published: Feb. 5, 2025

Paraneoplastic dermatoses (PDs) belong to a group of rare and polymorphous dermatoses, they can often be the first sign underlying malignancies. Therefore, dermatologists should able identify skin features earlier neoplasms. Indeed, lack familiarity with cutaneous clues internal malignancies lead delay in diagnosis an impairment prognosis patients. In this review, we described several PDs, including more common rarer PD. while malignant acanthosis nigricans, characterized by velvety, verrucous, hyperpigmented plaques that usually affect intertriginous areas, is well-known PD, necrolytic migratory erythema misdiagnosed because its clinical similar seborrheic dermatitis. Furthermore, focused on two paradigmatic namely paraneoplastic autoimmune multiorgan syndrome (PAMS) dermatomyositis. PAMS represents form obligate which always associated neoplasm, dermatomyositis belongs facultative neoplasia variable percentage cases.

Language: Английский

Citations

1
Environment and systemic lupus erythematosus DOI Open Access
Chiara Cardelli, Dina Zucchi, Elena Elefante

et al.

Clinical and Experimental Rheumatology, Journal Year: 2024, Volume and Issue: unknown

Published: May 14, 2024

Language: Английский

Citations

3
COVID-19 or systemic lupus erythematosus: Attention to similarity DOI Creative Commons
Abdülsamet Erden, Özlem Karakaş, Bahar Özdemir

et al.

Revista română de medicină de laborator, Journal Year: 2025, Volume and Issue: 33(1), P. 59 - 64

Published: Jan. 1, 2025

Abstract Background Arthralgia, myalgia, acute interstitial pneumonia-like presentation, venous thromboembolism, cytopenia, secondary hemophagocytic lymphohistiocytosis and cytokine storm are the clinical laboratory findings associated with Coronavirus disease (COVID-19), which may mimic rheumatic syndromes. Systemic lupus erythematosus (SLE) is a highly heterogeneous disease, various features can be seen in affected individuals. Differentiated diagnoses quite broad SLE. We present six patients systemic and/ or antiphospholipid syndrome mimicking COVID-19 pneumonia. Methods described demographic, clinical, radiological, characteristics of consecutive suspected between 16 April 1 June 2020—all presented symptoms. Results All had two polymerase chain reaction (PCR) tests, all them were negative. Four diagnosed (SLE), one syndrome, syndrome. The ages our 20 43. arthralgia. (66.6%) needed intensive care. Conclusions Arthralgia myalgia was observed to clue for disorder. Clinicians should mindful infectious non-infectious disorders that similarly COVID-19, particularly during pandemic.

Language: Английский

Citations

0
Ethnic heterogeneity of juvenile arthritis in the Republic of Sakha (Yakutia) related to a high human leukocyte antigen B27 frequency DOI
S.G. Boeskorova,

M.V. Afonskaya,

V.M. Argunova

et al.

World Journal of Clinical Pediatrics, Journal Year: 2025, Volume and Issue: 14(2)

Published: March 18, 2025

BACKGROUND Prevalence of the main rheumatic diseases in Republic Sakha (Yakutia) [RS(Y)], one regions Russian Federation, differs from other Federation due to its ethnic and geographic features. Knowledge regarding prevalence structure juvenile idiopathic arthritis (JIA) allows us shape work pediatric rheumatology service region correctly, optimize healthcare system need for medications. AIM To describe epidemiological, demographic, clinical, laboratory characteristics children with JIA RS(Y) evaluate outcomes. METHODS This retrospective cohort study assessed all data medical histories patients (n = 225) diagnosed (2016-2023) Cardiorheumatology Department M.E. Nikolaev National Center Medicine. Pearson's χ ² test, Fisher's exact Mann–Whitney Kruskal-Wallis tests were used statistical analyses. RESULTS The is higher than at 110.1 per 100000 69.4 children, respectively. among boys girls was similar, unlike Russians, where number predominated. categories as follows: (1) Systemic arthritis: 3.5%; (2) Oligoarthritis (persistent extended): 33.8%; (3) Rheumatoid factor (RF) (+) polyarthritis: 0.9%; (4) RF (-) 14.7%; (5) Enthesitis-related (ERA): 44%; (6) Psoriatic 3.1%. ERA category 4.4 times but systemic 2.9 lower compared Russians (P 0.0005). frequency uveitis 10.2%, human leukocyte antigen (HLA) B27 39.6% children. Biologic treatment received by 40.4% 45.3% achieved remission. CONCLUSION Higher prevalence, male predominance, related a HLA are typical RS(Y). These might improve health service.

Language: Английский

Citations

0
From infection to autoimmunity: can COVID-19 spark new auto-immune Conditions? DOI Creative Commons
Mourad Elghali, Mariem Mhiri,

I. Chaâbene

et al.

Respiratory Medicine Case Reports, Journal Year: 2025, Volume and Issue: 55, P. 102216 - 102216

Published: Jan. 1, 2025

Language: Английский

Citations

0
Incidence, management and prognosis of new-onset sarcoidosis post COVID-19 infection. DOI
Oliver Vij, Mrinalini Dey, Kirsty Morrison

et al.

PubMed, Journal Year: 2024, Volume and Issue: 41(1), P. e2024004 - e2024004

Published: March 26, 2024

SARS-CoV-2 infection has been linked to hyperinflammation in multiple organs with a potential mechanistic link resulting autoimmunity. There have reports of many inflammatory complications following COVID-19, including sarcoidosis. A literature review on new-onset sarcoidosis COVID-19 is lacking. We evaluated associations between and development

Language: Английский

Citations

3
Are the Comorbidities Constitute an Intrinsic Factor for Long COVID? DOI Open Access
Rasha Ashmawy, Esraa Abdellatif Hammouda, Yousra A. El‐Maradny

et al.

Published: May 2, 2024

Long COVID, a name often given to the persistent symptoms following acute SARS-CoV-2 infection, poses multifaceted challenge for health. This review explores intrinsic relationship between comorbidities and autoimmune responses in shaping trajectory of long COVID. Autoantibodies have emerged as significant players COVID-19 pathophysiology, with implications disease severity progression. Studies show immune dysregulation persisting months after marked by activated innate cells high cytokine levels. The presence autoantibodies against various autoantigens suggests their potential comorbid factors Additionally, formation complexes may lead severe progression, highlighting urgency early detection intervention. Furthermore, COVID is highly linked cardiovascular complications neurological symptoms, posing challenges diagnosis management. Multidisciplinary approaches, including vaccination, tailored rehabilitation, pharmacological interventions, are used mitigating COVID&#039;s burden. However, numerous persist, from evolving diagnostic criteria addressing psychosocial impact predicting outcomes. Leveraging AI-based applications holds promise enhancing patient management improving our understanding As research continues unfold, unravelling complexities remains paramount effective intervention care.

Language: Английский

Citations

3