Biomedicines,
Journal Year:
2023,
Volume and Issue:
11(10), P. 2694 - 2694
Published: Oct. 2, 2023
(1)
Background:
COVID-19
infection
often
provokes
symptoms
lasting
many
months:
most
commonly
fatigue,
dyspnea,
myalgia
and
mental
distress
symptoms.
In
this
study,
we
searched
for
clinical
features
of
post-COVID-19
condition
(PCC)
differences
between
patients
with
without
pulmonary
involvement.
(2)
Methods:
A
total
282
a
mean
age
57
years
(SD
+/−
12
years)
underwent
assessment
up
to
weeks
after
recovery.
The
course
acute
disease,
past
medical
history
were
gathered;
function
tests
performed;
radiographic
studies
assessed
follow-up
examinations
conducted.
Patients
detectable
lesions
divided
into
separate
groups.
(3)
Results:
within
the
group
more
older
(59
vs.
51
y.o.;
p
<
0.001)
males
(p
=
0.002)
that
COVID-19-related
hospitalization
either
ex-
or
active
smokers
median
20
pack-years.
We
also
managed
find
correlations
hypertension
0.01),
liver
failure
0.03),
such
as
dyspnea
0.001),
0.04),
headache
0.009),
sleeplessness
0.046),
(such
FVC,
TLCO,
RV
TLC;
several
basic
laboratory
(D-dimer,
cardiac
troponin,
WBC,
creatinine
others).
(4)
Conclusions:
Our
results
indicate
initial
involvement
alters
PCC,
it
can
be
used
individualize
approaches.
Biomolecules,
Journal Year:
2024,
Volume and Issue:
14(7), P. 835 - 835
Published: July 11, 2024
Long
COVID,
a
name
often
given
to
the
persistent
symptoms
following
acute
SARS-CoV-2
infection,
poses
multifaceted
challenge
for
health.
This
review
explores
intrinsic
relationship
between
comorbidities
and
autoimmune
responses
in
shaping
trajectory
of
long
COVID.
Autoantibodies
have
emerged
as
significant
players
COVID-19
pathophysiology,
with
implications
disease
severity
progression.
Studies
show
immune
dysregulation
persisting
months
after
marked
by
activated
innate
cells
high
cytokine
levels.
The
presence
autoantibodies
against
various
autoantigens
suggests
their
potential
comorbid
factors
Additionally,
formation
complexes
may
lead
severe
progression,
highlighting
urgency
early
detection
intervention.
Furthermore,
COVID
is
highly
linked
cardiovascular
complications
neurological
symptoms,
posing
challenges
diagnosis
management.
Multidisciplinary
approaches,
including
vaccination,
tailored
rehabilitation,
pharmacological
interventions,
are
used
mitigating
COVID’s
burden.
However,
numerous
persist,
from
evolving
diagnostic
criteria
addressing
psychosocial
impact
predicting
outcomes.
Leveraging
AI-based
applications
holds
promise
enhancing
patient
management
improving
our
understanding
As
research
continues
unfold,
unravelling
complexities
remains
paramount
effective
intervention
care.
Rheumatology Science and Practice,
Journal Year:
2024,
Volume and Issue:
62(1), P. 32 - 54
Published: Feb. 29, 2024
The
pandemic
of
coronavirus
disease
2019
(COVID-19),
etiologically
related
to
the
SARS-CoV-2
virus
(severe
acute
respiratory
syndrome
coronavirus-2),
has
drawn
attention
new
clinical
and
fundamental
problems
in
immunopathology
human
diseases
associated
with
virus-induced
autoimmunity
autoinflammation.
provision
that
“the
experience
gained
rheumatology
process
studying
pathogenetic
mechanisms
pharmacotherapy
immunoinflammatory
rheumatic
as
most
common
severe
forms
autoimmune
autoinflammatory
pathology
humans
will
be
demand
for
deciphering
nature
pathological
processes
underlying
COVID-19
developing
approaches
effective
pharmacotherapy”
was
confirmed
numerous
studies
conducted
over
next
3
years
midst
pandemic.
main
focus
on
a
critical
analysis
data
regarding
role
inflammation,
which
basis
pathogenesis
immune-mediated
context
COVID-19.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: April 10, 2024
Juvenile
dermatomyositis
(JDM)
is
the
most
common
inflammatory
myopathy
affecting
children,
being
marked
by
chronic
inflammation
which
mostly
impacts
on
both
skin
and
skeletal
muscles;
diagnostic
criteria
of
JDM
include
an
unforeseeable
mixture
clinical
features,
while
treatment
modalities
commonly
require
corticosteroids
or
immunosuppressant
agents.
Although
pathogenesis
not
completely
understood,
several
infectious
triggers
have
been
linked
to
its
priming
via
anecdotal
reports
related
children.
Pediatric
cases
recent-onset
temporally
associated
disease
power
increased
titers
circulating
antibodies
a
putative
agent,
including
parasites,
and/or
detectable
viral
RNA
bacterial
DNA.
With
this
narrative
review
we
offer
update
about
association
with
host
infections,
namely
parvovirus
B19,
Epstein-Barr
virus,
Coxsackie
human
immune
deficiency
severe
acute
respiratory
syndrome
coronavirus
2,
Journal of Clinical Medicine,
Journal Year:
2025,
Volume and Issue:
14(3), P. 1014 - 1014
Published: Feb. 5, 2025
Paraneoplastic
dermatoses
(PDs)
belong
to
a
group
of
rare
and
polymorphous
dermatoses,
they
can
often
be
the
first
sign
underlying
malignancies.
Therefore,
dermatologists
should
able
identify
skin
features
earlier
neoplasms.
Indeed,
lack
familiarity
with
cutaneous
clues
internal
malignancies
lead
delay
in
diagnosis
an
impairment
prognosis
patients.
In
this
review,
we
described
several
PDs,
including
more
common
rarer
PD.
while
malignant
acanthosis
nigricans,
characterized
by
velvety,
verrucous,
hyperpigmented
plaques
that
usually
affect
intertriginous
areas,
is
well-known
PD,
necrolytic
migratory
erythema
misdiagnosed
because
its
clinical
similar
seborrheic
dermatitis.
Furthermore,
focused
on
two
paradigmatic
namely
paraneoplastic
autoimmune
multiorgan
syndrome
(PAMS)
dermatomyositis.
PAMS
represents
form
obligate
which
always
associated
neoplasm,
dermatomyositis
belongs
facultative
neoplasia
variable
percentage
cases.
Revista română de medicină de laborator,
Journal Year:
2025,
Volume and Issue:
33(1), P. 59 - 64
Published: Jan. 1, 2025
Abstract
Background
Arthralgia,
myalgia,
acute
interstitial
pneumonia-like
presentation,
venous
thromboembolism,
cytopenia,
secondary
hemophagocytic
lymphohistiocytosis
and
cytokine
storm
are
the
clinical
laboratory
findings
associated
with
Coronavirus
disease
(COVID-19),
which
may
mimic
rheumatic
syndromes.
Systemic
lupus
erythematosus
(SLE)
is
a
highly
heterogeneous
disease,
various
features
can
be
seen
in
affected
individuals.
Differentiated
diagnoses
quite
broad
SLE.
We
present
six
patients
systemic
and/
or
antiphospholipid
syndrome
mimicking
COVID-19
pneumonia.
Methods
described
demographic,
clinical,
radiological,
characteristics
of
consecutive
suspected
between
16
April
1
June
2020—all
presented
symptoms.
Results
All
had
two
polymerase
chain
reaction
(PCR)
tests,
all
them
were
negative.
Four
diagnosed
(SLE),
one
syndrome,
syndrome.
The
ages
our
20
43.
arthralgia.
(66.6%)
needed
intensive
care.
Conclusions
Arthralgia
myalgia
was
observed
to
clue
for
disorder.
Clinicians
should
mindful
infectious
non-infectious
disorders
that
similarly
COVID-19,
particularly
during
pandemic.
World Journal of Clinical Pediatrics,
Journal Year:
2025,
Volume and Issue:
14(2)
Published: March 18, 2025
BACKGROUND
Prevalence
of
the
main
rheumatic
diseases
in
Republic
Sakha
(Yakutia)
[RS(Y)],
one
regions
Russian
Federation,
differs
from
other
Federation
due
to
its
ethnic
and
geographic
features.
Knowledge
regarding
prevalence
structure
juvenile
idiopathic
arthritis
(JIA)
allows
us
shape
work
pediatric
rheumatology
service
region
correctly,
optimize
healthcare
system
need
for
medications.
AIM
To
describe
epidemiological,
demographic,
clinical,
laboratory
characteristics
children
with
JIA
RS(Y)
evaluate
outcomes.
METHODS
This
retrospective
cohort
study
assessed
all
data
medical
histories
patients
(n
=
225)
diagnosed
(2016-2023)
Cardiorheumatology
Department
M.E.
Nikolaev
National
Center
Medicine.
Pearson's
χ
²
test,
Fisher's
exact
Mann–Whitney
Kruskal-Wallis
tests
were
used
statistical
analyses.
RESULTS
The
is
higher
than
at
110.1
per
100000
69.4
children,
respectively.
among
boys
girls
was
similar,
unlike
Russians,
where
number
predominated.
categories
as
follows:
(1)
Systemic
arthritis:
3.5%;
(2)
Oligoarthritis
(persistent
extended):
33.8%;
(3)
Rheumatoid
factor
(RF)
(+)
polyarthritis:
0.9%;
(4)
RF
(-)
14.7%;
(5)
Enthesitis-related
(ERA):
44%;
(6)
Psoriatic
3.1%.
ERA
category
4.4
times
but
systemic
2.9
lower
compared
Russians
(P
0.0005).
frequency
uveitis
10.2%,
human
leukocyte
antigen
(HLA)
B27
39.6%
children.
Biologic
treatment
received
by
40.4%
45.3%
achieved
remission.
CONCLUSION
Higher
prevalence,
male
predominance,
related
a
HLA
are
typical
RS(Y).
These
might
improve
health
service.
PubMed,
Journal Year:
2024,
Volume and Issue:
41(1), P. e2024004 - e2024004
Published: March 26, 2024
SARS-CoV-2
infection
has
been
linked
to
hyperinflammation
in
multiple
organs
with
a
potential
mechanistic
link
resulting
autoimmunity.
There
have
reports
of
many
inflammatory
complications
following
COVID-19,
including
sarcoidosis.
A
literature
review
on
new-onset
sarcoidosis
COVID-19
is
lacking.
We
evaluated
associations
between
and
development
Long
COVID,
a
name
often
given
to
the
persistent
symptoms
following
acute
SARS-CoV-2
infection,
poses
multifaceted
challenge
for
health.
This
review
explores
intrinsic
relationship
between
comorbidities
and
autoimmune
responses
in
shaping
trajectory
of
long
COVID.
Autoantibodies
have
emerged
as
significant
players
COVID-19
pathophysiology,
with
implications
disease
severity
progression.
Studies
show
immune
dysregulation
persisting
months
after
marked
by
activated
innate
cells
high
cytokine
levels.
The
presence
autoantibodies
against
various
autoantigens
suggests
their
potential
comorbid
factors
Additionally,
formation
complexes
may
lead
severe
progression,
highlighting
urgency
early
detection
intervention.
Furthermore,
COVID
is
highly
linked
cardiovascular
complications
neurological
symptoms,
posing
challenges
diagnosis
management.
Multidisciplinary
approaches,
including
vaccination,
tailored
rehabilitation,
pharmacological
interventions,
are
used
mitigating
COVID's
burden.
However,
numerous
persist,
from
evolving
diagnostic
criteria
addressing
psychosocial
impact
predicting
outcomes.
Leveraging
AI-based
applications
holds
promise
enhancing
patient
management
improving
our
understanding
As
research
continues
unfold,
unravelling
complexities
remains
paramount
effective
intervention
care.