Incorporating Physical Activity in a New Two-Oscillator Model of Circadian Activity in Nocturnal and Diurnal Mammals DOI Creative Commons
Anouk W. van Beurden, Johanna H. Meijer, Jos H. T. Rohling

et al.

Journal of Biological Rhythms, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 26, 2024

In both diurnal and nocturnal species, the neurons in suprachiasmatic nucleus (SCN) generate a daily pattern which impulse frequency peaks at midday is lowest during night. This pattern, common to day-active night-active has led long-standing notion that their functional difference relies merely on sign reversal SCN output. However, recent evidence shows response of animal’s physical activity opposite animals. finding suggests presence additional differences circadian system between species. We therefore attempted identify these neuronal network organization using A-B two-oscillator model, comprised Poincaré like oscillators. Based this we infer animals feedback from acts subpopulations do not receive light input; contrast, animals, light-receptive order produce high-amplitude rhythms.

Language: Английский

The Suprachiasmatic Nucleus at 50: Looking Back, Then Looking Forward DOI
Daisuke Ono, David R. Weaver, Michael H. Hastings

et al.

Journal of Biological Rhythms, Journal Year: 2024, Volume and Issue: 39(2), P. 135 - 165

Published: Feb. 16, 2024

It has been 50 years since the suprachiasmatic nucleus (SCN) was first identified as central circadian clock and 25 last overview of developments in field published Journal Biological Rhythms. Here, we explore new mechanisms concepts that have emerged subsequent years. Since 1997, methodological developments, such luminescent fluorescent reporter techniques, revealed intricate relationships between cellular network-level mechanisms. In particular, specific neuropeptides arginine vasopressin, vasoactive intestinal peptide, gastrin-releasing peptide key players synchronization rhythms within SCN. The discovery multiple oscillators governing behavioral physiological significantly advanced our understanding clock. interaction neurons glial cells found to play a crucial role regulating these Furthermore, properties SCN network vary across ontogenetic stages. application cell type–specific genetic manipulations components functional input-output system their correlation with functions. This review concludes high-risk effort identifying open questions challenges lie ahead.

Language: Английский

Citations

21
Threatened chronotopes: can chronobiology help endangered species? DOI
Stefanie Monecke

Journal of Comparative Physiology A, Journal Year: 2024, Volume and Issue: 210(4), P. 717 - 733

Published: Feb. 29, 2024

Language: Английский

Citations

4
A clock for all seasons DOI Creative Commons
Charlotte Helfrich‐Förster, Dirk Rieger

Journal of Comparative Physiology A, Journal Year: 2024, Volume and Issue: 210(4), P. 473 - 480

Published: June 19, 2024

Abstract Circadian clocks play an essential role in adapting locomotor activity as well physiological, and metabolic rhythms of organisms to the day-night cycles on Earth during four seasons. In addition, they can serve a time reference for measuring day length adapt advance annual changes environment, which be particularly pronounced at higher latitudes. The physiological responses are also known photoperiodism. This special issue Journal Comparative Physiology A aims account diurnal photoperiodic adaptations by presenting collection ten review articles, five original research three perspective pieces. contributions include historical accounts, circadian clock models, epigenetic, molecular, neuronal mechanisms seasonal adaptations, latitudinal differences studies wild that address challenges global change.

Language: Английский

Citations

4
Identification of angiotensin II-responsive circadian clock gene expression in adrenal zona glomerulosa cells and human adrenocortical H295R cells DOI Creative Commons
Tomohiro Otani, Takahito Miyake, Takumi Ota

et al.

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: March 26, 2025

The mammalian circadian timing system is organized in a hierarchy, with the master clock residing suprachiasmatic nucleus (SCN) of hypothalamus and subsidiary peripheral clocks tissues. Because diversity tissues cell-types body, existence autonomous identification its potential entrainment signals need to be empirically defined on cell type-by-cell type basis. In this study, we characterized basic properties adrenal zona glomerulosa cells, or ZG cells. Using isolated explants from Per2 Luc mice, dissociated cells Per2-dluc rats, related human adrenocortical line H295R, showed that possess genetically-encoded, self-sustained cell-autonomous clock. As signals, angiotensin II (Ang II) caused phase-dependent phase-shifts cultured slices. Ang treatment also drove initiation (or reset) gene expression H295R associated immediate up-regulation PER1 E4BP4 mRNA expression. We found I receptor blocker CV11974, one most widely used clinical drugs for hypertensive diseases, attenuation phase resetting Our vitro data provide basis understand argue gland as component entrainable clocks.

Language: Английский

Citations

0
Decoding Neuropeptide Complexity: Advancing Neurobiological Insights from Invertebrates to Vertebrates through Evolutionary Perspectives DOI
Lauren Fields, Tina C. Dang,

Vu Ngoc Huong Tran

et al.

ACS Chemical Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

Neuropeptides are vital signaling molecules involved in neural communication, hormonal regulation, and stress response across diverse taxa. Despite their critical roles, neuropeptide research remains challenging due to low abundance, complex post-translational modifications (PTMs), dynamic expression patterns. Mass spectrometry (MS)-based neuropeptidomics has revolutionized peptide identification quantification, enabling the high-throughput characterization of neuropeptides PTMs. However, complexity vertebrate networks poses significant challenges for functional studies. Invertebrate models, such as Cancer borealis, Drosophila melanogaster, Caenorhabditis elegans, offer simplified circuits, well-characterized systems, experimental tools elucidating roles neuropeptides. These models have revealed conserved families, including allatostatins, RFamides, tachykinin-related peptides, whose homologues regulate analogous physiological functions. Recent advancements MS techniques, ion mobility MALDI imaging, further enhanced spatial temporal resolution analysis, allowing insights into systems. not only expands our understanding functions but also informs translational applications development peptide-based therapeutics. This review highlights utility invertebrate discovery, emphasizing contributions uncovering fundamental biological principles relevance

Language: Английский

Citations

0
Dietary restriction modulates ultradian rhythms and autocorrelation properties in mice behavior DOI Creative Commons
Jackelyn Melissa Kembro, Ana Georgina Flesia, Victoria A. Acosta-Rodríguez

et al.

Communications Biology, Journal Year: 2024, Volume and Issue: 7(1)

Published: March 9, 2024

Abstract Animal behavior emerges from integration of many processes with different spatial and temporal scales. Dynamical behavioral patterns, including daily ultradian rhythms the dynamical microstructure (i.e., autocorrelations properties), can be differentially affected by external cues. Identifying these patterns is important for understanding how organisms adapt to their environment, yet unbiased methods quantify changes over multiple scales are lacking. Herein, we combine a wavelet approach Detrended Fluctuation Analysis identify evaluate 42-days in mice subjected dietary restriction paradigms. We show that feeding alters patterns: not only modulated but also presence, phase and/or strength ~12h-rhythms, as well nature autocorrelation properties feed-intake wheel running behaviors. These results highlight underlying complexity architecture offer insights into multi-scale impact habits on physiology.

Language: Английский

Citations

2
One seasonal clock fits all? DOI Creative Commons
Stephan Michel, Laura Kervezee

Journal of Comparative Physiology A, Journal Year: 2023, Volume and Issue: 210(4), P. 641 - 647

Published: Nov. 10, 2023

Adaptation of physiology and behavior to seasonal changes in the environment are for many organisms essential survival. Most our knowledge about underlying mechanisms comes from research on photoperiodic regulation reproduction plants, insects mammals. However, even humans, who mostly live environments with minimal influences, show annual rhythms (e.g., immune activity, brain function), sleep-wake cycles) disease prevalence infectious diseases). As variations environmental conditions may be drastically altered due climate change, understanding adaptation becomes more relevant. While species have developed specific solutions dedicated tasks regulation, we find a number common principles when comparing insect mammalian systems: (1) circadian system contributes regulation; (2) similar signaling molecules (VIP PDF) used transferring information neuroendocrine controlling response; (3) hormone melatonin participates as well mammals; (4) photoperiod affect neurotransmitter function both animal groups. The few examples overlap elaborated this perspective article, discussion relevance should seen encouragement unravel machinery multitude organisms.

Language: Английский

Citations

5
Photoperiod, food restriction and memory for objects and places in mice DOI Creative Commons

Sarah C. Power,

Mateusz Michalik, Brianne A. Kent

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Sept. 16, 2024

Language: Английский

Citations

0
The Functional Connectome Mediating Circadian Synchrony in the Suprachiasmatic Nucleus DOI Creative Commons
K. L. Nikhil, Bharat Singhal, Daniel Granados‐Fuentes

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 11, 2024

Abstract Circadian rhythms in mammals arise from the spatiotemporal synchronization of ∼20,000 neuronal clocks Suprachiasmatic Nucleus (SCN). While anatomical, molecular, and genetic approaches have revealed diverse cell types signaling mechanisms, network wiring that enables SCN cells to communicate synchronize remains unclear. To overcome challenges revealing functional connectivity fixed tissue, we developed MITE (Mutual Information & Transfer Entropy), an information theory approach infers directed cell-cell connections with high fidelity. By analyzing 3447 hours continuously recorded clock gene expression 9011 17 mice, found connectome was highly conserved bilaterally across sparse, organized into a dorsomedial ventrolateral module. most were local, discovered long-range ventral both dorsal SCN. Based on their connectivity, can be characterized as circadian signal generators, broadcasters, sinks, or bridges. For example, subset VIP neurons acts hubs generate signals critical daily neural network. Simulations experimentally inferred networks recapitulated stereotypical dorsal-to-ventral wave PER2 ability spontaneously synchronize, emergent dynamics are sculpted by connectivity. We conclude provides powerful method infer connectomes, architecture mediates synchrony space time mammalian Highlights MITE, method, accurately among cells. patterns spatially organize two regions function bridges information. One-third serve drive Key features mediate generation maintenance intercellular waves

Language: Английский

Citations

0
Incorporating Physical Activity in a New Two-Oscillator Model of Circadian Activity in Nocturnal and Diurnal Mammals DOI Creative Commons
Anouk W. van Beurden, Johanna H. Meijer, Jos H. T. Rohling

et al.

Journal of Biological Rhythms, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 26, 2024

In both diurnal and nocturnal species, the neurons in suprachiasmatic nucleus (SCN) generate a daily pattern which impulse frequency peaks at midday is lowest during night. This pattern, common to day-active night-active has led long-standing notion that their functional difference relies merely on sign reversal SCN output. However, recent evidence shows response of animal’s physical activity opposite animals. finding suggests presence additional differences circadian system between species. We therefore attempted identify these neuronal network organization using A-B two-oscillator model, comprised Poincaré like oscillators. Based this we infer animals feedback from acts subpopulations do not receive light input; contrast, animals, light-receptive order produce high-amplitude rhythms.

Language: Английский

Citations

0